Compounds > pregnenolone
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pregnenolone and heme

pregnenolone has been researched along with heme in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19907 (70.00)18.7374
1990's1 (10.00)18.2507
2000's0 (0.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Light, DR; Orme-Johnson, NR; Orme-Johnson, WH; White-Stevens, RW1
Hall, PF; Tilley, BE; Watanuki, M1
Burstein, S; Byon, CY; Gut, M; Kimball, HL1
Cooper, DY; Rosenthal, O; Schleyer, H1
Hall, PF; Shikita, M1
Gillette, JR; Menard, RH; Stripp, B1
Ginsberg, M; Josephson, AS; Levere, RD; Lowenthal, I; Swerdlow, F1
Auchus, RJ; Miller, WL1
Gregory, MC; Kincaid, JR; Mak, PJ; Sligar, SG1
DeVore, NM; Petrunak, EM; Porubsky, PR; Scott, EE1

Other Studies

10 other study(ies) available for pregnenolone and heme

ArticleYear
Steroid binding properties of beef adrenal cortical cytochrome P-450 which catalyzes the conversion of cholesterol into pregnenolone.
    The Journal of biological chemistry, 1979, Mar-25, Volume: 254, Issue:6

    Topics: Adrenal Cortex; Animals; Binding Sites; Cattle; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Heme; Hydroxycholesterols; Ligands; Pregnenolone; Steroids; Temperature

1979
Preparation and properties of side-chain cleavage cytochrome P-450 from bovine adrenal cortex by affinity chromatography with pregnenolone as ligand.
    Biochimica et biophysica acta, 1977, Aug-23, Volume: 493, Issue:2

    Topics: Adrenal Cortex; Adrenal Glands; Animals; Carbon Monoxide; Cattle; Cholesterol Side-Chain Cleavage Enzyme; Chromatography, Affinity; Cytochrome P-450 Enzyme System; Enzyme Activation; Heme; Mitochondria; Molecular Weight; Oxidoreductases; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Pregnenolone; Spectrophotometry

1977
Exclusion of 20(22)-dehydrocholesterol as an intermediate in the biosynthesis of pregnenolone in bovine adrenocortical mitochondrial acetone-dried powder preparations.
    Steroids, 1976, Volume: 27, Issue:5

    Topics: Adrenal Cortex; Adrenal Glands; Animals; Biotransformation; Cattle; Cholesterol; Heme; Hydroxycholesterols; In Vitro Techniques; Mass Spectrometry; Mitochondria; Pregnenolone

1976
The heme protein P-450 in steroid hydroxylation.
    Annals of the New York Academy of Sciences, 1973, Dec-31, Volume: 222

    Topics: Adrenal Glands; Animals; Binding Sites; Corticosterone; Cyanides; Cytochrome c Group; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Fluorides; Heme; Hemoglobins; Horses; Humans; Iron; Metyrapone; Myocardium; NADP; Pregnenolone; Protein Binding; Species Specificity; Spectrophotometry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Steroid Hydroxylases

1973
Cytochrome P-450 from bovine adrenocortical mitochondria: an enzyme for the side chain cleavage of cholesterol. I. Purification and properties.
    The Journal of biological chemistry, 1973, Aug-25, Volume: 248, Issue:16

    Topics: Adrenal Glands; Animals; Carbon Isotopes; Catalysis; Cattle; Cholesterol; Cholic Acids; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytochrome P-450 Enzyme System; Drug Stability; Glycerol; Heme; Kinetics; Mitochondria; Molecular Weight; Multienzyme Complexes; Oxidoreductases; Phospholipids; Pregnenolone; Structure-Activity Relationship; Ultracentrifugation

1973
Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism.
    Endocrinology, 1974, Volume: 94, Issue:6

    Topics: Animals; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Cytochromes; Dogs; Female; Guinea Pigs; Heme; Liver; Male; Methyltestosterone; Mice; Microsomes; Pregnenolone; Progesterone; Rabbits; Rats; Spironolactone; Steroid Hydroxylases; Testis; Testosterone

1974
Porphyrin synthesis by cultured lymphocytes.
    Blood, 1972, Volume: 39, Issue:4

    Topics: 5-Aminolevulinate Synthetase; Carbon Isotopes; Cells, Cultured; Enzyme Induction; Erythropoietin; Fluorometry; Heme; Humans; Ketosteroids; Lectins; Leucine; Levulinic Acids; Lymphocyte Activation; Lymphocytes; Microscopy, Fluorescence; Porphyrins; Pregnenolone

1972
Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:7

    Topics: Amino Acid Sequence; Bacterial Proteins; Binding Sites; Cytochrome P-450 Enzyme System; Heme; Humans; Mixed Function Oxygenases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; NADPH-Ferrihemoprotein Reductase; Pregnenolone; Protein Conformation; Sequence Homology, Amino Acid; Steroid 17-alpha-Hydroxylase

1999
Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17.
    Biochemistry, 2014, Jan-14, Volume: 53, Issue:1

    Topics: Catalytic Domain; Heme; Humans; Hydroxylation; Ligands; Pregnenolone; Progesterone; Spectrum Analysis, Raman; Steroid 17-alpha-Hydroxylase; Substrate Specificity

2014
Structures of human steroidogenic cytochrome P450 17A1 with substrates.
    The Journal of biological chemistry, 2014, Nov-21, Volume: 289, Issue:47

    Topics: 17-alpha-Hydroxyprogesterone; Androstenes; Androstenols; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Dehydroepiandrosterone; Estrogens; Heme; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Mutation; Oxidation-Reduction; Pregnenolone; Progesterone; Protein Binding; Protein Structure, Secondary; Steroid 17-alpha-Hydroxylase; Steroids; Substrate Specificity; Testosterone

2014