Compounds > pregnenolone carbonitrile
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pregnenolone carbonitrile and lithocholic acid

pregnenolone carbonitrile has been researched along with lithocholic acid in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's0 (0.00)18.2507
2000's5 (62.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brown, KK; Goodwin, B; Hawkins-Brown, D; Jones, SA; Klaassen, CD; Kliewer, SA; Koller, BH; LaTour, A; Liu, Y; MacKenzie, KI; Reinhard, J; Staudinger, JL; Willson, TM1
Jekerle, V; Piquette-Miller, M; Teng, S1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Einarsson, K; Gustafsson, JA1
Gonzalez, FJ; Hori, W; Miyata, M; Nagata, K; Shimada, M; Watase, H; Yamazoe, Y1
Akase, T; Gonzalez, FJ; Kitada, H; Matsuda, Y; Miyata, M; Nagata, K; Shimada, M; Tsuchiya, H; Yamazoe, Y1
Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER1
Hori, W; Miyata, M; Mizuki, T; Nagayasu, M; Ninomiya, S; Nomoto, M; Sotodate, F; Yamazoe, Y; Yokokawa, S1

Other Studies

8 other study(ies) available for pregnenolone carbonitrile and lithocholic acid

ArticleYear
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Mar-13, Volume: 98, Issue:6

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cholestasis, Intrahepatic; Cholesterol 7-alpha-Hydroxylase; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gene Expression Regulation, Enzymologic; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid

2001
Induction of ABCC3 (MRP3) by pregnane X receptor activators.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:11

    Topics: Animals; Cell Line, Tumor; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mifepristone; Multidrug Resistance-Associated Proteins; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; RNA, Messenger

2003
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Effect of 16alpha-cyanopregnenolone on the hydroxylation of lithocholic acid by rat liver microsomes.
    Biochemical pharmacology, 1974, Jan-01, Volume: 23, Issue:1

    Topics: Animals; Bile Acids and Salts; Chromatography, Thin Layer; Hydroxylation; Lithocholic Acid; Male; Microsomes, Liver; NADP; Organ Size; Pregnenolone Carbonitrile; Rats; Stimulation, Chemical; Tritium

1974
Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.
    Xenobiotica; the fate of foreign compounds in biological systems, 2006, Volume: 36, Issue:7

    Topics: Animals; DNA-Binding Proteins; Feces; Lithocholic Acid; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Sulfotransferases; Transcription Factors

2006
Chenodeoxycholic acid-mediated activation of the farnesoid X receptor negatively regulates hydroxysteroid sulfotransferase.
    Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:4

    Topics: Animals; Cells, Cultured; Chenodeoxycholic Acid; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Regulation, Enzymologic; Humans; Lithocholic Acid; Liver; Mice; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sulfotransferases; Transcription Factors

2006
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
    Toxicology letters, 2009, Jul-10, Volume: 188, Issue:1

    Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors

2009
Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis.
    European journal of pharmacology, 2010, Jun-25, Volume: 636, Issue:1-3

    Topics: Animals; Biliary Tract; Biomarkers; Fatty Acids; Female; Gene Expression Profiling; Hepatocytes; Lipogenesis; Lithocholic Acid; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Phosphatidylcholines; Pregnenolone Carbonitrile; Time Factors

2010