pregnenolone sulfate has been researched along with pregnenolone in 364 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (9.89) | 18.7374 |
| 1990's | 99 (27.20) | 18.2507 |
| 2000's | 126 (34.62) | 29.6817 |
| 2010's | 89 (24.45) | 24.3611 |
| 2020's | 14 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Lyons, CD; Strott, CA | 1 |
| Barnard, EA; Darlison, MG; Harvey, RJ; Shingai, R; Zaman, SH | 1 |
| Miledi, R; Polenzani, L; Woodward, RM | 1 |
| Baulieu, EE; Corpéchot, C; Egestad, B; Morfin, R; Sjövall, J; Young, J | 1 |
| Berrino, L; Leyva, J; Maione, S; Rossi, F; Vitagliano, S | 1 |
| Flood, JF; Morley, JE; Roberts, E | 2 |
| Farb, DH; Gibbs, TT; Wu, FS | 1 |
| Majewska, MD; Vaupel, DB | 1 |
| Garay, RP; Mesangeau, D; Moinet, G; Nazaret, C | 1 |
| Hirato, K; Hondo, T; Saito, H; Suzuki, T; Yanaihara, T | 1 |
| Anundi, I; Kauffman, FC; Thurman, RG; Whittaker, M | 1 |
| Chibbar, R; Mitchell, BF | 1 |
| Mienville, JM; Vicini, S | 1 |
| Abdallah, MA; Baulieu, EE; Jo, DH; Robel, P; Young, J | 1 |
| Belelli, D; Gee, KW; Joy, DS | 1 |
| Baulieu, EE; Bluet-Pajot, MT; Majewska, MD; Robel, P | 1 |
| Johnston, GA; Kerr, DI; Ong, J | 1 |
| Godfrey, BM; Petrucco, OM; Seamark, RF; Stone, BA | 1 |
| de la Torre, B; Hedman, M; Norén, S; Sjöberg, B | 1 |
| Walsh, SW | 1 |
| Kakumoto, Y; Kamiya, T; Kiryu, Y; Maruyama, T; Nakamoto, H; Ookawa, H; Suzuki, O; Yasui, T; Yasumura, K; Yokomori, H | 1 |
| Bisserbe, JC; Eskay, RL; Majewska, MD | 1 |
| Bertrand, J; David, M; de Peretti, E; Forest, MG; François, R; Loras, B; Morel, Y | 1 |
| Majewska, MD; Schwartz, RD | 1 |
| Berthezene, F; Boizel, R; Bost, M; Cathiard, AM; de Peretti, E; Halimi, S; Saez, JM | 1 |
| Majewska, MD; Mienville, JM; Vicini, S | 1 |
| Jenkin, G; McKay, SA; Thorburn, GD | 1 |
| Hashino, M; Komatsuzaki, K; Kosaki, T; Mori, H; Nakayama, T; Yanaihara, T | 1 |
| Challis, JR; Lukash, L; Mitchell, BF | 1 |
| Heap, PA; Seamark, RF; Stone, BA | 1 |
| Phillis, JW | 1 |
| Axelson, M; Baulieu, EE; Corpéchot, C; Robel, P; Sjövall, J; Synguelakis, M; Talha, S; Vihko, R | 1 |
| Deppe, WM; Joubert, SM; Marivate, M; Norman, RJ | 1 |
| Capella-Pavlovsky, M; Castanier, M; Chartier, M; Daffos, F; Forestier, F; Nahoul, K; Scholler, R | 1 |
| Hemsell, PG; Korte, K; Mason, JI | 1 |
| Taylor, NF | 1 |
| de Peretti, E; Mappus, E | 1 |
| Carr, BR; Mason, JI; Parker, CR; Simpson, ER | 1 |
| Carette, B; Poulain, P | 1 |
| Lukkarinen, O; Ruokonen, A; Vihko, R | 1 |
| Hemsell, PG; Mason, JI | 1 |
| Kontturi, M; Leinonen, P; Ruokonen, A; Vihko, R | 1 |
| Goff, AK; Lyons, CD; Strott, CA | 1 |
| Gromadzińska, E; Lachowicz, L; Rebas, E; Zylińska, L | 1 |
| Fernández-Guasti, A; Picazo, O | 1 |
| Bowlby, MR | 1 |
| Fahey, JM; Lindquist, DG; Miller, LG; Pritchard, GA | 1 |
| Itzhak, Y; Norenberg, MD | 1 |
| Baulieu, EE; Mahé, V; Monnet, FP; Robel, P | 1 |
| Roberts, E | 1 |
| Lachowicz, A; Lachowicz, L; Rebas, E | 1 |
| Irwin, RP; Lin, SZ; Paul, SM; Purdy, RH; Rogawski, MA | 1 |
| Moore, FL; Murray, TF; Orchinik, M | 1 |
| Costa, E; Ducić, I; Puia, G; Vicini, S | 1 |
| Danks, P; ffrench-Mullen, JM; Spence, KT | 1 |
| Isaacson, RL; Varner, J; Yoder, PE | 1 |
| Boudou, P; Fiet, J; Soliman, HR; Villette, JM | 1 |
| Santen, RJ; Santner, SJ | 1 |
| Guldner, J; Hemmeter, U; Holsboer, F; Rothe, B; Rupprecht, R; Steiger, A; Trachsel, L; Vedder, H | 1 |
| Baars, JM; De Wied, D; Isaacson, RL; Varner, JA | 1 |
| Bergeron, R; de Montigny, C; Debonnel, G | 2 |
| Chuang, DM; Gao, XM; Hough, CJ; Irwin, RP; Rogawski, MA | 1 |
| Devaud, LL; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Hauser, CA; Holsboer, F; Rupprecht, R; Wetzel, CH | 1 |
| Bohr, I; Gniot-Szulzycka, J | 1 |
| Matsumoto, K; Ojima, K; Watanabe, H | 1 |
| Bãckström, T; Purdy, RH; Seippel, L; Wang, M | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Bondoux, D; Chapouthier, G; Clément, Y; Launay, JM; Martin, B; Robel, P; Venault, P; Young, J | 1 |
| Andrés-Trelles, F; Baamonde, A; Hidalgo, A; Meana, A; Menendez, L; SanMartin, S | 1 |
| Krueger, KE; Vicini, S; Wang, JF; Zhu, WJ | 1 |
| Baulieu, EE; Corpéchot, C; Eychenne, B; Haug, M; Perché, F; Robel, P; Young, J | 1 |
| Büküşoğlu, C; Sarlak, F | 1 |
| Mathis, C; Meziane, H; Paul, SM; Ungerer, A | 1 |
| Maurice, T; Privat, A; Roman, FJ | 1 |
| Givalois, L; Li, S; Pelletier, G | 1 |
| Garcia de Yebenes, E; Li, S; Pelletier, G | 1 |
| Chen, SC; Tsai, JJ; Wu, FS | 1 |
| Bleck, VG; Harris, RA; Mascia, MP | 1 |
| Chen, SC; Wu, FS | 2 |
| Bäckström, T; Wahlström, G; Wang, MD | 2 |
| Bäckström, T; Landgren, S; Wang, MD | 1 |
| Gillies, GE; Murray, HE | 1 |
| Feltz, P; Poisbeau, P; Schlichter, R | 1 |
| Richardson, CM; Wakerley, JB | 3 |
| Matsumoto, K; Nguyen, TT; Watanabe, H; Yamasaki, K | 1 |
| Farb, DH; Gibbs, TT; Malayev, AA; Park-Chung, M; Purdy, RH; Wu, FS | 1 |
| Baulieu, EE; Corpéchot, C; Darnaudéry, M; Koehl, M; Le Moal, M; Mayo, W; Robel, P; Simon, H; Vallée, M; Young, J | 1 |
| Kasparov, S; Kravitz, EA; Rahamimoff, R; Teschemacher, A | 1 |
| Chapell, R; Leidenheimer, NJ | 1 |
| Legutko, B; Zylińska, L | 1 |
| Goldhawk, DE; Hobkirk, R | 1 |
| Horiguchi, J; Kagaya, A; Takebayashi, M; Uchitomi, Y; Yamawaki, S; Yokota, N | 1 |
| Kulkarni, SK; Reddy, DS | 2 |
| Akwa, Y; Baulieu, EE; El-Etr, M; Robel, P | 1 |
| Covey, DF; Nilsson, KR; Zorumski, CF | 1 |
| Matsunaga, T; Miyahara, H; Yamamoto, T; Yamanaka, T | 1 |
| Maurice, T; Privat, A; Urani, A | 1 |
| Farb, DH; Gibbs, TT; Weaver, CE; Wu, FS | 1 |
| Farb, DH; Gibbs, TT; Malayev, A; Russek, SJ; Yaghoubi, N | 1 |
| Cascio, C; De Leo, G; Guarneri, P; Guarneri, R; Piccoli, F; Russo, D | 1 |
| Darnaudéry, M; Day, J; Le Moal, M; Mayo, W; Pallarés, M | 1 |
| Darnaudéry, M; Koehl, M; Le Moal, M; Mayo, W; Pallarés, M | 1 |
| Kaur, G; Kulkarni, SK; Reddy, DS | 1 |
| Chen, PX; Chen, ZH; Feng, JQ; Ren, J; Wu, Q | 1 |
| Wang, L; Wang, Q; Wardwell-Swanson, J | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Fujinami, A; Kobayashi, Y; Tagawa, N; Tsuruta, H | 1 |
| Cascio, C; De Leo, G; Guarneri, P; Guarneri, R; Piccoli, F; Piccoli, T; Russo, D; Sciuto, V | 1 |
| Beaujean, D; Do-Rego, JL; Luu-The, V; Mensah-Nyagan, AG; Pelletier, G; Vaudry, H | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Pang, KS; Tan, E; Tirona, RG | 1 |
| Gromadzińska, E; Lachowicz, L; Zylińska, L | 1 |
| Bouyer, JJ; Darnaudéry, M; Le Moal, M; Mayo, W; Pallarés, M | 2 |
| Kominami, S; Takase, M; Tsutsui, K; Ukena, K; Yamazaki, T | 1 |
| Covey, DF; Mennerick, S; Shen, W; Zorumski, CF; Zorumski, EC | 1 |
| Farb, DH; Gibbs, TT; Malayev, A; Park-Chung, M; Purdy, RH | 1 |
| Juhng, KN; Kirkby, RD; Kokate, TG; Llamas, J; Rogawski, MA; Yamaguchi, S | 1 |
| Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H | 1 |
| Mathis, C; Meziane, H; Ungerer, A | 1 |
| Barrot, M; Gingras, MA; Le Moal, M; Mayo, W; Piazza, PV; Vallée, M | 1 |
| Farr, SA; Flood, JF; Johnson, DA; Li, PK; Morley, JE | 1 |
| Darnaudéry, M; Koehl, M; Le Moal, M; Mayo, W; Piazza, PV | 1 |
| Baulieu, E; Blair-West, J; Denton, D; Eychenne, B; Ladurelle, N; Robel, P; Schumacher, M | 1 |
| Kawato, S; Mukai, H; Uchino, S | 1 |
| Shimizu, Y; Yanaihara, T | 1 |
| Covey, DF; Mennerick, S; Shen, W; Zorumski, CF | 1 |
| Cascio, C; De Leo, G; Guarneri, M; Guarneri, P; Guarneri, R; Piccoli, F; Russo, D | 2 |
| Nabeshima, T; Nakata, Y; Sasa, M; Yamada, K; Zou, LB | 1 |
| Hayashi, T; Maurice, T; Su, TP | 1 |
| Browning, MD; Costa, ET; Ferreira, VM; Frausto, S; Meyer, DA; Olivera, DS; Savage, DD; Soto, EE; Valenzuela, CF | 1 |
| Bicíková, M; Hill, M; Stárka, L; Számel, I; Tallová, J | 1 |
| Christ, M; Falkenstein, E; Feuring, M; Tillmann, HC; Wehling, M | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Hayashi, T; Su, TP | 1 |
| Bicíková, M; Hampl, R; Hill, M; Krausová, Z; Tallová, J | 1 |
| Barbosa, AD; Morato, GS | 4 |
| Partridge, LD; Valenzuela, CF | 2 |
| Ceccon, M; Rumbaugh, G; Vicini, S | 1 |
| Akk, G; Bracamontes, J; Steinbach, JH | 1 |
| Jhangri, GS; Le Mellédo, JM; Semeniuk, T | 1 |
| Amino, N; Fukata, S; Izumi, Y; Kobayashi, Y; Kuma, K; Tada, H; Tagawa, N; Takano, T | 1 |
| Lachowicz, A; Pawlikowski, M; Rebas, E | 1 |
| Bicíková, M; Hill, M; Putz, Z; Tallová, J; Tomandl, J; Vañuga, A | 1 |
| Peeke, HV; Snyder, MJ | 1 |
| Simmonds, MA; Sooksawate, T | 1 |
| Akwa, Y; Baulieu, EE; Covey, DF; Ladurelle, N | 1 |
| Bertram, EH; Kapur, J; Mtchedlishvili, Z | 1 |
| Guillemain, I; Maurice, T; Phan, VL; Urani, A | 1 |
| Le Moal, M; Mayo, W; Vallée, M | 1 |
| Farb, DH; Gibbs, TT; Malayev, A | 1 |
| Hagenbuch, B; Meier, PJ; St-Pierre, MV; Stallmach, T; Ugele, B | 1 |
| Bicíková, M; Calda, P; Hampl, R; Hill, M; Klak, J; Zizka, Z | 1 |
| Benz, A; Covey, DF; Eisenman, LN; Fields, C; Fu, T; He, Y; Mathews, J; Mennerick, S; Steinbach, JH; Wang, M; Zeng, CM; Zorumski, CF; Zorumski, E | 1 |
| Hampl, R; Havlíková, H; Hill, M; Stárka, L | 1 |
| Carta, M; Covey, DF; Meyer, DA; Partridge, LD; Valenzuela, CF | 1 |
| Lachowicz, A; Rebas, E | 1 |
| Fujiwara, M; Furusawa, H; Higashi, S; Maeda, Y; Matsu, T; Nakahara, H; Nanba, K; Setoguchi, T; Tanaka, E; Watanabe, R | 1 |
| Heydari, B; Le Mellédo, JM | 1 |
| Darnaudéry, M; Le Moal, M; Mayo, W; Pallarès, M; Piazza, PV | 1 |
| Akwa, Y; Baulieu, EE; David, JP; Delacourte, A; Eychenne, B; Liere, P; Pianos, A; Sazdovitch, V; Schumacher, M; Weill-Engerer, S | 1 |
| Kashimoto, T; Kudo, K; Tachikawa, E | 1 |
| Hattori, TA; Kawato, S; Kimoto, T; Takahashi, T; Tanabe, N; Yasumatsu, N | 1 |
| Daifu, Y; Higashi, T; Ikeshima, T; Shimada, K; Yagi, T | 1 |
| Altobelli, D; Cannizzaro, C; D'Amico, M; Martire, M; Preziosi, P | 1 |
| Homanics, GE; Huguenard, JR; Huntsman, MM; Mihalek, RM; Porcello, DM | 1 |
| Ortega, E; Torres, JM | 1 |
| Carta, M; Partridge, LD; Savage, DD; Valenzuela, CF | 1 |
| CALVIN, HI; LIEBERMAN, S | 1 |
| KILLINGER, DW; SOLOMON, S | 1 |
| SCHEDEWIE, H; TAMM, J; VOIGT, KD; VOLKWEIN, U | 1 |
| BEGUE, JA | 1 |
| Kapur, J; Mtchedlishvili, Z | 1 |
| Abrous, N; Bouyer, JJ; Darbra, S; Darnaudéry, M; George, O; Le Moal, M; Lemaire-Mayo, V; Mayo, W; Pallarès, M; Piazza, PV; Vallée, M | 1 |
| Kamei, H; Nabeshima, T; Noda, Y; Yamada, K | 1 |
| Kawato, S | 1 |
| Kapur, J; Mtchedlishvili, Z; Williamson, J | 1 |
| Bicíková, M; Budesínský, M; Cerný, I; Hampl, R; Hill, M; Pouzar, V | 1 |
| Bouyer, JJ; Darbra, S; George, O; Le Moal, M; Mayo, W; Piazza, PV | 1 |
| Farb, DH; Jang, MK; Mierke, DF; Russek, SJ | 1 |
| Boyd, SK; Goetz, FW; Hollis, DM; Roberts, SB | 1 |
| Bicíková, M; Hampl, R; Havlíková, H; Hill, M; Jirák, R; Rípová, D; Tallová, J | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Walkowiak, J; Wisłowska, A; Zienowicz, M | 1 |
| Baulieu, EE; Cambourg, A; Eychenne, B; Griffiths, W; Liere, P; Liu, S; Pianos, A; Schumacher, M; Sjövall, J | 1 |
| Hou, YN; Yan, CZ | 1 |
| Monnet, FP; Morin-Surun, MP; Schumacher, M; Sliwinski, A | 1 |
| Chodounska, H; Horak, M; Petrovic, M; Vlcek, K; Vyklicky, L | 1 |
| Abrous, DN; Cayre, M; Kharouby, M; Le Moal, M; Lemaire, V; Malaterre, J; Mayo, W; Piazza, PV; Rodriguez, JJ; Rougon, G; Stewart, MG | 1 |
| Carta, M; Mameli, M; Partridge, LD; Valenzuela, CF | 1 |
| Carta, M; Li, PK; Mameli, M; Partridge, LD; Thomas, MJ; Valenzuela, CF | 1 |
| Dong, Y; Fu, YM; Sun, FY; Sun, JL; Zheng, P; Zhu, YH | 1 |
| Johnston, AN; Migues, PV; Rose, SP | 1 |
| Cerný, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Popov, P; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Akaike, A; Kaneko, S; Katsuki, H; Kume, T; Shirakawa, H | 1 |
| Chen, L; Sokabe, M | 1 |
| Partridge, LD; Schiess, AR | 1 |
| Martín-García, E; Pallarès, M | 5 |
| Shimizu, Y | 2 |
| Frändberg, PA; Johansson, T; Le Grevès, P; Nyberg, F | 1 |
| Chodounska, H; Horak, M; Vlcek, K; Vyklicky, L | 1 |
| George, O; Le Moal, M; Mayo, W; Vallée, M | 1 |
| Mameli, M; Valenzuela, CF | 1 |
| Hou, YN; Wang, N; Wu, HH | 1 |
| Akwa, Y; Baulieu, EE; El-Etr, M; Schumacher, M | 1 |
| Bamber, BA; Jorgensen, EM; Marik, PS; Piper, D; Rutar, T; Wardell, B | 1 |
| Barbosa, AD; Debatin, T | 1 |
| Citraro, R; De Sarro, G; Di Paola, ED; Gratteri, S; Ibbadu, GF; Marra, R; Russo, E | 1 |
| Cerny, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Grube, M; Jedlitschky, G; Karner, S; Köck, K; Kroemer, HK; Reuther, S; Ritter, CA | 1 |
| Partridge, LD; Schiess, AR; Scullin, CS | 1 |
| Bäckström, T; Johansson, IM; Lindblad, C; Rahman, M; Wang, MD | 1 |
| Chen, CW; Chen, SC; Liu, BC; Wu, FS | 1 |
| Farb, DH; Gibbs, TT; Russek, SJ | 1 |
| Fujiyoshi, Y; Hige, T; Takahashi, T | 1 |
| Akk, G; Evers, AS; Li, P; Manion, BD; Steinbach, JH | 1 |
| Gentile, L; Hall, A; Hall, J; Knight, L; Morgan, A; Stoll, L; Van Buren, N; Van Deusen, H; Zuger, S | 1 |
| Bäckström, T; Johansson, IM; Rahman, M; Wang, MD; Zhu, D | 1 |
| Darbra, S; Martin-García, E; Pallarès, M | 2 |
| Birgner, C; Elfverson, M; Frändberg, PA; Johansson, T; Le Grevès, P; Nyberg, F | 1 |
| Hamann, M; Richter, A; Richter, F | 1 |
| Mameli, M; Meyer, DA; Partridge, LD; Valenzuela, CF | 1 |
| Chen, L; Furuya, K; Miyamoto, Y; Mori, N; Sokabe, M | 1 |
| Ahmed, RS; Mahajan, P; Mediratta, PK; Sahaya, K; Sharma, KK | 1 |
| Bamber, BA; Covey, DF; Tartaglia, AL; Twede, V | 1 |
| Gruol, DL; Sabeti, J | 1 |
| Fuda, H; Hanyu, O; Kohjitani, A; Strott, CA | 1 |
| Adinoff, B; Leslie Morrow, A; O'Buckley, TK; Porcu, P | 1 |
| Cheng, ZX; Dong, Y; Dong, YL; Ma, L; Qi, YJ; Wang, ZM; Wu, PY; Zheng, P; Zhu, Y; Zhu, YH | 1 |
| Basta-Kaim, A; Budziszewska, B; Jagla, G; Jantas, D; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Nowak, W; Regulska, M | 1 |
| Bäckström, T; Borra, VB; Isaksson, M; Johansson, IM; Ragagnin, G; Rahman, M; Wang, MD | 1 |
| Elfverson, M; Johansson, T; Le Grevès, P; Linde, AM; Nyberg, F; Zhou, Q | 1 |
| Akk, G; Bracamontes, J; Covey, DF; Li, P; Reichert, DE; Steinbach, JH | 1 |
| Farb, DH; Gibbs, TT; Whittaker, MT | 1 |
| Farb, DH; Gibbs, TT; Janis, GC; Pierce, RC; Sadri-Vakili, G | 1 |
| Akan, P; Fadiloglu, M; Genc, S; Kizildag, S; Oktem, MA; Ormen, M | 1 |
| Düfer, M; Flockerzi, V; Lambert, S; Lis, A; Loch, S; Mannebach, S; Mathar, I; Oberwinkler, J; Philipp, SE; Straub, I; Wagner, TF | 1 |
| Nilius, B; Voets, T | 1 |
| Bäckström, T; Haage, D; Lundgren, P; Strömberg, J; Taube, M; Wang, M | 1 |
| Cais, O; Chodounska, H; Horak, M; Petrovic, M; Sedlacek, M; Vyklicky, L | 1 |
| Hill, M; Meloun, M; Vceláková-Havlíková, H | 1 |
| Bradford, DW; Buchanan, RW; Dunn, L; Hamer, RM; Keefe, RS; Kilts, JD; Leimone, LA; Lieberman, JA; Marx, CE; Morrow, AL; Naylor, JC; Payne, VM; Porcu, P; Savitz, AJ; Shampine, LJ; Strauss, JL | 1 |
| Ikeda, K; Kobayashi, T; Washiyama, K | 1 |
| Baker, C; Bamber, BA; Sturt, BL | 1 |
| Beech, DJ; Beri, D; Harteneck, C; Hou, B; Jiang, S; Jones, C; Kearney, MT; Kumar, B; Li, J; Majeed, Y; McKeown, L; Milligan, CJ; Naylor, J; O'Regan, D; Porter, KE; Sedo, A; Seymour, VA; Sukumar, P; Wheatcroft, SB; Yuldasheva, N; Zeng, F | 1 |
| Anjard, C; Behrens, MM; Loomis, WF; Williams, ME | 1 |
| Beech, DJ; Ciurtin, C; Emery, P; English, AA; Majeed, Y; Naylor, J; Sukumar, P | 1 |
| Dusková, M; Hill, M; Kancheva, R; Kubátová, J; Stárka, L; Vceláková, H; Vrbíková, J; Zárubová, J | 1 |
| Agarwal, AK; Beech, DJ; Fishwick, CW; Jiang, S; Majeed, Y; Muraki, K; Naylor, J; Seymour, VA | 1 |
| Cho, JH; Choi, BJ; Choi, IS; Jang, IS; Lee, KH; Lee, MG; Park, HM | 1 |
| Elfverson, M; Johansson, T; Nyberg, F; Zhou, Q | 1 |
| Darbra, S; Pallarès, M | 1 |
| Akwa, Y; Covey, DF; Krishnan, K; Moricard, Y; Petit, GH; Rondi-Reig, L; Tobin, C | 1 |
| Agarwal, AK; Amer, MS; Beech, DJ; Fishwick, CW; Majeed, Y; McKeown, L; Muraki, K; Naylor, J; O'Regan, DJ; Porter, KE | 1 |
| Valenzuela, CF; Zamudio-Bulcock, PA | 1 |
| Elfverson, M; Johansson, T; Le Grevès, P; Nyberg, F; Zhou, Q | 1 |
| Beaumont, M; Maccaferri, G | 1 |
| Chisari, M; Mennerick, S; Wu, K; Zorumski, CF | 1 |
| Darbra, S; Mòdol, L; Pallarès, M | 2 |
| Benoit, M; Chen, X; Gudermann, T; Hofmann, T; Janssens, A; Kerselaers, S; Nilius, B; Oberwinkler, J; Owsianik, G; Philipp, SE; Stab, J; Vennekens, R; Voets, T; Vriens, J; Xue, F | 1 |
| Farb, DH; Gibbs, TT; Jang, MK; Kostakis, E; Russek, SJ | 1 |
| Müller, I; Rössler, OG; Thiel, G | 1 |
| Everett, J; Harteneck, C; Valenzuela, CF; Zamudio-Bulcock, PA | 1 |
| Agarwal, AK; Beech, DJ; Fishwick, CW; Green, BL; Jiang, S; Majeed, Y; Muraki, K; Naylor, J; O'Regan, DJ; Picton, HM; Porter, KE; Seymour, VA; Tumova, S; Woods, DM | 1 |
| Chang, F; Chen, L; Sokabe, M; Xie, G; Xu, B; Yang, R | 1 |
| Cheng, F; Meng, B; Song, W; Sun, X; Yang, B; Yuan, H | 1 |
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| Bakhaus, K; Bergmann, M; Brehm, R; Fietz, D; Geyer, J; Grosser, G; Günther, S; Petzinger, E; Schweigmann, H; Ugele, B | 1 |
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| Farb, DH; Gibbs, TT; Jang, MK; Kostakis, E; Martin, SC; Richards, KG; Russek, SJ; Smith, C | 1 |
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| Brancato, A; Cannizzaro, C; Cannizzaro, E; Marino, RA; Plescia, F | 1 |
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| Bernhardt, R; Geyer, J; Hartmann, MF; Mosa, A; Neunzig, J; Sánchez-Guijo, A; Wudy, SA | 1 |
| Farb, DH; Gibbs, TT; Martin, SC; Russek, SJ; Smith, CC; Sugunan, K | 1 |
| Doherty, JJ; Eisenman, LN; Emnett, CM; Mennerick, S; Mohan, J; Paul, SM; Taylor, AA; Zorumski, CF | 1 |
| Hui, X; Lesch, A; Lipp, P; Thiel, G | 1 |
| Dury, AY; Gonthier, R; Isabelle, M; Ke, Y; Labrie, F; Simard, JN | 1 |
| Chang, I; Park, WS; Shin, DM; Son, GY; Yang, YM | 1 |
| Brown, RL; Duvoisin, RM; Morgans, CW; Peters, JH; Reed, BT; Strycharska-Orczyk, I; Tekmen-Clark, M; Xiong, WH | 1 |
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| Chang, CC; Lee, J; Sze, Y; Wong, P; Zhang, X | 1 |
| Ghosh, D; Halaszovich, CR; Konrad, M; Leitner, MG; Mohr, F; Oberwinkler, J; Tóth, BI; Voets, T; Vriens, J | 1 |
| Chopra, DA; Dravid, SM; Monaghan, DT | 1 |
| Dastgheib, M; Dehpour, AR; Heidari, M; Moezi, L | 1 |
| Asuthkar, S; Cohen, A; Demirkhanyan, L; Tominaga, M; Uchida, K; Zakharian, E | 1 |
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| Beitz, AJ; Choi, HS; Choi, SR; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
| Colasanti, M; Del Grosso, F; Fini, M; Lauro, F; Malafoglia, V; Mollace, V; Muscoli, C; Persichini, T; Raffaeli, W; Russo, V; Salvemini, D; Scalici, M; Traversetti, L | 1 |
| Akan, P; Calan, OG; Cataler, A; Dogan, C; Kocturk, S | 1 |
| Caley, A; Gielen, MC; Harvey, RJ; Smart, TG; Wilkins, ME | 1 |
| Rubil, S; Thiel, G | 1 |
| An, BS; Hong, SH; Kang, EJ; Kim, SC; Lee, JE; Lee, SM; Yang, HS; Yi, PI | 1 |
| Bernhardt, R; Gerber, A; Hartmann, MF; Neunzig, J; Oji, V; Sánchez-Guijo, A; Schuppe, HC; Traupe, H; Wudy, SA | 1 |
| Huettner, JE; Lopez, MN; Wilding, TJ | 1 |
| Auchus, RJ; Karashima, S; Kasa-Vubu, JZ; Lerario, AM; Nakamura, Y; Rainey, WE; Rege, J; Sasano, H; Smith, JM; White, PC | 1 |
| Lesch, A; Rössler, OG; Thiel, G | 1 |
| Bertini, ES; Biagini, G; Cusmai, R; Gecz, J; Giannone, G; Lucchi, C; Rustichelli, C; Specchio, N; Terracciano, A; Trivisano, M; Ubertini, GM; Vigevano, F | 1 |
| Auchus, RJ; Avila, NA; Elman, MS; Mallappa, A; Marko, J; Merke, DP; Rao, H; Tsodikov, A; Turcu, AF | 1 |
| Lishko, PV; Mannowetz, N; Miller, MR | 1 |
| Bernhardt, R; Neunzig, J | 1 |
| Badheka, D; Borbiro, I; Hartle, CM; Mirshahi, T; Rohacs, T; Yazici, A; Yudin, Y | 1 |
| Bernhardt, R; Hartmann, MF; Klymiuk, MC; Neunzig, J; Sánchez-Guijo, A; Schuler, G; Wudy, SA | 1 |
| Auchus, RJ; Nanba, AT; Peng, HM; Rainey, WE; Rege, J; Ren, J; Turcu, AF | 1 |
| Meltzer, HY; Rajagopal, L; Soni, D | 1 |
| Kalmbach, N; Klietz, M; Leffler, A; Schwarz, SC; Staege, S; Stanslowsky, N; Tharmarasa, S; Wegner, F | 1 |
| Fujiki, J; Ieko, T; Inoue, H; Iwano, H; Iwasaki, T; Maeda, N; Sato, M; Yokota, H | 1 |
| Hartmann, MF; Sánchez-Guijo, A; Tiosano, D; Wang, R; Wudy, SA | 1 |
| Balinas, C; Cabanas, H; Eaton, N; Marshall-Gradisnik, S; Muraki, K; Staines, D | 1 |
| Alfaidy, N; Berkane, N; Cambourg, A; Chabbert-Buffet, N; Galichon, P; Hertig, A; Lefevre, G; Liere, P; Nahed, RA; Oudinet, JP; Pianos, A; Rousseau, A; Rozenberg, P; Schumacher, M; Simon, T; Vincent, J | 1 |
| Burnell, ES; Dore, K; Fang, G; Irvine, M; Jane, DE; Malinow, R; Monaghan, DT; Sapkota, K; Tang, K | 1 |
| Dixon, BP; Kleene, NK; Kleene, SJ; Landero-Figueroa, JA; Lu, L; Pachciarz, NW; Siroky, BJ | 1 |
| Chaudhari, K; Hersh, J; Liu, R; Prah, J; Winters, A; Yang, SH | 1 |
| Brannigan, G; Klein, EA; Martin, JV; Moffett, SX | 1 |
| Rohacs, T; Yudin, Y; Zhao, S | 1 |
| Fujiki, J; Ieko, T; Iwano, H; Kawamura, Y; Maeda, N; Mukai, K; Sato, M; Sugiyama, K; Yokota, H | 1 |
| Balik, A; Cerny, J; Chodounska, H; Hrcka Krausova, B; Korinek, M; Kudova, E; Kysilov, B; Ladislav, M; Smejkalova, T; Vyklicky, L; Vyklicky, V | 1 |
| Liu, D; Tang, W; Traynelis, SF; Yuan, H | 1 |
| Akk, G; Evers, AS; Germann, AL; Pierce, SR; Steinbach, JH; Sugasawa, Y | 1 |
| Arnold, RA; Fenwick, AJ; Lindberg, JEM; Peters, JH; Peterson, B; Ragozzino, FJ; Riley, TP | 1 |
| Chen, Z; Guo, L; Jin, XD; Li, Y; Liu, J; Shi, B; Wang, S; Xu, Y; Zhang, X; Zhao, M | 1 |
| Baraldi, C; Bellei, E; Bergamini, S; Ferrari, A; Lo Castro, F; Monari, E; Rustichelli, C; Tomasi, A | 1 |
| Rohacs, T; Zhao, S | 1 |
| Chodounska, H; Chvojkova, M; Holubova, K; Hrcka Krausova, B; Kudova, E; Vales, K; Vyklicky, L; Vyklicky, V | 1 |
| Akk, G; Germann, AL; Pierce, SR; Steinbach, JH | 1 |
| Everaerts, W; Kerstens, A; Mulier, M; Nogueira Freitas, AC; Van Ranst, N; Vanneste, M; Voets, T | 1 |
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| Ernst, M; Frølund, B; Krall, J; Mortensen, M; Shehata, MA; Smart, TG; Xu, Y | 1 |
19 review(s) available for pregnenolone sulfate and pregnenolone
| Article | Year |
|---|---|
[2 surgically treated cases of adrenocortical carcinoma producing steroid hormones without endocrinological symptoms--case report and a review of cases in the Japanese literature].
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adult; Carcinoma; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Etiocholanolone; Humans; Male; Pregnenolone | 1988 |
Review: placental sulphatase deficiency.
Topics: Acid Anhydride Hydrolases; Copper; Estrogens; Female; Fetus; Fibroblasts; Gestational Age; Humans; Hydrocortisone; Ichthyosis; Lipid Metabolism, Inborn Errors; Male; Obstetric Labor Complications; Phosphoric Monoester Hydrolases; Placenta; Pregnancy; Pregnancy Complications; Pregnancy, Prolonged; Pregnenolone; Prenatal Diagnosis; Prolactin; Transcortin; X Chromosome | 1982 |
Pregneolone--from Selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABAA receptor.
Topics: Adult; Aged; Animals; Binding Sites; Female; Humans; Male; Models, Molecular; Pregnenolone; Protein Structure, Secondary; Receptors, GABA-A | 1995 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Male; Menstruation; Pregnancy; Pregnanolone; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1995 |
[Steroid modulation of GABA(A) receptors].
Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; GABA Modulators; Lipid Metabolism; Pregnenolone; Proteins; Receptors, GABA-A; Steroids | 1995 |
[Models for the study of memory and neurosteroids].
Topics: Amnesia; Animals; Brain; Dehydroepiandrosterone Sulfate; Hippocampus; Humans; Learning; Memory; Mice; Models, Neurological; Models, Psychological; Pregnenolone; Rats | 1999 |
[Pregnenolone, pregnenolone sulfate].
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Pregnenolone | 1999 |
Multiple actions of steroid hormones--a focus on rapid, nongenomic effects.
Topics: Animals; Cholecalciferol; Glucocorticoids; Gonadal Steroid Hormones; Humans; Mineralocorticoids; Pregnenolone; Receptors, Steroid; Response Elements; Steroids; Triiodothyronine | 2000 |
Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging.
Topics: Aging; Animals; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hippocampus; Humans; Learning; Memory; Pregnenolone; Rats; Reproducibility of Results | 2001 |
Individual differences in cognitive aging: implication of pregnenolone sulfate.
Topics: Acetylcholine; Aging; Animals; Brain; Cognition; Humans; Neuronal Plasticity; Pregnenolone; Sleep | 2003 |
[Effects of sigma receptor ligands on psychiatric disorders].
Topics: Animals; Dehydroepiandrosterone; Disease Models, Animal; Humans; Learning Disabilities; Ligands; Memory Disorders; Mental Disorders; Pregnenolone; Progesterone; Receptors, sigma; Sigma-1 Receptor; Stress, Psychological; Substance-Related Disorders | 2003 |
[Neurosteroids are 4th generation neuromessengers which are synthesized and enhance/suppress learning and memory in the brain].
Topics: Animals; Cytochrome P-450 Enzyme System; Estradiol; Hippocampus; Humans; Learning; Long-Term Potentiation; Memory; Pregnenolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Testosterone | 2003 |
[Pregnenolone, pregnenolone sulfate].
Topics: Adrenal Hyperplasia, Congenital; Biomarkers; Chromatography, High Pressure Liquid; Disorders of Sex Development; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Pregnancy; Pregnenolone; Radioimmunoassay | 2005 |
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.
Topics: Acetylcholine; Aging; Animals; Brain Stem; Dehydroepiandrosterone Sulfate; Humans; Memory; Memory Disorders; Pregnanolone; Pregnenolone; Prosencephalon; Sleep; Sleep Wake Disorders | 2006 |
Sulfated steroids as endogenous neuromodulators.
Topics: Animals; Brain Chemistry; Dehydroepiandrosterone Sulfate; Humans; Models, Molecular; Neurotransmitter Agents; Pregnenolone; Receptors, Glutamate; Receptors, Neurotransmitter; Steroids; Sulfatases; Sulfates; Sulfotransferases | 2006 |
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder.
Topics: Animals; Brain; Dehydroepiandrosterone Sulfate; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Glutamine; Humans; Neurons; Pregnancy; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Steroids; Synaptic Transmission | 2008 |
Pregnenolone sulfate: from steroid metabolite to TRP channel ligand.
Topics: Animals; Humans; Ligands; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transient Receptor Potential Channels | 2013 |
Nongenomic actions of neurosteroid pregnenolone and its metabolites.
Topics: 17-alpha-Hydroxypregnenolone; Animals; Depression; Humans; Microtubules; Neurodegenerative Diseases; Neurotransmitter Agents; Pregnanolone; Pregnenolone | 2016 |
Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases.
Topics: Animals; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone Sulfate; Hormones; Humans; Pregnenolone; Steroid Hydroxylases; Steroids | 2018 |
2 trial(s) available for pregnenolone sulfate and pregnenolone
| Article | Year |
|---|---|
Secretion of steroid sulfates from human testis and their response to a single intramuscular injection of 5000 IU hCG.
Topics: Adult; Aged; Androstenediol; Androstenediols; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Kinetics; Male; Middle Aged; Pregnenolone; Testis; Testosterone; Veins | 1981 |
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Topics: Adult; Aged; Brain; Brain Chemistry; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Placebos; Pregnanolone; Pregnenolone; Schizophrenia; Treatment Outcome; Up-Regulation | 2009 |
343 other study(ies) available for pregnenolone sulfate and pregnenolone
| Article | Year |
|---|---|
Pregnenolone sulfate binding in the guinea pig adrenal cortex: comparison with pregnenolone binding.
Topics: Adrenal Cortex; Animals; Binding, Competitive; Cytosol; Guinea Pigs; Kinetics; Pregnenolone; Receptors, Cell Surface | 1978 |
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.
Topics: Animals; Base Sequence; DNA; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Molecular Sequence Data; Oocytes; Polymerase Chain Reaction; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1992 |
Effects of steroids on gamma-aminobutyric acid receptors expressed in Xenopus oocytes by poly(A)+ RNA from mammalian brain and retina.
Topics: Animals; Bicuculline; Brain; Cattle; Cerebral Cortex; gamma-Aminobutyric Acid; Membrane Potentials; Oocytes; Poly A; Pregnenolone; Rats; Receptors, GABA-A; Retina; RNA; Steroids; Transfection; Xenopus | 1992 |
Neurosteroids: pregnenolone in human sciatic nerves.
Topics: Adult; Aged; Aged, 80 and over; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Esters; Female; Humans; Male; Mass Spectrometry; Middle Aged; Pregnenolone; Radioimmunoassay; Sciatic Nerve | 1992 |
Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.
Topics: Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Male; Memory; Mice; Pregnenolone; Steroids; Testosterone | 1992 |
Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Chick Embryo; N-Methylaspartate; Pregnenolone; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1991 |
Steroid control of uterine motility via gamma-aminobutyric acidA receptors in the rabbit: a novel mechanism?
Topics: Animals; Female; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Progesterone; Progestins; Rabbits; Receptors, GABA-A; Stimulation, Chemical; Uterine Contraction | 1991 |
The neurosteroid pregnenolone sulfate inhibits membrane anion transport and has natriuretic activity.
Topics: Animals; Carrier Proteins; Chloride-Bicarbonate Antiporters; Erythrocyte Membrane; Ion Pumps; Natriuresis; Pregnenolone; Rats; Sodium Chloride Symporters; Sodium-Potassium-Chloride Symporters; Symporters | 1991 |
Steroid sulfatase activities in human leukocytes: biochemical and clinical aspects.
Topics: Arylsulfatases; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estrone; Female; Humans; Ichthyosis Vulgaris; Ichthyosis, X-Linked; Leukocytes; Male; Placenta; Pregnenolone; Steryl-Sulfatase; Tritium | 1991 |
Futile cycling of a sulfate conjugate by isolated hepatocytes.
Topics: Animals; Arylsulfatases; Biological Transport; Cell-Free System; Glucuronates; Hymecromone; In Vitro Techniques; Liver; Microsomes, Liver; Pregnenolone; Rats; Rats, Inbred Strains; Sulfates; Sulfotransferases | 1991 |
Steroid sulfohydrolase in human chorion and decidua: studies using pregnenolone sulfate and dehydroepiandrosterone sulfate as substrate.
Topics: Arylsulfatases; Chorion; Culture Techniques; Decidua; Dehydroepiandrosterone; Estrogens; Estrone; Female; Humans; Hydrogen-Ion Concentration; Hydrolysis; Labor, Obstetric; Microsomes; Pregnancy; Pregnenolone; Progesterone; Steryl-Sulfatase; Sulfatases; Temperature | 1990 |
Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Chloride Channels; Chlorides; Ion Channels; Membrane Potentials; Membrane Proteins; Pentobarbital; Picrotoxin; Pregnenolone; Rats; Receptors, GABA-A | 1989 |
Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain.
Topics: Animals; Brain Chemistry; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Esters; Estrus; Fatty Acids; Female; Male; Orchiectomy; Pregnenolone; Radioimmunoassay; Rats; Rats, Inbred Strains | 1989 |
Complex interactions between pregnenolone sulfate and the t-butylbicyclophosphorothionate-labeled chloride ionophore in rat brain.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cerebral Cortex; Chloride Channels; Chlorides; Drug Interactions; Ionophores; Kinetics; Male; Membrane Proteins; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Pregnenolone sulfate antagonizes barbiturate-induced hypnosis.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Hypnosis, Anesthetic; Injections, Intraperitoneal; Injections, Intraventricular; Male; Pentobarbital; Pregnenolone; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1989 |
Pregnenolone and its sulphate modulate GABAA-receptor-mediated contractile responses in the guinea-pig isolated ileum.
Topics: Animals; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Pregnenolone; Receptors, GABA-A | 1987 |
Concentrations of steroid hormones, and of prolactin, in washings of the human uterus during the menstrual cycle.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Gonadal Steroid Hormones; Humans; Menstrual Cycle; Pregnenolone; Prolactin; Proteins; Uterus | 1986 |
Blood and tissue steroid levels and their interrelationship in men with pathological conditions of the reproductive organs.
Topics: Adult; Aged; Aged, 80 and over; Arteries; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Epididymis; Genital Diseases, Male; Humans; Male; Middle Aged; Pregnenolone; Steroids; Testis; Testosterone; Vas Deferens; Veins | 1986 |
Progesterone and estradiol production by normal and preeclamptic placentas.
Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Humans; In Vitro Techniques; Placenta; Pre-Eclampsia; Pregnancy; Pregnenolone; Progesterone | 1988 |
Glucocorticoids are modulators of GABAA receptors in brain.
Topics: Adrenalectomy; Animals; Brain; Corticosterone; Dexamethasone; Glucocorticoids; Muscimol; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1985 |
Usefulness of plasma pregnenolone sulfate in testing pituitary-adrenal function in children.
Topics: Adolescent; Adrenal Gland Diseases; Adrenal Insufficiency; Adrenocorticotropic Hormone; Aging; Child; Child, Preschool; Cortodoxone; Dexamethasone; Female; Humans; Hydrocortisone; Infant; Metyrapone; Pituitary Diseases; Pregnenolone | 1986 |
Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain?
Topics: Adrenal Glands; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Male; Muscimol; Picrotoxin; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical | 1987 |
Pattern of plasma levels of cortisol, dehydroepiandrosterone and pregnenolone sulphate in normal subjects and in patients with homozygous familial hypercholesterolaemia during ACTH infusion.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Hyperlipoproteinemia Type II; Male; Pregnenolone | 1986 |
Neurosteroid pregnenolone sulfate antagonizes electrophysiological responses to GABA in neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Bicuculline; Cells, Cultured; Cerebral Cortex; Flumazenil; gamma-Aminobutyric Acid; Pentobarbital; Pregnenolone; Rats; Steroids | 1988 |
Peripheral plasma concentrations of pregnenolone sulphate, pregnenolone, progesterone and 20 alpha-hydroxy-4-pregnen-3-one in ewes throughout the oestrous cycle.
Topics: 20-alpha-Dihydroprogesterone; Animals; Dexamethasone; Estrus; Female; Ovariectomy; Pregnenolone; Progesterone; Sheep | 1987 |
[Metabolism of pregnenolone sulfate in feto-placental unit].
Topics: Female; Fetus; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy Trimester, Third; Pregnenolone | 1987 |
Progesterone synthesis by human amnion, chorion, and decidua at term.
Topics: 20-alpha-Dihydroprogesterone; Amnion; Cesarean Section; Chorion; Decidua; Female; Humans; In Vitro Techniques; Labor, Obstetric; Pregnancy; Pregnenolone; Progesterone | 1987 |
Changes in peripheral progestagen levels in early pregnant gilts following injection of human chorionic gonadotrophin.
Topics: Animals; Chorionic Gonadotropin; Female; Half-Life; Pregnancy; Pregnancy, Animal; Pregnenolone; Progesterone; Swine | 1987 |
Potentiation of the depression by adenosine of rat cerebral cortical neurones by progestational agents.
Topics: Adenosine; Animals; Cerebral Cortex; Cyproterone; Depression, Chemical; Drug Synergism; Male; Neurons; Norethindrone; Pregnenolone; Progesterone; Progestins; Rats; Rats, Inbred Strains | 1986 |
Pregnenolone and its sulfate ester in the rat brain.
Topics: Animals; Brain; Brain Chemistry; Dehydroepiandrosterone; Kinetics; Male; Pregnenolone; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium | 1983 |
Umbilical artery concentrations of androstenedione increased in early labour in the leading twin fetus.
Topics: Androstenedione; Cesarean Section; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Fetal Blood; Humans; Labor Stage, First; Labor Stage, Second; Labor, Obstetric; Pregnancy; Pregnenolone; Progesterone; Twins | 1984 |
[Fetal hormonology by direct sampling of fetal blood during the 2d trimester of pregnancy. Study of fetal and maternal 5-ene steroid sulfates].
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Blood Specimen Collection; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Fetal Blood; Humans; Male; Pregnancy; Pregnancy Trimester, Second; Pregnenolone; Prenatal Diagnosis | 1984 |
Steroidogenesis in dispersed cells of human fetal adrenal.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Cyanoketone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Pituitary Hormones; Pregnenolone; Steroid 17-alpha-Hydroxylase; Tetrahydronaphthalenes | 1983 |
Pattern of plasma pregnenolone sulfate levels in humans from birth to adulthood.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aging; Child; Child, Preschool; Chorionic Gonadotropin; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Female; Fetal Blood; Humans; Infant; Infant, Newborn; Male; Metyrapone; Middle Aged; Pregnenolone | 1983 |
Effect of prostaglandins on steroid secretion by human fetal adrenal tissue.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Estradiol; Female; Fetus; Humans; Hydrocortisone; In Vitro Techniques; Pregnancy; Pregnenolone; Prostaglandins E; Prostaglandins F; Radioimmunoassay | 1983 |
Excitatory effect of dehydroepiandrosterone, its sulphate ester and pregnenolone sulphate, applied by iontophoresis and pressure, on single neurones in the septo-preoptic area of the guinea pig.
Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Guinea Pigs; Membrane Potentials; Neurons; Pregnenolone; Preoptic Area; Septum Pellucidum; Synaptic Transmission | 1984 |
Cholesterol sulfate metabolism in human fetal adrenal mitochondria.
Topics: Adolescent; Adrenal Glands; Adult; Aging; Calcium; Cholesterol; Cholesterol Esters; Female; Fetus; Humans; Hydroxycholesterols; Infant; Male; Mitochondria; Pregnancy; Pregnenolone | 1982 |
Effects of estrogen treatment on human testicular unconjugated steroid and steroid sulfate production in vivo.
Topics: Adult; Aged; Androgens; Antineoplastic Agents; Diethylstilbestrol; Estradiol; Estradiol Congeners; Humans; Male; Middle Aged; Organophosphorus Compounds; Pregnenolone; Progesterone; Prostatic Neoplasms; Steroids; Sulfuric Acids; Testis | 1981 |
Functional differences between the outer and inner zones of the guinea pig adrenal cortex.
Topics: Adrenal Cortex; Animals; Cytosol; Guinea Pigs; Hydrocortisone; Male; Pregnenolone; Tritium | 1981 |
Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive.
Topics: Amygdala; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Limbic System; Male; Maze Learning; Mice; Pregnenolone; Retention, Psychology | 1995 |
Neuroactive steroids modulate in vivo the Mg2+/Ca(2+)-ATPase activity in rat cortical and cerebellar synaptosomal membranes.
Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calmodulin; Cell Membrane; Cerebellum; Cerebral Cortex; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Pregnenolone; Rats; Rats, Wistar; Reference Values; Synaptosomes | 1995 |
Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Dose-Response Relationship, Drug; Female; Motor Activity; Oxidation-Reduction; Pregnenolone; Progesterone; Rats; Rats, Wistar; Reaction Time | 1995 |
Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Fura-2; Glycine; N-Methylaspartate; Nimodipine; Pregnenolone; Spermine | 1995 |
Attenuation of ammonia toxicity in mice by PK 11195 and pregnenolone sulfate.
Topics: Ammonia; Animals; Clonazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Isoquinolines; Male; Mice; Pregnenolone | 1994 |
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Guanidines; Haloperidol; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ovariectomy; Pertussis Toxin; Piperazines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereotaxic Techniques; Virulence Factors, Bordetella | 1995 |
Estradiol and pregnenolone sulfate could modulate PMA-stimulated and Ca2+/calmodulin-dependent synaptosomal membrane protein phosphorylation from rat brain in vivo.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Estradiol; Female; Hippocampus; Membrane Proteins; Phosphorylation; Pregnenolone; Protein Kinase C; Rats; Rats, Wistar; Synapsins; Synaptosomes; Tetradecanoylphorbol Acetate | 1995 |
Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: structure-activity studies.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Hippocampus; N-Methylaspartate; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
Steroid modulation of GABAA receptors in an amphibian brain.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Convulsants; Corticosterone; Flunitrazepam; Kinetics; Male; Mammals; Neurons; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Salamandridae; Species Specificity; Steroids; Sulfur Radioisotopes; Synaptosomes; Tritium | 1994 |
Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?
Topics: Allosteric Regulation; Animals; Cell Line; Cells, Cultured; Cerebral Cortex; Chlorides; Electrophysiology; Humans; Pregnanolone; Pregnenolone; Protein Conformation; Rats; Receptors, GABA-A; Recombinant Proteins | 1993 |
Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Ventricles; Corticosterone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guinea Pigs; Hippocampus; In Vitro Techniques; Infusions, Parenteral; Kinetics; Neurons; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Pregnenolone; Pyramidal Cells; Thionucleotides; Virulence Factors, Bordetella | 1994 |
The effects of pregnenolone on acquisition and retention of a food search task.
Topics: Animals; Appetitive Behavior; Hypothalamo-Hypophyseal System; Male; Motivation; Orientation; Pituitary-Adrenal System; Pregnenolone; Rats; Retention, Psychology; Reversal Learning | 1994 |
Enzyme-catalyzed synthesis of radiolabeled 5-pregnen-3 beta-ol-20-one sulfate.
Topics: Animals; Isotope Labeling; Liver; Pregnenolone; Rats; Sulfotransferases; Tritium | 1993 |
Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens.
Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Binding, Competitive; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Kinetics; Mammary Neoplasms, Experimental; Polyunsaturated Alkamides; Pregnenolone; Rats; Rats, Sprague-Dawley; Sulfatases; Tamoxifen | 1993 |
Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation.
Topics: Adult; Androstanols; Electroencephalography; Growth Hormone; Humans; Hydrocortisone; Male; Pregnenolone; Receptors, GABA-A; Sleep | 1993 |
The effects of pregnenolone sulfate and ethylestrenol on retention of a passive avoidance task.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Ethylestrenol; Male; Pregnenolone; Rats; Rats, Wistar; Reaction Time; Retention, Psychology | 1995 |
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.
Topics: Animals; Anisoles; Dehydroepiandrosterone; Drug Synergism; Female; Guanidines; Haloperidol; Hippocampus; Iontophoresis; Ligands; Male; N-Methylaspartate; Pertussis Toxin; Pregnenolone; Progesterone; Propylamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Spiperone; Virulence Factors, Bordetella | 1996 |
Carbamazepine inhibition of N-methyl-D-aspartate-evoked calcium influx in rat cerebellar granule cells.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Cerebellum; Cytoplasmic Granules; Drug Synergism; Glycine; Intracellular Fluid; N-Methylaspartate; Potassium Chloride; Pregnenolone; Rats | 1996 |
Sex steroids and memory.
Topics: Animals; Clinical Trials as Topic; GABA Modulators; Gonadal Steroid Hormones; Humans; Memory; Pregnanolone; Pregnenolone; Progesterone; Steroids | 1995 |
Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.
Topics: Animals; Anti-Anxiety Agents; Cell Line; Cell Membrane; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypothalamus; Kinetics; Membrane Potentials; Molecular Sequence Data; Muscimol; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1996 |
Neurosteroidal modulation of social isolation-induced decrease in pentobarbital sleep in mice.
Topics: Adrenalectomy; Allosteric Regulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Brain; Corticotropin-Releasing Hormone; Desoxycorticosterone; GABA-A Receptor Antagonists; Male; Methoxamine; Mice; Mice, Inbred Strains; Pentobarbital; Pregnenolone; Receptors, GABA-A; Sleep; Social Behavior; Social Isolation; Stress, Psychological; Yohimbine | 1996 |
Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one.
Topics: 5-alpha-Dihydroprogesterone; Adult; Female; Hormones; Humans; Luteal Phase; Menstrual Cycle; Osmolar Concentration; Pregnanediones; Pregnanolone; Pregnenolone; Premenstrual Syndrome | 1996 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures.
Topics: Animals; Brain Chemistry; Carbolines; Convulsants; Drug Resistance; Evaluation Studies as Topic; Female; Male; Mice; Mice, Mutant Strains; Pentylenetetrazole; Pregnanolone; Pregnenolone; Radioligand Assay; Receptors, GABA-A; Seizures | 1996 |
Interaction among alfaxalone, pregnenolone sulfate, and two GABAA agonists on hippocampal slices.
Topics: Allosteric Regulation; Animals; Evoked Potentials; GABA Agonists; GABA-A Receptor Agonists; Hippocampus; Male; Mice; Muscimol; Pregnanediones; Pregnenolone; Taurine | 1996 |
Delta subunit inhibits neurosteroid modulation of GABAA receptors.
Topics: Allosteric Regulation; Anesthetics; Animals; Cells, Cultured; Cerebellum; Chlorides; Desoxycorticosterone; DNA, Complementary; GABA-A Receptor Agonists; Gene Expression Regulation, Developmental; Ion Channel Gating; Membrane Potentials; Neurons; Patch-Clamp Techniques; Polymerase Chain Reaction; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1996 |
Neurosteroids in the mouse brain: behavioral and pharmacological effects of a 3 beta-hydroxysteroid dehydrogenase inhibitor.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Brain; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Female; Humans; Mice; Pregnanolone; Pregnenolone; Progesterone; Sexual Behavior, Animal | 1996 |
Pregnenolone sulfate increases intracellular Ca2+ levels in a pituitary cell line.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Dose-Response Relationship, Drug; Pituitary Gland; Pregnenolone; Rats | 1996 |
The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Eating; Injections, Intraventricular; Learning; Male; Memory; Mice; Pregnenolone; Scopolamine | 1996 |
Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors.
Topics: Acetylcholine; Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Drug Synergism; Female; Hippocampus; Male; N-Methylaspartate; Ovariectomy; Pregnenolone; Progesterone; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stimulation, Chemical; Testosterone | 1996 |
Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to sigma 1 receptors in the mouse forebrain.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Cerebral Cortex; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Gonadal Steroid Hormones; Hippocampus; Male; Mice; Phenazocine; Pregnancy; Pregnenolone; Progesterone; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium | 1996 |
Involvement of neurosteroids in the effect of the endogenous benzodiazepine receptor ligand octadecaneuropeptide (ODN) on gonadotropin-releasing hormone gene expression in rat brain.
Topics: 3-Hydroxysteroid Dehydrogenases; 5-alpha Reductase Inhibitors; Adrenalectomy; Animals; Diazepam Binding Inhibitor; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; Gene Expression; Gonadotropin-Releasing Hormone; Male; Neuropeptides; Orchiectomy; Peptide Fragments; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley | 1997 |
Regulation of proopiomelanocortin gene expression by endogenous ligands of the GABAA receptor complex as evaluated by in situ hybridization in the rat pars intermedia.
Topics: Adrenalectomy; Animals; Carrier Proteins; Cerebral Ventricles; Diazepam Binding Inhibitor; Dihydrotestosterone; Enzyme Inhibitors; Finasteride; GABA Agonists; In Situ Hybridization; Injections, Intravenous; Injections, Intraventricular; Male; Neurons; Neuropeptides; Orchiectomy; Peptide Fragments; Pituitary Gland; Pregnenolone; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic | 1997 |
Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons.
Topics: Animals; Binding, Competitive; Cells, Cultured; Chick Embryo; Glycine; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnenolone; Spinal Cord | 1997 |
Glycine receptors from long-sleep and short-sleep mice: genetic differences in drug sensitivity.
Topics: Animals; Ethanol; Evoked Potentials; Female; Glycine; Mice; Mice, Inbred Strains; Oocytes; Pregnenolone; Propofol; Receptors, Glycine; Recombinant Proteins; RNA, Messenger; Sleep; Species Specificity; Spinal Cord; Strychnine; Xenopus laevis | 1997 |
Mechanism underlying the effect of pregnenolone sulfate on the kainate-induced current in cultured chick spinal cord neurons.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Chick Embryo; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ion Channel Gating; Kainic Acid; Neurons; Patch-Clamp Techniques; Pregnenolone; Receptors, Kainic Acid; Spinal Cord | 1997 |
Pregnenolone sulphate and pregnenolone do not interact with 5 beta-pregnanolone- and hexobarbitone-induced anaesthesia in the rat.
Topics: Albumins; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Hexobarbital; Male; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley | 1997 |
The effects of allopregnanolone, pregnenolone sulphate and pregnenolone on the CA1 population spike of the rat hippocampus after 17 beta-oestradiol priming.
Topics: Animals; Estradiol; Evoked Potentials; GABA Modulators; Male; Pregnanolone; Pregnenolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1997 |
Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures.
Topics: Animals; Bicuculline; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dopamine; Drug Synergism; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Pregnanolone; Pregnenolone; Rats; Somatostatin | 1997 |
Modulation of GABAA receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model.
Topics: Animals; Animals, Newborn; Cells, Cultured; Electrophysiology; Female; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypothalamo-Hypophyseal System; Membrane Potentials; Pentobarbital; Pregnancy; Pregnanes; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
The neurosteroid pregnenolone sulphate enhances NMDA-induced phasic firing of vasopressin neurones in the rat supraoptic nucleus.
Topics: Animals; Dehydroepiandrosterone Sulfate; Drug Synergism; Evoked Potentials; Female; Hypothalamus; In Vitro Techniques; N-Methylaspartate; Neurons; Picrotoxin; Pregnenolone; Rats; Rats, Wistar; Supraoptic Nucleus; Time Factors; Vasopressins | 1997 |
Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids.
Topics: Animals; Corticotropin-Releasing Hormone; Desoxycorticosterone; Dose-Response Relationship, Drug; Ginsenosides; Hormone Antagonists; Hypnotics and Sedatives; Male; Mice; Pentobarbital; Peptide Fragments; Pregnenolone; Receptors, GABA-A; Saponins; Sleep; Social Isolation; Stress, Physiological | 1997 |
Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.
Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cells, Cultured; Chick Embryo; Hippocampus; N-Methylaspartate; Neurons; Oxidation-Reduction; Polyamines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Structure-Activity Relationship; Xenopus laevis | 1997 |
Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus.
Topics: Aging; Animals; Cognition; Hippocampus; Male; Pregnenolone; Rats; Rats, Sprague-Dawley | 1997 |
Presynaptic action of the neurosteroid pregnenolone sulfate on inhibitory transmitter release in cultured hippocampal neurons.
Topics: Animals; Cells, Cultured; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; Neurons; Patch-Clamp Techniques; Pregnenolone; Presynaptic Terminals; Rats | 1997 |
The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain; Hypothalamus; Infusions, Intravenous; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroids; Tissue Distribution | 1997 |
Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors.
Topics: Animals; Anti-Anxiety Agents; Chloride Channels; Desoxycorticosterone; Enzyme Activation; Female; gamma-Aminobutyric Acid; Humans; Kinetics; Oocytes; Phorbol Esters; Pregnenolone; Protein Kinase C; Receptors, GABA-A; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Xenopus laevis | 1997 |
Neuroactive steroids modulate in vitro the Mg(2+)-dependent Ca(2+)-ATPase activity in cultured rat neurons.
Topics: Animals; Calcium-Transporting ATPases; Cerebral Cortex; Enzyme Activation; Estradiol; Neurons; Pregnenolone; Rats; Rats, Wistar | 1998 |
Transfer of steroidal and nonsteroidal compounds across guinea pig fetal membranes.
Topics: Amnion; Animals; Chorion; Estrogens, Conjugated (USP); Estrone; Extraembryonic Membranes; Female; Gestational Age; Guinea Pigs; Pregnancy; Pregnenolone; Steroids | 1998 |
Differential regulation by pregnenolone sulfate of intracellular Ca2+ increase by amino acids in primary cultured rat cortical neurons.
Topics: Acetylcholine; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; gamma-Aminobutyric Acid; N-Methylaspartate; Neurons; Potassium; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1998 |
The effects of neurosteroids on acquisition and retention of a modified passive-avoidance learning task in mice.
Topics: Animals; Avoidance Learning; Dehydroepiandrosterone Sulfate; Dopamine Antagonists; Haloperidol; Male; Mice; Pregnenolone; Receptors, sigma; Reproducibility of Results; Retention, Psychology | 1998 |
Opposing effects of different steroid sulfates on GABAA receptor-mediated chloride uptake.
Topics: Animals; Biological Transport; Cerebral Cortex; Chlorides; Dehydroepiandrosterone Sulfate; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; In Vitro Techniques; Ionophores; Male; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 1998 |
Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.
Topics: Animals; Cells, Cultured; Dehydroepiandrosterone Sulfate; GABA Modulators; Hippocampus; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Stereoisomerism | 1998 |
The neurosteroid pregnenolone sulfate excites medial vestibular nucleus neurons.
Topics: Animals; Cats; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Neurons; Pregnenolone; Sodium Chloride; Vestibular Nuclei | 1998 |
The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with sigma1 (sigma1) receptors.
Topics: Animals; Anisoles; Dehydroepiandrosterone Sulfate; Learning Disabilities; Male; Maze Learning; Mice; Muscarinic Antagonists; Pregnenolone; Progesterone; Propylamines; Receptors, sigma; Scopolamine; Swimming | 1998 |
Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment.
Topics: Aging; Amnesia; Animals; Avoidance Learning; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Enzyme Inhibitors; Learning Disabilities; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nootropic Agents; Pregnenolone | 1998 |
Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons.
Topics: Aniline Compounds; Animals; Calcimycin; Calcium; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fetus; Hippocampus; N-Methylaspartate; Neurons; Potassium; Pregnenolone; Rats; Receptors, N-Methyl-D-Aspartate; Xanthenes | 1998 |
Neurosteroid modulation of recombinant ionotropic glutamate receptors.
Topics: Adrenal Cortex Hormones; Animals; Dose-Response Relationship, Drug; GluK2 Kainate Receptor; Kainic Acid; Microinjections; Neurotransmitter Agents; Oocytes; Pregnenolone; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Complementary; Xenopus | 1998 |
Induction of neurosteroid synthesis by NMDA receptors in isolated rat retina: a potential early event in excitotoxicity.
Topics: Animals; Bicuculline; Cell Death; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Retina; Time Factors | 1998 |
The neurosteroid pregnenolone sulfate infused into the nucleus basalis increases both acetylcholine release in the frontal cortex or amygdala and spatial memory.
Topics: Acetylcholine; Amygdala; Animals; Behavior, Animal; Conditioning, Psychological; Extracellular Space; Frontal Lobe; Locomotion; Male; Memory; Microdialysis; Parietal Lobe; Pregnenolone; Rats; Rats, Sprague-Dawley; Space Perception; Substantia Innominata | 1998 |
The neurosteroid pregnenolone sulfate increases cortical acetylcholine release: a microdialysis study in freely moving rats.
Topics: Acetylcholine; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Frontal Lobe; Injections, Intraventricular; Male; Microdialysis; Pregnenolone; Rats; Rats, Sprague-Dawley | 1998 |
Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test.
Topics: Animals; Anisoles; Antidepressive Agents; Behavior, Animal; Dehydroepiandrosterone Sulfate; Female; Hypokinesia; Immobilization; Injections, Intraperitoneal; Injections, Subcutaneous; Ligands; Male; Mice; Mice, Inbred Strains; Pregnenolone; Progesterone; Propylamines; Rats; Rats, Wistar; Receptors, sigma; Stress, Physiological; Swimming; Time Factors | 1998 |
[Effect of pregnenolone sulfate on delayed rectifier K+ channel in pyramidial neuron of cerebral cortex].
Topics: Animals; Animals, Newborn; Cerebral Cortex; Female; Male; Neurons; Patch-Clamp Techniques; Potassium Channels; Pregnenolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1997 |
Modulation of cloned human neuronal voltage-gated potassium channels (hKv1.1 and hKv2.1) by neurosteroids.
Topics: Animals; CHO Cells; Cloning, Molecular; Cricetinae; Electric Conductivity; Gene Expression; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Potassium Channels; Pregnanolone; Pregnenolone; Steroids | 1998 |
Supraoptic oxytocin and vasopressin neurones show differential sensitivity to the neurosteroid pregnenolone sulphate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Agonists; Female; Glutamic Acid; N-Methylaspartate; Neurons; Oxytocin; Pregnenolone; Rats; Rats, Wistar; Supraoptic Nucleus; Vasopressins | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Prevention of co-elution of steroid sulfates with serum proteins from pre-column in column-switching HPLC system.
Topics: Blood Proteins; Chromatography, High Pressure Liquid; Dehydroepiandrosterone Sulfate; Estriol; Humans; Pregnenolone; Quaternary Ammonium Compounds | 1998 |
Pregnenolone sulfate modulates NMDA receptors, inducing and potentiating acute excitotoxicity in isolated retina.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; L-Lactate Dehydrogenase; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
Immunocytochemical localization and biological activity of hydroxysteroid sulfotransferase in the frog brain.
Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dehydroepiandrosterone Sulfate; Immunohistochemistry; Male; Phosphoadenosine Phosphosulfate; Pregnenolone; Rabbits; Rana ridibunda; Sulfotransferases; Sulfur Radioisotopes; Tritium | 1999 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors | 1998 |
Differential effects of the neurosteroid pregnenolone sulphate on oxytocin and vasopressin neurones in vitro.
Topics: Animals; Evoked Potentials; Female; In Vitro Techniques; Neurons; Oxytocin; Pregnenolone; Rats; Supraoptic Nucleus; Vasopressins | 1998 |
Lack of zonal uptake of estrone sulfate in enriched periportal and perivenous isolated rat hepatocytes.
Topics: Animals; Biological Transport; Cells, Cultured; Drug Interactions; Estrone; Kinetics; Liver; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Sodium | 1999 |
Short-time effects of neuroactive steroids on rat cortical Ca2+-ATPase activity.
Topics: Animals; Brain; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Dehydroepiandrosterone Sulfate; Enzyme Activation; Estradiol; Pregnenolone; Rats; Rats, Wistar; Synaptosomes; Testosterone; Up-Regulation | 1999 |
The promnesic neurosteroid pregnenolone sulfate increases paradoxical sleep in rats.
Topics: Animals; Electroencephalography; Male; Memory; Pregnenolone; Rats; Rats, Sprague-Dawley; Sleep, REM; Spatial Behavior | 1999 |
Pregnenolone, pregnenolone sulfate, and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes.
Topics: Amphibians; Animals; Blotting, Western; Brain; Cerebellum; Cholesterol Side-Chain Cleavage Enzyme; Diencephalon; Female; Male; Mesencephalon; Ovary; Pregnenolone; Ranidae; Seasons; Telencephalon; Testis; Xenopus laevis | 1999 |
Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors.
Topics: Animals; Chloride Channels; Dehydroepiandrosterone Sulfate; Female; gamma-Aminobutyric Acid; Macromolecular Substances; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis | 1999 |
Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites.
Topics: Animals; Cells, Cultured; Chick Embryo; Dehydroepiandrosterone Sulfate; GABA Modulators; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Steroids; Sulfuric Acid Esters; Xenopus laevis | 1999 |
Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties.
Topics: Animals; GABA Modulators; Male; Memory; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Sleep; Sleep, REM; Substantia Innominata; Wakefulness | 1999 |
Convulsant actions of the neurosteroid pregnenolone sulfate in mice.
Topics: Animals; Convulsants; Disease Susceptibility; Drug Synergism; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Pregnenolone; Receptors, GABA-A; Seizures | 1999 |
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 1999 |
The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens.
Topics: Affect; Animals; Dopamine; Injections, Intraventricular; Male; Microdialysis; Morphine; Motivation; Narcotics; Nucleus Accumbens; Pregnenolone; Rats; Rats, Sprague-Dawley; Reward | 1999 |
Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally administered dehydroepiandrosterone sulfate but not pregnenolone sulfate.
Topics: Animals; Arylsulfatases; Avoidance Learning; Brain Mapping; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrone; Hippocampus; Injections; Male; Maze Learning; Mice; Pregnenolone; Retention, Psychology; Steryl-Sulfatase | 1999 |
Pregnenolone sulfate increases hippocampal acetylcholine release and spatial recognition.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Hippocampus; Male; Memory; Microdialysis; Pregnenolone; Rats; Rats, Sprague-Dawley; Spatial Behavior | 2000 |
Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse.
Topics: 5-alpha-Dihydroprogesterone; Animals; Behavior, Animal; Cognition; Infusion Pumps, Implantable; Injections, Intraventricular; Male; Maze Learning; Memory; Mice; Neuroprotective Agents; Pregnanediones; Pregnanolone; Pregnenolone; Prosencephalon; Space Perception | 2000 |
Effects of neurosteroids on Ca(2+) signaling mediated by recombinant N-methyl-D-aspartate receptor expressed in Chinese hamster ovary cells.
Topics: Action Potentials; Animals; Calcium; Calcium Signaling; CHO Cells; Cricetinae; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Steroids | 2000 |
Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization.
Topics: Animals; beta-Alanine; Cells, Cultured; gamma-Aminobutyric Acid; Hippocampus; Kinetics; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Synaptic Transmission; Taurine | 2000 |
Pregnenolone sulfate, a naturally occurring excitotoxin involved in delayed retinal cell death.
Topics: Adjuvants, Immunologic; Animals; Apoptosis; Cycloheximide; Dehydroepiandrosterone Sulfate; DNA Fragmentation; Estradiol; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Neurotoxins; Pregnenolone; Progesterone; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Retina; Superoxide Dismutase; Superoxides; Thiobarbituric Acid Reactive Substances | 2000 |
Effects of sigma(1) receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats.
Topics: Animals; Anisoles; Antipsychotic Agents; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory; Nootropic Agents; Piperazines; Pregnenolone; Progesterone; Propylamines; Psychomotor Performance; Rats; Rats, Wistar; Receptors, sigma; Steroids; Time Factors | 2000 |
Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.
Topics: Animals; Bradykinin; Calcium; Calcium Signaling; Dizocilpine Maleate; Morpholines; Nifedipine; Oligonucleotides, Antisense; Pentazocine; Potassium Chloride; Pregnenolone; Rabbits; Receptors, sigma; Tumor Cells, Cultured | 2000 |
Fetal alcohol exposure alters neurosteroid modulation of hippocampal N-methyl-D-aspartate receptors.
Topics: Animals; Cells, Cultured; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Glycine; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pregnancy; Pregnenolone; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2000 |
Allopregnanolone, pregnenolone sulfate, and epitestosterone in breast cyst fluid.
Topics: Adult; Epitestosterone; Exudates and Transudates; Female; Fibrocystic Breast Disease; Humans; Luteal Phase; Middle Aged; Pregnanolone; Pregnenolone; Reference Values | 2001 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Regulating ankyrin dynamics: Roles of sigma-1 receptors.
Topics: Ankyrins; Calcium Channels; Calcium Signaling; Cell Communication; Cocaine; Glioma; Humans; Inositol 1,4,5-Trisphosphate Receptors; Macromolecular Substances; Microscopy, Confocal; Neoplasm Proteins; Neuroblastoma; Pregnenolone; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Receptors, sigma; Sigma-1 Receptor; Tumor Cells, Cultured | 2001 |
Serum concentrations of some neuroactive steroids in women suffering from mixed anxiety-depressive disorder.
Topics: 17-alpha-Hydroxypregnenolone; Adult; Anxiety; Depressive Disorder; Female; Follicular Phase; Humans; Menstrual Cycle; Middle Aged; Osmolar Concentration; Pregnenolone; Steroids | 2000 |
Effect of epipregnanolone and pregnenolone sulfate on chronic tolerance to ethanol.
Topics: Animals; Central Nervous System Depressants; Drug Tolerance; Ethanol; Male; Mice; Motor Skills; Pregnanolone; Pregnenolone | 2000 |
Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices.
Topics: Animals; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Male; Neuronal Plasticity; Organ Culture Techniques; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2001 |
Distinct effect of pregnenolone sulfate on NMDA receptor subtypes.
Topics: Animals; Animals, Newborn; Bicuculline; Cell Line; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperazines; Pregnenolone; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2001 |
Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit.
Topics: Binding Sites; Cell Line; Estranes; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Ligands; Membrane Potentials; Mutagenesis; Nitriles; Patch-Clamp Techniques; Pentobarbital; Piperidines; Pregnenolone; Receptors, GABA-A; Transfection | 2001 |
Neuroactive steroid levels in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Dehydroepiandrosterone; Female; gamma-Aminobutyric Acid; Humans; Male; Pregnanolone; Pregnenolone; Receptors, GABA-A | 2001 |
Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism.
Topics: Adult; Androstenediol; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Pregnenolone; Sex Characteristics; Sex Hormone-Binding Globulin; Thyroxine | 2001 |
Pregnenolone sulfate modulates angiotensin II-induced inositol 1,4,5-trisphosphate changes in the anterior pituitary of female rat.
Topics: Adjuvants, Immunologic; Angiotensin II; Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Estradiol; Female; Inositol 1,4,5-Trisphosphate; Ovary; Pituitary Gland; Pregnenolone; Progesterone; Rats | 2001 |
Effect of treatment of hypothyroidism on the plasma concentrations of neuroactive steroids and homocysteine.
Topics: Adjuvants, Immunologic; Adult; Aged; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Homocysteine; Humans; Hypothyroidism; Male; Microsomes; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Thyrotropin; Thyroxine; Time Factors; Triiodothyronine | 2001 |
Neuroactive steroids modulate crustacean locomotor activity.
Topics: Animals; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Gonadal Steroid Hormones; Male; Motor Activity; Nephropidae; Pregnanolone; Pregnenolone | 2001 |
Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.
Topics: Animals; Cell Membrane; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Pregnenolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A | 2001 |
The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: distinct mechanisms?
Topics: 2-Amino-5-phosphonovalerate; Animals; Cognition; Excitatory Amino Acid Antagonists; Male; Memory, Short-Term; Mice; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroids; Task Performance and Analysis | 2001 |
Influence of neurosteroids on the development of rapid tolerance to ethanol in mice.
Topics: Animals; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Ethanol; Male; Mice; Motor Activity; Muscimol; Pregnenolone; Steroids | 2001 |
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Pyridines; Rats; Receptors, GABA-A; Zinc; Zolpidem | 2001 |
Differential involvement of the sigma(1) (sigma(1)) receptor in the anti-amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse.
Topics: Amnesia; Animals; Avoidance Learning; Behavior, Animal; Binding Sites; Blotting, Western; Brain; Cerebral Cortex; Dehydroepiandrosterone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Learning Disabilities; Male; Maze Learning; Memory; Mice; Morpholines; Oligonucleotides, Antisense; Phenazocine; Pregnenolone; Receptors, sigma; Sigma-1 Receptor | 2001 |
Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Models, Biological; Oocytes; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 2002 |
Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta.
Topics: Biological Transport; Cells, Cultured; Estrone; Female; Giant Cells; Humans; Oocytes; Organic Anion Transporters; Placenta; Pregnancy; Pregnenolone; RNA, Messenger; Trophoblasts | 2002 |
Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid.
Topics: Amniotic Fluid; Female; Fetal Blood; Gonadal Steroid Hormones; History, 16th Century; Humans; Pregnancy; Pregnancy Trimester, Second; Pregnanolone; Pregnenolone; Sensitivity and Specificity | 2002 |
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.
Topics: Amino Acid Substitution; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Flumazenil; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hydroxysteroids; Lorazepam; Oocytes; Patch-Clamp Techniques; Pregnanes; Pregnenolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Synapses; Xenopus laevis | 2002 |
Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects.
Topics: Adolescent; Adult; Aged; Aging; Child; Epitestosterone; Female; Humans; Male; Middle Aged; Osmolar Concentration; Pregnenolone; Reference Values; Sex Characteristics; Testosterone | 2002 |
Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors.
Topics: Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Central Nervous System; Chelating Agents; Egtazic Acid; Electrophysiology; Glutamic Acid; Haloperidol; Hippocampus; Neurons; Pertussis Toxin; Pregnenolone; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Steroids; Virulence Factors, Bordetella | 2002 |
Neurosteroids enhance bandpass filter characteristics of the rat Schaffer collateral-to-CA1 synapse.
Topics: Animals; Hippocampus; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2002 |
Gender differences in steroid modulation of angiotensin II-induced protein kinase C activity in anterior pituitary of the rat.
Topics: Angiotensin II; Animals; Dehydroepiandrosterone Sulfate; Estradiol; Female; Male; Ovariectomy; Phosphorylation; Pituitary Gland, Anterior; Pregnenolone; Progesterone; Protein Kinase C; Rats; Rats, Wistar; Sex Factors; Synapsins | 2002 |
Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol.
Topics: Alcoholism; Animals; Body Temperature; Central Nervous System Depressants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Pregnenolone | 2002 |
Accumulation of 4- and 5-ene steroid sulfates in human breast cyst fluids.
Topics: Adult; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Exudates and Transudates; Female; Fibrocystic Breast Disease; Humans; Middle Aged; Pregnenolone | 2002 |
Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia.
Topics: Adult; Arousal; Dehydroepiandrosterone; Humans; Male; Middle Aged; Phobic Disorders; Pilot Projects; Pregnanolone; Pregnenolone; Reference Values | 2002 |
The neurosteroid pregnenolone sulfate infused into the medial septum nucleus increases hippocampal acetylcholine and spatial memory in rats.
Topics: Acetylcholine; Animals; Hippocampus; Male; Memory; Microdialysis; Motor Activity; Pregnenolone; Rats; Rats, Sprague-Dawley; Septum of Brain; Space Perception | 2002 |
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Brain Chemistry; Cerebellum; Corpus Striatum; Dehydroepiandrosterone Sulfate; Female; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Hippocampus; Humans; Hypothalamus; Male; Pregnanolone; Pregnenolone; Progesterone; Protein Structure, Secondary; Steroids; tau Proteins | 2002 |
Inhibition by pregnenolone sulfate of nicotinic acetylcholine response in adrenal chromaffin cells.
Topics: Acetylcholine; Adrenal Medulla; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Competitive Bidding; Dose-Response Relationship, Drug; Nicotine; Pregnenolone; Receptors, Nicotinic; Sodium; Tritium | 2002 |
A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-specific caspase-2 activation in the retinal cell death.
Topics: Animals; Apoptosis; Caspase 2; Caspase 3; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Estradiol; In Situ Nick-End Labeling; In Vitro Techniques; Male; Neuroprotective Agents; Neurotoxins; Oxidation-Reduction; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Signal Transduction | 2002 |
Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons.
Topics: Androstanols; Animals; Calcium; Calcium Signaling; Cells, Cultured; Corticosterone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Hippocampus; Hormone Antagonists; Membrane Potentials; Mifepristone; Mitochondria; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate | 2002 |
Studies on neurosteroids XV. Development of enzyme-linked immunosorbent assay for examining whether pregnenolone sulfate is a veritable neurosteroid.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Male; Neurotransmitter Agents; Pregnenolone; Rabbits; Rats; Rats, Wistar | 2003 |
Neurosteroid modulation of the presynaptic NMDA receptors regulating hippocampal noradrenaline release in normal rats and those exposed prenatally to diazepam.
Topics: Animals; Diazepam; Female; Glycine; Hippocampus; Male; Norepinephrine; Pregnancy; Pregnenolone; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2003 |
Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit.
Topics: Anesthetics; Animals; Desoxycorticosterone; Evoked Potentials; Female; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Neural Pathways; Pregnenolone; Receptors, GABA-A; Synapses; Thalamus | 2003 |
DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration.
Topics: Adrenocorticotropic Hormone; Animals; Blood; Brain; Corticotropin-Releasing Hormone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Male; Pregnenolone; Rats; Rats, Wistar | 2003 |
Neurosteroid modulation of glutamate release in hippocampal neurons: lack of an effect of a chronic prenatal ethanol exposure paradigm.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Female; Glutamic Acid; Hippocampus; Male; Neurons; Pregnancy; Pregnenolone; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Steroids | 2003 |
EVIDENCE THAT STEROID SULFATES SERVE AS BIOSYNTHETIC INTERMEDIATES. II. IN VITRO CONVERSION OF PREGNENOLONE-3H SULFATE-35S TO 17ALPHA-HYDROXYPREGNENOLONE-3H SULFATE-35S.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Chromatography; Cushing Syndrome; Dehydroepiandrosterone; Humans; In Vitro Techniques; Infrared Rays; Metabolism; Pregnanediol; Pregnenolone; Sulfates; Sulfur Isotopes; Tritium; Urine | 1964 |
SYNTHESIS OF PREGNENOLONE SULFATE, DEHYDROISOANDROSTERONE SULFATE, 17-ALPHA-HYDROXYPREGNENOLONE SULFATE AND DELTA-5-PREGNENETRIOL SULFATE BY THE NORMAL HUMAN ADRENAL GLAND.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Chromatography; Crystallization; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Metabolism; Pregnanediol; Pregnanetriol; Pregnenes; Pregnenolone; Sulfates; Tritium | 1965 |
METABOLISM OF PREGNENOLONE-3-SULPHATE IN THE PERFUSED DOG LIVER.
Topics: 17-alpha-Hydroxypregnenolone; Androstenols; Chromatography; Dehydroepiandrosterone; Dogs; Liver; Perfusion; Pregnenolone; Progesterone; Research; Sulfates; Testosterone | 1965 |
[IDENTIFICATION OF PREGNENOLONE SULFATE IN NORMAL HUMAN PLASMA].
Topics: Blood Chemical Analysis; Chromatography; Humans; Plasma; Pregnenolone | 1965 |
A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission.
Topics: Action Potentials; Animals; gamma-Aminobutyric Acid; GTP-Binding Proteins; Hippocampus; Pertussis Toxin; Pregnenolone; Rats; Receptors, sigma; Sigma-1 Receptor; Synaptic Transmission | 2003 |
Characterization of the convulsant action of pregnenolone sulfate.
Topics: Animals; Convulsants; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Pregnenolone; Rats; Status Epilepticus | 2004 |
Synthesis of [19- 2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates.
Topics: Androstanes; Combinatorial Chemistry Techniques; Dehydroepiandrosterone; Deuterium; Molecular Structure; Pregnanolone; Pregnenolone | 2004 |
Sleep-wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus.
Topics: Analysis of Variance; Animals; Cortical Synchronization; Dose-Response Relationship, Drug; Electroencephalography; Male; Pedunculopontine Tegmental Nucleus; Pregnenolone; Rats; Rats, Sprague-Dawley; Sleep Stages; Wakefulness | 2004 |
A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Dimerization; Glutamic Acid; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Molecular Sequence Data; Pregnenolone; Protein Structure, Quaternary; Protein Structure, Tertiary; Protons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2004 |
Acute neurosteroid modulation and subunit isolation of the gamma-aminobutyric acidA receptor in the bullfrog, Rana catesbeiana.
Topics: Amino Acid Sequence; Anesthetics; Animals; Brain; Cell Membrane; Cloning, Molecular; GABA Agonists; Male; Molecular Sequence Data; Muscimol; Pregnanolone; Pregnenolone; Protein Isoforms; Protein Subunits; Radioligand Assay; Rana catesbeiana; Receptors, GABA-A; Sequence Alignment; Tritium | 2004 |
Plasma levels of 7-hydroxylated dehydroepiandrosterone (DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer's disease and vascular dementia.
Topics: 17-alpha-Hydroxypregnenolone; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dementia, Vascular; Dipeptides; Female; Glutathione; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Predictive Value of Tests; Pregnenolone; Radioimmunoassay; Sensitivity and Specificity; Sex Factors; Statistics, Nonparametric; Sulfhydryl Compounds | 2004 |
Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine.
Topics: Alanine; Amino Acids; Animals; Bicuculline; Convulsants; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Male; Mice; Microinjections; N-Methylaspartate; Picrotoxin; Pregnenolone; Seizures | 2004 |
Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain.
Topics: Animals; Brain; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Gas Chromatography-Mass Spectrometry; Male; Pregnenolone; Rats; Rats, Sprague-Dawley | 2004 |
Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain.
Topics: Animals; Brain; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Male; Morphine Dependence; Pregnenolone; Progesterone; Random Allocation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2004 |
Mechanism underlying inhibition of the capsaicin receptor-mediated current by pregnenolone sulfate in rat dorsal root ganglion neurons.
Topics: Animals; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Drug; Time Factors | 2004 |
Pregnenolone sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Bicuculline; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Pregnenolone; Rats; Receptors, N-Methyl-D-Aspartate | 2004 |
Molecular mechanism of pregnenolone sulfate action at NR1/NR2B receptors.
Topics: Animals; Animals, Newborn; Cells, Cultured; Glutamic Acid; Hippocampus; Humans; Ion Channel Gating; Kinetics; Models, Biological; Neurons; Patch-Clamp Techniques; Pregnenolone; Probability; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2004 |
Pregnenolone sulfate enhances neurogenesis and PSA-NCAM in young and aged hippocampus.
Topics: Age Factors; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Count; Dose-Response Relationship, Drug; Gene Expression Regulation; Hippocampus; Injections, Intraventricular; Male; Microscopy, Immunoelectron; Neural Cell Adhesion Molecule L1; Neuronal Plasticity; Neurons; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sialic Acids; Time Factors | 2005 |
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Calcium; Calcium Channel Blockers; Chelating Agents; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Pregnenolone; Presynaptic Terminals; Quinolinic Acids; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors | 2005 |
Neurosteroid paradoxical enhancement of paired-pulse inhibition through paired-pulse facilitation of inhibitory circuits in dentate granule cells.
Topics: Animals; Dentate Gyrus; Dose-Response Relationship, Drug; Male; Nerve Net; Neural Inhibition; Neurotransmitter Agents; Pregnenolone; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2005 |
Neurosteroid enhances glutamate release in rat prelimbic cortex via activation of alpha1-adrenergic and sigma1 receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Models, Biological; Neostriatum; Neurotransmitter Agents; Pregnenolone; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, sigma; Sigma-1 Receptor; Signal Transduction | 2005 |
Sex differences in pregnenolone sulphate in the chick brain after training.
Topics: Animals; Avoidance Learning; Chickens; Cholesterol Side-Chain Cleavage Enzyme; Female; Male; Memory; Pregnenolone; Prosencephalon; Rhombencephalon; Sex Characteristics | 2005 |
Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction.
Topics: Alcoholism; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Progesterone; Radioimmunoassay; Stereoisomerism; Steroids; Time Factors | 2005 |
Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Estrone; Excitatory Amino Acid Agonists; Membrane Potentials; Neurons; Neuroprotective Agents; Organ Culture Techniques; Pregnenolone; Rats; Rats, Wistar; Receptors, AMPA; Steryl-Sulfatase | 2005 |
Presynaptic modulation of synaptic transmission by pregnenolone sulfate as studied by optical recordings.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Analysis of Variance; Animals; Benzylidene Compounds; Bicuculline; Bungarotoxins; Calcium; Calcium Channel Blockers; Diagnostic Imaging; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethylenediamines; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Haloperidol; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pregnenolone; Presynaptic Terminals; Pyridines; Rats; Rats, Wistar; Synaptic Transmission; Tetrodotoxin; Time Factors | 2005 |
Pregnenolone sulfate acts through a G-protein-coupled sigma1-like receptor to enhance short term facilitation in adult hippocampal neurons.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GTP-Binding Protein alpha Subunits, Gi-Go; Hippocampus; In Vitro Techniques; Male; Morpholines; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Piperazines; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Synapses; Synaptic Transmission; Time Factors | 2005 |
Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats.
Topics: Administration, Oral; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Drug Interactions; Ethanol; Exploratory Behavior; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Self Medication | 2005 |
Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Frontal Lobe; Male; Piperidines; Pregnanolone; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 2005 |
The neurosteroid pregnenolone sulfate neutralized the learning impairment induced by intrahippocampal nicotine in alcohol-drinking rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Body Weight; Choice Behavior; Conditioning, Operant; Drug Interactions; Extinction, Psychological; Food Deprivation; Hippocampus; Learning Disabilities; Male; Nicotine; Pregnenolone; Rats; Rats, Wistar | 2005 |
Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats.
Topics: Animals; Body Weight; Ethanol; Hippocampus; Male; Motor Activity; Nicotine; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome | 2005 |
The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cholinergic Fibers; Dose-Response Relationship, Drug; Epilepsy, Reflex; Hippocampus; Male; Microinjections; Nicotine; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Statistics, Nonparametric | 2005 |
Subtype-dependence of N-methyl-D-aspartate receptor modulation by pregnenolone sulfate.
Topics: Humans; Patch-Clamp Techniques; Pregnenolone; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 2006 |
Alcohol increases efficacy of immature synapses in a neurosteroid-dependent manner.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethanol; Excitatory Postsynaptic Potentials; Female; Hippocampus; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Pregnancy; Pregnenolone; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Tyramine | 2006 |
[Effects of morphine dependence on the levels of neurosteroids in rat brain].
Topics: Amygdala; Animals; Brain; Conditioning, Operant; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hypothalamus; Male; Morphine Dependence; Nucleus Accumbens; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley | 2005 |
The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptors.
Topics: Animals; Cells, Cultured; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Hypothalamus; Mice; N-Methylaspartate; Pregnenolone; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Vesicular Glutamate Transport Protein 2 | 2006 |
Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans Proteins; Dimerization; Dose-Response Relationship, Drug; Female; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Chimeric Proteins; Mutation; Oocytes; Picrotoxin; Pregnenolone; Rats; Receptors, GABA-A; Sequence Homology, Amino Acid; Xenopus laevis | 2006 |
Effect of isopregnanolone on rapid tolerance to the anxiolytic effect of ethanol.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Ataxia; Drug Tolerance; Ethanol; Hypothermia; Male; Maze Learning; Mice; Motor Activity; Pregnenolone; Receptors, GABA-A | 2006 |
Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy, Absence; Male; Microinjections; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Time Factors | 2006 |
Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age.
Topics: Adult; Aging; Dehydroepiandrosterone; Estradiol; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Isomerism; Luteal Phase; Pregnanolone; Pregnenolone; Progesterone; Receptors, GABA-A | 2006 |
Modification of OATP2B1-mediated transport by steroid hormones.
Topics: Animals; Biological Transport; Dehydroepiandrosterone Sulfate; Dogs; Estrone; Gene Expression; Humans; Isotope Labeling; Kinetics; Mifepristone; Organic Anion Transporters; Pregnenolone; Progesterone; Steroids; Testosterone | 2006 |
Neurosteroid-induced enhancement of short-term facilitation involves a component downstream from presynaptic calcium in hippocampal slices.
Topics: Action Potentials; Animals; Calcium; Electrophysiology; Excitatory Postsynaptic Potentials; Fluorescent Dyes; Glycine; Hippocampus; Neurotransmitter Agents; Patch-Clamp Techniques; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Xanthenes | 2006 |
Neurosteroid modulation of recombinant rat alpha5beta2gamma2L and alpha1beta2gamma2L GABA(A) receptors in Xenopus oocyte.
Topics: Androstane-3,17-diol; Animals; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Male; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pregnanediol; Pregnanes; Pregnenolone; Protein Subunits; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; RNA, Messenger; Steroids; Xenopus laevis; Zolpidem | 2006 |
Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats.
Topics: Animals; Cannabinoids; Capsaicin; Dose-Response Relationship, Drug; Ganglia, Spinal; Injections, Intradermal; Male; Neurons; Pain; Pregnenolone; Rats; Rats, Sprague-Dawley; Time Factors | 2006 |
Neurosteroid pregnenolone sulfate enhances glutamatergic synaptic transmission by facilitating presynaptic calcium currents at the calyx of Held of immature rats.
Topics: Animals; Animals, Newborn; Brain Stem; Calcium; Calcium Channels; Cell Line; Colforsin; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Humans; In Vitro Techniques; Membrane Potentials; Patch-Clamp Techniques; Phorbol Esters; Pregnenolone; Presynaptic Terminals; Rabbits; Rats; Rats, Wistar; Synaptic Transmission; Time Factors; Transfection | 2006 |
Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.
Topics: Animals; Behavior, Animal; Binding Sites; Dose-Response Relationship, Drug; Estradiol; Ethanol; Female; Kinetics; Larva; Pregnanolone; Pregnenolone; Protein Binding; Protein Subunits; Receptors, GABA-A | 2007 |
Differential regulation of ionotropic glutamate receptors.
Topics: Binding Sites; Ligands; Models, Molecular; Pregnanolone; Pregnenolone; Protein Structure, Tertiary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Zinc | 2007 |
3Beta-hydroxysteroids and pregnenolone sulfate inhibit recombinant rat GABA(A) receptor through different channel property.
Topics: Animals; Chloride Channels; Dose-Response Relationship, Drug; Female; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Hydroxysteroids; Inhibitory Concentration 50; Kinetics; Oocytes; Patch-Clamp Techniques; Pregnenolone; Rats; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 2007 |
Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats.
Topics: Alcohol Drinking; Alcohols; Anesthetics; Animals; Behavior, Animal; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking Behavior; Food Deprivation; Glucose; Hippocampus; Linear Models; Male; Pregnanolone; Pregnenolone; Rats; Rats, Wistar | 2007 |
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells.
Topics: 2-Amino-5-phosphonovalerate; Cell Adhesion; Cell Line, Tumor; Excitatory Amino Acid Agonists; Glioma; Glutamic Acid; Humans; Hybrid Cells; Neurites; Neuroblastoma; Piperidines; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Steroids | 2007 |
Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.
Topics: Animals; Animals, Genetically Modified; Cricetinae; Dehydroepiandrosterone; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Mesocricetus; Pregnanolone; Pregnenolone | 2007 |
PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling.
Topics: Animals; Calcium; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Electrophysiology; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Long-Term Potentiation; N-Methylaspartate; Phosphorylation; Pregnenolone; Rats; Receptors, N-Methyl-D-Aspartate | 2007 |
Reversal of lindane-induced impairment of step-down passive avoidance and oxidative stress by neurosteroids in rats.
Topics: Administration, Oral; Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Diazepam; Drug Antagonism; Drug Therapy, Combination; Hexachlorocyclohexane; Insecticides; Male; Malondialdehyde; Maze Learning; Oxidative Stress; Pregnenolone; Progesterone; Rats; Rats, Wistar; Recovery of Function | 2007 |
The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Caenorhabditis elegans Proteins; Cells, Cultured; Dehydroepiandrosterone Sulfate; GABA Antagonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Mutation; Oocytes; Pregnenolone; Receptors, GABA-A; Xenopus | 2007 |
Emergence of NMDAR-independent long-term potentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: role for sigma-receptors.
Topics: Age Factors; Alcoholism; Animals; Central Nervous System Depressants; Dendrites; Electrophysiology; Ethanol; Hippocampus; Long-Term Potentiation; Male; Neuronal Plasticity; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Synapses; Synaptic Transmission | 2008 |
Regulation of SULT2B1a (pregnenolone sulfotransferase) expression in rat C6 glioma cells: relevance of AMPA receptor-mediated NO signaling.
Topics: Animals; Benzothiadiazines; Cell Line, Tumor; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Isoenzymes; Neuroglia; Nitric Oxide; Pregnenolone; Quinoxalines; Rats; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfotransferases | 2008 |
Differential hypothalamic-pituitary-adrenal activation of the neuroactive steroids pregnenolone sulfate and deoxycorticosterone in healthy controls and alcohol-dependent subjects.
Topics: Adult; Alcohol-Related Disorders; Analysis of Variance; Animals; Case-Control Studies; Corticotropin-Releasing Hormone; Cosyntropin; Desoxycorticosterone; Dexamethasone; Drug Synergism; Feedback, Physiological; Hormones; Humans; Hypothalamo-Hypophyseal System; Male; Matched-Pair Analysis; Middle Aged; Naloxone; Narcotic Antagonists; Pituitary-Adrenal System; Pregnenolone; Reference Values; Sheep; Stimulation, Chemical; Tobacco Use Disorder | 2008 |
Neuroactive steroid pregnenolone sulphate inhibits long-term potentiation via activation of alpha2-adrenoreceptors at excitatory synapses in rat medial prefrontal cortex.
Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Potentiation; N-Methylaspartate; Prefrontal Cortex; Pregnenolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Synapses | 2008 |
Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Brain; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; Neurons; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Pregnanolone; Pregnenolone; Staurosporine; Steroids | 2008 |
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.
Topics: Analysis of Variance; Anesthetics; Animals; Body Temperature; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone | 2007 |
A comparison of the pharmacological properties of recombinant human and rat alpha(1)beta(2)gamma(2L) GABA(A) receptors in Xenopus oocytes.
Topics: Allosteric Regulation; Animals; Catalytic Domain; Cloning, Molecular; Electrophysiology; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Oocytes; Pregnenolone; Protein Isoforms; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis | 2008 |
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A.
Topics: Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cricetulus; Hippocampus; Ion Channels; Male; Piperidines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2008 |
Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration.
Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Enzyme Inhibitors; Finasteride; Gonadal Steroid Hormones; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 2008 |
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
Topics: Amino Acid Substitution; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutant Proteins; Mutation; Piperidines; Pregnanetriol; Pregnanolone; Pregnenolone; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Serine; Steroids; Tryptophan | 2008 |
A post-training intrahippocampal anxiogenic dose of the neurosteroid pregnenolone sulfate impairs passive avoidance retention.
Topics: Animals; Anxiety; Avoidance Learning; Electric Stimulation; Hippocampus; Learning; Male; Memory; Neuropsychological Tests; Pregnenolone; Rats; Rats, Wistar; Reinforcement, Psychology; Stress, Psychological; Teaching | 2008 |
Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Microscopy, Electron, Scanning; N-Methylaspartate; Potassium Chloride; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium; Valine | 2008 |
Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo.
Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; N-Methylaspartate; Pregnenolone; Rats; Receptors, sigma; Signal Transduction | 2008 |
Pregnenolone protects the PC-12 cell line against amyloid beta peptide toxicity but its sulfate ester does not.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cytoprotection; Dose-Response Relationship, Drug; Microscopy, Fluorescence; Nitrophenols; PC12 Cells; Peptide Fragments; Pregnenolone; Rats; Time Factors | 2009 |
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells.
Topics: Animals; Biophysical Phenomena; Calcium Signaling; Cations, Monovalent; Cell Line; Down-Regulation; Extracellular Space; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Mice; Nifedipine; Permeability; Pregnenolone; Rats; Receptors, Steroid; RNA, Small Interfering; TRPM Cation Channels | 2008 |
A TRP channel-steroid marriage.
Topics: Animals; Humans; Insulin-Secreting Cells; Ion Channel Gating; Mice; Pregnenolone; Rats; Receptors, Steroid; TRPM Cation Channels | 2008 |
The effect of the neuroactive steroid 5beta-pregnane-3beta, 20(R)-diol on the time course of GABA evoked currents is different to that of pregnenolone sulphate.
Topics: Animals; Electrophysiology; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Male; Neurons; Patch-Clamp Techniques; Pregnanediol; Pregnenolone; Preoptic Area; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
Pregnenolone sulfate modulation of N-methyl-D-aspartate receptors is phosphorylation dependent.
Topics: Animals; Calcium; Cell Line; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Hippocampus; Humans; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphorylation; Pregnenolone; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
Minimizing the effects of multicollinearity in the polynomial regression of age relationships and sex differences in serum levels of pregnenolone sulfate in healthy subjects.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Female; Health; Humans; Linear Models; Male; Middle Aged; Pregnenolone; Sex Characteristics | 2009 |
Pregnenolone sulfate potentiates the inwardly rectifying K channel Kir2.3.
Topics: Animals; Potassium Channels; Pregnenolone; RNA, Messenger; Xenopus laevis | 2009 |
Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans Proteins; Desoxycorticosterone; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Ion Channel Gating; Molecular Sequence Data; Oocytes; Patch-Clamp Techniques; Pregnenolone; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A | 2010 |
Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.
Topics: Animals; Cell Line; Cell Proliferation; Cholesterol; Humans; Mice; Muscle Contraction; Muscle, Smooth, Vascular; Pregnenolone; RNA, Messenger; Structure-Activity Relationship; TRPM Cation Channels | 2010 |
Pregnenolone sulfate and cortisol induce secretion of acyl-CoA-binding protein and its conversion into endozepines from astrocytes.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Astrocytes; Brain; Diazepam Binding Inhibitor; Dictyostelium; Glutamic Acid; Hydrocortisone; Mice; Neuroglia; Neurons; Peptides; Pregnenolone; Signal Transduction | 2010 |
TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan.
Topics: Animals; Antibodies, Blocking; Arthritis, Rheumatoid; Calcium Signaling; Cell Line; CHO Cells; Cricetinae; Cricetulus; Drug Synergism; Fibroblasts; Humans; Hyaluronic Acid; Pregnenolone; Rabbits; Sphingosine; Synovial Membrane; TRPM Cation Channels | 2010 |
Sulphates of 3beta-hydroxy-5-ene steroids in women with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Dehydroepiandrosterone Sulfate; Epilepsy; Female; Follicular Phase; Humans; Luteal Phase; Middle Aged; Pregnenolone; Young Adult | 2010 |
Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels.
Topics: Animals; Calcium; Cell Line; Humans; Mice; Patch-Clamp Techniques; Pregnenolone; Stereoisomerism; Structure-Activity Relationship; Transfection; TRPM Cation Channels | 2010 |
Pregnenolone sulfate enhances spontaneous glutamate release by inducing presynaptic Ca2+-induced Ca2+ release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Biophysics; Cadmium Chloride; Calcium; Calcium Channel Blockers; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Neurons; Patch-Clamp Techniques; Piperazines; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin | 2010 |
Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration.
Topics: Allosteric Regulation; Animals; Brain; Dehydroepiandrosterone; Male; Morphine; Neurotransmitter Agents; Opioid-Related Disorders; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Interaction between early postnatal neurosteroid manipulations and adult infusion of neurosteroids into CA1 hippocampal region on the open field behaviour.
Topics: 5-alpha Reductase Inhibitors; Adaptation, Physiological; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Exploratory Behavior; Finasteride; Male; Microinjections; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Spatial Behavior | 2011 |
[Pregnenolone, pregnenolone sulfate].
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Pregnancy; Pregnenolone | 2010 |
Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice.
Topics: Animals; Hippocampus; Male; Memory; Mice; Mice, Knockout; N-Methylaspartate; Pregnenolone; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Space Perception; Stereoisomerism; Steroids | 2011 |
Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids.
Topics: Calcium; Cells, Cultured; Dihydrotestosterone; Estradiol; Gonadal Steroid Hormones; HEK293 Cells; Humans; Lysophospholipids; Myocytes, Smooth Muscle; Patch-Clamp Techniques; Phospholipids; Pregnenolone; Progesterone; Sphingosine; Stereoisomerism; Structure-Activity Relationship; TRPC Cation Channels | 2011 |
Pregnenolone sulfate increases glutamate release at neonatal climbing fiber-to-Purkinje cell synapses.
Topics: Afferent Pathways; Animals; Animals, Newborn; Cerebellar Cortex; Glutamic Acid; Organ Culture Techniques; Pregnenolone; Presynaptic Terminals; Purkinje Cells; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Time Factors; Up-Regulation | 2011 |
Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors.
Topics: Allosteric Regulation; Anabolic Agents; Androgens; Animals; Dehydroepiandrosterone Sulfate; Frontal Lobe; Kinetics; Male; Nandrolone; Nandrolone Decanoate; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2011 |
Is connexin36 critical for GABAergic hypersynchronization in the hippocampus?
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Carbenoxolone; Connexins; Epilepsy; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gap Junctions; Hippocampus; In Vitro Techniques; Interneurons; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Models, Neurological; Patch-Clamp Techniques; Pregnenolone; Receptors, GABA-A | 2011 |
Hydrophobic anions potently and uncompetitively antagonize GABA(A) receptor function in the absence of a conventional binding site.
Topics: Animals; Anions; Binding Sites; Cell Membrane; Cells, Cultured; Electric Capacitance; Female; GABA-A Receptor Antagonists; Hippocampus; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Neurons; Patch-Clamp Techniques; Picrates; Pregnenolone; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Sensitivity and Specificity; Structure-Activity Relationship; Synaptic Potentials; Synaptic Transmission; Tetraphenylborate; Xenopus laevis | 2011 |
Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning.
Topics: Animals; Anxiety; Avoidance Learning; Body Weight; CA1 Region, Hippocampal; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Statistics, Nonparametric | 2011 |
TRPM3 is a nociceptor channel involved in the detection of noxious heat.
Topics: Acrylamides; Animals; Behavior, Animal; Blood Glucose; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Capsaicin; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Humans; Hyperalgesia; Inflammation; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Mustard Plant; Nifedipine; Pain Measurement; Pain Threshold; Patch-Clamp Techniques; Plant Oils; Pregnenolone; Sensory Receptor Cells; Telemetry; Time Factors; Transfection; Transient Receptor Potential Channels; Trigeminal Ganglion; TRPA1 Cation Channel; TRPM Cation Channels | 2011 |
Allopregnanolone infused into the dorsal (CA1) hippocampus increases prepulse inhibition of startle response in Wistar rats.
Topics: Animals; CA1 Region, Hippocampal; Male; Microinjections; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Sensory Gating | 2012 |
A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons.
Topics: Alternative Splicing; Animals; Crystallography, X-Ray; Exons; Female; Neural Inhibition; Point Mutation; Pregnenolone; Protein Structure, Tertiary; Protein Subunits; Protons; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2011 |
Pregnenolone sulfate activates basic region leucine zipper transcription factors in insulinoma cells: role of voltage-gated Ca2+ channels and transient receptor potential melastatin 3 channels.
Topics: Animals; Calcium Channels; Cell Line, Tumor; Cell Polarity; Insulinoma; Leucine Zippers; Mice; Pancreatic Neoplasms; Pregnenolone; Primary Cell Culture; Rats; TRPM Cation Channels; Up-Regulation | 2011 |
Activation of steroid-sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats.
Topics: Amino Acid Sequence; Animals; Animals, Newborn; Cerebellum; Glutamic Acid; Male; Molecular Sequence Data; Neurons; Pregnenolone; Protein Transport; Purkinje Cells; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPM Cation Channels | 2011 |
Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone.
Topics: Adrenal Cortex Hormones; Animals; Calcium Signaling; Cattle; Dihydrotestosterone; Estradiol; Female; Granulosa Cells; HEK293 Cells; Humans; Ion Channel Gating; Mifepristone; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nifedipine; Pregnenolone; Progesterone; Protein Binding; Receptors, Progesterone; TRPM Cation Channels | 2012 |
Neurosteroid PREGS protects neurite growth and survival of newborn neurons in the hippocampal dentate gyrus of APPswe/PS1dE9 mice.
Topics: Alzheimer Disease; Animals; Animals, Newborn; Dehydroepiandrosterone; Dentate Gyrus; Disease Models, Animal; Humans; Male; Mice; Mice, Transgenic; Neural Stem Cells; Neurites; Neurogenesis; Pregnenolone | 2012 |
Pregnenolone sulfate decreases intraocular pressure and changes expression of sigma receptor in a model of chronic ocular hypertension.
Topics: Animals; Cell Count; Disease Models, Animal; Gene Expression; Glaucoma; Intraocular Pressure; Neuroprotective Agents; Pregnenolone; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, sigma; Retina; Retinal Ganglion Cells; Sigma-1 Receptor | 2012 |
Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors.
Topics: Binding Sites; Cloning, Molecular; Models, Molecular; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Receptors, Ionotropic Glutamate; Spectrometry, Fluorescence | 2012 |
Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit.
Topics: Animals; Biological Clocks; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Calcium Signaling; Dentate Gyrus; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Feedback, Physiological; GABAergic Neurons; Interneurons; Mossy Fibers, Hippocampal; Nerve Net; Neuronal Plasticity; Perforant Pathway; Pregnenolone; Presynaptic Terminals; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theta Rhythm | 2012 |
Naturally occurring steroids in Xenopus oocyte during meiotic maturation. Unexpected presence and role of steroid sulfates.
Topics: Animals; Dehydroepiandrosterone Sulfate; Female; Gonadal Hormones; Luteinizing Hormone; Meiosis; Oocytes; Ovary; Ovulation; Pregnenolone; Steryl-Sulfatase; Sulfonic Acids; Xenopus laevis | 2012 |
Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated sodium channels expressed in Xenopus oocytes.
Topics: Animals; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; NAV1.2 Voltage-Gated Sodium Channel; Oocytes; Pregnenolone; Sodium Channel Blockers; Xenopus laevis | 2012 |
Anti-amnesic effect of neurosteroid PREGS in Aβ25-35-injected mice through σ1 receptor- and α7nAChR-mediated neuroprotection.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amnesia; Amyloid beta-Peptides; Animals; Apoptosis; Behavior, Animal; Blotting, Western; CA1 Region, Hippocampal; Hippocampus; Male; MAP Kinase Signaling System; Maze Learning; Memory; Mice; Mice, Inbred ICR; Neuroprotective Agents; Nicotinic Agonists; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pregnenolone; Proto-Oncogene Proteins c-akt; Receptors, Nicotinic; Receptors, sigma; Sigma-1 Receptor | 2012 |
Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3.
Topics: Animals; Benzoin; Calcium; Calcium Channel Blockers; Calcium Signaling; Citrus; Drug Evaluation, Preclinical; Fabaceae; Flavanones; Ganglia, Spinal; HEK293 Cells; Hesperidin; Humans; Membrane Potentials; Mice; Mice, Inbred C57BL; Pregnenolone; Rats; Rats, Wistar; Secondary Metabolism; TRPM Cation Channels | 2013 |
Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus.
Topics: Amino Acid Sequence; Animals; Cell Line; Dehydroepiandrosterone Sulfate; Diencephalon; Gene Expression Profiling; Gonadotropin-Releasing Hormone; Hypothalamus; In Situ Hybridization; Male; Microscopy, Confocal; Molecular Sequence Data; Neurons; Pituitary Gland; Pregnenolone; Protein Isoforms; Ranidae; Receptors, LHRH; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfotransferases | 2013 |
Cloning and functional characterization of the mouse sodium-dependent organic anion transporter Soat (Slc10a6).
Topics: Animals; Blotting, Western; Cell Line; Cloning, Molecular; Fluorescent Antibody Technique; Gonadal Steroid Hormones; Humans; Immunohistochemistry; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Pregnenolone; Reverse Transcriptase Polymerase Chain Reaction; Skin; Testis; Urinary Bladder | 2013 |
Pregnenolone sulfate modulates glycinergic transmission in rat medullary dorsal horn neurons.
Topics: Animals; Cell Membrane; Glycine; Glycine Agents; Inhibitory Postsynaptic Potentials; Posterior Horn Cells; Pregnenolone; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2013 |
The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.
Topics: Animals; Calcium; Cells, Cultured; Exocytosis; GTP-Binding Proteins; N-Methylaspartate; Neurons; Oocytes; Pregnenolone; Protein Kinase C; Protein Transport; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Xenopus laevis | 2013 |
Simultaneous determination of pregnenolone sulphate, dehydroepiandrosterone and allopregnanolone in rat brain areas by liquid chromatography-electrospray tandem mass spectrometry.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Hippocampus; Male; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
The role of pregnenolone sulphate in spatial orientation-acquisition and retention: an interplay between cognitive potentiation and mood regulation.
Topics: Affect; Animals; Cognition; Data Interpretation, Statistical; Depression; Learning; Longitudinal Studies; Male; Memory; Motor Activity; Nootropic Agents; Orientation; Pregnenolone; Rats; Rats, Wistar; Space Perception; Swimming | 2013 |
Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo.
Topics: Animals; Calcium; Cell Survival; Dose-Response Relationship, Drug; Female; Flavanones; Flavonoids; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Pregnenolone; Rats; Rats, Wistar; TRPM Cation Channels; TRPV Cation Channels | 2013 |
Lack of correlation between the amplitudes of TRP channel-mediated responses to weak and strong stimuli in intracellular Ca(2+) imaging experiments.
Topics: Acrolein; Animals; Calcium; Calcium Signaling; Capsaicin; CHO Cells; Cricetinae; Cricetulus; Flow Cytometry; Fura-2; HEK293 Cells; Humans; Leucine; Menthol; Pregnenolone; Sulfonamides; Transfection; TRPV Cation Channels | 2013 |
Pregnenolone sulphate enhances spatial orientation and object discrimination in adult male rats: evidence from a behavioural and electrophysiological study.
Topics: Action Potentials; Animals; Cerebral Cortex; Discrimination, Psychological; Hippocampus; Male; Neurons; Nootropic Agents; Orientation; Pregnenolone; Rats; Rats, Wistar; Space Perception | 2014 |
Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels.
Topics: Animals; Base Sequence; Binding Sites; HEK293 Cells; Humans; Mice; Molecular Sequence Data; Nifedipine; Pregnenolone; TRPM Cation Channels | 2014 |
Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats.
Topics: Animals; Cerebellum; Cyclic GMP; Disease Models, Animal; Glutamic Acid; Hyperammonemia; Learning; Male; Microdialysis; Nitric Oxide; Pregnenolone; Psychomotor Performance; Rats; Rats, Wistar; Receptors, GABA-A; Treatment Outcome | 2014 |
Pregnenolone sulfate activates NMDA receptor channels.
Topics: Calcium; Calcium Signaling; HEK293 Cells; Humans; Ion Channel Gating; Pregnenolone; Receptors, N-Methyl-D-Aspartate | 2013 |
Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ₂₅₋₃₅ peptide-induced toxicity in vitro and in vivo in mice.
Topics: Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Cell Line, Tumor; Cell Survival; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Lipid Peroxidation; Male; Mice; Neurites; Neuroprotective Agents; Peptide Fragments; Pregnenolone; Rats | 2014 |
Activation and inhibition of transient receptor potential TRPM3-induced gene transcription.
Topics: Dose-Response Relationship, Drug; Down-Regulation; Early Growth Response Protein 1; ets-Domain Protein Elk-1; Genes, Reporter; HEK293 Cells; Humans; Mefenamic Acid; Membrane Transport Modulators; Pregnenolone; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Time Factors; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation; Transfection; TRPM Cation Channels | 2014 |
Free and sulfated steroids secretion in postpubertal boars (Sus scrofa domestica).
Topics: Androstenedione; Animals; Dehydroepiandrosterone; Estradiol; Estrone; Male; Pregnenolone; Sus scrofa; Swine; Testis; Testosterone | 2014 |
A steroidogenic pathway for sulfonated steroids: the metabolism of pregnenolone sulfate.
Topics: Cytochromes b5; Escherichia coli; HEK293 Cells; Humans; Hydroxylation; Plasmids; Pregnenolone; Steroid 17-alpha-Hydroxylase | 2014 |
A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation.
Topics: Animals; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Inhibitory Concentration 50; Male; MAP Kinase Signaling System; Pregnenolone; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Potentials | 2014 |
Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; Hydroxycholesterols; Norsteroids; Pregnenolone; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2015 |
Transient receptor potential melastatin-3 (TRPM3)-induced activation of AP-1 requires Ca2+ ions and the transcription factors c-Jun, ATF2, and ternary complex factor.
Topics: Activating Transcription Factor 2; Calcium; Cations; ets-Domain Protein Elk-1; HEK293 Cells; Humans; Pregnenolone; Proto-Oncogene Proteins c-jun; Ternary Complex Factors; Transcription Factor AP-1; Transcription, Genetic; TRPM Cation Channels; Up-Regulation | 2015 |
Validated LC-MS/MS simultaneous assay of five sex steroid/neurosteroid-related sulfates in human serum.
Topics: Androsterone; Chromatography, Liquid; Dehydroepiandrosterone Sulfate; Estrone; Humans; Limit of Detection; Pregnanolone; Pregnenolone; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells.
Topics: Biomechanical Phenomena; Bone Remodeling; Boron Compounds; Calcium Channel Blockers; Calcium Signaling; Cell Culture Techniques; Cells, Cultured; Gene Silencing; Humans; Hypotonic Solutions; Morpholines; Osteoprotegerin; Periodontal Ligament; Phorbols; Pregnenolone; Pyrroles; RANK Ligand; RNA, Messenger; RNA, Small Interfering; Ruthenium Red; Signal Transduction; Stress, Mechanical; TRPM Cation Channels; TRPV Cation Channels | 2015 |
TRPM3 expression in mouse retina.
Topics: Animals; Calcium Signaling; CHO Cells; Cricetinae; Cricetulus; Electroretinography; Gene Expression; Mice; Mice, Transgenic; Pregnenolone; Protein Isoforms; Protein Transport; Recombinant Fusion Proteins; Retina; Retinal Ganglion Cells; TRPM Cation Channels | 2015 |
Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate.
Topics: Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Dehydroepiandrosterone Sulfate; GABA-A Receptor Antagonists; HEK293 Cells; Humans; Molecular Sequence Data; Pregnenolone; Protein Binding; Receptors, GABA-A | 2015 |
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Topics: Animals; Calcium; Cell Membrane Permeability; HEK293 Cells; Hot Temperature; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channel Gating; Ligands; Mice, Inbred C57BL; Nerve Endings; Neuropeptides; Nociception; Pain; Pregnenolone; Quinolines; Sensory Receptor Cells; Transfection; TRPM Cation Channels | 2015 |
Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.
Topics: Animals; Behavior, Animal; Blotting, Western; Dopamine Plasma Membrane Transport Proteins; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Knockout; Pregnenolone; Proto-Oncogene Proteins c-akt; Schizophrenia | 2015 |
Regulation of the transient receptor potential channel TRPM3 by phosphoinositides.
Topics: Adenosine Triphosphate; Cell Line; Cell Membrane; HEK293 Cells; Humans; Hyperalgesia; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Pregnenolone; Sensory Receptor Cells; TRPM Cation Channels | 2015 |
Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu.
Topics: Calcium; Extracellular Fluid; HEK293 Cells; Humans; Intracellular Fluid; Ion Channel Gating; Nerve Tissue Proteins; Pregnenolone; Receptors, N-Methyl-D-Aspartate | 2015 |
The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bile Ducts; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Disease Models, Animal; GABA-A Receptor Antagonists; Liver Cirrhosis, Biliary; Male; Memory; Memory Disorders; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2015 |
Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers.
Topics: Cell Line; Clotrimazole; HEK293 Cells; Hot Temperature; Humans; Hyperalgesia; Insulin-Secreting Cells; Ion Channel Gating; Lipid Bilayers; Nifedipine; Phosphatidylinositol 4,5-Diphosphate; Pregnenolone; TRPM Cation Channels | 2016 |
Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism.
Topics: Adenosine Triphosphate; Animals; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylenediamines; Hyperalgesia; Male; Pain Measurement; Pregnenolone; Purinergic P2X Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X; Receptors, sigma; Time Factors | 2016 |
Transient Receptor Potential Melastatin-3 (TRPM3) Mediates Nociceptive-Like Responses in Hydra vulgaris.
Topics: Animals; Gene Expression Regulation; Heat-Shock Response; HSP70 Heat-Shock Proteins; Hydra; Nociception; Pregnenolone; Protein Transport; RNA, Messenger; Superoxide Dismutase; TRPM Cation Channels | 2016 |
Amyloid Beta Peptides Affect Pregnenolone and Pregnenolone Sulfate Levels in PC-12 and SH-SY5Y Cells Depending on Cholesterol.
Topics: Amyloid beta-Peptides; Animals; Cell Survival; Cholesterol; Humans; PC12 Cells; Pregnenolone; Rats | 2016 |
Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation.
Topics: Desoxycorticosterone; Glycine; HEK293 Cells; Humans; Hyperekplexia; Models, Molecular; Mutation, Missense; Picrotoxin; Pregnenolone; Receptors, Glycine; Zinc | 2016 |
Activation of gene transcription via CIM0216, a synthetic ligand of transient receptor potential melastatin-3 (TRPM3) channels.
Topics: HEK293 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Ligands; Pregnenolone; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Transcription Factor AP-1; Transcription, Genetic; TRPM Cation Channels | 2017 |
Pregnenolone sulfate regulates prolactin production in the rat pituitary.
Topics: Animals; Cell Proliferation; Gonadotropin-Releasing Hormone; Pituitary Gland; Pregnenolone; Prolactin; Rats; Signal Transduction; Tumor Cells, Cultured | 2016 |
Role of steroid sulfatase in steroid homeostasis and characterization of the sulfated steroid pathway: Evidence from steroid sulfatase deficiency.
Topics: Adolescent; Adult; Aged; Case-Control Studies; Child; Child, Preschool; Dehydroepiandrosterone; Estradiol Dehydrogenases; Homeostasis; Humans; Ichthyosis, X-Linked; Middle Aged; Pregnenolone; Steroid 17-alpha-Hydroxylase; Steroids; Steryl-Sulfatase; Sulfates; Young Adult | 2016 |
Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains.
Topics: Allosteric Regulation; Animals; Arachidonic Acid; Calcium; Dimerization; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Excitatory Amino Acid Agonists; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydroxycholesterols; Kainic Acid; Membrane Potentials; Models, Molecular; N-Methylaspartate; Patch-Clamp Techniques; Pregnenolone; Protein Domains; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Transfection | 2016 |
Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate.
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adrenal Glands; Adult; Age Factors; Androstenediol; Cell Culture Techniques; Child; Child, Preschool; Cytochromes b5; Dehydroepiandrosterone Sulfate; Female; Human Development; Humans; Infant; Male; Pregnenolone; Progesterone Reductase; Young Adult | 2016 |
Extracellular Signal-Regulated Protein Kinase, c-Jun N-Terminal Protein Kinase, and Calcineurin Regulate Transient Receptor Potential M3 (TRPM3) Induced Activation of AP-1.
Topics: Blotting, Western; Calcineurin; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Lentivirus; Phosphorylation; Pregnenolone; RNA, Small Interfering; Transcription Factor AP-1; TRPM Cation Channels | 2017 |
Reduced steroidogenesis in patients with PCDH19-female limited epilepsy.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Cadherins; Case-Control Studies; Child; Child, Preschool; DNA Mutational Analysis; Epilepsy; Estradiol; Female; Genetic Diseases, X-Linked; Gonadal Steroid Hormones; Humans; Hydrocortisone; Intellectual Disability; Pregnanolone; Pregnenolone; Progesterone; Prospective Studies; Protocadherins; Puberty, Precocious; Reference Values | 2017 |
11-Oxygenated Androgens Are Biomarkers of Adrenal Volume and Testicular Adrenal Rest Tumors in 21-Hydroxylase Deficiency.
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenal Rest Tumor; Adult; Age Determination by Skeleton; Aged; Androgens; Androstenedione; Androstenes; Child; Child, Preschool; Cortodoxone; Cross-Sectional Studies; Female; Hirsutism; Humans; Hydroxytestosterones; Male; Menstruation Disturbances; Middle Aged; Organ Size; Pregnenolone; Testicular Neoplasms; Testosterone; Young Adult | 2017 |
Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids.
Topics: Calcium Channels; Contraceptive Agents, Male; Estradiol; Female; Fertility; Humans; Hydrocortisone; Hydrolases; In Vitro Techniques; Kinetics; Male; Pentacyclic Triterpenes; Phytosterols; Pregnenolone; Sperm Capacitation; Sperm Motility; Spermatozoa; Steroids; Testosterone; Triterpenes | 2017 |
Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits.
Topics: Animals; Baclofen; Behavior Rating Scale; Calcium; Ganglia, Spinal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; HEK293 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Intracellular Signaling Peptides and Proteins; Mice; Neurons; Pregnenolone; Somatostatin; TRPM Cation Channels | 2017 |
Efficiency of the sulfate pathway in comparison to the Δ4- and Δ5-pathway of steroidogenesis in the porcine testis.
Topics: Animals; Cytochromes b5; Hydroxylation; Male; Metabolic Networks and Pathways; Microsomes; NADPH-Ferrihemoprotein Reductase; Pregnenolone; Progesterone; Recombinant Proteins; Steroid 17-alpha-Hydroxylase; Sulfates; Swine; Testis | 2018 |
Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Case-Control Studies; Cells, Cultured; Dehydroepiandrosterone Sulfate; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Male; Middle Aged; Pregnenolone; Prognosis | 2018 |
Neurosteroid pregnenolone sulfate, alone, and as augmentation of lurasidone or tandospirone, rescues phencyclidine-induced deficits in cognitive function and social interaction.
Topics: Animals; Antipsychotic Agents; Cognition; Drug Therapy, Combination; Interpersonal Relations; Isoindoles; Lurasidone Hydrochloride; Male; Mice, Inbred C57BL; Neurotransmitter Agents; Phencyclidine; Piperazines; Pregnenolone; Pyrimidines; Random Allocation; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology | 2018 |
Calcium, Sodium, and Transient Receptor Potential Channel Expression in Human Fetal Midbrain-Derived Neural Progenitor Cells.
Topics: Calcium Channels; Cell Differentiation; Cell Proliferation; Fetus; Gene Expression Regulation, Developmental; Humans; Mesencephalon; Neural Stem Cells; Pregnenolone; Stem Cells; Sulfonamides; TRPA1 Cation Channel; Voltage-Gated Sodium Channels | 2018 |
Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells.
Topics: Adrenal Glands; Animals; Cell Line; Corticosterone; Glucocorticoids; Mice; Models, Biological; Muscle, Skeletal; Pregnenolone | 2018 |
Characterizing the steroidal milieu in amniotic fluid of mid-gestation: A LC-MS/MS study.
Topics: 17-alpha-Hydroxypregnenolone; Amniotic Fluid; Androsterone; Chromatography, Liquid; Dehydroepiandrosterone; Epitestosterone; Estriol; Estrone; Female; Gestational Age; Humans; Male; Pregnancy; Pregnancy Trimester, Second; Pregnenolone; Steroids; Tandem Mass Spectrometry | 2019 |
Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.
Topics: Adult; Fatigue Syndrome, Chronic; Female; Humans; Killer Cells, Natural; Male; Middle Aged; Pregnenolone; TRPM Cation Channels | 2018 |
Abnormal steroidogenesis and aromatase activity in preeclampsia.
Topics: Adult; Androstenedione; Aromatase; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Mass Spectrometry; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Pregnenolone; Vascular Endothelial Growth Factor Receptor-1; Young Adult | 2018 |
The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators.
Topics: Allosteric Regulation; Animals; Calcium; Carboxylic Acids; Female; Fluorescence Resonance Energy Transfer; Naphthalenes; Neurons; Oocytes; Pregnenolone; Protein Domains; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2019 |
The TRPP2-dependent channel of renal primary cilia also requires TRPM3.
Topics: Animals; Calcium Signaling; Cell Line; Cilia; Epithelial Cells; Flavonoids; Gene Knockout Techniques; Humans; Kidney; Mice; Pregnenolone; TRPM Cation Channels; TRPP Cation Channels | 2019 |
Cholesterol sulfate alters astrocyte metabolism and provides protection against oxidative stress.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Death; Cell Line; Cell Survival; Cholesterol Esters; Energy Metabolism; Glutamic Acid; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Oxidative Stress; Pregnenolone; Primary Cell Culture; Reactive Oxygen Species | 2019 |
L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors.
Topics: Animals; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Inhibitory Concentration 50; Kinetics; Molecular Structure; Nicotinic Antagonists; Oocytes; Pregnenolone; Receptors, GABA-A; Receptors, Nicotinic; Torpedo; Triiodothyronine | 2019 |
Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms.
Topics: Calcium; Cells, Cultured; Ganglia, Spinal; HEK293 Cells; Humans; Mutation; Pregnenolone; TRPM Cation Channels | 2020 |
Local biosynthesis of corticosterone in rat skeletal muscle.
Topics: Animals; Corticosterone; Male; Muscle, Skeletal; Pregnenolone; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase | 2020 |
Site of Action of Brain Neurosteroid Pregnenolone Sulfate at the N-Methyl-D-Aspartate Receptor.
Topics: Alanine; Animals; Binding Sites; Cell Membrane; Cholesterol; Electrophysiological Phenomena; HEK293 Cells; Humans; Molecular Dynamics Simulation; Patch-Clamp Techniques; Pregnenolone; Protein Conformation; Rats; Receptors, N-Methyl-D-Aspartate | 2020 |
Positive allosteric modulators that target NMDA receptors rectify loss-of-function GRIN variants associated with neurological and neuropsychiatric disorders.
Topics: Allosteric Regulation; Animals; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Genetic Variation; Humans; Loss of Function Mutation; Mental Disorders; Nerve Tissue Proteins; Nervous System Diseases; Pregnenolone; Protein Structure, Secondary; Receptors, N-Methyl-D-Aspartate; Serine; Tobramycin; Xenopus laevis | 2020 |
Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA
Topics: Allosteric Regulation; Binding Sites; GABA-A Receptor Agonists; HEK293 Cells; Humans; Multiprotein Complexes; Muscimol; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; Steroids; Tritium | 2020 |
TRPM3 expression and control of glutamate release from primary vagal afferent neurons.
Topics: Action Potentials; Animals; Excitatory Postsynaptic Potentials; Exocytosis; Glutamic Acid; Hot Temperature; Male; Neurons, Afferent; Pregnenolone; Rats; Rats, Sprague-Dawley; TRPM Cation Channels; Vagus Nerve | 2021 |
TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves.
Topics: Adult; Aged; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Female; Heterocyclic Compounds, 4 or More Rings; Humans; Male; Middle Aged; Muscle Contraction; Nephrectomy; Neurokinin A; Organ Culture Techniques; Pregnenolone; Primidone; Sensory Receptor Cells; TRPM Cation Channels; Ureter | 2021 |
Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study.
Topics: Aged; Estradiol; Female; Humans; Migraine Disorders; Pregnanolone; Pregnenolone | 2021 |
The newest TRP channelopathy: Gain of function TRPM3 mutations cause epilepsy and intellectual disability.
Topics: Epilepsy; Gain of Function Mutation; Ganglia, Spinal; Intellectual Disability; Pregnenolone | 2021 |
Pitfalls of NMDA Receptor Modulation by Neuroactive Steroids. The Effect of Positive and Negative Modulation of NMDA Receptors in an Animal Model of Schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilpine Maleate; Elevated Plus Maze Test; HEK293 Cells; Humans; Male; Pregnenolone; Rats, Long-Evans; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Steroids | 2021 |
The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the
Topics: Animals; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; GABA Antagonists; Humans; Neurosteroids; Pregnenolone; Protein Stability; Receptors, GABA-A; Xenopus laevis | 2022 |
TRPM3 Is Expressed in Afferent Bladder Neurons and Is Upregulated during Bladder Inflammation.
Topics: Animals; Cyclophosphamide; Cystitis; Female; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurons, Afferent; Pregnenolone; RNA, Messenger; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels; Up-Regulation; Urinary Bladder | 2021 |
Pre- and postsynaptic modulation of hippocampal inhibitory synaptic transmission by pregnenolone sulphate.
Topics: Animals; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Neurosteroids; Pregnenolone; Rats; Receptors, GABA-A; Synaptic Transmission; TRPM Cation Channels | 2023 |
Pregnenolone sulfate analogues differentially modulate GABA
Topics: gamma-Aminobutyric Acid; Pregnenolone; Receptors, GABA-A | 2023 |