Compounds > pregnenolone carbonitrile
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pregnenolone carbonitrile and triiodothyronine

pregnenolone carbonitrile has been researched along with triiodothyronine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Hashmi, R; Hood, A; Klaassen, CD1
Hood, A; Klaassen, CD1
Klaassen, CD; Vansell, NR2
Chen, C; Klaassen, CD; Staudinger, JL1
Habeebu, SM; Klaassen, CD; Muppidi, JR; Vansell, NR1
Klaassen, CD; Richardson, TA2

Other Studies

9 other study(ies) available for pregnenolone carbonitrile and triiodothyronine

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
    Toxicology and applied pharmacology, 1999, Oct-15, Volume: 160, Issue:2

    Topics: Animals; Cell Count; Cell Division; Chlorodiphenyl (54% Chlorine); Enzyme Activation; Hyperplasia; Hypertrophy; Male; Methylcholanthrene; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

1999
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation.
    Toxicological sciences : an official journal of the Society of Toxicology, 2000, Volume: 55, Issue:1

    Topics: Animals; Chlorodiphenyl (54% Chlorine); Detergents; Enzyme Induction; Glucuronides; Glucuronosyltransferase; In Vitro Techniques; Iodine Radioisotopes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroxine; Triiodothyronine

2000
Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites.
    Toxicological sciences : an official journal of the Society of Toxicology, 2002, Volume: 65, Issue:2

    Topics: Animals; Bile; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Iodine Radioisotopes; Male; Methylcholanthrene; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Triiodothyronine

2002
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:3

    Topics: Animals; Blotting, Northern; Chlorodiphenyl (54% Chlorine); Electrophoresis, Agar Gel; Enzyme Induction; Glucuronosyltransferase; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substrate Specificity; Thyroid Hormones; Thyroxine; Transcription, Genetic; Triiodothyronine

2002
Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:7

    Topics: Administration, Oral; Animals; Bilirubin; Chloramphenicol; Enzyme Induction; Food; Glucuronosyltransferase; Male; Mice; Mice, Mutant Strains; Microsomes, Liver; Naphthols; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger; Thyroxine; Time Factors; Triiodothyronine; Up-Regulation

2003
Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB).
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 81, Issue:1

    Topics: Adenoma; Animals; Antithyroid Agents; Body Weight; Carcinoma; Chlorodiphenyl (54% Chlorine); Eating; Environmental Pollutants; Glucuronides; Hyperplasia; Male; Organ Size; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Neoplasms; Thyrotropin; Thyroxine; Triiodothyronine

2004
Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 116, Issue:2

    Topics: Androsterone; Animals; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Male; Microsomes; Pregnenolone Carbonitrile; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Triiodothyronine

2010
Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation.
    Toxicology and applied pharmacology, 2010, Oct-01, Volume: 248, Issue:1

    Topics: Animals; Cell Proliferation; Chlorodiphenyl (54% Chlorine); Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Gunn; Rats, Wistar; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine

2010