pregnenolone carbonitrile has been researched along with spironolactone in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (85.29) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choudhuri, S; Guo, GL; Klaassen, CD | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Castle, MC | 2 |
| Selye, H; Taché, J; Taché, Y | 1 |
| Hamada, N; Madhukar, BV; Matsumura, F; Peterson, RE; Yang, KH | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Da Silva, OM; Kourounakis, P; Lykissas, ED | 1 |
| Garg, BD; Kourounakis, P; Tuchweber, B | 1 |
| Bjondahl, K | 1 |
| Kourounakis, P; Rapp, U; Selye, H | 1 |
| Brookman, S; Kourounakis, P | 1 |
| Salas, M; Tuchweber, B | 1 |
| Klaassen, CD | 4 |
| Paumgartner, G; Schwarz, HP; von Bergmann, K | 2 |
| Kourounakis, PN; Rekka, E | 2 |
| Mécs, I; Selye, H; Szabo, S | 1 |
| Japundzić, I; Japundzić, M; Szabo, S | 1 |
| Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 1 |
| Selye, H | 1 |
| Kourounakis, P; Selye, H; Szabo, S | 2 |
| Solymoss, B; Zsigmond, G | 3 |
| Beaulieu, T; Jago, MV; Kovacs, K; Tuchweber, B | 1 |
| Bellward, GD; Gontovnick, LS; Sunahara, G | 1 |
| Couture, C; Gagnon, MJ | 1 |
| Kourounakis, PN; Tani, E | 1 |
1 review(s) available for pregnenolone carbonitrile and spironolactone
| Article | Year |
|---|---|
Effects of steroids upon the liver ultrastructure.
Topics: Animals; Benzopyrenes; Desoxycorticosterone; Endocrine Glands; Enzyme Induction; Glucocorticoids; Glycogen; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Norpregnenes; Phenobarbital; Pregnenolone Carbonitrile; Protein Biosynthesis; RNA; Spironolactone; Steroids | 1973 |
33 other study(ies) available for pregnenolone carbonitrile and spironolactone
| Article | Year |
|---|---|
Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways.
Topics: Animals; Blotting, Northern; DNA Probes; Enzyme Induction; Gene Expression Regulation, Enzymologic; Ligands; Liver; Liver-Specific Organic Anion Transporter 1; Male; Membranes; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2002 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Digitoxin metabolism by rat liver homogenates, subcellular fractions and isolated hepatocytes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
Topics: Animals; Biotransformation; Digitoxin; In Vitro Techniques; Liver; Male; Microsomes, Liver; NAD; NADP; Pregnenolone Carbonitrile; Rats; Spironolactone; Subcellular Fractions | 1979 |
Inhibition of the effects of alfathesin and other steroid anesthetics by catatoxic steroids in rats.
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Female; Ketosteroids; Phenobarbital; Phenytoin; Prednisolone; Pregnanediones; Pregnanes; Pregnenes; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Thyroxine; Time Factors | 1975 |
Reversal of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced depression of ouabain biliary excretion by pregnenolone-16 alpha-carbonitrile and spironolactone in isolated perfused rat livers.
Topics: Adenosine Triphosphatases; Animals; Bile; Dioxins; In Vitro Techniques; Liver; Male; Ouabain; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Rats; Spironolactone | 1979 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Alterations in the hepatic subcellular composition of nucleic acids and proteins in rats treated with pregnenolone-16alpha-carbonitrile, spironolactone or phenobarbital.
Topics: Animals; Cell Nucleus; DNA; Female; Liver; Phenobarbital; Pregnenolone Carbonitrile; Proteins; Rats; RNA; Spironolactone | 1979 |
Fine structural changes in the liver of young and old rats as influenced by microsomal enzyme inducers.
Topics: Aging; Animals; Dexamethasone; Endoplasmic Reticulum; Enzyme Induction; Liver; Male; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1979 |
A study on cerium-induced liver injury in rats after pretreatment with spironolactone, phenobarbital, pregnenolone-16 alpha-carbonitrile and nafenopin.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cerium; Chemical and Drug Induced Liver Injury; Female; Nafenopin; Phenobarbital; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Time Factors; Triglycerides | 1978 |
Effect of steroids and diethylstilbestrol on cocaine toxicity, plasma concentrations and urinary excretion.
Topics: Animals; Cocaine; Diethylstilbestrol; Drug Interactions; Estradiol; Female; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Time Factors; Triamcinolone | 1979 |
Influence of imipramine and various steroids on hepatic in vitro N-demethylation of tricyclic antidepressants.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Dealkylation; Dexamethasone; Female; Imipramine; In Vitro Techniques; Liver; Organ Size; Pregnanes; Pregnenolone Carbonitrile; Rats; Spironolactone | 1977 |
Prevention by steroids of cerium hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estradiol; Fatty Liver; Female; Golgi Apparatus; Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Steroids; Triglycerides | 1976 |
Studies on the mechanism of spironolactone protection against indomethacin toxicity.
Topics: Animals; Bile; Depression, Chemical; Enzyme Induction; In Vitro Techniques; Indomethacin; Male; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors | 1976 |
Effect of microsomal enzyme inducers on the biliary excretion of an exogenous load of bilirubin in newborn rats.
Topics: Age Factors; Animals; Animals, Newborn; Bile; Bilirubin; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1976 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on bile formation in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Body Weight; Cholesterol; Liver; Male; Organ Size; Phenobarbital; Phospholipids; Pregnenolone Carbonitrile; Rats; Spironolactone; Taurocholic Acid | 1975 |
Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents.
Topics: Alanine Transaminase; Animals; Arthritis, Experimental; Chemical and Drug Induced Liver Injury; Female; Lipid Peroxidation; Liver; Liver Function Tests; Organ Size; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Steroids; Triamcinolone; Triglycerides | 1991 |
Protection by catatoxic steroids against the paralysis caused by combined treatment with thyroxine and methylphenidate.
Topics: Androstenols; Animals; Drug Synergism; Estradiol; Ethylestrenol; Female; Humans; Hydroxysteroids; Hyperkinesis; Ketosteroids; Methylphenidate; Norpregnanes; Paralysis; Phenobarbital; Phenytoin; Prednisolone; Pregnenolone Carbonitrile; Progesterone; Propionates; Rats; Rats, Inbred Strains; Spironolactone; Steroids; Thyroxine | 1972 |
Induction of ethylmorphine demethylation and aniline p-hydroxylation by various catatoxic steroids in regenerating rat liver.
Topics: Androstenols; Aniline Compounds; Animals; Cycloheximide; Dactinomycin; Enzyme Induction; Female; Hepatectomy; Ketosteroids; Liver; Liver Regeneration; Mixed Function Oxygenases; Morphinans; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Propionates; Rats; Spectrophotometry; Spironolactone; Steroids; Steroids, Fluorinated; Time Factors | 1974 |
Influence of various catatoxic steroids upon chronic dihydrotachysterol intoxication.
Topics: Animals; Dihydrotachysterol; Ethylestrenol; Female; Fluoxymesterone; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Steroids | 1971 |
Letter: Effect of various steroids and ACTH on methyprylon plasma levels and sleeping time in rats.
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Desoxycorticosterone; Female; Fludrocortisone; Piperidones; Pregnenolone Carbonitrile; Rats; Sleep; Spironolactone; Triamcinolone | 1973 |
Effect of pharmacologic conditioning on sulfadiazine toxicity and concentrations in plasma.
Topics: Adrenocorticotropic Hormone; Androstenols; Animals; Depression, Chemical; Desoxycorticosterone; Estradiol; Female; Ketosteroids; Kidney; Organ Size; Phenobarbital; Prednisolone; Pregnanediones; Pregnenolone Carbonitrile; Propionates; Rats; Spironolactone; Stimulation, Chemical; Sulfadiazine; Thyroxine; Triamcinolone | 1974 |
Effect of microsomal enzyme inducers on the liver changes produced by common bile-duct ligature.
Topics: Animals; Bilirubin; Common Bile Duct; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme Induction; Female; Glucuronosyltransferase; Hepatomegaly; Ligation; Liver; Liver Cirrhosis, Biliary; Microsomes, Liver; NADH, NADPH Oxidoreductases; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1974 |
Proceedings: Increased cholesterol saturation in rat bile induced by spironolactone and pregnenolone-16alpha-carbonitrile.
Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Male; Phenobarbital; Phospholipids; Pregnenolone Carbonitrile; Rats; Spironolactone | 1974 |
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine | 1974 |
Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Enzyme Induction; Liver; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium | 1974 |
Effect of various steroids on the hepatic glucuronidation and biliary excretion of bilirubin.
Topics: Animals; Bile; Bile Pigments; Bilirubin; Body Weight; Female; Glucuronates; Hexosyltransferases; Hydrocortisone; Kinetics; Liver; Microsomes, Liver; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1973 |
Increased canalicular bile production induced by pregnenolone-16alpha-carbonitrile, spironolactone and cortisol in rats.
Topics: Bile; Bile Acids and Salts; Bile Ducts, Intrahepatic; Carbon Radioisotopes; Erythritol; Hydrocortisone; Metabolic Clearance Rate; Pregnenolone Carbonitrile; Secretory Rate; Spironolactone; Stimulation, Chemical | 1974 |
Effect of steroidal and nonsteroidal microsomal enzyme inducers on the hepatotoxicity of pyrrolizidine alkaloids in rats.
Topics: Animals; Enzyme Induction; Ethylestrenol; Female; Hepatectomy; Kidney; Liver; Lung; Male; Microsomes, Liver; Phenobarbital; Phenytoin; Pregnenolone Carbonitrile; Prodigiosin; Pyrroles; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Spironolactone | 1974 |
Nonadditive effects of combined in vivo hepatic microsomal enzyme inducers in the Wistar rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Stilbenes | 1983 |
Glucuronidation of digitalis glycosides by rat liver microsomes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
Topics: Animals; Digitalis Glycosides; Digitoxin; Digoxigenin; Digoxin; Female; Glucuronates; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Spironolactone; Stimulation, Chemical | 1980 |
Effect of spironolactone and PCN (pregnenolone-16-alpha-carbonitrile) on the hepatotoxicity induced by dimethylmercury in rat.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Induction; Female; Liver; Methylmercury Compounds; Pregnenolone Carbonitrile; Rats; Spironolactone | 1980 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on rat hepatic beta-glucuronidase.
Topics: Animals; Female; Glucuronidase; Liver; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Spironolactone | 1995 |
Effect of spironolactone on dimethyl mercury toxicity. A possible molecular mechanism.
Topics: Alanine Transaminase; Animals; Bilirubin; Blood Urea Nitrogen; Body Weight; Ethylmorphine-N-Demethylase; Female; Methylmercury Compounds; Mutagens; Nervous System Diseases; Neuritis; Organ Size; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Spironolactone; Zoxazolamine | 1994 |