pregnenolone sulfate has been researched along with pregnanolone in 72 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (34.72) | 18.2507 |
| 2000's | 35 (48.61) | 29.6817 |
| 2010's | 10 (13.89) | 24.3611 |
| 2020's | 2 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Barnard, EA; Darlison, MG; Harvey, RJ; Shingai, R; Zaman, SH | 1 |
| Majewska, MD; Vaupel, DB | 1 |
| Baulieu, EE; Mahé, V; Monnet, FP; Robel, P | 1 |
| Moore, FL; Murray, TF; Orchinik, M | 1 |
| Costa, E; Ducić, I; Puia, G; Vicini, S | 1 |
| Devaud, LL; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Hauser, CA; Holsboer, F; Rupprecht, R; Wetzel, CH | 1 |
| Bãckström, T; Purdy, RH; Seippel, L; Wang, M | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Bondoux, D; Chapouthier, G; Clément, Y; Launay, JM; Martin, B; Robel, P; Venault, P; Young, J | 1 |
| Baulieu, EE; Corpéchot, C; Eychenne, B; Haug, M; Perché, F; Robel, P; Young, J | 1 |
| Bäckström, T; Wahlström, G; Wang, MD | 1 |
| Bäckström, T; Landgren, S; Wang, MD | 1 |
| Gillies, GE; Murray, HE | 1 |
| Feltz, P; Poisbeau, P; Schlichter, R | 1 |
| Farb, DH; Gibbs, TT; Malayev, AA; Park-Chung, M; Purdy, RH; Wu, FS | 1 |
| Akwa, Y; Baulieu, EE; El-Etr, M; Robel, P | 1 |
| Covey, DF; Nilsson, KR; Zorumski, CF | 1 |
| Wang, L; Wang, Q; Wardwell-Swanson, J | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Farb, DH; Gibbs, TT; Malayev, A; Park-Chung, M; Purdy, RH | 1 |
| Bouyer, JJ; Darnaudéry, M; Le Moal, M; Mayo, W; Pallarés, M | 1 |
| Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H | 1 |
| Baulieu, E; Blair-West, J; Denton, D; Eychenne, B; Ladurelle, N; Robel, P; Schumacher, M | 1 |
| Bicíková, M; Hill, M; Stárka, L; Számel, I; Tallová, J | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Barbosa, AD; Morato, GS | 2 |
| Jhangri, GS; Le Mellédo, JM; Semeniuk, T | 1 |
| Bicíková, M; Hill, M; Putz, Z; Tallová, J; Tomandl, J; Vañuga, A | 1 |
| Peeke, HV; Snyder, MJ | 1 |
| Simmonds, MA; Sooksawate, T | 1 |
| Bertram, EH; Kapur, J; Mtchedlishvili, Z | 1 |
| Farb, DH; Gibbs, TT; Malayev, A | 1 |
| Bicíková, M; Calda, P; Hampl, R; Hill, M; Klak, J; Zizka, Z | 1 |
| Heydari, B; Le Mellédo, JM | 1 |
| Akwa, Y; Baulieu, EE; David, JP; Delacourte, A; Eychenne, B; Liere, P; Pianos, A; Sazdovitch, V; Schumacher, M; Weill-Engerer, S | 1 |
| Cascio, C; De Leo, G; Guarneri, M; Guarneri, P; Guarneri, R; Piccoli, F; Russo, D | 1 |
| Bicíková, M; Budesínský, M; Cerný, I; Hampl, R; Hill, M; Pouzar, V | 1 |
| Boyd, SK; Goetz, FW; Hollis, DM; Roberts, SB | 1 |
| Cerný, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Popov, P; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Martín-García, E; Pallarès, M | 3 |
| Frändberg, PA; Johansson, T; Le Grevès, P; Nyberg, F | 1 |
| George, O; Le Moal, M; Mayo, W; Vallée, M | 1 |
| Hou, YN; Wang, N; Wu, HH | 1 |
| Citraro, R; De Sarro, G; Di Paola, ED; Gratteri, S; Ibbadu, GF; Marra, R; Russo, E | 1 |
| Cerny, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Akk, G; Evers, AS; Li, P; Manion, BD; Steinbach, JH | 1 |
| Gentile, L; Hall, A; Hall, J; Knight, L; Morgan, A; Stoll, L; Van Buren, N; Van Deusen, H; Zuger, S | 1 |
| Darbra, S; Martin-García, E; Pallarès, M | 2 |
| Hamann, M; Richter, A; Richter, F | 1 |
| Basta-Kaim, A; Budziszewska, B; Jagla, G; Jantas, D; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Nowak, W; Regulska, M | 1 |
| Elfverson, M; Johansson, T; Le Grevès, P; Linde, AM; Nyberg, F; Zhou, Q | 1 |
| Akk, G; Bracamontes, J; Covey, DF; Li, P; Reichert, DE; Steinbach, JH | 1 |
| Bradford, DW; Buchanan, RW; Dunn, L; Hamer, RM; Keefe, RS; Kilts, JD; Leimone, LA; Lieberman, JA; Marx, CE; Morrow, AL; Naylor, JC; Payne, VM; Porcu, P; Savitz, AJ; Shampine, LJ; Strauss, JL | 1 |
| Elfverson, M; Johansson, T; Nyberg, F; Zhou, Q | 1 |
| Darbra, S; Pallarès, M | 1 |
| Elfverson, M; Johansson, T; Le Grevès, P; Nyberg, F; Zhou, Q | 1 |
| Darbra, S; Mòdol, L; Pallarès, M | 2 |
| Bartle, E; Borkowski, B; Cameron, K; Fanelli, D; Gentile, L; Kahlson, M; Kangala, M; Kim, J; Pham, M; Pollard, B; Rhoads, S; Roark, R; Rocha, M | 1 |
| Lucchi, C; Pinetti, D; Puia, G; Ravazzini, F; Rustichelli, C | 1 |
| Dury, AY; Gonthier, R; Isabelle, M; Ke, Y; Labrie, F; Simard, JN | 1 |
| Chung, BC; Weng, JH | 1 |
| Bertini, ES; Biagini, G; Cusmai, R; Gecz, J; Giannone, G; Lucchi, C; Rustichelli, C; Specchio, N; Terracciano, A; Trivisano, M; Ubertini, GM; Vigevano, F | 1 |
| Akk, G; Evers, AS; Germann, AL; Pierce, SR; Steinbach, JH; Sugasawa, Y | 1 |
| Baraldi, C; Bellei, E; Bergamini, S; Ferrari, A; Lo Castro, F; Monari, E; Rustichelli, C; Tomasi, A | 1 |
3 review(s) available for pregnenolone sulfate and pregnanolone
| Article | Year |
|---|---|
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Male; Menstruation; Pregnancy; Pregnanolone; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1995 |
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.
Topics: Acetylcholine; Aging; Animals; Brain Stem; Dehydroepiandrosterone Sulfate; Humans; Memory; Memory Disorders; Pregnanolone; Pregnenolone; Prosencephalon; Sleep; Sleep Wake Disorders | 2006 |
Nongenomic actions of neurosteroid pregnenolone and its metabolites.
Topics: 17-alpha-Hydroxypregnenolone; Animals; Depression; Humans; Microtubules; Neurodegenerative Diseases; Neurotransmitter Agents; Pregnanolone; Pregnenolone | 2016 |
1 trial(s) available for pregnenolone sulfate and pregnanolone
| Article | Year |
|---|---|
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Topics: Adult; Aged; Brain; Brain Chemistry; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Placebos; Pregnanolone; Pregnenolone; Schizophrenia; Treatment Outcome; Up-Regulation | 2009 |
68 other study(ies) available for pregnenolone sulfate and pregnanolone
| Article | Year |
|---|---|
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.
Topics: Animals; Base Sequence; DNA; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Molecular Sequence Data; Oocytes; Polymerase Chain Reaction; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1992 |
Steroid control of uterine motility via gamma-aminobutyric acidA receptors in the rabbit: a novel mechanism?
Topics: Animals; Female; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Progesterone; Progestins; Rabbits; Receptors, GABA-A; Stimulation, Chemical; Uterine Contraction | 1991 |
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Guanidines; Haloperidol; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ovariectomy; Pertussis Toxin; Piperazines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereotaxic Techniques; Virulence Factors, Bordetella | 1995 |
Steroid modulation of GABAA receptors in an amphibian brain.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Convulsants; Corticosterone; Flunitrazepam; Kinetics; Male; Mammals; Neurons; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Salamandridae; Species Specificity; Steroids; Sulfur Radioisotopes; Synaptosomes; Tritium | 1994 |
Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?
Topics: Allosteric Regulation; Animals; Cell Line; Cells, Cultured; Cerebral Cortex; Chlorides; Electrophysiology; Humans; Pregnanolone; Pregnenolone; Protein Conformation; Rats; Receptors, GABA-A; Recombinant Proteins | 1993 |
Sex steroids and memory.
Topics: Animals; Clinical Trials as Topic; GABA Modulators; Gonadal Steroid Hormones; Humans; Memory; Pregnanolone; Pregnenolone; Progesterone; Steroids | 1995 |
Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.
Topics: Animals; Anti-Anxiety Agents; Cell Line; Cell Membrane; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypothalamus; Kinetics; Membrane Potentials; Molecular Sequence Data; Muscimol; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1996 |
Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one.
Topics: 5-alpha-Dihydroprogesterone; Adult; Female; Hormones; Humans; Luteal Phase; Menstrual Cycle; Osmolar Concentration; Pregnanediones; Pregnanolone; Pregnenolone; Premenstrual Syndrome | 1996 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures.
Topics: Animals; Brain Chemistry; Carbolines; Convulsants; Drug Resistance; Evaluation Studies as Topic; Female; Male; Mice; Mice, Mutant Strains; Pentylenetetrazole; Pregnanolone; Pregnenolone; Radioligand Assay; Receptors, GABA-A; Seizures | 1996 |
Neurosteroids in the mouse brain: behavioral and pharmacological effects of a 3 beta-hydroxysteroid dehydrogenase inhibitor.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Brain; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Female; Humans; Mice; Pregnanolone; Pregnenolone; Progesterone; Sexual Behavior, Animal | 1996 |
Pregnenolone sulphate and pregnenolone do not interact with 5 beta-pregnanolone- and hexobarbitone-induced anaesthesia in the rat.
Topics: Albumins; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Hexobarbital; Male; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley | 1997 |
The effects of allopregnanolone, pregnenolone sulphate and pregnenolone on the CA1 population spike of the rat hippocampus after 17 beta-oestradiol priming.
Topics: Animals; Estradiol; Evoked Potentials; GABA Modulators; Male; Pregnanolone; Pregnenolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1997 |
Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures.
Topics: Animals; Bicuculline; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dopamine; Drug Synergism; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Pregnanolone; Pregnenolone; Rats; Somatostatin | 1997 |
Modulation of GABAA receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model.
Topics: Animals; Animals, Newborn; Cells, Cultured; Electrophysiology; Female; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypothalamo-Hypophyseal System; Membrane Potentials; Pentobarbital; Pregnancy; Pregnanes; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.
Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cells, Cultured; Chick Embryo; Hippocampus; N-Methylaspartate; Neurons; Oxidation-Reduction; Polyamines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Structure-Activity Relationship; Xenopus laevis | 1997 |
Opposing effects of different steroid sulfates on GABAA receptor-mediated chloride uptake.
Topics: Animals; Biological Transport; Cerebral Cortex; Chlorides; Dehydroepiandrosterone Sulfate; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; In Vitro Techniques; Ionophores; Male; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 1998 |
Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.
Topics: Animals; Cells, Cultured; Dehydroepiandrosterone Sulfate; GABA Modulators; Hippocampus; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Stereoisomerism | 1998 |
Modulation of cloned human neuronal voltage-gated potassium channels (hKv1.1 and hKv2.1) by neurosteroids.
Topics: Animals; CHO Cells; Cloning, Molecular; Cricetinae; Electric Conductivity; Gene Expression; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Potassium Channels; Pregnanolone; Pregnenolone; Steroids | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors | 1998 |
Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites.
Topics: Animals; Cells, Cultured; Chick Embryo; Dehydroepiandrosterone Sulfate; GABA Modulators; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Steroids; Sulfuric Acid Esters; Xenopus laevis | 1999 |
Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties.
Topics: Animals; GABA Modulators; Male; Memory; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Sleep; Sleep, REM; Substantia Innominata; Wakefulness | 1999 |
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 1999 |
Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse.
Topics: 5-alpha-Dihydroprogesterone; Animals; Behavior, Animal; Cognition; Infusion Pumps, Implantable; Injections, Intraventricular; Male; Maze Learning; Memory; Mice; Neuroprotective Agents; Pregnanediones; Pregnanolone; Pregnenolone; Prosencephalon; Space Perception | 2000 |
Allopregnanolone, pregnenolone sulfate, and epitestosterone in breast cyst fluid.
Topics: Adult; Epitestosterone; Exudates and Transudates; Female; Fibrocystic Breast Disease; Humans; Luteal Phase; Middle Aged; Pregnanolone; Pregnenolone; Reference Values | 2001 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Effect of epipregnanolone and pregnenolone sulfate on chronic tolerance to ethanol.
Topics: Animals; Central Nervous System Depressants; Drug Tolerance; Ethanol; Male; Mice; Motor Skills; Pregnanolone; Pregnenolone | 2000 |
Neuroactive steroid levels in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Dehydroepiandrosterone; Female; gamma-Aminobutyric Acid; Humans; Male; Pregnanolone; Pregnenolone; Receptors, GABA-A | 2001 |
Effect of treatment of hypothyroidism on the plasma concentrations of neuroactive steroids and homocysteine.
Topics: Adjuvants, Immunologic; Adult; Aged; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Homocysteine; Humans; Hypothyroidism; Male; Microsomes; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Thyrotropin; Thyroxine; Time Factors; Triiodothyronine | 2001 |
Neuroactive steroids modulate crustacean locomotor activity.
Topics: Animals; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Gonadal Steroid Hormones; Male; Motor Activity; Nephropidae; Pregnanolone; Pregnenolone | 2001 |
Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.
Topics: Animals; Cell Membrane; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Pregnenolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A | 2001 |
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Pyridines; Rats; Receptors, GABA-A; Zinc; Zolpidem | 2001 |
Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Models, Biological; Oocytes; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 2002 |
Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid.
Topics: Amniotic Fluid; Female; Fetal Blood; Gonadal Steroid Hormones; History, 16th Century; Humans; Pregnancy; Pregnancy Trimester, Second; Pregnanolone; Pregnenolone; Sensitivity and Specificity | 2002 |
Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia.
Topics: Adult; Arousal; Dehydroepiandrosterone; Humans; Male; Middle Aged; Phobic Disorders; Pilot Projects; Pregnanolone; Pregnenolone; Reference Values | 2002 |
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Brain Chemistry; Cerebellum; Corpus Striatum; Dehydroepiandrosterone Sulfate; Female; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Hippocampus; Humans; Hypothalamus; Male; Pregnanolone; Pregnenolone; Progesterone; Protein Structure, Secondary; Steroids; tau Proteins | 2002 |
A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-specific caspase-2 activation in the retinal cell death.
Topics: Animals; Apoptosis; Caspase 2; Caspase 3; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Estradiol; In Situ Nick-End Labeling; In Vitro Techniques; Male; Neuroprotective Agents; Neurotoxins; Oxidation-Reduction; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Signal Transduction | 2002 |
Synthesis of [19- 2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates.
Topics: Androstanes; Combinatorial Chemistry Techniques; Dehydroepiandrosterone; Deuterium; Molecular Structure; Pregnanolone; Pregnenolone | 2004 |
Acute neurosteroid modulation and subunit isolation of the gamma-aminobutyric acidA receptor in the bullfrog, Rana catesbeiana.
Topics: Amino Acid Sequence; Anesthetics; Animals; Brain; Cell Membrane; Cloning, Molecular; GABA Agonists; Male; Molecular Sequence Data; Muscimol; Pregnanolone; Pregnenolone; Protein Isoforms; Protein Subunits; Radioligand Assay; Rana catesbeiana; Receptors, GABA-A; Sequence Alignment; Tritium | 2004 |
Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction.
Topics: Alcoholism; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Progesterone; Radioimmunoassay; Stereoisomerism; Steroids; Time Factors | 2005 |
Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats.
Topics: Administration, Oral; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Drug Interactions; Ethanol; Exploratory Behavior; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Self Medication | 2005 |
Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Frontal Lobe; Male; Piperidines; Pregnanolone; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 2005 |
Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats.
Topics: Animals; Body Weight; Ethanol; Hippocampus; Male; Motor Activity; Nicotine; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome | 2005 |
The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cholinergic Fibers; Dose-Response Relationship, Drug; Epilepsy, Reflex; Hippocampus; Male; Microinjections; Nicotine; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Statistics, Nonparametric | 2005 |
[Effects of morphine dependence on the levels of neurosteroids in rat brain].
Topics: Amygdala; Animals; Brain; Conditioning, Operant; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hypothalamus; Male; Morphine Dependence; Nucleus Accumbens; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley | 2005 |
Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy, Absence; Male; Microinjections; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Time Factors | 2006 |
Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age.
Topics: Adult; Aging; Dehydroepiandrosterone; Estradiol; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Isomerism; Luteal Phase; Pregnanolone; Pregnenolone; Progesterone; Receptors, GABA-A | 2006 |
Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.
Topics: Animals; Behavior, Animal; Binding Sites; Dose-Response Relationship, Drug; Estradiol; Ethanol; Female; Kinetics; Larva; Pregnanolone; Pregnenolone; Protein Binding; Protein Subunits; Receptors, GABA-A | 2007 |
Differential regulation of ionotropic glutamate receptors.
Topics: Binding Sites; Ligands; Models, Molecular; Pregnanolone; Pregnenolone; Protein Structure, Tertiary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Zinc | 2007 |
Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats.
Topics: Alcohol Drinking; Alcohols; Anesthetics; Animals; Behavior, Animal; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking Behavior; Food Deprivation; Glucose; Hippocampus; Linear Models; Male; Pregnanolone; Pregnenolone; Rats; Rats, Wistar | 2007 |
Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.
Topics: Animals; Animals, Genetically Modified; Cricetinae; Dehydroepiandrosterone; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Mesocricetus; Pregnanolone; Pregnenolone | 2007 |
Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Brain; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; Neurons; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Pregnanolone; Pregnenolone; Staurosporine; Steroids | 2008 |
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.
Topics: Analysis of Variance; Anesthetics; Animals; Body Temperature; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone | 2007 |
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A.
Topics: Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cricetulus; Hippocampus; Ion Channels; Male; Piperidines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2008 |
Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration.
Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Enzyme Inhibitors; Finasteride; Gonadal Steroid Hormones; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 2008 |
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
Topics: Amino Acid Substitution; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutant Proteins; Mutation; Piperidines; Pregnanetriol; Pregnanolone; Pregnenolone; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Serine; Steroids; Tryptophan | 2008 |
Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration.
Topics: Allosteric Regulation; Animals; Brain; Dehydroepiandrosterone; Male; Morphine; Neurotransmitter Agents; Opioid-Related Disorders; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Interaction between early postnatal neurosteroid manipulations and adult infusion of neurosteroids into CA1 hippocampal region on the open field behaviour.
Topics: 5-alpha Reductase Inhibitors; Adaptation, Physiological; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Exploratory Behavior; Finasteride; Male; Microinjections; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Spatial Behavior | 2011 |
Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors.
Topics: Allosteric Regulation; Anabolic Agents; Androgens; Animals; Dehydroepiandrosterone Sulfate; Frontal Lobe; Kinetics; Male; Nandrolone; Nandrolone Decanoate; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2011 |
Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning.
Topics: Animals; Anxiety; Avoidance Learning; Body Weight; CA1 Region, Hippocampal; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Statistics, Nonparametric | 2011 |
Allopregnanolone infused into the dorsal (CA1) hippocampus increases prepulse inhibition of startle response in Wistar rats.
Topics: Animals; CA1 Region, Hippocampal; Male; Microinjections; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Sensory Gating | 2012 |
Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors.
Topics: Binding Sites; Cloning, Molecular; Models, Molecular; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Receptors, Ionotropic Glutamate; Spectrometry, Fluorescence | 2012 |
Simultaneous determination of pregnenolone sulphate, dehydroepiandrosterone and allopregnanolone in rat brain areas by liquid chromatography-electrospray tandem mass spectrometry.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Hippocampus; Male; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Validated LC-MS/MS simultaneous assay of five sex steroid/neurosteroid-related sulfates in human serum.
Topics: Androsterone; Chromatography, Liquid; Dehydroepiandrosterone Sulfate; Estrone; Humans; Limit of Detection; Pregnanolone; Pregnenolone; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
Reduced steroidogenesis in patients with PCDH19-female limited epilepsy.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Cadherins; Case-Control Studies; Child; Child, Preschool; DNA Mutational Analysis; Epilepsy; Estradiol; Female; Genetic Diseases, X-Linked; Gonadal Steroid Hormones; Humans; Hydrocortisone; Intellectual Disability; Pregnanolone; Pregnenolone; Progesterone; Prospective Studies; Protocadherins; Puberty, Precocious; Reference Values | 2017 |
Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA
Topics: Allosteric Regulation; Binding Sites; GABA-A Receptor Agonists; HEK293 Cells; Humans; Multiprotein Complexes; Muscimol; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; Steroids; Tritium | 2020 |
Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study.
Topics: Aged; Estradiol; Female; Humans; Migraine Disorders; Pregnanolone; Pregnenolone | 2021 |