Compounds > primaquine
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primaquine and 2-tert-butylprimaquine

primaquine has been researched along with 2-tert-butylprimaquine in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jain, M; Jain, R; Jena, GB; Kaul, CL; Ramarao, P; Sachdeva, S; Singh, PP; Singh, S; Tikoo, K; Vangapandu, S1
Harada, S; Huy, NT; Jain, M; Jain, R; Kamei, K; Kaur, K; Mizunuma, K; Nhien, NT; Uyen, DT1
Jacob, MR; Jain, M; Jain, R; Kaur, K; Khan, SI; Singh, PP; Singh, S; Tekwani, BL2
Jain, M; Jain, R; Mayatra, SJ; Prasad, B; Singh, S1
Garg, A; Jain, M; Jain, R; Prasad, B; Singh, S; Takwani, H1

Other Studies

6 other study(ies) available for primaquine and 2-tert-butylprimaquine

ArticleYear
Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity.
    Journal of medicinal chemistry, 2004, Jan-15, Volume: 47, Issue:2

    Topics: Animals; Antimalarials; Malaria; Methemoglobin; Mice; Plasmodium berghei; Plasmodium falciparum; Plasmodium yoelii; Primaquine; Structure-Activity Relationship

2004
2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Animals; Antimalarials; Erythrocytes; Hemeproteins; Hemolysis; Humans; Malaria, Falciparum; Parasitic Sensitivity Tests; Plasmodium falciparum; Primaquine

2007
Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines).
    Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1

    Topics: Aminoquinolines; Animals; Anti-Infective Agents; Antiprotozoal Agents; Hemeproteins; Humans; Methemoglobin

2011
Amino acid, dipeptide and pseudodipeptide conjugates of ring-substituted 8-aminoquinolines: synthesis and evaluation of anti-infective, β-haematin inhibition and cytotoxic activities.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Amino Acids; Aminoquinolines; Animals; Anti-Infective Agents; Chemistry Techniques, Synthetic; Chlorocebus aethiops; Dipeptides; Fungi; Hemeproteins; Leishmania donovani; Mice; Peptidomimetics; Plasmodium falciparum; Vero Cells

2012
Development and validation of a sensitive and selective UHPLC-MS/MS method for quantitation of an investigational anti-malarial compound, 2-tert-butylprimaquine (NP-96) in rat plasma, and its application in a preclinical pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 2010, Jul-08, Volume: 52, Issue:3

    Topics: Animals; Antimalarials; Calibration; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Stability; Drugs, Investigational; Freezing; Male; Molecular Structure; Primaquine; Quality Control; Random Allocation; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Temperature; Time Factors

2010
Evidence of the formation of direct covalent adducts of primaquine, 2-tert-butylprimaquine (NP-96) and monohydroxy metabolite of NP-96 with glutathione and N-acetylcysteine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Jan-01, Volume: 879, Issue:1

    Topics: Acetylcysteine; Animals; Chromatography, High Pressure Liquid; Glutathione; Humans; Microsomes, Liver; Primaquine; Rats; Tandem Mass Spectrometry

2011