Compounds > pregnenolone carbonitrile
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pregnenolone carbonitrile and pirinixic acid

pregnenolone carbonitrile has been researched along with pirinixic acid in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Argikar, UA; Larson, EE; Remmel, RP; Senekeo-Effenberger, K; Tukey, RH1
Benoki, S; Kodama, S; Miyata, M; Numakura, Y; Shizu, R; Yamazoe, Y; Yoshinari, K1

Other Studies

4 other study(ies) available for pregnenolone carbonitrile and pirinixic acid

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.
    Xenobiotica; the fate of foreign compounds in biological systems, 2009, Volume: 39, Issue:11

    Topics: Animals; Anticonvulsants; Chromatography, High Pressure Liquid; Enzyme Induction; Female; GABA Modulators; Gas Chromatography-Mass Spectrometry; Glucuronosyltransferase; Hepatocytes; Humans; Kinetics; Lamotrigine; Male; Metabolic Clearance Rate; Mice; Mice, Transgenic; Microsomes, Liver; Peroxisome Proliferator-Activated Receptors; Peroxisome Proliferators; Phenobarbital; Pregnenolone Carbonitrile; Pyrimidines; Triazines

2009
Xenobiotic-induced hepatocyte proliferation associated with constitutive active/androstane receptor (CAR) or peroxisome proliferator-activated receptor α (PPARα) is enhanced by pregnane X receptor (PXR) activation in mice.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenobarbital; PPAR alpha; Pregnane X Receptor; Pregnenolone Carbonitrile; Primary Cell Culture; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Xenobiotics

2013