Compounds > pregnenolone carbonitrile
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pregnenolone carbonitrile and digoxin

pregnenolone carbonitrile has been researched along with digoxin in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Klaassen, CD1
Castle, MC1
Chen, X; Liu, S; Pang, KS; Tam, D1
Higashi, R; Maeda, T; Nagata, K; Oyabu, M; Tamai, I; Yamazoe, Y; Yotsumoto, T1

Other Studies

6 other study(ies) available for pregnenolone carbonitrile and digoxin

ArticleYear
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 191, Issue:2

    Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine

1974
Glucuronidation of digitalis glycosides by rat liver microsomes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
    Biochemical pharmacology, 1980, Jun-01, Volume: 29, Issue:11

    Topics: Animals; Digitalis Glycosides; Digitoxin; Digoxigenin; Digoxin; Female; Glucuronates; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Spironolactone; Stimulation, Chemical

1980
P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha-carbonitrile.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Computer Simulation; Cytochrome P-450 CYP3A; Digoxin; Drug Administration Routes; Enzyme Induction; Intestinal Absorption; Intestine, Small; Male; Models, Biological; Perfusion; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Tritium; Water

2006
Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:9

    Topics: Animals; Area Under Curve; Cations; Cell Separation; Cells, Cultured; Digoxin; Hepatocytes; In Vitro Techniques; Kinetics; Ligands; Liver; Male; Organic Cation Transporter 1; Pharmaceutical Preparations; Pregnane X Receptor; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection; Trichloroacetic Acid

2007