pregnenolone carbonitrile has been researched along with tamoxifen in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Forkert, PG; Jellinck, PH; Martucci, CP; Newcombe, AM | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Dehal, SS; Kupfer, D | 1 |
| Moorthy, B; Randerath, E; Randerath, K; Sriram, P | 1 |
| Ali, RY; Matheny, CJ; Pollack, GM; Yang, X | 1 |
7 other study(ies) available for pregnenolone carbonitrile and tamoxifen
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Distinct forms of hepatic androgen 6 beta-hydroxylase induced in the rat by indole-3-carbinol and pregnenolone carbonitrile.
Topics: Androstenedione; Androsterone; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hydroxylation; Immunoblotting; Indoles; Liver; Male; Metyrapone; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Tamoxifen | 1994 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
Evidence that the catechol 3,4-Dihydroxytamoxifen is a proximate intermediate to the reactive species binding covalently to proteins.
Topics: Animals; Antineoplastic Agents, Hormonal; Biotransformation; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Cytochrome P-450 Enzyme System; Female; Hydroxylation; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tamoxifen | 1996 |
Effects of cytochrome P450 inducers on tamoxifen genotoxicity in female mice in vivo.
Topics: Animals; Cytochrome P-450 Enzyme System; DNA Adducts; Enzyme Induction; Estrogen Antagonists; Female; Mice; Mice, Inbred ICR; Phenobarbital; Pregnenolone Carbonitrile; Tamoxifen | 1997 |
Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues.
Topics: Actins; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Cytochrome P-450 CYP3A; Dexamethasone; Drug Administration Schedule; Enzyme Induction; Gene Expression Regulation; Hypericum; Intestine, Small; Intubation; Liver; Male; Mice; Mice, Inbred Strains; Nifedipine; Oxidoreductases, N-Demethylating; Plant Extracts; Pregnane X Receptor; Pregnenolone Carbonitrile; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Tamoxifen; Time Factors | 2004 |