pregnenolone sulfate has been researched along with n-methylaspartate in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (55.17) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 3 (10.34) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berrino, L; Leyva, J; Maione, S; Rossi, F; Vitagliano, S | 1 |
| Farb, DH; Gibbs, TT; Wu, FS | 1 |
| Bowlby, MR | 1 |
| Fahey, JM; Lindquist, DG; Miller, LG; Pritchard, GA | 1 |
| Baulieu, EE; Mahé, V; Monnet, FP; Robel, P | 1 |
| Irwin, RP; Lin, SZ; Paul, SM; Purdy, RH; Rogawski, MA | 1 |
| Bergeron, R; de Montigny, C; Debonnel, G | 2 |
| Chuang, DM; Gao, XM; Hough, CJ; Irwin, RP; Rogawski, MA | 1 |
| Richardson, CM; Wakerley, JB | 2 |
| Farb, DH; Gibbs, TT; Malayev, AA; Park-Chung, M; Purdy, RH; Wu, FS | 1 |
| Horiguchi, J; Kagaya, A; Takebayashi, M; Uchitomi, Y; Yamawaki, S; Yokota, N | 1 |
| Farb, DH; Gibbs, TT; Weaver, CE; Wu, FS | 1 |
| Cascio, C; De Leo, G; Guarneri, P; Guarneri, R; Piccoli, F; Piccoli, T; Russo, D; Sciuto, V | 1 |
| Juhng, KN; Kirkby, RD; Kokate, TG; Llamas, J; Rogawski, MA; Yamaguchi, S | 1 |
| Browning, MD; Costa, ET; Ferreira, VM; Frausto, S; Meyer, DA; Olivera, DS; Savage, DD; Soto, EE; Valenzuela, CF | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Hattori, TA; Kawato, S; Kimoto, T; Takahashi, T; Tanabe, N; Yasumatsu, N | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Walkowiak, J; Wisłowska, A; Zienowicz, M | 1 |
| Monnet, FP; Morin-Surun, MP; Schumacher, M; Sliwinski, A | 1 |
| Akwa, Y; Baulieu, EE; El-Etr, M; Schumacher, M | 1 |
| Chen, L; Furuya, K; Miyamoto, Y; Mori, N; Sokabe, M | 1 |
| Cheng, ZX; Dong, Y; Dong, YL; Ma, L; Qi, YJ; Wang, ZM; Wu, PY; Zheng, P; Zhu, Y; Zhu, YH | 1 |
| Farb, DH; Gibbs, TT; Whittaker, MT | 1 |
| Farb, DH; Gibbs, TT; Janis, GC; Pierce, RC; Sadri-Vakili, G | 1 |
| Akwa, Y; Covey, DF; Krishnan, K; Moricard, Y; Petit, GH; Rondi-Reig, L; Tobin, C | 1 |
| Farb, DH; Gibbs, TT; Jang, MK; Kostakis, E; Martin, SC; Richards, KG; Russek, SJ; Smith, C | 1 |
| Huettner, JE; Lopez, MN; Wilding, TJ | 1 |
29 other study(ies) available for pregnenolone sulfate and n-methylaspartate
| Article | Year |
|---|---|
Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intraperitoneal; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Seizures | 1992 |
Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Chick Embryo; N-Methylaspartate; Pregnenolone; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1991 |
Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Electrophysiology; Glycine; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine | 1993 |
Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Chick Embryo; Dizocilpine Maleate; Fura-2; Glycine; N-Methylaspartate; Nimodipine; Pregnenolone; Spermine | 1995 |
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Guanidines; Haloperidol; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ovariectomy; Pertussis Toxin; Piperazines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereotaxic Techniques; Virulence Factors, Bordetella | 1995 |
Steroid potentiation and inhibition of N-methyl-D-aspartate receptor-mediated intracellular Ca++ responses: structure-activity studies.
Topics: Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Hippocampus; N-Methylaspartate; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1994 |
Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors.
Topics: Animals; Anisoles; Dehydroepiandrosterone; Drug Synergism; Female; Guanidines; Haloperidol; Hippocampus; Iontophoresis; Ligands; Male; N-Methylaspartate; Pertussis Toxin; Pregnenolone; Progesterone; Propylamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Spiperone; Virulence Factors, Bordetella | 1996 |
Carbamazepine inhibition of N-methyl-D-aspartate-evoked calcium influx in rat cerebellar granule cells.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Cerebellum; Cytoplasmic Granules; Drug Synergism; Glycine; Intracellular Fluid; N-Methylaspartate; Potassium Chloride; Pregnenolone; Rats | 1996 |
Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors.
Topics: Acetylcholine; Animals; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Drug Synergism; Female; Hippocampus; Male; N-Methylaspartate; Ovariectomy; Pregnenolone; Progesterone; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stimulation, Chemical; Testosterone | 1996 |
The neurosteroid pregnenolone sulphate enhances NMDA-induced phasic firing of vasopressin neurones in the rat supraoptic nucleus.
Topics: Animals; Dehydroepiandrosterone Sulfate; Drug Synergism; Evoked Potentials; Female; Hypothalamus; In Vitro Techniques; N-Methylaspartate; Neurons; Picrotoxin; Pregnenolone; Rats; Rats, Wistar; Supraoptic Nucleus; Time Factors; Vasopressins | 1997 |
Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.
Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cells, Cultured; Chick Embryo; Hippocampus; N-Methylaspartate; Neurons; Oxidation-Reduction; Polyamines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Structure-Activity Relationship; Xenopus laevis | 1997 |
Differential regulation by pregnenolone sulfate of intracellular Ca2+ increase by amino acids in primary cultured rat cortical neurons.
Topics: Acetylcholine; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; gamma-Aminobutyric Acid; N-Methylaspartate; Neurons; Potassium; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1998 |
Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons.
Topics: Aniline Compounds; Animals; Calcimycin; Calcium; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fetus; Hippocampus; N-Methylaspartate; Neurons; Potassium; Pregnenolone; Rats; Receptors, N-Methyl-D-Aspartate; Xanthenes | 1998 |
Supraoptic oxytocin and vasopressin neurones show differential sensitivity to the neurosteroid pregnenolone sulphate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Agonists; Female; Glutamic Acid; N-Methylaspartate; Neurons; Oxytocin; Pregnenolone; Rats; Rats, Wistar; Supraoptic Nucleus; Vasopressins | 1998 |
Pregnenolone sulfate modulates NMDA receptors, inducing and potentiating acute excitotoxicity in isolated retina.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; L-Lactate Dehydrogenase; Male; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina | 1998 |
Convulsant actions of the neurosteroid pregnenolone sulfate in mice.
Topics: Animals; Convulsants; Disease Susceptibility; Drug Synergism; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Pentylenetetrazole; Pregnenolone; Receptors, GABA-A; Seizures | 1999 |
Fetal alcohol exposure alters neurosteroid modulation of hippocampal N-methyl-D-aspartate receptors.
Topics: Animals; Cells, Cultured; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Glycine; Hippocampus; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pregnancy; Pregnenolone; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2000 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Corticosterone acutely prolonged N-methyl-d-aspartate receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons.
Topics: Androstanols; Animals; Calcium; Calcium Signaling; Cells, Cultured; Corticosterone; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Hippocampus; Hormone Antagonists; Membrane Potentials; Mifepristone; Mitochondria; N-Methylaspartate; Neurons; Pregnenolone; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate | 2002 |
Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine.
Topics: Alanine; Amino Acids; Animals; Bicuculline; Convulsants; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Male; Mice; Microinjections; N-Methylaspartate; Picrotoxin; Pregnenolone; Seizures | 2004 |
Pregnenolone sulfate enhances long-term potentiation in CA1 in rat hippocampus slices through the modulation of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Bicuculline; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; N-Methylaspartate; Pregnenolone; Rats; Receptors, N-Methyl-D-Aspartate | 2004 |
The neuroactive steroid pregnenolone sulfate stimulates the release of gonadotropin-releasing hormone from GT1-7 hypothalamic neurons, through N-methyl-D-aspartate receptors.
Topics: Animals; Cells, Cultured; Glutamic Acid; Glycine; Gonadotropin-Releasing Hormone; Hypothalamus; Mice; N-Methylaspartate; Pregnenolone; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Vesicular Glutamate Transport Protein 2 | 2006 |
PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling.
Topics: Animals; Calcium; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Electrophysiology; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Long-Term Potentiation; N-Methylaspartate; Phosphorylation; Pregnenolone; Rats; Receptors, N-Methyl-D-Aspartate | 2007 |
Neuroactive steroid pregnenolone sulphate inhibits long-term potentiation via activation of alpha2-adrenoreceptors at excitatory synapses in rat medial prefrontal cortex.
Topics: Adenylyl Cyclases; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Potentiation; N-Methylaspartate; Prefrontal Cortex; Pregnenolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Synapses | 2008 |
Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Microscopy, Electron, Scanning; N-Methylaspartate; Potassium Chloride; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Tritium; Valine | 2008 |
Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo.
Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; N-Methylaspartate; Pregnenolone; Rats; Receptors, sigma; Signal Transduction | 2008 |
Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice.
Topics: Animals; Hippocampus; Male; Memory; Mice; Mice, Knockout; N-Methylaspartate; Pregnenolone; Prosencephalon; Receptors, N-Methyl-D-Aspartate; Space Perception; Stereoisomerism; Steroids | 2011 |
The neuroactive steroid pregnenolone sulfate stimulates trafficking of functional N-methyl D-aspartate receptors to the cell surface via a noncanonical, G protein, and Ca2+-dependent mechanism.
Topics: Animals; Calcium; Cells, Cultured; Exocytosis; GTP-Binding Proteins; N-Methylaspartate; Neurons; Oocytes; Pregnenolone; Protein Kinase C; Protein Transport; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Xenopus laevis | 2013 |
Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains.
Topics: Allosteric Regulation; Animals; Arachidonic Acid; Calcium; Dimerization; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Excitatory Amino Acid Agonists; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydroxycholesterols; Kainic Acid; Membrane Potentials; Models, Molecular; N-Methylaspartate; Patch-Clamp Techniques; Pregnenolone; Protein Domains; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Fusion Proteins; Transfection | 2016 |