pregnenolone has been researched along with pk 11195 in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (68.42) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavallaro, S; Costa, E; Guidotti, A; Korneyev, A | 1 |
| Krueger, KE; Papadopoulos, V | 1 |
| Ambrosio, C; Barbaccia, ML; Massotti, M; Roscetti, G; Trabucchi, M | 1 |
| Cascio, C; Guarneri, P; Guarneri, R; Papadopoulos, V; Piccoli, F | 1 |
| Itzhak, Y; Norenberg, MD | 1 |
| Gee, KW; Lan, NC; McCauley, LD; Park, CH; Shively, JE; Tomich, JM | 1 |
| Antkiewicz-Michaluk, L; Martin, B; Slobodyansky, E | 1 |
| Cavallaro, S; Costa, E; Guidotti, A; Korneyev, A; Kozikowski, AP; Ma, D; Polo, A; Romeo, E | 1 |
| Williams, DC; Zisterer, DM | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Benavides, J; Brault, E; Dalibert, I; Ferzaz, B; Gandolfo, P; Lacor, P; Schumacher, M; Tonon, MC | 1 |
| Biggio, G; Carotti, A; Franco, M; Latrofa, A; Liso, G; Ricciardi, L; Sanna, E; Serra, M; Trapani, G | 1 |
| Dong, E; Matsumoto, K; Watanabe, H | 1 |
| Bellandi, M; Cosimelli, B; Costa, B; Da Pozzo, E; Da Settimo, F; Greco, G; La Motta, C; Marini, AM; Martini, C; Morelli, M; Novellino, E; Salerno, S; Simola, N; Simorini, F; Taliani, S | 1 |
| Boyd, KN; Kumar, S; Morrow, AL; O'Buckley, TK; Porcu, P | 1 |
| Da Pozzo, E; Guarino, C; Ittner, LM; Kassiou, M; Luus, C; Martini, C; Scarf, AM; Selleri, S | 1 |
| Kalinina, TS; Kudriashov, NV; Seredenin, SB; Shimshirt, AA; Voronina, TA | 1 |
| Barresi, E; Costa, B; Da Pozzo, E; Da Settimo, F; Giacomelli, C; Martini, C; Taliani, S | 1 |
| Cavallini, C; Costa, B; Da Pozzo, E; Da Settimo, F; Martini, C; Taliani, S | 1 |
19 other study(ies) available for pregnenolone and pk 11195
| Article | Year |
|---|---|
Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Benzodiazepinones; Convulsants; Corticosterone; Cyclic AMP; Cycloheximide; Diazepam Binding Inhibitor; Hypophysectomy; Isoquinolines; Male; Mitochondria; Molecular Sequence Data; Neuropeptides; Pregnenolone; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; RNA | 1992 |
Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Cell Line; Cholesterol; Electron Transport Complex IV; Intracellular Membranes; Isoquinolines; Kinetics; Mitochondria; Monoamine Oxidase; Pregnenolone; Receptors, GABA-A | 1990 |
Modulatory mechanisms of cyclic AMP-stimulated steroid content in rat brain cortex.
Topics: 1-Methyl-3-isobutylxanthine; Adrenalectomy; Animals; Benzodiazepinones; Bucladesine; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; In Vitro Techniques; Isoquinolines; Male; Orchiectomy; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear | 1994 |
gamma-Aminobutyric acid type A/benzodiazepine receptors regulate rat retina neurosteroidogenesis.
Topics: Animals; Flunitrazepam; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Kinetics; Male; Neuroglia; Neurotransmitter Agents; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Retina; Steroids; Synaptic Transmission | 1995 |
Attenuation of ammonia toxicity in mice by PK 11195 and pregnenolone sulfate.
Topics: Ammonia; Animals; Clonazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Isoquinolines; Male; Mice; Pregnenolone | 1994 |
Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria.
Topics: Amino Acid Sequence; Animals; Benzodiazepines; Benzodiazepinones; Brain; In Vitro Techniques; Isoquinolines; Male; Mitochondria; Molecular Sequence Data; Peptides; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1995 |
Purification of a novel DBI processing product, DBI39-75, and characterization of its binding site in rat brain.
Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Binding Sites; Brain; Carrier Proteins; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Diazepam Binding Inhibitor; Isoquinolines; Male; Mitochondria; Molecular Sequence Data; Neuropeptides; Peptide Fragments; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley | 1994 |
Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex.
Topics: Adrenal Glands; Adrenalectomy; Animals; Behavior, Animal; Benzodiazepinones; Binding, Competitive; Brain; Carrier Proteins; Corticosterone; Diazepam Binding Inhibitor; In Vitro Techniques; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Orchiectomy; Pregnenolone; Rats; Rats, Sprague-Dawley; Solubility; Steroids; Tricarboxylic Acids | 1993 |
Calmidazolium and other imidazole compounds affect steroidogenesis in Y1 cells: lack of involvement of the peripheral-type benzodiazepine receptor.
Topics: Adrenal Cortex; Animals; Binding, Competitive; Cholesterol Side-Chain Cleavage Enzyme; Dose-Response Relationship, Drug; Drug Interactions; Econazole; Imidazoles; Isoquinolines; Ligands; Mice; Miconazole; Pregnenolone; Receptors, GABA-A | 1997 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis.
Topics: Animals; Antineoplastic Agents; Benzodiazepinones; Chromatography, High Pressure Liquid; Convulsants; Diazepam Binding Inhibitor; Freezing; Gene Expression Regulation; Isoquinolines; Ligands; Myelin Sheath; Nerve Regeneration; Neuropeptides; Peptide Fragments; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatic Nerve; Tritium; Wallerian Degeneration | 1999 |
Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity, and in vivo studies.
Topics: Animals; Cloning, Molecular; Desoxycorticosterone; Female; Humans; Imidazoles; Isoquinolines; Ligands; Male; Oocytes; Pregnenolone; Progesterone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Xenopus | 1999 |
Involvement of peripheral type of benzodiazepine receptor in social isolation stress-induced decrease in pentobarbital sleep in mice.
Topics: Animals; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA Modulators; Hypnotics and Sedatives; Indoleacetic Acids; Isoquinolines; Male; Mice; Pentobarbital; Pregnenolone; Receptors, GABA-A; Sleep; Social Isolation; Stress, Physiological | 1999 |
Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.
Topics: Amides; Animals; Anti-Anxiety Agents; Cell Line, Tumor; Cell Membrane; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Isoquinolines; Kidney; Maze Learning; Pregnenolone; Radioligand Assay; Rats | 2008 |
Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Brain; Central Nervous System Depressants; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Ethanol; GABA Agents; Gene Expression Regulation; Glucocorticoids; Hypophysectomy; Imidazoles; Immunoglobulin G; Immunoprecipitation; Isoquinolines; Male; Melphalan; Phosphoproteins; Pregnanolone; Pregnenolone; Protein Synthesis Inhibitors; Pyridines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Steroids | 2010 |
Evidence for complex binding profiles and species differences at the translocator protein (TSPO) (18 kDa).
Topics: Animals; Benzodiazepines; Binding, Competitive; GABA Antagonists; HEK293 Cells; Humans; Isoquinolines; Ligands; Lipopolysaccharides; Mitochondria; Nitric Oxide; Pregnenolone; Protein Binding; Rats; Receptors, GABA; Species Specificity | 2012 |
[Neurosteroidogenesis and exploratory responses in rodents].
Topics: 5-alpha Reductase Inhibitors; Animals; Behavior, Animal; Brain; Conditioning, Classical; Exploratory Behavior; Finasteride; Indomethacin; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mitochondrial Proteins; Neurotransmitter Agents; Pregnenolone; Protein Transport; Rats; Rats, Wistar; Stress, Psychological | 2014 |
TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy.
Topics: Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Cell Line, Tumor; Dose-Response Relationship, Drug; GABA Agonists; Gene Expression; Humans; Indoles; Isoquinolines; Kinetics; Ligands; Neuroglia; Pregnenolone; Protein Binding; Receptors, GABA; Thermodynamics; Time Factors; Tritium | 2016 |
Long Residence Time at the Neurosteroidogenic 18 kDa Translocator Protein Characterizes the Anxiolytic Ligand XBD173.
Topics: Adrenal Glands; Animals; Anti-Anxiety Agents; Antineoplastic Agents; Carrier Proteins; Cell Line, Tumor; Cell Membrane; Dose-Response Relationship, Drug; Glioma; Isoquinolines; Kidney; Ligands; Pregnenolone; Protein Binding; Purines; Rats; Receptors, GABA-A; Time Factors; Tritium | 2016 |