pregnenolone carbonitrile has been researched along with acetaminophen in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Klaassen, CD; Madhu, C; Maziasz, T | 1 |
| Klaassen, CD; Madhu, C | 1 |
| De Vries, J; Groot, EJ; van Bree, L | 1 |
| Choung, SY; Kim, HJ; Kim, SJ; Oh, MH; Seo, KW | 1 |
| Aleksunes, LA; Gonzalez, FJ; Guo, GL; Kliewer, SA; Manautou, JE; Moffit, JS; Nicol, CJ; Slitt, AL; Ward, JM | 1 |
7 other study(ies) available for pregnenolone carbonitrile and acetaminophen
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Bile; Dexamethasone; Glutathione; L-Iditol 2-Dehydrogenase; Liver; Male; Mice; Mortality; Necrosis; Pregnenolone Carbonitrile | 1992 |
Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters.
Topics: Acetaminophen; Alanine Transaminase; Animals; Biliary Tract; Cricetinae; Cysteine; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; L-Iditol 2-Dehydrogenase; Liver; Male; Mesocricetus; Pregnenolone Carbonitrile | 1991 |
Reduction by acetylsalicylic acid of paracetamol-induced hepatic glutathione depletion in rats treated with 4,4'-dichlorobiphenyl, phenobarbitone and pregnenolone-16-alpha-carbonitrile.
Topics: Acetaminophen; Animals; Aspirin; Cytochrome P-450 Enzyme System; Enzyme Induction; Gastric Mucosa; Glutathione; In Vitro Techniques; Liver; Male; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Salicylates | 1989 |
Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice.
Topics: Acetaminophen; Animals; Cells, Cultured; Dexamethasone; Glucocorticoids; Liver; Male; Mice; Mice, Inbred ICR; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Species Specificity; Sulfates | 1999 |
Enhanced acetaminophen toxicity by activation of the pregnane X receptor.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blotting, Northern; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Membrane Proteins; Mice; Mice, Knockout; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Pregnenolone Carbonitrile; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Sulfhydryl Compounds | 2004 |