pregnenolone carbonitrile has been researched along with rifampin in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (16.13) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Burk, O; Eichelbaum, M; Geick, A | 1 |
| Jekerle, V; Piquette-Miller, M; Teng, S | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Baucom, CC; Chang, TK; Lau, AJ; Rajaraman, G; Yang, G | 2 |
| Bonzo, JA; Cheng, J; Gonzalez, FJ; Idle, JR; Johnson, CH; Kang, DW; Krausz, KW; Luecke, H | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bonfils, C; Daujat, M; Fabre, G; Fabre, I; Maurel, P; Pichard, L; Pineau, T | 1 |
| Gerstner, E; Heubel, F; Reuter, T | 1 |
| Bailey, BS; Barwick, J; Guzelian, P; Hartle, HT; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Davis, M; Smith, HM; Tredger, JM; Williams, R | 1 |
| Davis, M; Powell-Jackson, PR; Smith, HM; Tredger, JM; Williams, R | 1 |
| Goerz, G; Ruzicka, T; Vizethum, W | 1 |
| Chenery, RJ; Hawksworth, GM; Williams, JA | 1 |
| Barwick, JL; Guzelian, PS; Mills, AS; Potenza, C; Quattrochi, LC; Tukey, RH | 1 |
| Benet, LZ; Salphati, L | 1 |
| Bornheim, L; Brimer, C; Cole, TJ; Kamataki, T; Myles, K; Schmid, W; Schuetz, EG; Schutz, G; Yasuda, K | 1 |
| Endo, Y; Honma, R; Jarukamjorn, K; Kuroiwa, M; Nemoto, N; Ohara, A; Sakuma, T; Takai, M | 1 |
| LeCluyse, EL | 1 |
| Handschin, C; Hoffmann, K; Meyer, UA; Podvinec, M; Stöckli, J | 1 |
| Ali, RY; Matheny, CJ; Pollack, GM; Yang, X | 1 |
| Matsubara, T; Nagata, K; Noracharttiyapot, W; Toriyabe, T; Yamazoe, Y; Yoshinari, K | 1 |
| Back, DJ; Martin, P; Owen, A; Riley, R | 1 |
| Cheung, C; Gonzalez, FJ; Idle, JR; Krausz, KW; Ma, X; Shah, YM; Wang, T | 1 |
| Smith, EM; Wilson, JY | 1 |
| Aisaki, K; Blumberg, B; Igarashi, K; Ikeno, E; Kanno, J; Kitajima, S; Matsuda, N; Moriyama, N; Saga, Y; Tanemura, K; Taquahashi, Y | 1 |
| Buler, M; Hakkola, J; Hukkanen, J; Ruskoaho, H; Rysä, J; Savolainen, MJ | 1 |
| Alston, L; Hansen, A; Hirota, SA; Terc, J | 1 |
| Bi, H; Chen, P; Chen, X; Deng, R; Huang, M; Jin, J; Niu, L; Wang, Y; Xu, C; Ying, M; Zhou, X | 1 |
| Hakkola, J; Herzig, KH; Hukkanen, J; Makela, KA; Rysa, J; Savolainen, MJ | 1 |
| Hakkola, J; Hukkanen, J; Kummu, O; Lehenkari, P; Nabil, H; Risteli, J; Rysä, J | 1 |
1 review(s) available for pregnenolone carbonitrile and rifampin
| Article | Year |
|---|---|
Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Mice; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Pregnenolone Carbonitrile; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Species Specificity; Xenobiotics | 2001 |
3 trial(s) available for pregnenolone carbonitrile and rifampin
| Article | Year |
|---|---|
Pregnane X receptor agonists impair postprandial glucose tolerance.
Topics: Adult; Animals; C-Peptide; Cross-Over Studies; Down-Regulation; Female; Glucose Tolerance Test; Glucose Transporter Type 2; Humans; Insulin; Insulin Resistance; Liver; Male; Mice; Mice, Inbred C57BL; Postprandial Period; Pregnane X Receptor; Pregnenolone Carbonitrile; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Rifampin | 2013 |
The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans.
Topics: Adolescent; Adult; Animals; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Male; Peptide YY; Postprandial Period; Pregnane X Receptor; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Rifampin; Young Adult | 2015 |
Rifampicin induces the bone form of alkaline phosphatase in humans.
Topics: Alkaline Phosphatase; Animals; Cross-Over Studies; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Osteoblasts; Pregnane X Receptor; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Rifampin; RNA, Messenger | 2022 |
27 other study(ies) available for pregnenolone carbonitrile and rifampin
| Article | Year |
|---|---|
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Dimerization; DNA; DNA Primers; Gene Expression Regulation; Humans; Intestinal Mucosa; Intestines; Molecular Sequence Data; Pregnane X Receptor; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Receptors, Steroid; Retinoid X Receptors; Rifampin; Transcription Factors | 2001 |
Induction of ABCC3 (MRP3) by pregnane X receptor activators.
Topics: Animals; Cell Line, Tumor; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mifepristone; Multidrug Resistance-Associated Proteins; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger | 2003 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.
Topics: Animals; Cell Line, Tumor; Cells, Cultured; Constitutive Androstane Receptor; Cyclopentanes; Furans; Ginkgolides; Hep G2 Cells; Hepatocytes; Humans; Pregnane X Receptor; Rats; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Species Specificity | 2012 |
Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice.
Topics: alpha-Tocopherol; Animals; Biomarkers; Biotransformation; Chromatography, Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Partial Agonism; Gene Expression Regulation, Enzymologic; Genes, Reporter; Hep G2 Cells; Humans; Isoenzymes; Liver; Male; Mass Spectrometry; Metabolomics; Mice; Mice, Knockout; Mice, Transgenic; Pregnane X Receptor; Receptors, Steroid; Species Specificity; Time Factors; Transfection | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Culture Techniques; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Fetus; Humans; Liver; Male; Pregnancy; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; Sex Characteristics; Troleandomycin | 1991 |
Differences between induction effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene and phenobarbitone.
Topics: Animals; Cytochrome P-450 Enzyme System; Diazepam; Enzyme Induction; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Rifampin; Warfarin | 1989 |
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Topics: Animals; Base Sequence; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Gerbillinae; Glucocorticoids; Liver; Male; Mesocricetus; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; RNA, Messenger; Species Specificity; Troleandomycin | 1985 |
Use of a direct high performance liquid chromatography method for multiple testosterone hydroxylations in studies of microsomal monooxygenase activities.
Topics: Acetanilides; Aldrin; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Ethylmorphine; Male; Mesocricetus; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; Testosterone | 1984 |
Effect of rifampicin on the mouse hepatic mixed-function oxidase system.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rifampin; Sodium Fluoride | 1981 |
Inducibility of drug-metabolizing enzymes in the rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADH Dehydrogenase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rifampin; Skin | 1980 |
Induction of CYP3A enzymes in human and rat hepatocyte cultures.
Topics: Adult; Animals; Cells, Cultured; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Humans; Liver; Male; Mixed Function Oxygenases; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Rifampin | 1994 |
Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Cells, Cultured; Chloramphenicol O-Acetyltransferase; Consensus Sequence; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Glucocorticoids; Humans; Liver; Male; Mixed Function Oxygenases; Models, Biological; Molecular Sequence Data; Multigene Family; Oligodeoxyribonucleotides; Plasmids; Pregnenolone Carbonitrile; Promoter Regions, Genetic; Rabbits; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Rifampin; Species Specificity; Transcriptional Activation; Transfection | 1996 |
Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Gene Expression; Liver; Male; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Rifampin; RNA, Messenger; Sex Characteristics; Troleandomycin | 1998 |
The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver.
Topics: Aldosterone; Animals; Binding, Competitive; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Mutant Strains; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Pregnenolone Carbonitrile; Rabbits; Receptors, Glucocorticoid; Rifampin; RNA, Messenger; Steroids; Tritium | 2000 |
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Castration; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Estradiol; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Developmental; Liver; Male; Membrane Proteins; Methylcholanthrene; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; RNA, Messenger; Sex Characteristics; Sexual Maturation; Testosterone | 2000 |
Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.
Topics: Animals; Avian Proteins; beta-Naphthoflavone; Cell Line; Chickens; Clotrimazole; Colforsin; Constitutive Androstane Receptor; Cyclic AMP; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Glutethimide; Growth Inhibitors; Hormone Antagonists; Humans; Metyrapone; Mifepristone; Okadaic Acid; Pregnane X Receptor; Pregnenolone Carbonitrile; Protein Binding; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Signal Transduction; Trans-Activators; Transcription Factors | 2001 |
Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues.
Topics: Actins; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Cytochrome P-450 CYP3A; Dexamethasone; Drug Administration Schedule; Enzyme Induction; Gene Expression Regulation; Hypericum; Intestine, Small; Intubation; Liver; Male; Mice; Mice, Inbred Strains; Nifedipine; Oxidoreductases, N-Demethylating; Plant Extracts; Pregnane X Receptor; Pregnenolone Carbonitrile; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Rifampin; Tamoxifen; Time Factors | 2004 |
Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene.
Topics: Animals; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Fungicides, Industrial; Gene Expression Regulation, Enzymologic; Humans; Immunoblotting; Insecticides; Liver; Luciferases; Male; Mice; Mice, Inbred ICR; Pregnane X Receptor; Pregnenolone Carbonitrile; Promoter Regions, Genetic; Receptors, Steroid; Rifampin; RNA, Messenger; RNA, Small Interfering; Transcription, Genetic | 2007 |
Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells.
Topics: Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Caco-2 Cells; Cell Culture Techniques; Cells, Cultured; Chenodeoxycholic Acid; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Induction; Epithelial Cells; Hepatocytes; Humans; Intestinal Mucosa; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Research Design; Rifampin; RNA, Messenger; Transcription Factors; Up-Regulation | 2008 |
A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4.
Topics: Animals; Carbamates; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Furans; Gene Expression; Gene Expression Regulation; HIV Protease Inhibitors; Humans; Intestine, Small; Ketoconazole; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Microsomes, Liver; Models, Animal; Nelfinavir; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Rifampin; Saquinavir; Sex Characteristics; Sulfonamides | 2008 |
Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16alpha-carbonitrile, rifampicin, and beta-naphthoflavone.
Topics: Animals; beta-Naphthoflavone; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Female; Fundulidae; Liver; Male; Microsomes, Liver; Oncorhynchus mykiss; Pregnenolone Carbonitrile; Rifampin; Statistics, Nonparametric | 2010 |
Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.
Topics: Aged; Animals; Binding Sites; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP3A; Female; Gene Expression; Genes, Reporter; Ginkgo biloba; Ginkgolides; Hep G2 Cells; Hepatocytes; Humans; Lactones; Male; Middle Aged; Nuclear Receptor Coactivator 1; Plant Extracts; Pregnane X Receptor; Pregnenolone Carbonitrile; Rats; Receptors, Steroid; Rifampin; Steroid Hydroxylases; Testosterone; Transfection | 2010 |
Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence.
Topics: Animals; Animals, Genetically Modified; Carboxylic Ester Hydrolases; Cytochrome P-450 CYP3A; Female; Humans; Intestine, Small; Ligands; Liver; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Rifampin; RNA, Messenger | 2012 |
Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis.
Topics: Animals; Caco-2 Cells; Cell Movement; Colitis; Colon; Dextran Sulfate; Diphosphonates; Disease Models, Animal; Epithelial Cells; Gastrointestinal Agents; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Rifampin; Rifamycins; Rifaximin; Signal Transduction; Time Factors; Wound Healing | 2014 |
Resveratrol suppresses the inducible expression of CYP3A4 through the pregnane X receptor.
Topics: Animals; Cells, Cultured; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression; Hepatocytes; Male; Membrane Proteins; Mice, Inbred BALB C; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Steroid; Resveratrol; Rifampin; Stilbenes; Transcriptional Activation | 2014 |