pretubulysin and propargyl-ether

pretubulysin has been researched along with propargyl-ether* in 1 studies

Other Studies

1 other study(ies) available for pretubulysin and propargyl-ether

Article	Year
Synthesis of pretubulysin-derivatives via the TubUgi-approach. Organic & biomolecular chemistry, 2015, Jun-07, Volume: 13, Issue:21 The Ugi reaction is found to be a very powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction of various functionalized side chains in only one step. While polar groups such as amides are not well tolerated, unpolar side chains such as allyl or propargyl ether are well accepted. These functionalities also allow subsequent modifications in the side chain, e.g. via ring closing metathesis or Click reaction. Topics: Alkynes; Click Chemistry; Cyclization; Ethers; Myxococcales; Oligopeptides	2015

Article

Year

Synthesis of pretubulysin-derivatives via the TubUgi-approach.

Organic & biomolecular chemistry, 2015, Jun-07, Volume: 13, Issue:21

The Ugi reaction is found to be a very powerful tool for the synthesis of (pre)tubulysin derivatives, allowing the introduction of various functionalized side chains in only one step. While polar groups such as amides are not well tolerated, unpolar side chains such as allyl or propargyl ether are well accepted. These functionalities also allow subsequent modifications in the side chain, e.g. via ring closing metathesis or Click reaction.

Topics: Alkynes; Click Chemistry; Cyclization; Ethers; Myxococcales; Oligopeptides

2015