pregnenolone carbonitrile has been researched along with erythromycin in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Amacher, DE; Retsema, JA; Schomaker, SJ | 1 |
| Bonfils, C; Daujat, M; Fabre, G; Fabre, I; Maurel, P; Pichard, L; Pineau, T | 1 |
| Bellward, GD; Chang, T; Levine, M | 1 |
| Delaforge, M; Sartori, E | 1 |
| Arlotto, MP; Klaassen, CD; Parkinson, A; Sonderfan, AJ | 1 |
| Beaune, P; Delaforge, M; Mansuy, D; Sartori, E | 1 |
| Bailey, BS; Barwick, J; Guzelian, P; Hartle, HT; Maurel, P; Schuetz, EG; Watkins, PB; Wrighton, SA; Young, B | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Floreani, M; Geroni, C; Napoli, E; Quintieri, L; Rosato, A; Sola, F; Zanovello, P | 1 |
| Dhawan, A; Parmar, D; Seth, PK; Singh, RL; Yadav, S | 1 |
12 other study(ies) available for pregnenolone carbonitrile and erythromycin
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the effects of the new azalide antibiotic, azithromycin, and erythromycin estolate on rat liver cytochrome P-450.
Topics: Animals; Azithromycin; Body Weight; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Erythromycin Estolate; Liver; Male; Micrococcus; Microsomes; Microsomes, Liver; Mixed Function Oxygenases; NADPH-Ferrihemoprotein Reductase; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1991 |
Induction protocols for cytochromes P450IIIA in vivo and in primary cultures of animal and human hepatocytes.
Topics: Animals; Anti-Bacterial Agents; Cells, Cultured; Culture Techniques; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Fetus; Humans; Liver; Male; Pregnancy; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; Sex Characteristics; Troleandomycin | 1991 |
Influence of sex and inducer treatment on the high- and low-affinity forms of hepatic microsomal erythromycin N-demethylase in rats.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Dexamethasone; Enzyme Induction; Erythromycin; Female; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1990 |
Specific drug binding to rat liver cytochrome P-450 isozymes induced by pregnenolone-16 alpha-carbonitrile and macrolide antibiotics. Implications for drug interactions.
Topics: Animals; Anti-Bacterial Agents; Cytochrome P-450 Enzyme System; Enzyme Induction; Ergotamine; Ergotamines; Erythromycin; Ethinyl Estradiol; Ethylmorphine; Ferricyanides; Isoenzymes; Male; Microsomes, Liver; Norethindrone; Prednisolone; Prednisone; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spectrophotometry; Theophylline | 1990 |
Studies on the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Erythromycin; Female; Glucuronosyltransferase; Isoenzymes; Kinetics; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Steroid Hydroxylases; Troleandomycin | 1987 |
Some erythromycin derivatives are strong inducers in rats of a cytochrome P-450 very similar to that induced by 16 alpha-pregnenolone carbonitrile.
Topics: Animals; Cytochrome P-450 Enzyme System; Erythromycin; In Vitro Techniques; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Troleandomycin | 1985 |
Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.
Topics: Animals; Base Sequence; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Erythromycin; Female; Gerbillinae; Glucocorticoids; Liver; Male; Mesocricetus; Phenobarbital; Pregnenolone Carbonitrile; Rabbits; Rats; Rats, Inbred Strains; Rifampin; RNA, Messenger; Species Specificity; Troleandomycin | 1985 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: role of cytochrome P450 3A.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Bone Marrow; Coculture Techniques; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Doxorubicin; Erythromycin; Female; Leukemia, Experimental; Liver; Liver Neoplasms, Experimental; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; NADP; Neoplasm Transplantation; Neoplasms, Experimental; Oxidoreductases, N-Demethylating; Pregnenolone Carbonitrile; Protein Synthesis Inhibitors; Time Factors; Troleandomycin; Tumor Cells, Cultured | 2000 |
Cytochrome P4503A: evidence for mRNA expression and catalytic activity in rat brain.
Topics: Animals; Brain; Catalysis; Cytochrome P-450 CYP3A; Erythromycin; Hippocampus; Hypothalamus; Isoenzymes; Kinetics; Liver; Male; Pregnenolone Carbonitrile; Rats; Rats, Wistar; RNA, Messenger | 2006 |