pro-diazepam has been researched along with diazepam in 12 studies
*Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. [MeSH]
*Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Karlsson, B; Lindgren, B; Millquist, E; Sandberg, M; Sellström, A | 1 |
| Broxup, B; Clement, JG | 1 |
| Baubichon, D; Blanchet, G; Brochier, G; Clarencon, D; Galonnier, M; Lallement, G; Mestries, JC | 1 |
| Blanchet, G; Carlsson Bratt, I; Clair, P; Granelli, I; Wiberg, K | 1 |
| Baubichon, D; Burckhart, MF; Clarençon, D; Galonnier, M; Jourdil, N; Lallement, G; Peoc'h, M; Renault, F | 1 |
| Breton, P; Buée, J; Calvet, JH; Christin, D; Delamanche, S; Taysse, L | 1 |
| Aas, P; Enger, S; Myhrer, T | 1 |
| Bellier, B; Breton, P; Daulon, S; Delamanche, S; Taysse, L | 1 |
| Abbara, C; Bardot, I; Clair, P; Comets, E; Diquet, B; Lallement, G; Rousseau, JM; Turcant, A | 1 |
| Georg, GI; Kapoor, M; Lis, L; Siegel, RA; Winter, T | 1 |
| Cloyd, JC; Rautiola, D; Siegel, RA | 1 |
| Nelson, KM; Rautiola, D; Siegel, RA; Updyke, JL | 1 |
1 trial(s) available for pro-diazepam and diazepam
| Article | Year |
|---|---|
Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers.
Topics: Adolescent; Adult; Area Under Curve; Atropine; Biological Availability; Chromatography, High Pressure Liquid; Cross-Over Studies; Diazepam; Dipeptides; Drug Combinations; Humans; Injections, Intramuscular; Male; Middle Aged; Pralidoxime Compounds; Prodrugs; Solubility; Tandem Mass Spectrometry; Water | 2009 |
11 other study(ies) available for pro-diazepam and diazepam
| Article | Year |
|---|---|
On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig.
Topics: Animals; Antidotes; Chromatography, Gas; Diazepam; Dipeptides; Guinea Pigs; Injections, Intraperitoneal; Lethal Dose 50; Male; Organophosphate Poisoning; Soman | 1990 |
Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats.
Topics: Animals; Brain; Diazepam; Dipeptides; Molecular Structure; Prodrugs; Rats; Rats, Sprague-Dawley; Seizures; Self Administration; Soman; Time Factors | 1993 |
Efficacy of atropine/pralidoxime/diazepam or atropine/HI-6/prodiazepam in primates intoxicated by soman.
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electrocardiography; Electroencephalography; Macaca fascicularis; Male; Oximes; Poisoning; Pralidoxime Compounds; Prodrugs; Pyridinium Compounds; Soman | 1997 |
Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning.
Topics: Antidotes; Atropine; Cholinergic Antagonists; Cholinesterase Reactivators; Chromatography, High Pressure Liquid; Diazepam; Dipeptides; Drug Combinations; Drug Stability; Organophosphate Poisoning; Oximes; Prodrugs; Pyridinium Compounds | 2000 |
Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics.
Topics: Animals; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Therapy, Combination; Electroencephalography; Macaca fascicularis; Male; Pralidoxime Compounds; Soman | 2000 |
Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
Topics: Animals; Anticonvulsants; Atropine; Brain; Chemical Warfare Agents; Cholinesterase Inhibitors; Diazepam; Dipeptides; Drug Interactions; Electroencephalography; Guinea Pigs; Histocytochemistry; Muscarinic Antagonists; Nervous System Diseases; Pralidoxime Compounds; Prodrugs; Pyridostigmine Bromide; Respiratory Insufficiency; Sarin; Seizures | 2003 |
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats.
Topics: Animals; Anticonvulsants; Atropine; Brain; Diazepam; Dipeptides; Drug Combinations; Lethal Dose 50; Male; Oximes; Pentobarbital; Procyclidine; Pyridinium Compounds; Rats; Rats, Wistar; Seizures; Soman | 2006 |
Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig.
Topics: Animals; Anticonvulsants; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Dipeptides; Electroencephalography; Guinea Pigs; Neuroprotective Agents; Neurotoxicity Syndromes; Respiratory Insufficiency; Soman | 2006 |
Rapid delivery of diazepam from supersaturated solutions prepared using prodrug/enzyme mixtures: toward intranasal treatment of seizure emergencies.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Cell Membrane Permeability; Diazepam; Dipeptides; Dogs; Emergency Medical Services; Enzyme Activation; Kinetics; Madin Darby Canine Kidney Cells; Prodrugs; Seizures; Solubility | 2014 |
Conversion of a soluble diazepam prodrug to supersaturated diazepam for rapid intranasal delivery: Kinetics and stability.
Topics: Aspergillus oryzae; Diazepam; Dipeptides; Drug Stability; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Peptide Hydrolases; Phase Transition; Prodrugs; Solubility; Solvents; Temperature; Water | 2018 |
Diazepam Prodrug Stabilizes Human Aminopeptidase B during Lyophilization.
Topics: Aminopeptidases; Biocatalysis; Diazepam; Dipeptides; Drug Stability; Enzyme Stability; Freeze Drying; Freezing; Humans; Mannitol; Prodrugs; Proteolysis; Trehalose | 2020 |