Compounds > pregnenolone

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pregnenolone and picrotoxin

pregnenolone has been researched along with picrotoxin in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (13.33)	18.7374
1990's	6 (40.00)	18.2507
2000's	5 (33.33)	29.6817
2010's	2 (13.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
ffrench-Mullen, JM; Plata-Salaman, CR; Spence, KT	1
Akeson, M; Deamer, DW; Oliver, AE	1
Demirgören, S; London, ED; Majewska, MD	1
Mienville, JM; Vicini, S	1
Majewska, MD; Schwartz, RD	1
Richardson, CM; Wakerley, JB	1
Greenfield, LJ; Macdonald, RL; Neelands, TR; Turner, RS; Zhang, J	1
Covey, DF; Mennerick, S; Shen, W; Zorumski, CF; Zorumski, EC	1
Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J	1
Eisenman, LN; Fields, C; He, Y; Mennerick, S; Zorumski, CF	1
Bidziński, A; Członkowska, AI; Krzaścik, P; Lehner, M; Maciejak, P; Płaźnik, A; Skórzewska, A; Szyndler, J; Taracha, E; Turzyńska, D; Walkowiak, J; Wisłowska, A; Zienowicz, M	1
Bamber, BA; Jorgensen, EM; Marik, PS; Piper, D; Rutar, T; Wardell, B	1
Goyal, R; Kumar, A; Prakash, A	1
Caley, A; Gielen, MC; Harvey, RJ; Smart, TG; Wilkins, ME	1
Bright, DP; Seljeset, S; Smart, TG; Thomas, P	1

Other Studies

15 other study(ies) available for pregnenolone and picrotoxin

Article	Year
The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block Ca2+ currents in acutely isolated hippocampal CA1 neurons. Life sciences, 1991, Volume: 49, Issue:26 Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Kinetics; Membrane Potentials; Neurons; Picrotoxin; Pregnenolone; Progesterone	1991
Evidence that sensitivity to steroid anesthetics appears late in evolution. Brain research, 1991, Aug-23, Volume: 557, Issue:1-2 Topics: Alcohols; Anesthetics; Animals; Annelida; Arthropods; Biological Evolution; Chordata, Nonvertebrate; Echinodermata; Escape Reaction; Ether; Eukaryota; Membrane Proteins; Mollusca; Picrotoxin; Platyhelminths; Postural Balance; Pregnenolone; Reflex; Species Specificity	1991
Binding of pregnenolone sulfate to rat brain membranes suggests multiple sites of steroid action at the GABAA receptor. European journal of pharmacology, 1990, Oct-30, Volume: 189, Issue:4-5 Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Membranes; Picrotoxin; Pregnenolone; Protein Binding; Rats; Rats, Inbred F344; Receptors, GABA-A; Sulfur Radioisotopes; Synaptosomes	1990
Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency. Brain research, 1989, Jun-05, Volume: 489, Issue:1 Topics: Animals; Cells, Cultured; Cerebral Cortex; Chloride Channels; Chlorides; Ion Channels; Membrane Potentials; Membrane Proteins; Pentobarbital; Picrotoxin; Pregnenolone; Rats; Receptors, GABA-A	1989
Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain? Brain research, 1987, Feb-24, Volume: 404, Issue:1-2 Topics: Adrenal Glands; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Male; Muscimol; Picrotoxin; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stimulation, Chemical	1987
The neurosteroid pregnenolone sulphate enhances NMDA-induced phasic firing of vasopressin neurones in the rat supraoptic nucleus. Neuroscience letters, 1997, Apr-25, Volume: 226, Issue:2 Topics: Animals; Dehydroepiandrosterone Sulfate; Drug Synergism; Evoked Potentials; Female; Hypothalamus; In Vitro Techniques; N-Methylaspartate; Neurons; Picrotoxin; Pregnenolone; Rats; Rats, Wistar; Supraoptic Nucleus; Time Factors; Vasopressins	1997
GABAA receptor pharmacology and subtype mRNA expression in human neuronal NT2-N cells. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Jul-01, Volume: 18, Issue:13 Topics: Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Diuretics; DNA Primers; Furosemide; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypnotics and Sedatives; Lanthanum; Neurons; Patch-Clamp Techniques; Pentobarbital; Phenobarbital; Picrotoxin; Polymerase Chain Reaction; Pregnanediones; Pregnenolone; Pyridines; Receptors, GABA-A; RNA, Messenger; Teratocarcinoma; Triazoles; Tumor Cells, Cultured; Zinc; Zolpidem	1998
Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors. Neuropharmacology, 1999, Volume: 38, Issue:2 Topics: Animals; Chloride Channels; Dehydroepiandrosterone Sulfate; Female; gamma-Aminobutyric Acid; Macromolecular Substances; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis	1999
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2 Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids	2000
Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current. The Journal of physiology, 2003, Aug-01, Volume: 550, Issue:Pt 3 Topics: Animals; Electrophysiology; Female; GABA-A Receptor Antagonists; Hippocampus; Kinetics; Membrane Potentials; Neurons; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pregnenolone; Recombinant Proteins; Sesterterpenes; Sulfates; Xenopus	2003
Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine. Pharmacology, biochemistry, and behavior, 2004, Volume: 78, Issue:4 Topics: Alanine; Amino Acids; Animals; Bicuculline; Convulsants; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Male; Mice; Microinjections; N-Methylaspartate; Picrotoxin; Pregnenolone; Seizures	2004
Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate. British journal of pharmacology, 2006, Volume: 148, Issue:2 Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans Proteins; Dimerization; Dose-Response Relationship, Drug; Female; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Chimeric Proteins; Mutation; Oocytes; Picrotoxin; Pregnenolone; Rats; Receptors, GABA-A; Sequence Homology, Amino Acid; Xenopus laevis	2006
Possible GABAergic mechanism in the protective effect of allopregnenolone against immobilization stress. European journal of pharmacology, 2009, Jan-14, Volume: 602, Issue:2-3 Topics: Animals; Anxiety; Behavior, Animal; GABA Agents; Immobilization; Mice; Muscimol; Oxidative Stress; Picrotoxin; Pregnenolone; Stereoisomerism; Stress, Psychological	2009
Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation. The Journal of physiology, 2016, 07-01, Volume: 594, Issue:13 Topics: Desoxycorticosterone; Glycine; HEK293 Cells; Humans; Hyperekplexia; Models, Molecular; Mutation, Missense; Picrotoxin; Pregnenolone; Receptors, Glycine; Zinc	2016
Probing GABA Neuropharmacology, 2018, 07-01, Volume: 136, Issue:Pt A Topics: Animals; Binding Sites; Cell Line; Humans; Membrane Potentials; Mice; Neurotransmitter Agents; Pentobarbital; Picrotoxin; Pregnenolone; Protein Domains; Receptors, GABA-A; Recombinant Proteins	2018