Compounds > pregnenolone carbonitrile
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pregnenolone carbonitrile and digitoxin

pregnenolone carbonitrile has been researched along with digitoxin in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19905 (83.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Castle, MC2
Garg, BD; Kourounakis, P; Kovacs, K; Szabo, S; Tuchweber, B1
Arlotto, MP; McKinney, MM; Parkinson, A; Sonderfan, AJ1
Klaassen, CD1

Other Studies

6 other study(ies) available for pregnenolone carbonitrile and digitoxin

ArticleYear
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Digitoxin metabolism by rat liver homogenates, subcellular fractions and isolated hepatocytes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:1

    Topics: Animals; Biotransformation; Digitoxin; In Vitro Techniques; Liver; Male; Microsomes, Liver; NAD; NADP; Pregnenolone Carbonitrile; Rats; Spironolactone; Subcellular Fractions

1979
Studies on drug metabolism and liver ultrastructure after conjoint treatment with pregnenolone-16alpha-carbonitrile and dl-ethionine.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 227, Issue:2

    Topics: Animals; Digitoxin; Drug Interactions; Ethionine; Female; Hexobarbital; In Vitro Techniques; Liver; Microscopy, Electron; Paralysis; Pharmaceutical Preparations; Phenobarbital; Pregnenolone Carbonitrile; Rats; Seizures; Sleep; Zoxazolamine

1977
Digitoxin metabolism by liver microsomal cytochrome P-450 and UDP-glucuronosyltransferase and its role in the protection of rats from digitoxin toxicity by pregnenolone-16 alpha-carbonitrile.
    Archives of biochemistry and biophysics, 1986, Nov-15, Volume: 251, Issue:1

    Topics: Age Factors; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Digitoxin; Female; Glucuronosyltransferase; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Sex Factors; Troleandomycin

1986
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
    The Journal of pharmacology and experimental therapeutics, 1974, Volume: 191, Issue:2

    Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine

1974
Glucuronidation of digitalis glycosides by rat liver microsomes: stimulation by spironolactone and pregnenolone-16 alpha-carbonitrile.
    Biochemical pharmacology, 1980, Jun-01, Volume: 29, Issue:11

    Topics: Animals; Digitalis Glycosides; Digitoxin; Digoxigenin; Digoxin; Female; Glucuronates; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Spironolactone; Stimulation, Chemical

1980