pregnenolone carbonitrile has been researched along with 3-methylcholanthrene in 70 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (62.86) | 18.7374 |
| 1990's | 12 (17.14) | 18.2507 |
| 2000's | 12 (17.14) | 29.6817 |
| 2010's | 2 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Fasco, MJ; Kaminsky, LS; Piper, LJ | 1 |
| Boobis, AR; Nebert, DW; Pelkonen, O | 1 |
| Cameron, RG; Farber, E; Griffin, MJ; Joly, JG; Murray, RK; Sharma, RN | 1 |
| Jaeger, RJ; Moslen, MT; Murphy, SD; Reynolds, ES; Szabo, S | 1 |
| Eaton, DL; Klaassen, CD | 1 |
| Gielen, JE; Kremers, P; Pasleau, F | 1 |
| Baird, MB; Birnbaum, LS; Massie, HR | 1 |
| Bresnick, E; Chuang, AH; Howard, EF | 1 |
| Klaassen, CD | 4 |
| Alexandrov, K; Frayssinet, C | 1 |
| Drew, RT; Fouts, JR; Lo, RJ; Roth, RP | 1 |
| Arcos, JC; Argus, MF; Bryant, GM; Buu-Hoi, NP; Valle, RT | 1 |
| Gangolli, SD; Lake, BG; Lloyd, AG; Longland, RC | 1 |
| Chen, S; Li, D; Moorthy, B; Randerath, K | 1 |
| Lutz, W | 1 |
| Watkins, JB | 1 |
| Kelley, M; Safe, S; Womack, J | 1 |
| Gregus, Z; Klaassen, CD; Madhu, C | 1 |
| Koliada, AIu | 1 |
| Bartsch, H; Béréziat, JC; Brun, G; Friedman, FK; Gelboin, HV; Hietanen, E; Malaveille, C; Park, SS | 1 |
| Gram, TE; Okine, LK | 1 |
| Burke, MD; Elcombe, CR; Haaparanta, T; Halpert, J; Mayer, RT; Thompson, S | 1 |
| Klaassen, CD; Thompson, TN | 2 |
| Arlotto, MP; Gorski, JR; Klaassen, CD; Parkinson, A | 1 |
| Juchau, MR; Namkung, MJ; Nelson, SD; Porubek, DJ | 1 |
| Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 1 |
| Hildebrandt, AG; Roots, I; Speck, M | 1 |
| Glaumann, H; Lindeborg, T | 1 |
| Gustafsson, JA; Ingelman-Sundberg, M | 1 |
| Mason, JI; Schacter, BA | 1 |
| Parkinson, A; Robertson, LW; Safe, SH | 1 |
| Bellward, GD; Gontovnick, LS; Sunahara, G | 1 |
| Mannering, GJ; Robbins, MS | 1 |
| Elshourbagy, NA; Guzelian, PS | 1 |
| Gustafsson, JA; Hansson, T; Rafter, J | 1 |
| Förlin, L | 1 |
| Baron, J; Greenspan, P; Kapke, GF; Redick, JA; Taira, Y | 1 |
| Batt, AM; Martin, N; Siest, G | 1 |
| Steggles, AW; Vlasuk, GP; Walz, FG | 1 |
| Guzelian, PS; Newman, SL | 1 |
| Levin, W; Ryan, DE; Thomas, PE; Vlasuk, GP; Walz, FG | 1 |
| Duvivier, J; Gielen, JE; Van Cantfort, J | 1 |
| Bridges, JW; Fennell, TR; Sweatman, BC | 1 |
| Goerz, G; Ruzicka, T; Vizethum, W | 1 |
| Baird, MB | 1 |
| Barter, RA; Klaassen, CD; Liu, J; Liu, Y | 1 |
| Kupfer, D; Mani, C; Parkinson, A; Pearce, R | 1 |
| Barter, RA; Klaassen, CD | 1 |
| Bammler, TK; Buetler, TM; Eaton, DL; Hayes, JD | 1 |
| Klaassen, CD; Kolaja, KL | 1 |
| Fujita, S; Funae, Y; Imaoka, S; Kazusaka, A; Maeda, Y; Masuda, M; Morita, K | 1 |
| Hashmi, R; Hood, A; Klaassen, CD | 1 |
| Law, MY; Moody, DE; Slawson, MH | 1 |
| Engelken, DT; Klaassen, CD; Kolaja, KL | 1 |
| Endo, Y; Honma, R; Jarukamjorn, K; Kuroiwa, M; Nemoto, N; Ohara, A; Sakuma, T; Takai, M | 1 |
| Hood, A; Klaassen, CD | 1 |
| Hartley, DP; Klaassen, CD; Meier, PJ; Rausch-Derra, LC | 1 |
| Klaassen, CD; Vansell, NR | 3 |
| Habeebu, SS; Johnson, DR; Klaassen, CD | 1 |
| Allen, ML; Hood, A; Klaassen, CD; Liu, J; Liu, Y | 1 |
| Han, Y; Sugiyama, Y | 1 |
| Kon, J; Mitaka, T; Miyamoto, S; Ninomiya, S; Ooe, H; Ozone, Y | 1 |
| Klaassen, CD; Richardson, TA | 1 |
2 review(s) available for pregnenolone carbonitrile and 3-methylcholanthrene
| Article | Year |
|---|---|
[Expression of cytochrome P-450 genes].
Topics: Animals; Cytochrome P-450 Enzyme System; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Liver; Methylcholanthrene; Mice; Oxidation-Reduction; Phenobarbital; Pituitary Hormones, Anterior; Pregnenolone Carbonitrile; Transcription, Genetic | 1992 |
Effects of steroids upon the liver ultrastructure.
Topics: Animals; Benzopyrenes; Desoxycorticosterone; Endocrine Glands; Enzyme Induction; Glucocorticoids; Glycogen; Gonadal Steroid Hormones; Humans; Lipid Metabolism; Liver; Membranes; Methylcholanthrene; Microsomes, Liver; Mitochondria, Liver; Norpregnenes; Phenobarbital; Pregnenolone Carbonitrile; Protein Biosynthesis; RNA; Spironolactone; Steroids | 1973 |
68 other study(ies) available for pregnenolone carbonitrile and 3-methylcholanthrene
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Cumene hydroperoxide-supported microsomal hydroxylations of warfarin--a probe of cytochrome P-450 multiplicity and specificity.
Topics: Animals; Benzene Derivatives; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Peroxides; Phenobarbital; Pregnenolone Carbonitrile; Rats; Stereoisomerism; Warfarin | 1979 |
Effects of microsomal enzyme inducers in vivo and inhibitors in vitro on the covalent binding of benzo[a]pyrene metabolites to DNA catalyzed by liver microsomes from genetically responsive and nonresponsive mice.
Topics: Animals; Benzopyrenes; Cyclohexanes; DNA; Enzyme Induction; Enzyme Inhibitors; Ethanol; Flavonoids; In Vitro Techniques; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Species Specificity | 1979 |
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics.
Topics: 2-Acetylaminofluorene; Animals; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Ethanol; Female; Male; Methylcholanthrene; Microsomes, Liver; Oxygenases; Peptide Biosynthesis; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Safrole | 1979 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; Endoplasmic Reticulum; Enzyme Induction; Glutathione; Hexachlorobenzene; Hydrocarbons, Chlorinated; Liver; Liver Neoplasms; Male; Methylcholanthrene; Mitochondria, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Vinyl Chloride; Vinyl Compounds | 1975 |
Effects of microsomal enzyme inducers on carrier-mediated transport systems in isolated rat hepatocytes.
Topics: Animals; Biological Transport, Active; Enzyme Induction; In Vitro Techniques; Kinetics; Liver; Male; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Procainamide; Rats; Taurocholic Acid | 1979 |
Is steroid-16alpha-hydroxylase supported by more than one monooxygenase?
Topics: Animals; Female; Flavonoids; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Naphthalenes; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Sex Factors; Steroid Hydroxylases | 1978 |
Pregnenolone-16alpha-carbonitrile-inducible cytochrome P450 in rat liver.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Molecular Weight; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1976 |
Aryl hydrocarbon hydroxylase in mouse mammary gland: in vitro study using mammary cell lines.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Cells, Cultured; Enzyme Induction; Epithelial Cells; Epithelium; Female; Flavonoids; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylcholanthrene; Mice; Mice, Inbred A; Mice, Inbred C3H; Neoplasm Transplantation; Pregnenolone Carbonitrile | 1977 |
Effect of microsomal enzyme inducers on the biliary excretion of an exogenous load of bilirubin in newborn rats.
Topics: Age Factors; Animals; Animals, Newborn; Bile; Bilirubin; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone | 1976 |
Aryl and aniline hydroxylases in rat nuclear membranes after pretreatment with pregnenolone 16alpha-carbonitrile, phenobarbital and methylcholanthrene.
Topics: Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cell Nucleus; Enzyme Induction; Liver; Male; Membranes; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1975 |
Biliary excretion of drugs: role of ligandin in newborn immaturity and in the action of microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Biotransformation; Carrier Proteins; Enzyme Induction; Glutathione Transferase; In Vitro Techniques; Liver; Male; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Protein Binding; Rats; Sulfobromophthalein; Time Factors | 1975 |
Dichloromethane inhalation, carboxyhemoglobin concentrations, and drug metabolizing enzymes in rabbits.
Topics: Animals; Carbon Tetrachloride; Carboxyhemoglobin; Hemoglobins; Hydrocarbons, Chlorinated; Male; Methylcholanthrene; Methylene Chloride; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rabbits | 1975 |
Dimethylnitrosamine-demethylase: molecular size-dependence of repression by polynuclear hydrocarbons. Nonhydrocarbon repressors.
Topics: Animals; Dimethylnitrosamine; Enzyme Repression; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Oxidoreductases, N-Demethylating; Phenobarbital; Polycyclic Compounds; Pregnenolone Carbonitrile; Rats | 1976 |
The influence of some foreign compounds on hepatic xenobiotic metabolism and the urinary excretion of D-glucuronic acid metabolites in the rat.
Topics: Animals; Butylated Hydroxytoluene; DDT; Female; Glucuronates; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1976 |
Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA Replication; Enzyme Induction; Female; Kidney; Liver; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Thymidine | 1992 |
Effect of microsomal enzyme inducing agents on hepatic biotransformation in cotton rats (Sigmodon hispidus): comparison to that in Sprague-Dawley rats.
Topics: Animals; Arylsulfotransferase; Biotransformation; Cytochrome P-450 Enzyme System; Dinitrochlorobenzene; Enzyme Induction; Ethacrynic Acid; Female; Glucuronosyltransferase; Glutathione Transferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sulfobromophthalein; Sulfotransferases | 1991 |
Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins.
Topics: Animals; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Oxazines; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Pyridines; Safrole; Testosterone | 1990 |
Inducibility of glutathione S-transferases in hamsters.
Topics: Animals; Butylated Hydroxyanisole; Cats; Cricetinae; Dexamethasone; Dogs; Enzyme Induction; Ethanol; Glutathione Transferase; Guinea Pigs; Isoniazid; Liver; Male; Mesocricetus; Methylcholanthrene; Mice; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnenolone Carbonitrile; Quail; Rabbits; Rats; Species Specificity; Stilbenes; Trout | 1989 |
[Cytochrome P-450 isoforms in the liver of rats treated with phenobarbital, 3-methylcholanthrene and Aroclor 1254 studied by monoclonal antibodies].
Topics: Animals; Antibodies, Monoclonal; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Clone Cells; Cytochrome P-450 Enzyme System; Imidazoles; Immunization; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred BALB C; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains | 1986 |
Monoclonal antibody-directed analysis of cytochrome P-450-dependent monooxygenases and mutagen activation in the livers of DBA/2 and C57BL/6 mice.
Topics: Animals; Antibodies, Monoclonal; Biotransformation; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Activation; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mixed Function Oxygenases; Mutagenicity Tests; Phenobarbital; Pregnenolone Carbonitrile; Salmonella typhimurium | 1986 |
In vitro studies on the metabolism and covalent binding of [14C]1,1-dichloroethylene by mouse liver, kidney and lung.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Carbon Monoxide; Cytochrome P-450 Enzyme System; Dichloroethylenes; Enzyme Induction; Glutathione; Hot Temperature; Hydrocarbons, Chlorinated; In Vitro Techniques; Kidney; Liver; Lung; Methylcholanthrene; Mice; Mice, Inbred C57BL; NADP; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Proadifen; Subcellular Fractions | 1986 |
Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450.
Topics: Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Enzyme Induction; Ethers; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxazines; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Substrate Specificity | 1985 |
Hepatic presystemic elimination of diethylstilbestrol by rats and effect of pretreatment with inducers of UDP-glucuronosyltransferase.
Topics: Animals; Bile; Diethylstilbestrol; Enzyme Induction; Glucuronates; Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1985 |
Age- and sex-dependent induction of liver microsomal benzo[a]pyrene hydroxylase activity in rats treated with pregnenolone-16 alpha-carbonitrile (PCN).
Topics: Age Factors; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1985 |
Regulation of aromatic oxidation of estradiol-17 beta in maternal hepatic, fetal hepatic and placental tissues: comparative effects of a series of inducing agents.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP1A1; Estradiol; Ethanol; Female; Liver; Male; Methylcholanthrene; Phenobarbital; Placenta; Polychlorinated Dibenzodioxins; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Steroid Hydroxylases | 1985 |
Possible control of hydrogen peroxide production and degradation in microsomes during mixed function oxidation reaction.
Topics: Aminopyrine; Animals; Azides; Catalase; Cytochrome P-450 Enzyme System; Hemeproteins; Hydrogen Peroxide; Hydroxylation; In Vitro Techniques; Male; Methylcholanthrene; Microsomes, Liver; NADP; Oxidation-Reduction; Phenobarbital; Pregnenolone Carbonitrile; Rats; Time Factors | 1973 |
Effect of a catatoxic steroid pregnenolone-16alpha-carbonitrile, on rat liver microsomal subfractions.
Topics: Adenosine Triphosphatases; Aminopyrine N-Demethylase; Animals; Benzopyrenes; Cycloheximide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytochromes; Dose-Response Relationship, Drug; Female; Glucose-6-Phosphatase; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Nucleosides; Phenobarbital; Phospholipids; Phosphoric Monoester Hydrolases; Pregnenolone Carbonitrile; Proteins; Rats | 1974 |
Effect of microsomal enzyme inducers on the biliary excretion of cardiac glycosides.
Topics: Analysis of Variance; Animals; Bile; Biotransformation; Cardiac Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Enzyme Induction; Lethal Dose 50; Liver; Male; Methylcholanthrene; Microsomes; Myocardium; Organ Size; Ouabain; Paralysis; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium; Zoxazolamine | 1974 |
Stimulation of the development of the hepatic excretory mechanism for ouabain in newborn rats with microsomal enzyme inducers.
Topics: Aging; Animals; Animals, Newborn; Bile; Enzyme Induction; Liver; Methylcholanthrene; Microsomes, Liver; Ouabain; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spironolactone; Time Factors; Tritium | 1974 |
Regulation and properties of a sex-specific hydroxylase system in female rat liver microsomes active on steroid sulfates. I. General characteristics.
Topics: Age Factors; Androstanes; Animals; Carbon Monoxide; Carbon Radioisotopes; Castration; Estradiol; Female; Hydroxysteroids; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Sex Factors; Steroid Hydroxylases; Sulfuric Acids; Testosterone | 1974 |
The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16 alpha-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450.
Topics: Animals; Benzopyrenes; Cytochrome P-450 Enzyme System; Heme; Male; Methylcholanthrene; Microsomes; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Spectrophotometry; Spectrophotometry, Ultraviolet; Spleen; Time Factors | 1974 |
Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl.
Topics: Animals; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Safrole; Spectrophotometry | 1983 |
Nonadditive effects of combined in vivo hepatic microsomal enzyme inducers in the Wistar rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Methylcholanthrene; Microsomes, Liver; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Spironolactone; Stilbenes | 1983 |
Effects of the interferon inducing agents tilorone and polyriboinosinic acid . polyribocytidylic acid (poly IC) on the hepatic monooxygenase systems of pregnant and fetal rats.
Topics: Aminopyrine N-Demethylase; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; Fetus; Fluorenes; Liver; Maternal-Fetal Exchange; Methylcholanthrene; Oxygenases; Phenobarbital; Poly I-C; Pregnancy; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Tilorone | 1984 |
Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.
Topics: Amino Acids; Animals; Cytochrome P-450 Enzyme System; Immunoassay; Immunodiffusion; Male; Methylcholanthrene; Microsomes, Liver; Peptide Fragments; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Effects of some common inducers on the hepatic microsomal metabolism of androstenedione in rainbow trout with special reference to cytochrome P-450-dependent enzymes.
Topics: Androstenedione; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Salmonidae; Trout | 1980 |
Effects of clophen A50, 3-methylcholanthrene, pregnenolone-16 alpha-carbonitrile, and phenobarbital on the hepatic microsomal cytochrome P-450-dependent monooxygenase system in rainbow trout, Salmo gairdneri, of different age and sex.
Topics: Aging; Animals; Benzopyrene Hydroxylase; Cytochrome P-450 Enzyme System; Female; Male; Methylcholanthrene; Microsomes, Liver; Nitroanisole O-Demethylase; Oxidoreductases; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Salmonidae; Sex Factors; Trout | 1980 |
Effects of phenobarbital, pregnenolone-16 alpha-carbonitrile, and 3-methylcholanthrene pretreatments on the distribution of NADPH-cytochrome c (P-450) reductase within the liver lobule.
Topics: Animals; Fluorescent Antibody Technique; Liver; Male; Methylcholanthrene; NADPH-Ferrihemoprotein Reductase; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice.
Topics: Animals; Aroclors; Benzoflavones; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Safrole; Substrate Specificity | 1981 |
Species differences in cytochromes P-450 and epoxide hydrolase: comparisons of xenobiotic-induced hepatic microsomal polypeptides in hamsters and rats.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cricetinae; Cytochrome P-450 Enzyme System; Enzyme Induction; Epoxide Hydrolases; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Species Specificity; Stilbenes | 1983 |
Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation.
Topics: Aldrin; Animals; Cytochrome P-450 Enzyme System; Epoxy Compounds; Female; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Sex Factors | 1983 |
Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics.
Topics: Animals; Aroclors; Chlordan; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Epoxide Hydrolases; Isomerism; Male; Methylcholanthrene; Microsomes, Liver; Peptide Biosynthesis; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Rats; Safrole; Stilbenes | 1982 |
The influence of five monoxygenase inducers on liver cytosol estradiol receptor levels in the ovariectomized adult rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Castration; Cytosol; Enzyme Induction; Female; Liver; Methylcholanthrene; Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Receptors, Estradiol; Receptors, Estrogen | 1981 |
The induction of hepatic cytochrome P-450 in C57 BL/10 and DBA/2 mice by isosafrole and piperonyl butoxide. A comparative study with other inducing agents.
Topics: Animals; Cytochrome P-450 Enzyme System; Dioxoles; Enzyme Induction; Isomerism; Liver; Male; Methylcholanthrene; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Phenobarbital; Piperonyl Butoxide; Pregnenolone Carbonitrile; Safrole | 1980 |
Inducibility of drug-metabolizing enzymes in the rat skin.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Liver; Male; Methylcholanthrene; Mixed Function Oxygenases; NADH Dehydrogenase; Oxidoreductases; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rifampin; Skin | 1980 |
Microsomal NADPH-dependent lipid peroxidation does not require the presence of intact cytochrome P450.
Topics: Allylisopropylacetamide; Animals; Cytochrome P-450 Enzyme System; Heme; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Methylcholanthrene; Microsomes, Liver; NADP; Phenobarbital; Pregnenolone Carbonitrile; Rats | 1980 |
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Enzyme Induction; Glucuronosyltransferase; Homeostasis; Liver; Male; Methylcholanthrene; Organ Size; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1995 |
Involvement of cytochrome P4503A in catalysis of tamoxifen activation and covalent binding to rat and human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzimidazoles; Biotransformation; Chickens; Cricetinae; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Erythromycin; Female; Humans; Hydrocortisone; Immunoglobulin G; Male; Mesocricetus; Methylcholanthrene; Metyrapone; Mice; Microsomes, Liver; Mixed Function Oxygenases; Phenobarbital; Pregnenolone Carbonitrile; Proadifen; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Tamoxifen; Troleandomycin | 1994 |
Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats.
Topics: Administration, Oral; Animals; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Phenobarbital; Polychlorinated Biphenyls; Pregnenolone Carbonitrile; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyroid Hormones | 1994 |
Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.
Topics: Aflatoxin B1; Aflatoxins; Animals; Anticarcinogenic Agents; Base Sequence; Biotransformation; Carcinogens; Clofibric Acid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Glutathione Transferase; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases; Pregnenolone Carbonitrile; Pyrazines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Species Specificity; Steroid Hydroxylases; Thiones; Thiophenes | 1996 |
The effects of hepatic microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats.
Topics: Animals; Bile; Biliary Tract; Enzyme Induction; Femoral Vein; Injections, Intravenous; Liver; Male; Methylcholanthrene; Microsomes, Liver; Organ Size; Ouabain; Phenobarbital; Portal Vein; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley | 1995 |
Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis.
Topics: Animals; Apoptosis; Chlorodiphenyl (54% Chlorine); Dose-Response Relationship, Drug; Enzyme Induction; Glucuronosyltransferase; Immunohistochemistry; Male; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Transforming Growth Factor beta | 1998 |
Strain differences in CYP3A-mediated C-8 hydroxylation (1,3,7-trimethyluric acid formation) of caffeine in Wistar and Dark Agouti rats. Rapid metabolism of caffeine in debrisoquine poor metabolizer model rats.
Topics: Aging; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Debrisoquin; Dexamethasone; Female; Humans; Hydroxylation; Male; Methylcholanthrene; Microsomes, Liver; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Wistar; Sex Characteristics; Species Specificity; Troleandomycin; Uric Acid | 1998 |
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Topics: Animals; Cell Count; Cell Division; Chlorodiphenyl (54% Chlorine); Enzyme Activation; Hyperplasia; Hypertrophy; Male; Methylcholanthrene; Organ Size; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 1999 |
Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat.
Topics: Amphetamine; Animals; Clofibrate; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Ethanol; Hydroxylation; Isoenzymes; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; p-Hydroxyamphetamine; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Safrole | 2000 |
Inhibition of gap-junctional-intercellular communication in intact rat liver by nongenotoxic hepatocarcinogens.
Topics: Animals; Apoptosis; Carcinogens; Cell Communication; Cell Division; Chlorodiphenyl (54% Chlorine); Dextrans; Fluorescent Dyes; Gap Junctions; Image Processing, Computer-Assisted; Immunohistochemistry; Isoquinolines; Liver; Male; Methylcholanthrene; Microscopy, Fluorescence; Phenobarbital; Pregnenolone Carbonitrile; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Sprague-Dawley; Rhodamines; Signal Transduction; Specific Pathogen-Free Organisms | 2000 |
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
Topics: Amino Acid Sequence; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Castration; Cloning, Molecular; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Estradiol; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Developmental; Liver; Male; Membrane Proteins; Methylcholanthrene; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone Carbonitrile; Rifampin; RNA, Messenger; Sex Characteristics; Sexual Maturation; Testosterone | 2000 |
Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation.
Topics: Animals; Chlorodiphenyl (54% Chlorine); Detergents; Enzyme Induction; Glucuronides; Glucuronosyltransferase; In Vitro Techniques; Iodine Radioisotopes; Male; Methylcholanthrene; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyroxine; Triiodothyronine | 2000 |
Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.
Topics: Animals; Anion Transport Proteins; Carrier Proteins; Enzyme Induction; Liver; Membrane Proteins; Methylcholanthrene; Microsomes, Liver; Organic Anion Transporters, Sodium-Independent; Phenobarbital; Pregnenolone Carbonitrile; Rats; RNA, Messenger; Time Factors | 2001 |
Increased biliary excretion of thyroxine by microsomal enzyme inducers.
Topics: Animals; Antithyroid Agents; Bile; Carcinogens; Chlorodiphenyl (54% Chlorine); Glucuronides; Male; Methylcholanthrene; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Thyrotropin; Thyroxine | 2001 |
Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites.
Topics: Animals; Bile; Chlorodiphenyl (54% Chlorine); Chromatography, High Pressure Liquid; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Iodine Radioisotopes; Male; Methylcholanthrene; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Triiodothyronine | 2002 |
Increase in rat liver UDP-glucuronosyltransferase mRNA by microsomal enzyme inducers that enhance thyroid hormone glucuronidation.
Topics: Animals; Blotting, Northern; Chlorodiphenyl (54% Chlorine); Electrophoresis, Agar Gel; Enzyme Induction; Glucuronosyltransferase; Isoenzymes; Male; Methylcholanthrene; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substrate Specificity; Thyroid Hormones; Thyroxine; Transcription, Genetic; Triiodothyronine | 2002 |
Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.
Topics: Animals; ATP-Binding Cassette Transporters; Benzopyrenes; Bile; Biliary Tract; Carrier Proteins; Drug Interactions; Gene Expression Regulation; Glutathione; Hyperbilirubinemia; Immunohistochemistry; Liver; Male; Membrane Transport Proteins; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfhydryl Compounds | 2002 |
Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers.
Topics: Administration, Oral; Animals; Cell Division; Chlorodiphenyl (54% Chlorine); Dose-Response Relationship, Drug; Enzyme Induction; Glucuronosyltransferase; Male; Methylcholanthrene; Mice; Mice, Inbred Strains; Microsomes, Liver; Phenobarbital; Pregnenolone Carbonitrile; Thyroid Gland; Thyrotropin | 2003 |
Expression and regulation of breast cancer resistance protein and multidrug resistance associated protein 2 in BALB/c mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cytochrome P-450 CYP3A; Depression, Chemical; Enzyme Induction; Intestinal Mucosa; Liver; Liver-Specific Organic Anion Transporter 1; Membrane Proteins; Membrane Transport Proteins; Methylcholanthrene; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Pregnenolone Carbonitrile; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Tissue Distribution | 2006 |
Cytochrome p450 expression of cultured rat small hepatocytes after long-term cryopreservation.
Topics: Animals; Carbon Radioisotopes; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Chromatography, High Pressure Liquid; Collagen; Cryopreservation; Cytochrome P-450 Enzyme System; Drug Combinations; Ethanol; Hepatocytes; Immunoblotting; Isoenzymes; L-Serine Dehydratase; Laminin; Liver; Methylcholanthrene; Phenobarbital; Pregnenolone Carbonitrile; Proteoglycans; Rats; Rats, Inbred F344; Testosterone; Time Factors | 2006 |
Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation.
Topics: Animals; Cell Proliferation; Chlorodiphenyl (54% Chlorine); Glucuronosyltransferase; Liver; Male; Methylcholanthrene; Microsomes, Liver; Pregnenolone Carbonitrile; Rats; Rats, Gunn; Rats, Wistar; Thyroid Gland; Thyrotropin; Thyroxine; Triiodothyronine | 2010 |