pregnenolone and nadp
pregnenolone has been researched along with nadp in 174 studies
Research
Studies (174)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 162 (93.10) | 18.7374 |
| 1990's | 8 (4.60) | 18.2507 |
| 2000's | 2 (1.15) | 29.6817 |
| 2010's | 2 (1.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hildebraunt, AG; Roots, I | 1 |
| Kalkman, ML; Van der Molen, HJ; Van der Vusse, GJ; Van Winsen, MP | 1 |
| Kitay, JI; Malendowicz, L | 1 |
| Shikita, M | 1 |
| Bedrak, E; Chap, Z | 1 |
| Farese, RV; Prudente, WJ | 2 |
| Geiss, M; Pirke, KM; Vogt, HJ | 1 |
| Gibb, W; Lavoie, JC; Roux, JF | 1 |
| Bogusławski, W; Klimek, J; Tiałowska, B | 1 |
| Fevold, HR; Slanina, SM; Wilson, PL | 1 |
| Arai, K; Okinaga, S; Sano, Y; Shibusawa, H; Yoshida, N | 1 |
| Bakker, CP; van der Molen, HJ; van der Plank-van Winsen, MP | 1 |
| Fan, DF; Oshima, H; Troen, P | 1 |
| Chan, ST; Lofts, B; Sandor, T | 1 |
| Kuksis, A; Subbiah, MT | 1 |
| Bu'Lock, DE; Jackson, CM | 1 |
| Stein, P; Tesone, M | 1 |
| Richardson, KA; Thierry-Palmer, M | 1 |
| López-Solache, I; Mendoza-Hernández, G; Rendón, JL | 1 |
| Jefcoate, CR; McNamara, BC | 2 |
| Grochowski, D; Szamatowicz, M | 3 |
| Angelastro, MR; Bey, P; Blohm, TR; Laughlin, ME; Schatzman, GL | 1 |
| Cooke, GM; Robaire, B | 1 |
| Balfour, C; Halpert, J; Jaw, JY; Johnson, EF; Mash, EA | 1 |
| Itagaki, E | 1 |
| Benraad, TJ; Hofman, JA; Kloppenborg, PW; Smals, AG; Weusten, JJ | 1 |
| Ghersi-Egea, JF; Minn, A; Siest, G; Walther, B | 1 |
| Hamamoto, I; Hiwatashi, A; Ichikawa, Y | 1 |
| Cheng, B; Hsu, DK; Kimura, T | 1 |
| Krémers, P | 1 |
| Gawienowski, AM; Piziak, VK | 1 |
| Kan, KW; Ungar, F | 1 |
| Matsumoto, K; Yamada, M; Yasue, S | 1 |
| Bedrak, E; Samoiloff, V; Sod-Moriah, UA | 1 |
| Bergheim, P; Netter, KJ; Rathgen, GH | 1 |
| Gunville, R; Seabloom, RW; Ungar, F | 1 |
| O, R; Tamaoki, BI | 1 |
| Oh, R; Tamaoki, B | 1 |
| Andersen, RN; Givens, JR; Pittaway, DE | 1 |
| Deshpande, N; Yates, J | 1 |
| Cooper, DY; Rosenthal, O; Schleyer, H | 1 |
| Jaffe, RB; Kawano, A; Payne, AH | 1 |
| Nozu, K; Tamaoki, B | 1 |
| Hochberg, RB; Ladany, S; Lieberman, S; Welch, M | 1 |
| Kitabchi, AE; Nathans, AH; Phillips, WL | 1 |
| Bogulawski, W; Klimek, J; Zelewski, L | 1 |
| Schulster, D | 1 |
| Altman, FP; Bitensky, L; Butcher, RG; Chayen, J | 1 |
| Reddy, VV | 1 |
| Aronin, PA; Coffey, JC; French, FS; Nayfeh, SN | 1 |
| Palmowski, B; Träger, L | 1 |
| Burstein, S; Gut, M | 1 |
| Kan, KW; McCoy, KE; Ungar, F | 1 |
| Johnson, LR; Nelson, DH; Ruhmann-Wennhold, A | 1 |
| Alonso, C; McIntosh, EN; Mitani, F; Salhanick, HA; Uzgiris, VI | 1 |
| Katukawa, H; Nakamura, T; Tanabe, Y | 1 |
| McKerns, KW; Nordstrand, E | 1 |
| Dorfman, RI; Forchielli, E; Ichii, S; Menon, K | 1 |
| Armstrong, DT; Black, DL | 1 |
| Hitzeman, JW | 1 |
| Müller, J | 1 |
| Dorrington, JH; Kilpatrick, R | 1 |
| Balogh, K; Bratt, H; Lloyd, CW; Pupkin, M; Weisz, J | 1 |
| McCarthy, JL; Rietz, CW; Wesson, LK | 1 |
| Guerra, F; McCarthy, JL; Péron, FG | 1 |
| Channing, CP; Villee, CA | 1 |
| Kao, KY; McGavack, TH; Trout, EC | 1 |
| Shin, SI | 1 |
| Ichii, S; Kobayashi, S; Omata, S | 1 |
| Inano, H; Shikita, M; Tamaoki, B | 1 |
| Inano, H; Nakano, H; Shikita, M; Tamaoki, BI | 1 |
| Hall, PF | 1 |
| Dorfman, RI; Forchielli, E; Menon, KM | 1 |
| Pincus, G; Shima, S; Urata, Y | 1 |
| Caldwell, BV; Péron, FG | 1 |
| Bote, V; Chieffi, G; Tramontana, S | 1 |
| Bjersing, L | 1 |
| Axelrod, LR; Goldzieher, JW | 2 |
| Ertel, RJ; Ungar, F | 1 |
| Caldwell, BV; McCarthy, JL; Péron, FG | 1 |
| Boyd, GS; Sulimovici, S | 2 |
| Fevold, HR; Pfeiffer, EW | 1 |
| Bransome, ED | 1 |
| Charreau, EH; Dufau, ML; Villee, CA; Villee, DB | 1 |
| Cohen, MP | 1 |
| Hall, PF; Young, DG | 3 |
| Jungmann, RA | 1 |
| Armstrong, DT; Jackanicz, TM | 1 |
| Gawienowski, AM; Masaracchia, RA | 1 |
| Bulbrook, RD; Deshpande, N; Doouss, TW; Jensen, V | 1 |
| Garren, LD | 1 |
| Billiar, RB; Hernandez, R; Knappenberger, M; Little, B; Tanaka, Y | 1 |
| Kowal, J | 1 |
| Rogers, WE | 1 |
| Cohen, MP; Moriwaki, K | 1 |
| Bedrak, E; Samuels, LT | 1 |
| Boyd, GS | 1 |
| Koritz, SB; Kumar, AM | 1 |
| Stabler, TA; Ungar, F | 1 |
| Gower, DB; Katkov, T | 1 |
| Briley, MS; Kuhn, NJ | 1 |
| Levy, HR; Raineri, R | 1 |
| Smith, LL; Van Lier, JE | 2 |
| Beutler, E; Mandula, B; Srivastava, SK | 1 |
| Butcher, RG; Chayen, J | 1 |
| Simpson, TH; Wright, RS | 1 |
| Horie, S; Mitani, F | 1 |
| Hart, MM; Straw, JA; Swackhamer, ES | 1 |
| Carballeira, A; Mehdi, AZ | 1 |
| Berger, GM; Jones, JD | 1 |
| Boyd, GS; Mason, JI | 1 |
| Juchau, MR | 1 |
| Bryan, GT; Lewis, AM | 1 |
| Cardinali, DP; Cuello, AE; Rosner, JM; Tramezzani, JH | 1 |
| Alonso, C; McIntosh, EN; Salhanick, HA; Uzgiris, VI | 2 |
| Bedrak, E; Finkelstein, Z; Samoiloff, V | 1 |
| Dardachti, D; Garg, BD; Khandekar, JD; Kovacs, K; Tuchweber, B | 1 |
| Ando, N; Horie, S | 1 |
| Solymoss, B; Toth, S; Werringloer, J | 1 |
| Robinson, J; Stevenson, PM | 1 |
| Niweliński, J; Sabiniarz-Dudek, G; Zamorska, L | 2 |
| Basch, RS; Finegold, MJ | 1 |
| Takemura, H | 1 |
| Burstein, S; Co, N; Cooper, DY; Dinh, J; Gut, M; Rosenthal, O; Schleyer, H | 1 |
| Björkhem, I | 1 |
| Booth, WD; Gower, DB; Katkov, T | 1 |
| Gower, DB; Loke, KH | 1 |
| Bai, RU; Bischoff, K; Diczfalusy, E; Macome, JC | 1 |
| Björkhem, I; Einarsson, K; Gustafsson, JA; Somell, A | 1 |
| Carson, P; Deshpande, N; Jensen, V | 1 |
| Grant, JK | 1 |
| Nakamura, T; Tanabe, Y | 1 |
| Hoogerbrugge, JW; Molenaar, R; Rommerts, FF; van der Molen, HJ | 1 |
| Gibb, W | 1 |
| Carreau, S; Drosdowsky, MA; Edery, M; Simon, MJ | 1 |
| Claus, R; Seiler, K; Seiler, R; Sterba, G | 1 |
| Nakayama, T; Sanai, Y; Suzuki, T; Yanaihara, T | 1 |
| Brandstetter, K; Kellermann, J; Rabe, T; Runnebaum, B | 1 |
| Johnson, DC; Tsai-Morris, CH | 1 |
| Hosaka, M; Oshima, H; Troen, P | 1 |
| Colby, HD | 1 |
| Jenkins, CM; Keeney, DS; Waterman, MR | 1 |
| Hanukoglu, I; Rapoport, R; Sklan, D | 1 |
| Jefcoate, CR; McNamara, BC; Yamazaki, T | 1 |
| Estabrook, RW; Mason, JI; Swart, AC; Swart, P; Waterman, MR | 1 |
| Miyazawa, M; Shimada, T; Sugie, A | 1 |
| WIEST, WG | 1 |
| HALL, PF; KORITZ, SB | 1 |
| BERLINER, DL; ELLIS, LG; TAYLOR, GN | 1 |
| VILLEE, DB | 1 |
| BJERSING, L; CARSTENSEN, H | 1 |
| PERON, FG | 1 |
| BUONASSISI, V; SATO, G; STOLLAR, V | 1 |
| KORITZ, SB | 1 |
| DORFMAN, RI; FORCHIELLI, E; MENON, KM; TOREN, D | 1 |
| BITENSKY, MW; TOMKINS, GM; YIELDING, KL | 1 |
| LORING, JM; VILLEE, CA | 1 |
| BERLINER, DL; ELLIS, LC | 1 |
| BETZ, G; WARREN, JC | 1 |
| NIELSON, MH; WARREN, JC | 1 |
| Fink-Gremmels, J; Maas-Bakker, RF; Malekinejad, H | 1 |
| Baba, T; Chung, BC; Hino, S; Ishihara, Y; Kang, D; Kimura, H; Miyabayashi, K; Morohashi, K; Nakao, M; Ogawa, H; Ohkawa, Y; Otake, H; Sato, T; Shima, Y; Shishido, Y; Suyama, M; Wang, CY; Yagi, M; Yamazaki, T | 1 |
| Efimova, VS; Isaeva, LV; Novikova, LA; Rubtsov, MA | 1 |
Reviews
5 review(s) available for pregnenolone and nadp
| Article | Year |
|---|---|
Adrenocorticotrophic hormone and the control of adrenal corticosteroidogenesis.
Topics: Adenylyl Cyclases; Adrenal Cortex; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anti-Bacterial Agents; Binding Sites; Cholesterol; Cyclic AMP; Glucosephosphate Dehydrogenase; Mitochondria; Models, Biological; NADP; Oxidation-Reduction; Permeability; Phosphoric Diester Hydrolases; Pregnenolone; Protein Binding; Protein Biosynthesis; Protein Kinases; Receptors, Drug; Species Specificity; Transcription, Genetic | 1974 |
Cellular biochemical assessment of steroid activity.
Topics: Animals; Binding Sites; Binding, Competitive; Biological Transport; Dehydroepiandrosterone; Densitometry; Endoplasmic Reticulum; Enzymes; Erythrocytes; Estriol; Glucosephosphate Dehydrogenase; Humans; Liver; Lysosomes; Mitochondria; NAD; NADP; Oxidoreductases; Pregnenolone; Protein Binding; Species Specificity; Steroids | 1974 |
Adrenal cortex.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Ascorbic Acid; Cholesterol; Cyclic AMP; Glucocorticoids; Gonadal Steroid Hormones; Humans; Mixed Function Oxygenases; NADP; Oxidoreductases; Pregnenolone; Progesterone; Protein Biosynthesis | 1968 |
The mechanism of action of adrenocorticotropic hormone.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Atrophy; Chemical Phenomena; Chemistry; Cholesterol; Corticosterone; Cyclic AMP; Cycloheximide; Hypophysectomy; Mitochondria; Models, Biological; NADP; Pregnenolone; Progesterone; Protein Biosynthesis; RNA; Steroids; Tritium | 1968 |
The biosynthesis of adrenocortical steroids.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Androstenes; Carbon Isotopes; Corticosterone; Flavoproteins; Humans; Hydrocortisone; In Vitro Techniques; Male; NADP; Pregnenolone; Progesterone; Tritium | 1972 |
Other Studies
169 other study(ies) available for pregnenolone and nadp
| Article | Year |
|---|---|
Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent formation and breakdown of hydrogen peroxide during mixed function oxidation reactions in liver microsomes.
Topics: Animals; Azides; Ethanol; Horseradish Peroxidase; Hydrogen Peroxide; Kinetics; Male; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases; Phenobarbital; Pregnenolone; Rats; Scopoletin | 1975 |
Effect of Ca2+, ruthenium red and ageing on pregnenolone production by mitochondrial fractions from normal and luteinizing hormone treated rat testes.
Topics: Aging; Animals; Calcium; Edetic Acid; Kinetics; Luteinizing Hormone; Male; Mitochondria; NADP; Pregnenolone; Rats; Ruthenium; Ruthenium Red; Testis | 1976 |
Estimation of pregnenolone synthesis in rat adrenal homogenates: some cofactor requirements: effects of stress, hypophysectomy, cortisone and ACTH.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Calcium; Cortisone; Cyanoketone; Female; Hypophysectomy; NADP; Pregnenolone; Rats; Serum Albumin, Bovine; Stress, Physiological | 1977 |
[Molecular mechanism of enzymic cleavage of cholesterol side chain (author's transl)].
Topics: Binding Sites; Chemical Phenomena; Chemistry; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Hydroxycholesterols; Models, Molecular; NADP; Oxidoreductases; Oxygen; Oxygen Isotopes; Pregnenolone; Stereoisomerism | 1977 |
In vitro testosterone synthesis by testicular tissue of old mouse: the metabolism of 3beta-hydroxy-5-ene steroids.
Topics: 17-alpha-Hydroxypregnenolone; Aging; Androgens; Androstenediols; Androstenedione; Animals; Dehydroepiandrosterone; Hydroxyprogesterones; Male; Mice; Mice, Inbred C57BL; NADP; Pregnenolone; Progesterone; Testis; Testosterone | 1977 |
Corticotropin-induced changes in a soluble desmolase preparation.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Caproates; Carbon Monoxide; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Cycloheximide; Cytosol; Male; Mitochondria; NADP; Oxidoreductases; Pregnenolone; Rats | 1978 |
In vitro and in vivo studies on Leydig cell function in old rats.
Topics: Age Factors; Androstenedione; Animals; Bucladesine; Cell Count; Chorionic Gonadotropin; Hydroxyprogesterones; Leydig Cells; Luteinizing Hormone; Male; NADP; Organ Size; Pregnenolone; Progesterone; Rats; Receptors, Cell Surface; Testis; Testosterone | 1978 |
3beta-Hydroxysteroid dehydrogenase activity in human fetal membranes.
Topics: 3-Hydroxysteroid Dehydrogenases; Amnion; Chorion; Dehydroepiandrosterone; Female; Humans; In Vitro Techniques; Microsomes; NAD; NADP; Placenta; Pregnancy; Pregnenolone; Subcellular Fractions; Substrate Specificity | 1978 |
Regulation of progesterone from pregnenolone biosynthesis by phosphopyridine nucleotides in the human placental mitochondrial fraction.
Topics: Cell Membrane; Cholesterol; Female; Humans; Isocitrates; Kinetics; Microvilli; Mitochondria; NAD; NADP; Oxidation-Reduction; Placenta; Pregnancy; Pregnenolone; Progesterone | 1978 |
On the role of calcium in adrenocorticotropin-induced changes in mitochondrial pregnenolone synthesis.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Calcium; Cholesterol; Cycloheximide; Cytochrome P-450 Enzyme System; Male; Mitochondria; NADP; Pregnenolone; Rats | 1978 |
ACTH-stimulated rabbit adrenal 17alpha-hydroxylase. Kinetic properties and a comparison with those of 3beta-hydroxysteroid dehydrogenase.
Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Carbon Monoxide; Cytochrome P-450 Enzyme System; Kinetics; Male; Microsomes; NADP; Pregnenolone; Rabbits; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases | 1978 |
Studies of the human fetal adrenal gland--properties of 17alpha-hydroxylase and C17-C20 lyase in the biosynthesis of dehydroepiandrosterone from pregnenolone.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Dehydroepiandrosterone; Female; Fetus; Humans; Hydrogen-Ion Concentration; Lyases; Microsomes; NADP; Oxidoreductases; Pregnancy; Pregnenolone; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Steroids; Subcellular Fractions | 1978 |
Effects of cholesterol, hydroxycholesterols and calcium on pregnenolone production rates in mitochondrial fractions from rat testes.
Topics: Animals; Calcium; Cholesterol; Cycloheximide; Hydroxycholesterols; Kinetics; Luteinizing Hormone; Male; Mitochondria; NADP; Pregnenolone; Rats; Structure-Activity Relationship; Testis | 1979 |
Studies on the human testis. VI. NADH-linked reactions of microsomal steroid 20alpha-and 20beta-hydroxysteroid dehydrogenase and 17alpha-hydroxylase.
Topics: Binding, Competitive; Hydrogen-Ion Concentration; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; Hydroxysteroids; Male; Microsomes; Mixed Function Oxygenases; NAD; NADP; Oxygen; Pregnenes; Pregnenolone; Progesterone; Temperature; Testis | 1975 |
A histological, histochemical, and biochemical study of the adrenal tissue of the chinese giant salamander (Andrias davidianus Blanchard).
Topics: Adenosine Triphosphate; Adrenal Glands; Animals; Carbon Radioisotopes; Female; Histocytochemistry; Hydroxysteroid Dehydrogenases; Male; NAD; NADP; Pregnenolone; Progesterone; Tritium; Urodela | 1975 |
Conversion of beta-sitosterol to steroid hormones by rat testes in vitro.
Topics: Animals; Cholesterol; Gonadal Steroid Hormones; In Vitro Techniques; Male; Mitochondria; NADP; Oxidation-Reduction; Pregnenolone; Progesterone; Rats; Sitosterols; Steroids; Testis; Testosterone | 1975 |
Suppression of testicular androgen synthesis in the rat by ethane 1,2, dimethanesulphonate.
Topics: Androgens; Animals; Cholesterol; Hydroxyprogesterones; Male; Mesylates; NADP; Pregnenolone; Rats; Testis; Testosterone | 1975 |
Effect of a NADPH generating system on the steroidogenic response in rat luteal cells.
Topics: Animals; Chorionic Gonadotropin; Corpus Luteum; Female; Gonadotropins, Equine; NADP; Pregnenolone; Progesterone; Rats | 1992 |
Synthesis and function of 8 alpha,25-dihydroxy-3-oxoneocholecalciferol in liver.
Topics: Animals; Antioxidants; Cholestenes; Chromatography, Thin Layer; Male; Microsomes, Liver; NAD; NADP; Phenylenediamines; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains | 1991 |
Delta 5-3 beta-hydroxysteroid dehydrogenase-isomerase activity in canine pancreas.
Topics: 3-Hydroxysteroid Dehydrogenases; Androstenedione; Animals; Cell Nucleus; Cytosol; Dehydroepiandrosterone; Dogs; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Microsomes; Mitochondria; NAD; NADP; Pancreas; Pregnenolone; Progesterone | 1990 |
Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from ACTH-treated rats: differential responses to different reducing precursors.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Calcium; Caprylates; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Edetic Acid; Guanosine Triphosphate; Hydroxycholesterols; Isocitrates; Kinetics; Mitochondria; NADP; Pregnenolone; Rats; Serum Albumin, Bovine; Succinates; Succinic Acid | 1990 |
[The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. II. Effects of LH, hCG, dbcAMP, 22-R-OH-cholesterol and cofactors on the synthesis of pregnenolone and testosteron
Topics: Animals; Bucladesine; Cells, Cultured; Chorionic Gonadotropin; Culture Media; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glucosephosphates; Humans; Hydroxycholesterols; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; NAD; NADP; Pregnenolone; Rats; Rats, Inbred Strains; Stimulation, Chemical; Testosterone | 1989 |
[The role of gonadotropins, cyclic AMP, 22-R-OH-cholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. III. Mechanisms responsible for "desensitization" of the Leydig cells of rats caused by high doses of hCG].
Topics: Aldehyde-Lyases; Animals; Bucladesine; Cells, Cultured; Chorionic Gonadotropin; Culture Media; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Resistance; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glucosephosphates; Humans; Hydroxycholesterols; In Vitro Techniques; Leydig Cells; Luteinizing Hormone; Male; Mixed Function Oxygenases; NAD; NADP; Pregnenolone; Rats; Rats, Inbred Strains; Steroid 17-alpha-Hydroxylase; Testosterone | 1989 |
[The role of gonadotropins, cyclic AMP, 22-R-hydroxycholesterol and cofactors in regulating endocrine functions of the Leydig cells in rats. I. Effect of cofactors on the synthesis of steroid hormones in the interstitial gland of rats].
Topics: Animals; Cells, Cultured; Culture Media; Drug Synergism; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Glucosephosphates; In Vitro Techniques; Leydig Cells; Male; NAD; NADP; Pregnenolone; Rats; Rats, Inbred Strains; Stimulation, Chemical; Testosterone | 1989 |
17 beta-(cyclopropylamino)-androst-5-en-3 beta-ol, a selective mechanism-based inhibitor of cytochrome P450(17 alpha) (steroid 17 alpha-hydroxylase/C17-20 lyase).
Topics: Androstenols; Binding, Competitive; Humans; Kinetics; Male; Microsomes; NADP; Pregnenolone; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Structure-Activity Relationship; Testis | 1989 |
Synergistic stimulation of pregnenolone synthesis in rat adrenal mitochondria by n-hexane and cardiolipin.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cardiolipins; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Cycloheximide; Drug Synergism; Female; Hexanes; Isocitrates; Kinetics; Mitochondria; NADP; Pregnenolone; Rats | 1988 |
Phospholipases modulate the rat testicular androgen biosynthetic pathway in vitro.
Topics: 17-Hydroxysteroid Dehydrogenases; Androgens; Animals; Hydrogen-Ion Concentration; Male; Microsomes; Multienzyme Complexes; NAD; NADP; Phospholipases; Phospholipases A; Phospholipases A2; Pregnenolone; Progesterone Reductase; Proteins; Rats; Rats, Inbred Strains; Steroid 17-alpha-Hydroxylase; Steroid Isomerases; Testis; Type C Phospholipases | 1988 |
Selective inactivation by 21-chlorinated steroids of rabbit liver and adrenal microsomal cytochromes P-450 involved in progesterone hydroxylation.
Topics: Adrenal Glands; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Hydroxylation; Kinetics; Male; Microsomes; Microsomes, Liver; NADP; Pregnenolone; Progesterone; Rabbits; Rifampin; Steroid 16-alpha-Hydroxylase; Steroid 21-Hydroxylase; Steroid Hydroxylases; Steroids | 1988 |
Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone.
Topics: Androstenedione; Hydrogen-Ion Concentration; Kinetics; Mitosporic Fungi; NADP; Oxidation-Reduction; Pregnenolone; Progesterone; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Testolactone | 1986 |
Early time sequence in pregnenolone metabolism to testosterone in homogenates of human and rat testis.
Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Aged; Animals; Chromatography, High Pressure Liquid; Humans; Hydroxyprogesterones; Kinetics; Male; Middle Aged; NAD; NADP; Pregnenolone; Progesterone; Rats; Testis; Testosterone | 1987 |
Brain mitochondrial cytochrome P-450scc: spectral and catalytic properties.
Topics: Aminoglutethimide; Animals; Brain; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Desoxycorticosterone; Male; Mitochondria; NADP; Oxidation-Reduction; Oxidoreductases; Pregnenolone; Rats; Rats, Inbred Strains; Spectrophotometry | 1987 |
Purification and kinetic properties of 3 beta-hydroxysteroid dehydrogenase from bovine adrenocortical microsomes.
Topics: 17-alpha-Hydroxypregnenolone; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Animals; Binding Sites; Binding, Competitive; Cattle; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Isoelectric Point; Kinetics; Microsomes; Molecular Weight; NAD; NADP; Pregnenolone | 1985 |
Utilization of intramitochondrial membrane cholesterol by cytochrome P-450-dependent cholesterol side-chain cleavage reaction in bovine adrenocortical mitochondria: steroidogenic and non-steroidogenic pools of cholesterol in the mitochondrial inner membra
Topics: Adrenal Cortex; Aminoglutethimide; Animals; Cattle; Cell Fractionation; Cholesterol; Cytochrome P-450 Enzyme System; Intracellular Membranes; Malates; Membrane Lipids; Mitochondria; NADP; Pregnenolone; Progesterone; Submitochondrial Particles | 1985 |
[Biochemical study of adrenal cortex 17-alpha-hydroxylase].
Topics: Adrenal Glands; Animals; Cattle; Endoplasmic Reticulum; In Vitro Techniques; Ions; Kinetics; NADP; Pregnenolone; Progesterone; Steroid Hydroxylases; Surface-Active Agents; Tritium | 1973 |
Biosynthesis of progesterone from endogenous steroid precursor by the guinea-pig placenta.
Topics: Animals; Cell Fractionation; Centrifugation; Female; Guinea Pigs; NAD; NADP; Placenta; Pregnenolone; Progesterone | 1973 |
Characterization of an adrenal activator for cholesterol side chain cleavage.
Topics: Adrenal Glands; Animals; Carrier Proteins; Cattle; Cholesterol; Chromatography, Gel; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Edetic Acid; Enzyme Activation; Glutathione; Mitochondria; NADP; Pregnenolone; Protein Binding; Solubility; Spectrophotometry; Steroid Hydroxylases; Time Factors; Tritium | 1973 |
Formation of C 21 -17-hydroxysteroids and C 19 -steroids from 3 -hydroxypregn-5-en-20-one and progesterone in vitro by germ cells from immature rat testes.
Topics: 17-Hydroxycorticosteroids; Androgens; Animals; Chromatography, Ion Exchange; Culture Techniques; Germ Cells; Male; NAD; NADP; Pregnenolone; Progesterone; Rats; Testis; Tritium | 1973 |
Metabolism of 3-beta-hydroxy-5-ene steroids by testes of rats acclimatized to a hot environment.
Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; Acclimatization; Androstanes; Androstenedione; Androstenes; Animals; Carbon Isotopes; Chromatography, Thin Layer; Cryptorchidism; Dehydroepiandrosterone; Hot Temperature; Hydroxyprogesterones; In Vitro Techniques; Male; NADP; Pregnenolone; Rats; Testis; Testosterone; Time Factors; Tissue Extracts | 1973 |
Interaction of drugs and steroids with human placental microsomes.
Topics: Acetanilides; Amphetamine; Anaerobiosis; Androgens; Aniline Compounds; Anisoles; Carbon Monoxide; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Electron Transport; Female; Glucosephosphate Dehydrogenase; Humans; Kinetics; Methyltransferases; Metyrapone; Microsomes; Mixed Function Oxygenases; Myocardium; NADP; Oxidation-Reduction; Oxidoreductases; Pharmaceutical Preparations; Placenta; Pregnancy; Pregnenolone; Progesterone | 1973 |
11-dehydrocorticosterone (compd. A) formation by the Microtus adrenal.
Topics: Adrenal Glands; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Corticosterone; Crystallization; Female; Glucosephosphate Dehydrogenase; Glucosephosphates; Hydroxysteroid Dehydrogenases; Hydroxysteroids; In Vitro Techniques; Ketosteroids; Male; NADP; Pregnanediones; Pregnenes; Pregnenolone; Progesterone; Rodentia; Tritium | 1973 |
In vitro steroidogenesis in feline testes.
Topics: Androstenedione; Androstenols; Animals; Carbon Radioisotopes; Castration; Cats; Chromatography, Thin Layer; Cytosol; Dehydroepiandrosterone; Hydrocortisone; Hydroxyprogesterones; Male; Microsomes; NAD; NADP; Oxidation-Reduction; Pregnenolone; Progesterone; Testis; Testosterone; Time Factors | 1973 |
In vitro biosynthesis of androgens in canine testes.
Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Animals; Carbon Radioisotopes; Cytosol; Dehydroepiandrosterone; Dogs; Hydroxyprogesterones; In Vitro Techniques; Male; Microsomes; Mitochondria; NAD; NADP; Pregnenolone; Progesterone; Stimulation, Chemical; Testis; Testosterone; Time Factors | 1973 |
In vitro on an HCG responsive, testosterone secreting adrenal cortical adenoma.
Topics: Acetates; Adenoma; Adenosine Triphosphate; Adrenal Gland Neoplasms; Androstenedione; Carbon Radioisotopes; Chorionic Gonadotropin; Coenzymes; Dehydroepiandrosterone; Estrone; Female; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Mitochondria; NAD; NADP; Pregnenolone; Progesterone; Radioimmunoassay; Subcellular Fractions; Testosterone; Tritium | 1973 |
Kinetic studies on the enzymes catalysing the conversion of 17alpha-hydroxyprogesterone and dehydroepiandrosterone to androstenedione in the human adrenal gland in vitro.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Androstenedione; Dehydroepiandrosterone; Depression, Chemical; Estradiol; Estrone; Female; Humans; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; Kinetics; Microsomes; NAD; NADP; Oxidoreductases; Pregnenolone; Progesterone | 1974 |
The heme protein P-450 in steroid hydroxylation.
Topics: Adrenal Glands; Animals; Binding Sites; Corticosterone; Cyanides; Cytochrome c Group; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fluorides; Heme; Hemoglobins; Horses; Humans; Iron; Metyrapone; Myocardium; NADP; Pregnenolone; Protein Binding; Species Specificity; Spectrophotometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Steroid Hydroxylases | 1973 |
Formation of dihydrotestosterone and other 5 alpha-reduced metabolites by isolated seminiferous tubules and suspension of interstitial cells in a human testis.
Topics: Adolescent; Androstanes; Androstenedione; Carbon Isotopes; Chromatography, Paper; Dihydrotestosterone; Humans; In Vitro Techniques; Male; NADP; Pregnenolone; Sulfates; Testis; Tritium | 1973 |
Characteristics of the nuclear and microsomal steroid delta-4-5 alpha-hydrogenase of the rat prostate.
Topics: Androstenedione; Androstenes; Animals; Carbon Radioisotopes; Cell Nucleus; Chromatography, Thin Layer; Corticosterone; Dehydroepiandrosterone; Hydrogen-Ion Concentration; Hydroxyprogesterones; Male; Microsomes; Microsomes, Liver; NADP; Oxidoreductases; Pregnenolone; Progesterone; Prostate; Temperature; Testosterone; Tritium | 1974 |
Cholesterol and cholesterol sulfate as substrates for the adrenal side-chain cleavage enzyme.
Topics: Adrenal Glands; Animals; Calcium; Carbon Radioisotopes; Cattle; Cholesterol; Esterases; Female; Glucuronates; Isocitrates; Kinetics; Mitochondria; Multienzyme Complexes; NADP; Oxidoreductases; Pregnenolone; Progesterone; Rats; Structure-Activity Relationship; Succinates; Sulfur Radioisotopes; Sulfuric Acids; Tritium | 1974 |
Corticosteroidogenic responsiveness to adrenocorticotropin and dibutyryl cyclic AMP in isolated adrenal cells of hypophysectomized rats.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Bucladesine; Corticosterone; Hypophysectomy; In Vitro Techniques; Male; NADP; Oxidation-Reduction; Pituitary Gland; Pregnenolone; Progesterone; Rats; Time Factors; Trypsin | 1974 |
The role of malate in the cleavage of cholesterol side-chain in the course of progesterone biosynthesis in human term placenta.
Topics: Carbon Radioisotopes; Cholesterol; Chromatography, Thin Layer; Colorimetry; Female; Humans; Kinetics; Malates; Mitochondria; NADP; Oxaloacetates; Placenta; Pregnancy; Pregnenolone; Progesterone; Pyruvates; Time Factors; Tritium | 1974 |
Malic enzyme inhibition by pregnenolone in bovine corpora lutea.
Topics: Animals; Cattle; Corpus Luteum; Cytoplasm; Estradiol; Female; Kinetics; Malate Dehydrogenase; Male; NADP; Pregnenolone; Progesterone; Spectrophotometry, Ultraviolet; Time Factors; Ultracentrifugation | 1974 |
Testosterone formation in testis of the immature androgen insensitive pseudohermaphrodite male rat (Stanley-Gumbreck rat).
Topics: Androgens; Androstenedione; Androstenols; Androsterone; Animals; Carbon Radioisotopes; Chromatography; Crystallization; Disorders of Sex Development; Glucosephosphate Dehydrogenase; In Vitro Techniques; Male; NADP; Oxidation-Reduction; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Testis; Testosterone; Time Factors; Tritium | 1974 |
[Conversion of 3beta-hydroxy-5-pregnen-20-one (pregnenolone) by Streptomyces hydrogenans (author's transl)].
Topics: Cell Membrane; Cell Wall; Chromatography, Thin Layer; Cyproterone; Hydroxysteroid Dehydrogenases; NAD; NADP; Oxidation-Reduction; Pregnenolone; Progesterone; Streptomyces; Testosterone; Tritium | 1974 |
Kinetic studies on the mechanism of conversion of cholesterol to pregnenolone.
Topics: Adrenal Cortex; Adrenal Glands; Animals; Cattle; Cholesterol; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Mitochondria; NADP; Pregnenolone | 1973 |
Activator and inhibitor factors in cholesterol side-chain cleavage.
Topics: Adrenal Glands; Animals; Carrier Proteins; Cattle; Cholesterol; Cytochrome P-450 Enzyme System; Depression, Chemical; Liver; Microsomes; Mitochondria; NADP; Phospholipids; Pregnenolone; Protein Binding; Serum Albumin, Bovine; Stimulation, Chemical; Tritium | 1973 |
The in vivo effect of ACTH on utilization of reducing energy for pregnenolone synthesis by adrenal mitochondria.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Electron Transport; Female; Hydroxybutyrates; Hypophysectomy; Isocitrates; Ketones; Kinetics; Malates; Mitochondria; NADP; Pregnenolone; Radioimmunoassay; Rats; Stimulation, Chemical | 1973 |
Comparative studies on mitochondrial and partially purified bovine corpus luteum cytochrome P-450.
Topics: Animals; Cattle; Cholesterol; Corpus Luteum; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Desoxycorticosterone; Electron Transport; Female; Ferredoxins; Kinetics; Mitochondria; NADP; Pregnenolone; Progesterone; Spectrum Analysis | 1973 |
Steroidogenesis in vitro by the ovarian tissue of the domestic fowl (Gallus domesticus).
Topics: 17-alpha-Hydroxypregnenolone; Androstenedione; Animals; Autoradiography; Carbon Radioisotopes; Chickens; Chromatography, Thin Layer; Dehydroepiandrosterone; Estradiol; Estrone; Female; Hydroxyprogesterones; In Vitro Techniques; NAD; NADP; Ovary; Pregnenolone; Progesterone; Steroids; Testosterone; Time Factors; Tritium | 1974 |
Stimulation of the rat ovary by gonadotropins and separation of steroids by gas chromatography.
Topics: 17-alpha-Hydroxypregnenolone; Androgens; Animals; Cholesterol; Chorionic Gonadotropin; Chromatography, Gas; Dehydroepiandrosterone; Estradiol; Estriol; Estrone; Female; Follicle Stimulating Hormone; Glucosephosphate Dehydrogenase; Gonadotropins, Equine; Hydroxyprogesterones; In Vitro Techniques; Luteinizing Hormone; NADP; Nandrolone; Ovary; Pregnenolone; Progesterone; Rats; Subcellular Fractions; Testosterone | 1965 |
A mechanism of action of the gonadotropins.
Topics: Adrenocorticotropic Hormone; Animals; Cattle; Cholesterol; Chorionic Gonadotropin; Corpus Luteum; Female; Follicle Stimulating Hormone; Humans; Hypophysectomy; In Vitro Techniques; Luteinizing Hormone; Male; Mitochondria; Mixed Function Oxygenases; NADP; Pregnenolone; Rats; Testis; Tissue Extracts | 1965 |
Influence of luteinizing hormone on corpus luteum metabolism and progesterone biosynthesis throughout the bovine estrous cycle.
Topics: Animals; Cattle; Corpus Luteum; Estrus; Female; Glucose; Hexosephosphates; In Vitro Techniques; Luteinizing Hormone; NADP; Pentosephosphates; Pregnancy; Pregnenolone; Progesterone | 1966 |
Production and utilization of reduced nicotinamide adenine dinucleotide phosphate in the mouse testis.
Topics: Animals; Cholesterol; Dehydroepiandrosterone; Enzymes; Glucosephosphate Dehydrogenase; Histocytochemistry; In Vitro Techniques; Isocitrate Dehydrogenase; Leydig Cells; Male; Mice; NADP; Oxidoreductases; Pregnenolone; Subcellular Fractions; Testis; Testosterone | 1965 |
Aldosterone stimulation in vitro. 3. Site of action of different aldosterone-stimulating substances on steroid biosynthesis.
Topics: Acetates; Adrenocorticotropic Hormone; Aldosterone; Ammonia; Angiotensin II; Animals; Carbon Isotopes; Cholesterol; Corticosterone; In Vitro Techniques; NADP; Potassium; Pregnenolone; Progesterone; Rats; Tritium | 1966 |
Effects of luteinzing hormone and nicotinamide adenine dinucleotide phosphate on synthesis of progestational steroids by rabbit ovarian tissue in vitro.
Topics: Animals; Female; Gluconates; Hexosephosphates; In Vitro Techniques; Luteinizing Hormone; NADP; Ovary; Pregnenolone; Progesterone; Rabbits | 1966 |
Dehydrogenase in the rat ovary. I. A histochemical study of delta-5-3-beta-and 20-alpha-hydroxysteroid dehydrogenases and enzymes of carbohydrate oxidation during the estrous cycle.
Topics: Animals; Dehydroepiandrosterone; Estrus; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Hydroxysteroid Dehydrogenases; L-Lactate Dehydrogenase; NAD; NADP; Ovary; Oxidoreductases; Pregnancy; Pregnenolone; Rats; Succinate Dehydrogenase; Tetrazolium Salts | 1966 |
Inhibition of adrenal corticosteroidogenesis in the rat by cyanotrimethylandrostenolone, a synthetic androstane.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Desoxycorticosterone; Hydroxysteroid Dehydrogenases; In Vitro Techniques; NADP; Pregnenolone; Progesterone; Rats; Steroids | 1966 |
Further studies on corticosteroidogenesis. IV. Inhibition of utilization of biological substrates for corticoid synthesis by high calcium concentrations. Possible role of transhydrogenase in corticosteroidogenesis.
Topics: Adenosine Triphosphate; Adrenal Glands; Animals; Antimycin A; Calcium; Citrates; Corticosterone; Desoxycorticosterone; Dinitrophenols; Ferrocyanides; Hydroxybutyrates; In Vitro Techniques; Ketoglutaric Acids; Mitochondria; NADP; Oligomycins; Oxidoreductases; Pregnenolone; Rats; Succinates | 1966 |
Stimulation of cholesterol metabolism in the luteinized rat ovary by luteinizing hormone.
Topics: Androgens; Animals; Cholesterol; Chromatography, Thin Layer; Crystallization; Dehydroepiandrosterone; Estrone; Female; Hydroxyprogesterones; In Vitro Techniques; Luteinizing Hormone; NADP; Ovary; Pregnenolone; Progesterone; Rats | 1966 |
Conversion of 17-alpha-hydroxypregnenolone to dehydroepiandrosterone by adrenal homogenates of immature and adult guinea pigs.
Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Adrenal Glands; Aging; Animals; Animals, Newborn; Chromatography, Ion Exchange; Chromatography, Thin Layer; Dehydroepiandrosterone; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Male; NADP; Pregnenolone; Tritium | 1967 |
Studies on interstitial cells in tissue culture: steroid biosynthesis in monolayers of mouse testicular interstitial cells.
Topics: Adenine Nucleotides; Animals; Chorionic Gonadotropin; Culture Techniques; Cycloheximide; Follicle Stimulating Hormone; Leydig Cell Tumor; Leydig Cells; Luteinizing Hormone; Male; Mice; Microscopy, Phase-Contrast; NAD; NADP; Neoplasm Transplantation; Pregnenolone; Progesterone; Prolactin; Testis | 1967 |
Purification and some properties of cholesterol 20-alpha-hydroxylase from hog adrenal mitochondria.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Cellulose; Cholesterol; Chromatography; Edetic Acid; Hydrogen-Ion Concentration; Iron; Kinetics; Metals; Mitochondria; Mixed Function Oxygenases; NADP; Pregnenolone; Swine; Tritium | 1967 |
Further studies on 20-alpha-hydroxysteroid dehydrogenase of rat testes.
Topics: Animals; Carbon Isotopes; Centrifugation; Chromatography, Thin Layer; Edetic Acid; Enzymes; Hydrogen-Ion Concentration; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; Kinetics; Male; NADP; Oxidation-Reduction; Pregnenolone; Rats; Sulfhydryl Compounds; Temperature; Testis | 1967 |
The influence of various factors upon testicular enzymes related to steroidogenesis.
Topics: 17-Ketosteroids; Androgens; Animals; Biotransformation; Carbon Isotopes; Edetic Acid; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Lyases; Male; Microsomes; Mixed Function Oxygenases; NADP; Oxygen; Pregnenolone; Rats; Steroids; Testis | 1967 |
Electron transport in relation to steroid biosynthesis. Inhibition of side-chain cleavage of cholesterol by hyperbaric oxygen.
Topics: Adrenal Glands; Animals; Cattle; Cholesterol; Depression, Chemical; Electron Transport; Female; Fluorometry; Hyperbaric Oxygenation; Mitochondria; NAD; NADP; Oxidation-Reduction; Pregnenolone; Rats; Succinates; Tritium | 1967 |
Influence of gonadtrophins on the cholesterol-sidechain cleavage reaction by rat-testis mitochondrial preparations.
Topics: Adrenocorticotropic Hormone; Animals; Caproates; Carbon Isotopes; Cholesterol; Chorionic Gonadotropin; Citrates; Fumarates; Gonadotropins; Humans; Hypophysectomy; In Vitro Techniques; Ketoglutaric Acids; Lysine; Male; Mitochondria; NADP; Pregnenolone; Prolactin; Protein Biosynthesis; Rats; Succinates; Testis; Thyrotropin | 1967 |
Secretion and synthesis of progestins by the luteinized rat ovary in vivo.
Topics: Animals; Carbon Isotopes; Cholesterol; Female; Luteinizing Hormone; NADP; Ovary; Pregnenolone; Progesterone; Rats | 1967 |
Steroid hydroxylations by guinea-pig adrenal tissue fractions.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Calcium; Electron Transport; Fluorometry; Guinea Pigs; Hydrocortisone; Hydroxyprogesterones; Male; Microsomes; Mitochondria; NAD; NADP; Oxygen Consumption; Pregnanes; Pregnenolone; Progesterone | 1967 |
Histochemical distribution of some hydroxysteroid dehydrogenases in the placenta, foetal membranes and uterine mucosa of the mouse.
Topics: 17-alpha-Hydroxypregnenolone; Androgens; Animals; Dehydroepiandrosterone; Endometrium; Estradiol; Extraembryonic Membranes; Female; Histocytochemistry; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; Mice; NAD; NADP; Placenta; Pregnancy; Pregnancy, Animal; Pregnenolone; Testosterone | 1968 |
On the morphology and endocrine function of granulosa cells in ovarian follicles and corpora lutea. Biochemical, histochemical, and ultrastructural studies on the porcine ovary with special reference to steroid hormone synthesis.
Topics: 17-alpha-Hydroxypregnenolone; Animals; Carbon Isotopes; Corpus Luteum; Endocrine Glands; Endoplasmic Reticulum; Female; Histocytochemistry; Hydroxysteroid Dehydrogenases; Male; NADP; Ovary; Oxidoreductases; Pregnenolone; Progesterone; Swine; Testosterone; Tritium | 1968 |
Free steroid biosynthesis from 5-[4-14C]pregnenolone in normal human adrenal tissue.
Topics: 17-Ketosteroids; Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Chromatography, Paper; Corticosterone; Humans; Hydrocortisone; Hydroxyprogesterones; In Vitro Techniques; Male; NADP; Pregnenolone; Progesterone; Wounds, Gunshot | 1968 |
20-alpha-Hydroxysteroid dehydrogenase and reductive pathways in mouse adrenal glands in vitro.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Carbon Isotopes; Chromatography, Thin Layer; Crystallization; Desoxycorticosterone; Female; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Metyrapone; Mice; NADP; Pregnanediol; Pregnenolone; Progesterone | 1968 |
Further studies on the 11-beta-hydroxylation of deoxycorticosterone and progesterone by rat adrenal mitochondria.
Topics: Adrenal Glands; Animals; Desoxycorticosterone; Mitochondria; NAD; NADP; Oxidation-Reduction; Oxygen Consumption; Polarography; Pregnenolone; Progesterone; Rats | 1968 |
The cholesterol side chain cleavage enzymes in immature rat ovary.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Ascorbic Acid; Carbon Isotopes; Cholesterol; Chorionic Gonadotropin; Chromatography, Gas; Chromatography, Thin Layer; Coenzymes; Female; Fumarates; Glutathione; Gonadotropins, Equine; Hexosephosphates; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Isomerases; Mitochondria; NAD; NADP; Ovary; Oxygen; Pregnanes; Pregnenolone; Progesterone; Rats; Succinates; Time | 1968 |
Androgen production in vitro by phalarope gonadal tissue homogenates.
Topics: 17-alpha-Hydroxypregnenolone; Androgens; Animals; Birds; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Crystallization; Dehydroepiandrosterone; Female; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Male; NADP; Ovary; Pregnanes; Pregnenolone; Testis; Testosterone; Tritium | 1968 |
Synthesis of 5-alpha-pregnane-3,20-dione by fetal and adult human adrenals.
Topics: Adrenal Glands; Adrenocortical Hyperfunction; Carbon Isotopes; Chromatography, Thin Layer; Countercurrent Distribution; Crystallization; Fetus; Humans; Hyperplasia; In Vitro Techniques; NADP; Pregnanes; Pregnenolone; Progesterone; Tritium | 1968 |
Aminoglutethimide inhibition of adrenal desmolase activity.
Topics: Adrenal Glands; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Cholesterol; Depression, Chemical; Glutethimide; Kinetics; Lyases; NADP; Pregnenolone; Pyridones; Rats | 1968 |
Cofactor requirements for the conversion of cholesterol sulfate to pregnenolone sulfate by a submitochondrial system from bovine adrenal ortex.
Topics: Adrenal Glands; Animals; Carbon Dioxide; Cattle; Cholesterol; Crystallization; Cytochromes; Hot Temperature; Light; Mitochondria; NADP; Oxidoreductases; Oxygen; Pregnenolone; Sulfates; Sulfur; Tritium | 1968 |
Androgen biosynthesis. I. Enzymatic cleavage of the cholesterol side-chain to dehydroepiandrosterone and 2-methylheptan-6-one.
Topics: Adrenal Glands; Androgens; Animals; Carbon Isotopes; Cholesterol; Chromatography, Paper; Chromatography, Thin Layer; Dehydroepiandrosterone; Fatty Acids; Female; Ketones; Male; Methods; NADP; Ovary; Pregnenolone; Rats; Testis; Tritium | 1968 |
Progesterone biosynthesis in rabbit ovarian interstitial tissue mitochondria.
Topics: Animals; Autoradiography; Carbon Isotopes; Cholesterol; Chromatography, Gas; Cyclic AMP; Female; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Luteinizing Hormone; Microscopy, Electron; Microsomes; Mitochondria; NADP; Ovary; Pregnenolone; Progesterone; Rabbits; Stimulation, Chemical | 1968 |
Diethylstilbestrol effect on the in vitro synthesis of progesterone in the bovine corpus luteum.
Topics: Animals; Cattle; Chromatography, Gas; Citrates; Corpus Luteum; Depression, Chemical; Diethylstilbestrol; Female; Glucosephosphate Dehydrogenase; In Vitro Techniques; NADP; Pregnenolone; Progesterone; Spectrophotometry; Tritium | 1969 |
The effect of NADPH on steroidogenesis by the human adrenal gland in vivo.
Topics: Adrenal Glands; Adrenalectomy; Breast Neoplasms; Castration; Dehydroepiandrosterone; Female; Humans; Hydrocortisone; NADP; Neoplasm Metastasis; Pregnenolone; Tritium | 1969 |
The delta-5-3-beta-hydroxysteroid dehydrogenase of rat ovarian tissue. The effect of adenosine 3',5'-cyclic-monophosphoric acid.
Topics: Adenine Nucleotides; Androstanes; Animals; Carbon Isotopes; Chromatography, Thin Layer; Cyclic AMP; Depression, Chemical; Female; Freeze Drying; Gonadotropins, Equine; Hydroxysteroid Dehydrogenases; Isomerases; Kinetics; Microsomes; Mitochondria; NAD; NADP; Nucleotides; Ovary; Pregnenolone; Progesterone; Rats; Solubility; Steroids | 1969 |
Influence of transcortin and albumin on the rate of reduction of progesterone on human placental 20-alpha-hydroxysteroid dehydrogenase.
Topics: Biotransformation; Carbon Isotopes; Chemistry, Clinical; Chromatography, Thin Layer; Depression, Chemical; Electrophoresis, Disc; Ethanol; Female; Humans; Hydroxysteroid Dehydrogenases; NADP; Placenta; Pregnenolone; Progesterone; Protein Binding; Serum Albumin; Transcortin; Tritium | 1969 |
Adrenal cells in tissue culture. 3. Effect of adrenocorticotropin and 3',5'-cyclic adenosine monophosphate on 11 beta-hydroxylase and other steroidogenic enzymes.
Topics: Adenine Nucleotides; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Animals; Calcium; Carbon Isotopes; Citrates; Clone Cells; Culture Techniques; Cyclic AMP; Hydroxysteroid Dehydrogenases; Mice; Mitochondria; Mixed Function Oxygenases; NADP; Neoplasms, Experimental; Pregnanes; Pregnenolone; Progesterone; Steroids; Sterols; Stimulation, Chemical; Time Factors; Tritium | 1969 |
Reexamination of enzyme activities thought to show evidence of a coenzyme role for vitamin A.
Topics: Adrenal Glands; Alcohol Oxidoreductases; Animals; Body Weight; Coenzymes; Diet; Enteral Nutrition; Feeding and Eating Disorders; Hexoses; Humans; Hydroxysteroid Dehydrogenases; Infections; Kinetics; Lactones; Liver; NADP; Nucleotidyltransferases; Pregnenolone; Rats; Starvation; Stress, Physiological; Sulfates; Time Factors; Vitamin A; Vitamin A Deficiency | 1969 |
The side-chain cleavage of cholesterol and cholesterol sulfate by enzymes from bovine adrenocortical mitochondria.
Topics: Adrenal Glands; Animals; Cattle; Cholesterol; Chromatography, Gas; Countercurrent Distribution; Crystallization; Cytochromes; Detergents; Dimethylformamide; Electron Transport; Iron; Kinetics; Mitochondria; NADP; Oxidoreductases; Pregnenolone; Serum Albumin, Bovine; Sulfates; Time Factors; Tritium | 1969 |
3',5'-cyclic AMP and the adrenal desmolase system.
Topics: Adenine Nucleotides; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Carbon Isotopes; Cholesterol; Cyclic AMP; Guinea Pigs; Lyases; NADP; Pregnenolone; Sterols; Tritium | 1969 |
Steroid biosynthesis by the equine testis.
Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Age Factors; Androstanes; Animals; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Dehydroepiandrosterone; Estradiol; Estrone; Haplorhini; Horses; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Leydig Cells; Lyases; Male; Mice; Mixed Function Oxygenases; NADP; Physiology, Comparative; Pregnenolone; Testis; Testosterone; Tritium | 1969 |
Cytochrome P-450 in steroid biogenesis.
Topics: Adrenal Glands; Androgens; Cholesterol; Corticosterone; Cytochromes; Female; Male; Mitochondria; NADP; Ovary; Placenta; Pregnenolone; Testis | 1969 |
On the mechanism of action of the adrenocorticotrophic hormone. The stimulation of the activity of enzymes involved in pregnenolone synthesis.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Calcium; Corticosterone; Cycloheximide; Electron Transport; Feedback; Kinetics; Magnesium; Male; Microsomes; Mitochondria; Mitochondrial Swelling; NAD; NADP; Pregnenolone; Rats; Succinates | 1970 |
An estrogen effect on 20 alpha-hydroxysteroid dehydrogenase activity in the mouse adrenal.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Animals; Enzyme Induction; Estradiol; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Liver; Male; Mice; NAD; NADP; Pregnanediol; Pregnanes; Pregnenolone; Spectrophotometry; Stimulation, Chemical; Testosterone | 1970 |
The effect of cofactors on steroid biosynthesis in normal ovarian tissue.
Topics: Adenosine Triphosphate; Adult; Carbon Isotopes; Chromatography, Paper; Female; Hot Temperature; Humans; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Lyases; Mixed Function Oxygenases; NAD; NADP; Nandrolone; Ovary; Pregnenolone; Progesterone; Protein Denaturation; Steroids; Tritium | 1970 |
The biosynthesis of androst-16-enes in boar testis tissue.
Topics: 17-alpha-Hydroxypregnenolone; Adenosine Triphosphate; Androstanes; Animals; Carbon Isotopes; Chromatography, Thin Layer; In Vitro Techniques; Male; NADP; Pregnenolone; Swine; Testis; Testosterone; Tritium | 1970 |
The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat.
Topics: Animals; Corpus Luteum; Female; Hydroxysteroid Dehydrogenases; Labor, Obstetric; Lactation; NAD; NADP; Ovary; Pregnancy; Pregnanes; Pregnenolone; Progesterone; Rats; Steroids | 1970 |
On the specificity of steroid interaction with mammary glucose 6-phosphate dehydrogenase.
Topics: Androstanes; Animals; Binding Sites; Dehydroepiandrosterone; Estranes; Female; Glucosephosphate Dehydrogenase; Humans; Hydrogen-Ion Concentration; Kinetics; Lactation; Mammary Glands, Animal; Models, Chemical; NADP; Pregnancy; Pregnenolone; Protein Binding; Rats; Steroids | 1970 |
Sterol metabolism. 8. Conversion of cholesterol 20 alpha-hydroperoxide to 20 alpha, 21- and 20 alpha, 22R-dihydroxycholesterol by adrenal cortex mitochondria.
Topics: Acetone; Adrenal Glands; Animals; Cattle; Cholesterol; Chromatography, Thin Layer; Cytochromes; Mitochondria; NADP; Oxygen; Peroxides; Pregnenolone; Solubility; Vibration | 1970 |
Hexose-6-phosphate dehydrogenase: distribution in rat tissues and effect of diet, age and steroids.
Topics: Adrenal Glands; Age Factors; Alcohol Oxidoreductases; Androstanes; Animals; Brain; Dehydroepiandrosterone; Dietary Carbohydrates; Female; Fetus; Fructose; Galactose; Glucose; Glucosephosphate Dehydrogenase; Hexosephosphates; Intestines; Kidney; Liver; Lung; Male; Mammary Glands, Animal; Microsomes; Microsomes, Liver; Muscles; Myocardium; NAD; NADP; Ovary; Pregnancy; Pregnanes; Pregnenolone; Progesterone; Prostate; Rats; Seminal Vesicles; Spleen; Steroids; Testis | 1970 |
Differential effects of reduced nicotinamide-adenine dinucleotide phosphate on cytoplasmic-mitochondrial interactions.
Topics: Animals; Cortisone; Cytoplasm; Glucosephosphate Dehydrogenase; In Vitro Techniques; Mitochondria, Liver; NADP; Phenazines; Phosphogluconate Dehydrogenase; Pregnenolone; Rats | 1970 |
Synthesis of corticosteroids by the interrenal gland of selachian elasmobranch fish.
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Aldosterone; Animals; Carbon Isotopes; Corticosterone; Desoxycorticosterone; Glucocorticoids; In Vitro Techniques; NADP; Pregnenolone; Progesterone; Sharks; Species Specificity | 1970 |
Sterol metabolism. XVI. Cholesterol 20-alpha-hydroperoxide as an intermediate in pregnenolone biosynthesis from cholesterol.
Topics: Adrenal Glands; Animals; Cattle; Cholesterol; Chromatography, Ion Exchange; Chromatography, Thin Layer; Mitochondria; NADP; Peroxides; Pregnenolone; Sterols; Tritium | 1970 |
Studies on P-450. VII. Reconstitution of a steroid 11-beta-hydroxulation system using a P-450 preparation extracted and partially purified from adenocortical mitochondria.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Cattle; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Corticosterone; Cytochromes; Desoxycorticosterone; Fluorometry; Hydrogen-Ion Concentration; Mitochondria; NADP; Oxidation-Reduction; Oxidoreductases; Oxygen Consumption; Pigments, Biological; Pregnenolone; Spectrophotometry | 1970 |
Steroid hydroxylation in bovine adrenocortical mitochondria. Competition between side-chain cleavage of cholesterol and 11 beta hydroxylation.
Topics: Adrenal Glands; Animals; Calcium; Carbon Isotopes; Cattle; Cell Fractionation; Cholesterol; Corticosterone; Cytochromes; Depression, Chemical; Desoxycorticosterone; Feedback; In Vitro Techniques; Kinetics; Metyrapone; Mitochondria; Mixed Function Oxygenases; NADP; Pregnenolone | 1971 |
Studies on the site of action of o,p'-DDD in the dog adrenal cortex. II. TPNH- and corticosteroid precursor-stimulation of o,p'-DDD inhibited steroidogenesis.
Topics: 17-Hydroxycorticosteroids; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Dexamethasone; Dichlorodiphenyldichloroethane; Dogs; Hydrocortisone; Ketosteroids; Male; Mitochondria; NADP; Prednisolone; Pregnanes; Pregnenolone; Tritium | 1971 |
Steroid biosynthesis by the American bullfrog (Rana catesbeiana) interrenals. I. In vitro studies with progesterone-4-14 C and delta 5-pregnenolone-4-14 C.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Aldosterone; Animals; Anura; Carbon Isotopes; Chromatography, Paper; Corticosterone; Desoxycorticosterone; Hydroxyprogesterones; In Vitro Techniques; Male; Microsomes; Mitochondria; Mixed Function Oxygenases; NADP; Pregnanes; Pregnenolone; Progesterone | 1971 |
Inhibition of corticosterone formation and 3 -hydroxysteroid dehydrogenase activity in cell-free preparations of rat adrenals.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adrenal Glands; Aminophylline; Androstanes; Animals; Cell-Free System; Corticosterone; Cyclic AMP; Depression, Chemical; Drug Synergism; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Kinetics; Male; Microsomes; Mitochondria; NAD; NADP; Niacinamide; Pregnenolone; Rats | 1971 |
The cholesterol side-chain cleavage enzyme system in mitochondria of human term placenta.
Topics: Carbon Isotopes; Carbon Monoxide; Cell Fractionation; Cholesterol; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cytochromes; Enzyme Inhibitors; Enzymes; Female; Flavoproteins; Freeze Drying; Humans; Kinetics; Light; Lipids; Mercaptoethylamines; Microsomes; Mitochondria; NADP; Oxygen Consumption; Phosphates; Phosphatidylcholines; Phosphatidylethanolamines; Placenta; Pregnancy; Pregnenolone; Progesterone; Temperature; Ultracentrifugation; Ultrasonics | 1971 |
Human placental hydroxylation of 3,4-benzpyrene during early gestation and at term.
Topics: 17-Ketosteroids; Androstanes; Animals; Benzopyrenes; Cholesterol; Dehydroepiandrosterone; Depression, Chemical; Estradiol; Estrone; Female; Fluorometry; Humans; Kinetics; Labor, Obstetric; Liver; Methylcholanthrene; Methyltestosterone; Mixed Function Oxygenases; NADP; Placenta; Pregnancy; Pregnenolone; Progesterone; Rats; Smoking; Testosterone | 1971 |
Cytochrome P450 and steroid 21-hydroxylation in microsomes from human adrenal cortex.
Topics: 17-Ketosteroids; Adrenal Glands; Androstanes; Carbon Monoxide; Cytochromes; Humans; Hydroxyprogesterones; Kinetics; Microsomes; NADP; Pregnanes; Pregnenolone; Progesterone; Protein Binding; Spectrophotometry | 1971 |
Effects of pinealectomy on the testicular function of the adult male duck.
Topics: 17-alpha-Hydroxypregnenolone; Analysis of Variance; Androstanes; Animals; Carbon Isotopes; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Crystallization; Dehydroepiandrosterone; Ducks; Hydroxyprogesterones; Male; NADP; Organ Size; Pineal Gland; Pregnenolone; Progesterone; Progestins; Seasons; Testis; Testosterone | 1971 |
Spectral properties, respiratory activity, and enzyme systems of bovine corpus luteum mitochondria.
Topics: Adenosine Diphosphate; Animals; Calcium Chloride; Carbon Isotopes; Cattle; Cholesterol; Chromatography, Thin Layer; Corpus Luteum; Cytochromes; Electron Transport; Female; Hemoglobins; Isocitrates; Malates; Mitochondria; NAD; NADP; Ovary; Oxidative Phosphorylation; Oxygen Consumption; Polarography; Pregnenolone; Progesterone; Spectrophotometry; Succinates; Tritium | 1971 |
Role of reversed electron transport in bovine corpus luteum mitochondrial steroid synthesis.
Topics: Adrenal Glands; Amobarbital; Animals; Antimycin A; Calcium Chloride; Cattle; Cholesterol; Corpus Luteum; Electron Transport; Female; Isocitrates; Malates; Metabolism; Mitochondria; Models, Biological; NADP; Oxidoreductases; Oxygenases; Polarography; Pregnenolone; Progesterone; Rotenone; Succinates; Tritium | 1971 |
Testosterone biosynthesis in the desert mouse, Acomys cahirinus.
Topics: 17-Ketosteroids; Androstanes; Animals; Body Weight; Carbon Isotopes; Cricetinae; Crystallization; Hydroxyprogesterones; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Male; Mice; NADP; Organ Size; Pregnenolone; Progesterone; Rats; Testis; Testosterone; Tritium | 1971 |
Effect of cycloheximide on the ultrastructural changes produced by spironolactone and pregnenolone-16 alpha-carbonitrile in the rat liver.
Topics: Animals; Cycloheximide; Endoplasmic Reticulum; Female; Liver; Microscopy, Electron; Microsomes, Liver; NADP; Nitriles; Pregnenolone; Rats; Spironolactone | 1971 |
Studies on P-450. 8. Effects of steroids on the reaction with oxygen and the rate of reduction of partially purified P-450 from adrenocortical mitochondria.
Topics: Adrenal Glands; Animals; Cattle; Cytochromes; Depression, Chemical; Desoxycorticosterone; Hydroxylation; In Vitro Techniques; Kinetics; Mitochondria; NADP; Oxidation-Reduction; Oxygen Consumption; Pigments, Biological; Pregnenolone; Spectrophotometry; Stimulation, Chemical; Sulfur | 1971 |
The influence of pregnenolone-16 -carbonitrile on hepatic mixed-function oxygenases.
Topics: Animals; Carbon Isotopes; Cytochromes; Enzyme Induction; Female; Half-Life; Liver; Metabolic Clearance Rate; Microsomes, Liver; NADP; Nitriles; Organ Size; Oxidoreductases; Pentobarbital; Pregnenolone; Proteins; Rats; Spironolactone; Stimulation, Chemical | 1971 |
Electron flow and cholesterol-side-chain cleavage in ovarian mitochondria.
Topics: Adenosine Diphosphate; Animals; Binding Sites; Carbon Isotopes; Cholesterol; Citric Acid Cycle; Corpus Luteum; Electron Transport; Electron Transport Complex IV; Female; Hydroxylation; Mitochondria; Mitochondria, Liver; NAD; NADP; Oxidoreductases; Pregnenolone; Progesterone; Succinates; Swine | 1971 |
Intracellular enzymes and -ketolic steroids of the gonads in Xenopus laevis Daud.
Topics: Androsterone; Animals; Chorionic Gonadotropin; Electron Transport Complex IV; Estradiol; Female; Glucosephosphate Dehydrogenase; Gonads; Ketosteroids; L-Lactate Dehydrogenase; Male; Mitochondria; NAD; NADP; Ovum; Oxidoreductases; Phosphogluconate Dehydrogenase; Pregnenolone; Sex Factors; Succinate Dehydrogenase; Testis; Xenopus | 1971 |
Oxidative enzymes and -ketolic steroids in the interrenal cells of the South African clawed toad Xenopus laevis Daud.
Topics: Androsterone; Animals; Chorionic Gonadotropin; Electron Transport Complex IV; Estradiol; Female; Glucosephosphate Dehydrogenase; Isocitrate Dehydrogenase; Ketosteroids; Kidney; L-Lactate Dehydrogenase; Malate Dehydrogenase; Male; NAD; NADP; Oxidoreductases; Phosphogluconate Dehydrogenase; Pregnenolone; Succinate Dehydrogenase; Xenopus | 1971 |
3 -Hydroxy steroid dehydrogenase activity in the mitochondria of rat adrenal homogenates.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Cell Fractionation; Centrifugation; Dehydroepiandrosterone; Electron Transport Complex IV; Female; Hydroxysteroid Dehydrogenases; In Vitro Techniques; Kinetics; Male; Microsomes; Mitochondria; Mixed Function Oxygenases; NAD; NADP; Pregnenolone; Rats; RNA; Tritium | 1971 |
[Significance of chorionic gonadotropin participating in biosynthesis of estrogens in placental chorionic tissue].
Topics: Androstanes; Chorionic Gonadotropin; Chromatography; Colorimetry; Cyclic AMP; Dehydroepiandrosterone; Estradiol; Estrogens; Estrone; Extraembryonic Membranes; Female; Humans; NAD; NADP; Placenta; Pregnancy; Pregnenolone; Progesterone; Stimulation, Chemical; Testosterone; Tritium | 1972 |
Kinetic studies on substrate-enzyme interaction in the adrenal cholesterol side-chain cleavage system.
Topics: Adrenal Glands; Animals; Carbon Isotopes; Cattle; Cholesterol; Chromatography, Thin Layer; Cytochromes; Kinetics; Mathematics; Mitochondria; NADP; Oxidoreductases; Pregnenolone; Tritium | 1972 |
On the rate-limiting step in microsomal hydroxylation of steroids.
Topics: Animals; Carbon Isotopes; Carbon Monoxide; Chemical Phenomena; Chemistry; Deuterium; Hydroxylation; Hydroxysteroids; Kinetics; Male; Microsomes, Liver; NADP; Pregnenolone; Rats; Sterols; Testosterone; Tritium; Water | 1972 |
The metabolism of 16-androstenes in boar salivary glands.
Topics: Androstanes; Androstenols; Animals; Carbon Isotopes; Dehydroepiandrosterone; Hydroxysteroid Dehydrogenases; Hydroxysteroids; Ketosteroids; Models, Biological; NAD; NADP; Parotid Gland; Pregnenolone; Saliva; Submandibular Gland; Testosterone; Tritium | 1972 |
The intermediary role of 5-pregnene-3 ,20 -diol in the biosynthesis of 16-unsaturated C 19 steroids in boar testis.
Topics: Alcohols; Androstenes; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Depression, Chemical; Hydroxysteroids; Ketones; Kinetics; Male; NADP; Pregnenes; Pregnenolone; Swine; Testis | 1972 |
Factors influencing placental steroidogenesis.
Topics: 17-Ketosteroids; Adenosine Triphosphate; Androstenes; Animals; Carbon Isotopes; Cholesterol; Chorionic Gonadotropin; Chromatography, Paper; Chromatography, Thin Layer; Countercurrent Distribution; Estradiol; Estrone; Female; Glucosephosphates; Humans; Immune Sera; Ketosteroids; NAD; NADP; Niacinamide; Placenta; Pregnancy; Pregnenolone; Progesterone; Rabbits; Tritium | 1972 |
Metabolism of 3 -hydroxy- 5 - and 3-oxo- 4 -C 19 and C 21 steroids in human liver microsomes.
Topics: Adult; Aged; Androstenes; Androsterone; Carbon Isotopes; Chromatography, Gas; Chromatography, Thin Layer; Culture Media; Dehydroepiandrosterone; Female; Humans; Male; Mass Spectrometry; Methods; Microsomes, Liver; Middle Aged; NAD; NADP; Pregnenolone; Progesterone; Sex Factors; Steroids; Testosterone; Time Factors | 1972 |
Some aspects of the control of dehydroepiandrosterone synthesis in the human adrenal gland in vitro.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Androstanols; Carbon Isotopes; Chromatography, Paper; Cyproterone; Dehydroepiandrosterone; Female; Humans; Hydroxylation; In Vitro Techniques; Kinetics; NADP; Pregnenolone; Subcellular Fractions | 1972 |
Pathways for androgen synthesis in vitro by the testes of Japanese quail (Coturnix coturnix japonica).
Topics: 17-alpha-Hydroxypregnenolone; 17-Ketosteroids; Androgens; Androstanes; Animals; Carbon Isotopes; Chromatography, Thin Layer; Coturnix; Dehydroepiandrosterone; Hydroxyprogesterones; In Vitro Techniques; Male; NAD; NADP; Pregnenolone; Progesterone; Testis; Testosterone; Tritium | 1972 |
Development of adenosine responsiveness after isolation of Leydig cells.
Topics: Adenosine; Animals; Cell Separation; Cells, Cultured; Cyclic AMP; Kinetics; Leydig Cells; Luteinizing Hormone; Male; Mice; NAD; NADP; Phenylisopropyladenosine; Pregnenolone; Rats | 1984 |
Substrate and nucleotide specificity of placental microsomal 3 beta-hydroxysteroid dehydrogenase.
Topics: 3-Hydroxysteroid Dehydrogenases; Dehydroepiandrosterone; Estrogens; Female; Humans; In Vitro Techniques; Kinetics; Microsomes; NAD; NADP; Placenta; Pregnancy; Pregnenolone; Steroids; Substrate Specificity | 1981 |
In vitro pregnenolone metabolism by mouse adrenal gland: II-Biosynthesis of androgens.
Topics: Adrenal Glands; Androgens; Animals; Breast Neoplasms; Castration; Dehydroepiandrosterone; Female; In Vitro Techniques; Male; Mice; NADP; Pregnenolone; Progesterone; Species Specificity; Testosterone | 1982 |
Spectrophotometric analyses of hydroxysteroid dehydrogenase activity in presumed steroid-producing tissues of the brook lamprey (Lampetra planeri bloch) in different developmental stages.
Topics: 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Androgens; Androstane-3,17-diol; Animals; Female; Fishes; Gonads; Kidney; Lampreys; Male; NAD; NADP; Pregnenolone; Seasons; Substrate Specificity | 1983 |
[20 alpha-Dihydropregnenolone-sulfate and 20 alpha-dihydroprogesterone biosynthesis and metabolism in feto-placental unit].
Topics: 20-alpha-Dihydroprogesterone; 20-Hydroxysteroid Dehydrogenases; Adenosine Triphosphate; Female; Fetus; Humans; Liver; Maternal-Fetal Exchange; NADP; Placenta; Pregnancy; Pregnenolone; Progesterone | 1984 |
Partial characterization of placental 3 beta-hydroxysteroid dehydrogenase (EC 1.1.1.145), delta 4-5isomerase (EC 5.3.3.1) in human term placental mitochondria.
Topics: 3-Hydroxysteroid Dehydrogenases; Dose-Response Relationship, Drug; Female; Humans; Hydrogen-Ion Concentration; Isomerases; Kinetics; Metals; Mitochondria; NAD; NADP; Placenta; Pregnancy; Pregnenolone; Steroid Isomerases; Temperature | 1982 |
The steroid 17 alpha-hydroxylase activity of the immature rat ovary.
Topics: Animals; Female; Gonadotropins, Equine; Hypophysectomy; Luteinizing Hormone; NADP; Ovary; Pregnenolone; Progesterone; Rats; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases | 1982 |
Studies of the human testis. XIV. Properties of C17-C20 lyase.
Topics: 17-alpha-Hydroxypregnenolone; 20-alpha-Dihydroprogesterone; Aldehyde-Lyases; Androstenediols; Estradiol; Humans; Hydrogen-Ion Concentration; Hydroxyprogesterones; Male; Microsomes; NADP; Pregnenolone; Steroid 17-alpha-Hydroxylase; Temperature; Testis; Testosterone | 1980 |
Relationship between the pregnenolone-induced difference spectrum and cytochrome b5 reduction in guinea-pig adrenal microsomes.
Topics: Adrenal Glands; Animals; Cytochromes; Guinea Pigs; Male; Microsomes; NAD; NADP; Oxidation-Reduction; Pregnenolone; Spectrophotometry | 1980 |
Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo.
Topics: Adrenal Glands; Adrenodoxin; Aldosterone; Animals; Base Sequence; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Female; Gene Expression Regulation, Enzymologic; Hydrocortisone; In Situ Hybridization; Mice; Mice, Inbred ICR; Molecular Sequence Data; NADP; NADPH-Ferrihemoprotein Reductase; Polymerase Chain Reaction; Pregnancy; Pregnenolone; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases | 1995 |
Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence.
Topics: Adrenal Cortex; Animals; Cattle; Cholesterol Side-Chain Cleavage Enzyme; Corticosterone; Cytochrome P-450 CYP11B2; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Electron Transport; Hydrocortisone; Hydrogen Peroxide; Hydroxylation; Hydroxytestosterones; Kinetics; Mitochondria; NADP; Oxidation-Reduction; Pregnenolone; Steroid 11-beta-Hydroxylase; Steroids; Superoxides | 1995 |
Competition for electron transfer between cytochromes P450scc and P45011 beta in rat adrenal mitochondria.
Topics: Adrenal Cortex; Adrenodoxin; Aminoglutethimide; Animals; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Cosyntropin; Desoxycorticosterone; Electron Transport; Female; Ferredoxin-NADP Reductase; Isocitrates; Isoenzymes; Metyrapone; Mitochondria; NADP; Oxidation-Reduction; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase; Succinates; Succinic Acid | 1993 |
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase.
Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Animals; Aryl Hydrocarbon Hydroxylases; Cell Line, Transformed; Chlorocebus aethiops; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; DNA; Humans; Hydroxyprogesterones; Ketoconazole; Kidney; Kinetics; Male; Microsomes; NADP; Pregnenolone; Progesterone; Steroid 16-alpha-Hydroxylase; Steroid 17-alpha-Hydroxylase; Steroid Hydroxylases; Testis; Transfection | 1993 |
Roles of human CYP2A6 and 2B6 and rat CYP2C11 and 2B1 in the 10-hydroxylation of (-)-verbenone by liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; beta-Naphthoflavone; Bicyclic Monoterpenes; Cell Line; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2B6; Cytochrome P450 Family 2; Enzyme Activation; Enzyme Induction; Female; Gene Expression; Humans; Hydroxylation; Male; Microsomes, Liver; Mixed Function Oxygenases; NADP; Oxidoreductases, N-Demethylating; Phenobarbital; Pregnenolone; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Steroid 16-alpha-Hydroxylase; Terpenes | 2003 |
IN VITRO METABOLISM OF PROGESTERONE AND 20ALPHA-HYDROXYPREGN-4-EN-3-ONE BY TISSUES OF THE FEMALE RAT.
Topics: Adipose Tissue; Adrenal Glands; Animals; Carbon Isotopes; Chromatography; Female; Humans; In Vitro Techniques; Kidney; Metabolism; NADP; Ovary; Oxidoreductases; Pharmacology; Pregnancy; Pregnancy, Animal; Pregnenolone; Progesterone; Pseudopregnancy; Rats; Research; Steroids; Uterus | 1963 |
THE CONVERSION OF CHOLESTEROL AND 20-ALPHA-HYDROXYCHOLESTEROL TO STEROIDS BY ACETONE POWDER OF PARTICLES FROM BOVINE CORPUS LUTEUM.
Topics: Acetone; Adrenal Glands; Animals; Carbon Isotopes; Cattle; Cholesterol; Chromatography; Corpus Luteum; Corpus Luteum Hormones; Female; Humans; Hydroxycholesterols; Infrared Rays; Luteinizing Hormone; Metabolism; NADP; Pregnenolone; Progesterone; Research; Steroids | 1964 |
THE EFFECTS OF IONIZING RADIATIONS ON ENDOCRINE CELLS. II. RESTORATION OF ANDROGEN PRODUCTION WITH A REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE-GENERATING SYSTEM AFTER IRRADIATION OF RAT TESTES.
Topics: Androgens; Carbon Isotopes; Endocrine Cells; Histocytochemistry; Humans; Hydroxyprogesterones; Male; Metabolism; NADP; Pregnenolone; Progesterone; Radiation Effects; Radiation, Ionizing; Rats; Research; Testis; Testosterone; Tritium | 1964 |
EFFECTS OF SUBSTRATES AND COFACTORS ON STEROID SYNTHESIS IN HYPERPLASTIC ADRENALS.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenal Glands; Adrenal Hyperplasia, Congenital; Carbon Isotopes; Chromatography; Corticosterone; Cushing Syndrome; Dehydroepiandrosterone; Estrone; Hexosephosphates; Hydrocortisone; Metabolism; NAD; NADP; Pregnenolone; Progesterone; Research; Tritium | 1964 |
THE ROLE OF THE GRANULOSA CELL IN THE BIOSYNTHESIS OF OVARIAN STEROID HORMONES.
Topics: Adenosine Triphosphate; Androgens; Animals; Chromatography; Estradiol; Estrone; Female; Fumarates; Granulosa Cells; Hormones; Humans; Hydroxyprogesterones; Isomerases; Metabolism; NAD; NADP; Niacinamide; Ovary; Oxidoreductases; Pharmacology; Pregnenolone; Progesterone; Research; Swine; Testosterone | 1964 |
THE EFFECT OF CALCIUM IONS ON CORTICOSTEROIDOGENESIS. CONVERSION OF PREGNENOLONE AND PROGESTERONE TO DEOXYCORTICOSTERONE IN RAT ADRENAL HOMOGENATE FRACTIONS FORTIFIED WITH DIPHOSPHOPYRIDINE NUCLEOTIDE PLUS GLUCOSE 6-PHOSPHATE.
Topics: Adrenal Glands; Calcium; Corticosterone; Desoxycorticosterone; Glucose; Glucose-6-Phosphate; Hexosephosphates; Ions; Metabolism; NAD; NADP; Oxidoreductases; Pharmacology; Phosphates; Pregnenolone; Progesterone; Rats; Research; Tetrazolium Salts | 1964 |
STUDIES ON HORMONE SECRETING ADRENOCORTICAL TUMOR IN TISSUE CULTURE.
Topics: Adenine Nucleotides; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Ascorbic Acid; Histocytochemistry; Metabolism; NADP; Neoplasms, Experimental; Oxidoreductases; Pharmacology; Pregnenolone; Research; Tissue Culture Techniques | 1964 |
THE CONVERSION OF PREGNENOLONE TO PROGESTERONE BY SMALL PARTICLES FROM RAT ADRENAL.
Topics: Adrenal Glands; Androgens; Chemical Phenomena; Chemistry; Cholesterol; Dehydroepiandrosterone; Enzyme Inhibitors; Metabolism; NAD; NADP; Physiology; Pregnenolone; Progesterone; Progestins; Rats; Research | 1964 |
BIOSYNTHESIS OF STEROID HORMONES IN THE TESTIS.
Topics: Aldehydes; Cholesterol; Humans; Male; Metabolism; NAD; NADP; Pregnenolone; Steroids; Testis; Testosterone | 1964 |
HORMONAL REGULATION OF ENZYME ACTIVITY.
Topics: Adenine Nucleotides; Alanine; Amino Acid Oxidoreductases; Diethylstilbestrol; Enzyme Inhibitors; Estradiol; Estriol; Estrone; Glutamate Dehydrogenase; Guanine Nucleotides; Hormones; Hydroxyprogesterones; Mercury; Metabolism; Models, Theoretical; NAD; NADP; Phenanthrolines; Pregnenolone; Progesterone; Research | 1965 |
SYNTHESIS OF STEROIDS IN THE NEWBORN HUMAN ADRENAL IN VITRO.
Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex Hormones; Adrenal Glands; Aging; Carbon Isotopes; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Humans; Hydrocortisone; In Vitro Techniques; Infant, Newborn; Metabolism; NADP; Pregnenolone; Progesterone; Radiometry; Steroids | 1965 |
THE EFFECTS OF IRRADIATION ON ENDOCRINE CELLS. V. A COMPARISON BETWEEN THE EFFECTS OF INANITION AND IRRADIATION ON ANDROGEN PRODUCTION BY MURINE TESTICULAR TISSUE.
Topics: Androgens; Animals; Body Weight; Carbon Isotopes; Endocrine Cells; Gonadotropins; Hexosephosphates; Humans; Hydroxyprogesterones; Male; Metabolism; Mice; NADP; Organ Size; Pregnenolone; Progesterone; Radiation Effects; Rats; Research; Seminal Vesicles; Starvation; Testis; Testosterone; Tritium | 1965 |
STUDIES WITH GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM HUMAN PLACENTA.
Topics: Androgens; Chemical Precipitation; Dehydroepiandrosterone; Enzyme Inhibitors; Enzymes; Estradiol; Female; Fluorometry; Follicle Stimulating Hormone; Glucose; Glucosephosphate Dehydrogenase; Humans; Luteinizing Hormone; NADP; Pharmacology; Phosphates; Placenta; Pregnancy; Pregnenolone; Spectrophotometry | 1965 |
STEROID EFFECTS ON GLUCOSE-6-PHOSPHATE DEHYDROGENASE FROM BOVINE CORPORA LUTEA.
Topics: Androgens; Animals; Cattle; Corpus Luteum; Dehydroepiandrosterone; Enzyme Inhibitors; Estradiol; Female; Glucosephosphate Dehydrogenase; Humans; NADP; Pharmacology; Pregnenolone; Research; Spectrophotometry | 1965 |
Enzyme kinetics of zearalenone biotransformation: pH and cofactor effects.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); Androstanes; Animals; Binding, Competitive; Biotransformation; Coenzymes; Etiocholanolone; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Mitochondria, Liver; Mycotoxins; NAD; NADP; Pregnenolone; Swine; Zearalenone; Zeranol | 2005 |
Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromatin Immunoprecipitation; Electrophoretic Mobility Shift Assay; Glucose; Glycolysis; Humans; Mice; NADP; Pregnenolone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Steroidogenic Factor 1 | 2014 |
Analysis of In Vivo Activity of the Bovine Cholesterol Hydroxylase/Lyase System Proteins Expressed in Escherichia coli.
Topics: Adrenodoxin; Animals; Cattle; Cholesterol Side-Chain Cleavage Enzyme; Escherichia coli; Ferredoxin-NADP Reductase; Gene Expression; Genetic Engineering; Hydroxycholesterols; Mass Spectrometry; NADP; Pregnenolone; Recombinant Proteins | 2019 |