Page last updated: 2024-08-20

pregnenolone and dehydroepiandrosterone sulfate

pregnenolone has been researched along with dehydroepiandrosterone sulfate in 130 studies

Research

Studies (130)

TimeframeStudies, this research(%)All Research%
pre-199027 (20.77)18.7374
1990's33 (25.38)18.2507
2000's44 (33.85)29.6817
2010's22 (16.92)24.3611
2020's4 (3.08)2.80

Authors

AuthorsStudies
Baulieu, EE; Corpéchot, C; Egestad, B; Morfin, R; Sjövall, J; Young, J1
Hirato, K; Hondo, T; Saito, H; Suzuki, T; Yanaihara, T1
Jalkanen, J1
Abdallah, MA; Baulieu, EE; Jo, DH; Robel, P; Young, J1
Adamo, MV; Balducci, R; Boscherini, B; Cives, C; Mangiantini, A; Toscano, V1
Gautier, T; Imperato-McGinley, J; Peterson, RE; Shackleton, C1
Benveniste, R; Ilekis, J; Moise, J; Scommegna, A1
Drife, JO1
Godfrey, BM; Petrucco, OM; Seamark, RF; Stone, BA1
de la Torre, B; Hedman, M; Norén, S; Sjöberg, B1
Baulieu, EE; Halberg, F; Robel, P; Synguelakis, M1
Walsh, SW1
Kakumoto, Y; Kamiya, T; Kiryu, Y; Maruyama, T; Nakamoto, H; Ookawa, H; Suzuki, O; Yasui, T; Yasumura, K; Yokomori, H1
Crabbe, J; Kolanowski, J; Ortega, N2
Bermúdez, JA; Flores, M; Herrera, J; Martin, O; Medina, M; Zárate, A1
Carr, BR; Mason, JI; Rainey, WE1
Berthezene, F; Boizel, R; Bost, M; Cathiard, AM; de Peretti, E; Halimi, S; Saez, JM1
Alén, M; Bolton, N; Ruokonen, A; Vihko, R1
D'Antona, N; De Leo, M; De Leo, V; Genazzani, AR; Inaudi, P; Verzetti, G1
Deppe, WM; Joubert, SM; Marivate, M; Norman, RJ1
Capella-Pavlovsky, M; Castanier, M; Chartier, M; Daffos, F; Forestier, F; Nahoul, K; Scholler, R1
Hirato, K; Nakayama, T; Noguchi, Y; Ogawa, K; Saitoh, H; Tahara, R; Yanaihara, T1
D'Ambrogio, G; Facchini, V; Genazzani, AR; Inaudi, P; Massafra, C1
Hemsell, PG; Korte, K; Mason, JI1
de Peretti, E; Mappus, E1
Carr, BR; Mason, JI; Parker, CR; Simpson, ER1
Carette, B; Poulain, P1
Lukkarinen, O; Ruokonen, A; Vihko, R1
Gromadzińska, E; Lachowicz, L; Rebas, E; Zylińska, L1
Baulieu, EE; Mahé, V; Monnet, FP; Robel, P1
Guth, L; Roberts, E; Zhang, Z1
Acosta, CK; Kim, HK; Rao, PN1
Santen, RJ; Santner, SJ1
Lieberman, S1
Baulieu, EE; Robel, P1
Bohr, I; Gniot-Szulzycka, J1
Di Lorenzo, D; Di Santo, E; Ghezzi, P; Mennini, T; Savoldi, G; Sironi, M; Zinetti, M1
Maurice, T; Privat, A; Roman, FJ1
Gillies, GE; Murray, HE1
Richardson, CM; Wakerley, JB1
Bélanger, A; Candas, B; Cusan, L; Gomez, JL; Labrie, F1
Kulkarni, SK; Reddy, DS4
Akwa, Y; Baulieu, EE; El-Etr, M; Robel, P1
Covey, DF; Nilsson, KR; Zorumski, CF1
Maurice, T; Privat, A; Urani, A1
Kaur, G; Kulkarni, SK; Reddy, DS1
Bender, AS; Norenberg, MD1
Fujinami, A; Kobayashi, Y; Tagawa, N; Tsuruta, H1
Beaujean, D; Do-Rego, JL; Luu-The, V; Mensah-Nyagan, AG; Pelletier, G; Vaudry, H1
Gromadzińska, E; Lachowicz, L; Zylińska, L1
Covey, DF; Mennerick, S; Shen, W; Zorumski, CF; Zorumski, EC1
Farb, DH; Gibbs, TT; Malayev, A; Park-Chung, M; Purdy, RH1
Mathis, C; Meziane, H; Ungerer, A1
Farr, SA; Flood, JF; Johnson, DA; Li, PK; Morley, JE1
Baumann, N; Eychenne, B; Lachapelle, F; Le Goascogne, C; Robel, P; Tonon, MC1
Akwa, Y; Britton, KT; Koob, GF; Purdy, RH1
Amino, N; Fujinami, A; Fukata, S; Kobayashi, Y; Kuma, K; Tada, H; Tagawa, N; Takano, T; Tamanaka, J1
Cascio, C; De Leo, G; Guarneri, M; Guarneri, P; Guarneri, R; Piccoli, F; Russo, D1
Nabeshima, T; Nakata, Y; Sasa, M; Yamada, K; Zou, LB1
Kamei, H; Kamei, Y; Nabeshima, T; Nagai, T; Nishida, M; Noda, Y1
Barbaccia, ML; Foddi, C; Ghezzi, P; Mennini, T; Sacco, S; Santo, ED1
Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J1
Betz, H; Laube, B; Maksay, G1
Amino, N; Fukata, S; Izumi, Y; Kobayashi, Y; Kuma, K; Tada, H; Tagawa, N; Takano, T1
Bicíková, M; Hill, M; Putz, Z; Tallová, J; Tomandl, J; Vañuga, A1
Averbuch, E; Kotler, M; Maayan, R; Mester, R; Spivak, B; Strous, RD; Weizman, A; Yoran-Hegesh, R1
Kobashi, M; Nagata, K; Shimada, M; Shimakawa, E; Tanabe, E; Yamazoe, Y; Yoshinari, K1
Barbosa, AD; Morato, GS2
Le Moal, M; Mayo, W; Vallée, M1
Lachowicz, A; Rebas, E1
Fujiwara, M; Furusawa, H; Higashi, S; Maeda, Y; Matsu, T; Nakahara, H; Nanba, K; Setoguchi, T; Tanaka, E; Watanabe, R1
Legler, J; Lemmen, JG; van den Brink, CE; van der Burg, B; van der Saag, PT1
Akwa, Y; Baulieu, EE; David, JP; Delacourte, A; Eychenne, B; Liere, P; Pianos, A; Sazdovitch, V; Schumacher, M; Weill-Engerer, S1
Dorner, M; Falk, W; Schölmerich, J; Straub, RH; Vogl, D1
Ortega, E; Torres, JM1
KILLINGER, DW; SOLOMON, S1
Azziz, R; Boots, LS; Moran, C; Reyna, R1
Goldstein, I; Guay, A; Jacobson, J; Munarriz, R; Quirk, F; Spark, R; Talakoub, L; Traish, A1
Bernardi, F; Casarosa, E; Genazzani, AR; Liut, M; Lombardi, I; Luisi, S; Monteleone, P; Palumbo, M; Petraglia, F; Quirici, B1
Bicíková, M; Hampl, R; Havlíková, H; Hill, M; Jirák, R; Rípová, D; Tallová, J1
Baulieu, EE; Cambourg, A; Eychenne, B; Griffiths, W; Liere, P; Liu, S; Pianos, A; Schumacher, M; Sjövall, J1
Hou, YN; Yan, CZ1
Bourguiba, S; Carreau, S; Marie, E1
Dorfman, P; Maayan, R; Morad, O; Overstreet, DH; Weizman, A; Yadid, G1
Fujita, R; Mizota, K; Uchida, H; Ueda, H; Yoshida, A1
Cerný, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Popov, P; Pouzar, V; Stárka, L; Vrbíková, J1
Gilad, R; Hermesh, H; Laufer, N; Maayan, R; Marom, S; Strous, R; Weizman, A1
Doron, R; Gispan-Herman, I; Lotan, S; Maayan, R; Shabat-Simon, M; Weizman, A; Yadid, G1
George, O; Le Moal, M; Mayo, W; Vallée, M1
Hou, YN; Wang, N; Wu, HH1
Grube, M; Jedlitschky, G; Karner, S; Köck, K; Kroemer, HK; Reuther, S; Ritter, CA1
Espallergues, J; Grégoire, C; Maurice, T1
Farb, DH; Gibbs, TT; Russek, SJ1
Mameli, M; Meyer, DA; Partridge, LD; Valenzuela, CF1
Bamber, BA; Covey, DF; Tartaglia, AL; Twede, V1
Bishnoi, M; Chopra, K; Kulkarni, SK1
Basta-Kaim, A; Budziszewska, B; Jagla, G; Jantas, D; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Nowak, W; Regulska, M1
Bunker, AM; Kushnir, MM; Meikle, AW; Owen, WE; Pattison, EG; Phanslkar, AR; Roberts, WL; Rockwood, AL; Sandrock, T; Terry, AH1
Budziszewska, B; Jantas, D; Lason, W; Leskiewicz, M1
Ballatori, N; Christian, WV; Cui, M; Fang, F; Gorman, SG; Huang, J; Tieu, K1
Dusková, M; Hill, M; Kancheva, R; Kubátová, J; Stárka, L; Vceláková, H; Vrbíková, J; Zárubová, J1
Balashov, AM1
Elfverson, M; Johansson, T; Le Grevès, P; Nyberg, F; Zhou, Q1
Chene, J; Dzugan, KS; Dzugan, SA; Dzugan, SS; Emhof, L; Medvedovsky, M; Michaelides, C; Rozakis, GW; Xydas, C1
Hill, M; Krzascik, P; Majewska, MD; Zajda, ME1
Dupré, A; Eychenne, B; Haccard, O; Jessus, C; Liere, P; Ozon, R; Pianos, A1
Horishita, T; Okura, D; Sata, T; Sudo, Y; Ueno, S; Uezono, Y; Yanagihara, N1
Burel, D; Do-Rego, JL; Kwon, HB; Li, JH; Luu-The, V; Pelletier, G; Seong, JY; Taragnat, C; Tillet, Y; Vaudry, H; Wang, AF1
Akwa, Y; Alméras, M; Covey, DF; El Bitar, F; Krishnan, K; Maurice, T; Meunier, J; Villard, V1
Bernhardt, R; Neunzig, J2
Aksoy-Poyraz, C; Bolayırlı, M; Savrun, M; Turan, Ş; Yıldırım, A1
Dury, AY; Gonthier, R; Isabelle, M; Ke, Y; Labrie, F; Simard, JN1
Bera, AK; Sachidanandan, D1
Beitz, AJ; Choi, HS; Choi, SR; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY1
Auchus, RJ; Karashima, S; Kasa-Vubu, JZ; Lerario, AM; Nakamura, Y; Rainey, WE; Rege, J; Sasano, H; Smith, JM; White, PC1
Chang, CH; Chen, HL; Chu, CL; Lee, SY; Lin, SH; Lu, RB; Lu, T; Wang, LJ; Wu, CC1
Chen, CC; Chong, MY; Hsu, ST; Huang, YC; Hung, CF; Lee, Y; Lin, CH; Lin, PY; Wang, LJ; Wu, CC1
Auchus, RJ; Nanba, AT; Peng, HM; Rainey, WE; Rege, J; Ren, J; Turcu, AF1
Cai, H; Dougherty, GG; Haas, GL; Keshavan, M; Montrose, DM; Reddy, RD; Yao, JK; Zhou, X1
Aleman, M; Chigerwe, M; Madigan, JE; McCue, PM1
De Lafollie, J; Hartmann, MF; Heckmann, M; Hübner, S; Ittermann, T; Ruhnau, J; Sunny, D; Wudy, SA1
Avallone, R; Bellei, E; Bergamini, S; Ferrari, A; Monari, E; Rustichelli, C; Tomasi, A1
Akk, G; Germann, AL; Pierce, SR; Steinbach, JH1
Akıncı, E; Bal, C; Erel, Ö; Eser, F; Güner, R; Hasanoglu, İ; Kalem, AK; Kayaaslan, B; Sezer, S; Yılmaz, G1

Reviews

13 review(s) available for pregnenolone and dehydroepiandrosterone sulfate

ArticleYear
Breast development in puberty.
    Annals of the New York Academy of Sciences, 1986, Volume: 464

    Topics: Adipose Tissue; Adolescent; Adult; Androgens; Breast; Breast Neoplasms; Cell Differentiation; Cell Division; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; DNA Replication; Epithelial Cells; Estradiol; Female; Gonadotropin-Releasing Hormone; Gonadotropins; Humans; Insulin-Like Growth Factor I; Male; Menarche; Menopause; Pregnancy; Pregnancy Trimester, Second; Pregnenolone; Puberty; Risk; Sex Characteristics; Time Factors

1986
[2 surgically treated cases of adrenocortical carcinoma producing steroid hormones without endocrinological symptoms--case report and a review of cases in the Japanese literature].
    Gan no rinsho. Japan journal of cancer clinics, 1988, Volume: 34, Issue:1

    Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Adult; Carcinoma; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Etiocholanolone; Humans; Male; Pregnenolone

1988
An abbreviated account of some aspects of the biochemistry of DHEA, 1934-1995.
    Annals of the New York Academy of Sciences, 1995, Dec-29, Volume: 774

    Topics: Animals; Cholesterol; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; History, 20th Century; Humans; Pregnenolone

1995
Dehydroepiandrosterone (DHEA) is a neuroactive neurosteroid.
    Annals of the New York Academy of Sciences, 1995, Dec-29, Volume: 774

    Topics: Acyltransferases; Adrenal Glands; Animals; Behavior, Animal; Brain; Cholesterol; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Ethanol; Female; Haplorhini; Humans; Hydroxysteroid Dehydrogenases; Male; Mice; Pregnenolone; Rats; Sensory Receptor Cells; Sexual Behavior, Animal; Steroid Hydroxylases; Stress, Physiological; Sulfatases; Sulfotransferases; Synaptosomes

1995
[Steroid modulation of GABA(A) receptors].
    Postepy higieny i medycyny doswiadczalnej, 1995, Volume: 49, Issue:3

    Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; GABA Modulators; Lipid Metabolism; Pregnenolone; Proteins; Receptors, GABA-A; Steroids

1995
[Models for the study of memory and neurosteroids].
    Journal de la Societe de biologie, 1999, Volume: 193, Issue:3

    Topics: Amnesia; Animals; Brain; Dehydroepiandrosterone Sulfate; Hippocampus; Humans; Learning; Memory; Mice; Models, Neurological; Models, Psychological; Pregnenolone; Rats

1999
Role of pregnenolone, dehydroepiandrosterone and their sulfate esters on learning and memory in cognitive aging.
    Brain research. Brain research reviews, 2001, Volume: 37, Issue:1-3

    Topics: Aging; Animals; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hippocampus; Humans; Learning; Memory; Pregnenolone; Rats; Reproducibility of Results

2001
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: Acetylcholine; Aging; Animals; Brain Stem; Dehydroepiandrosterone Sulfate; Humans; Memory; Memory Disorders; Pregnanolone; Pregnenolone; Prosencephalon; Sleep; Sleep Wake Disorders

2006
Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:4

    Topics: Amino Acid Sequence; Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Molecular Sequence Data; Neuroprotective Agents; Neurotransmitter Agents; Pregnenolone; Progesterone; Receptors, sigma; Sigma-1 Receptor; Steroids

2006
Sulfated steroids as endogenous neuromodulators.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:4

    Topics: Animals; Brain Chemistry; Dehydroepiandrosterone Sulfate; Humans; Models, Molecular; Neurotransmitter Agents; Pregnenolone; Receptors, Glutamate; Receptors, Neurotransmitter; Steroids; Sulfatases; Sulfates; Sulfotransferases

2006
Modulation of glutamatergic transmission by sulfated steroids: role in fetal alcohol spectrum disorder.
    Brain research reviews, 2008, Volume: 57, Issue:2

    Topics: Animals; Brain; Dehydroepiandrosterone Sulfate; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Glutamine; Humans; Neurons; Pregnancy; Pregnenolone; Receptors, N-Methyl-D-Aspartate; Steroids; Synaptic Transmission

2008
[Neurosteroids and addictive pathology].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010, Volume: 110, Issue:6

    Topics: Adrenal Cortex Hormones; Androstenedione; Behavior, Addictive; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Humans; Narcotics; Pregnenolone; Substance-Related Disorders

2010
Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases.
    The Journal of steroid biochemistry and molecular biology, 2018, Volume: 179

    Topics: Animals; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone Sulfate; Hormones; Humans; Pregnenolone; Steroid Hydroxylases; Steroids

2018

Trials

3 trial(s) available for pregnenolone and dehydroepiandrosterone sulfate

ArticleYear
Secretion of steroid sulfates from human testis and their response to a single intramuscular injection of 5000 IU hCG.
    Journal of steroid biochemistry, 1981, Volume: 14, Issue:12

    Topics: Adult; Aged; Androstenediol; Androstenediols; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Kinetics; Male; Middle Aged; Pregnenolone; Testis; Testosterone; Veins

1981
Analysis of neurosteroid levels in attention deficit hyperactivity disorder.
    The international journal of neuropsychopharmacology, 2001, Volume: 4, Issue:3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Male; Neurotransmitter Agents; Pregnenolone; Psychiatric Status Rating Scales; Steroids

2001
Adrenocortical hyperresponsiveness to corticotropin in polycystic ovary syndrome patients with adrenal androgen excess.
    Fertility and sterility, 2004, Volume: 81, Issue:1

    Topics: 17-alpha-Hydroxyprogesterone; 3-Hydroxysteroid Dehydrogenases; Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Androstenedione; Case-Control Studies; Cross-Sectional Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hyperandrogenism; Polycystic Ovary Syndrome; Pregnenolone; Progesterone; Prospective Studies; Steroid 17-alpha-Hydroxylase; Testosterone

2004

Other Studies

114 other study(ies) available for pregnenolone and dehydroepiandrosterone sulfate

ArticleYear
Neurosteroids: pregnenolone in human sciatic nerves.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Aug-01, Volume: 89, Issue:15

    Topics: Adult; Aged; Aged, 80 and over; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Esters; Female; Humans; Male; Mass Spectrometry; Middle Aged; Pregnenolone; Radioimmunoassay; Sciatic Nerve

1992
Steroid sulfatase activities in human leukocytes: biochemical and clinical aspects.
    Endocrinologia japonica, 1991, Volume: 38, Issue:6

    Topics: Arylsulfatases; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estrone; Female; Humans; Ichthyosis Vulgaris; Ichthyosis, X-Linked; Leukocytes; Male; Placenta; Pregnenolone; Steryl-Sulfatase; Tritium

1991
Interaction of 17 beta-estradiol and progesterone production in human granulosa-luteal cells.
    European journal of obstetrics, gynecology, and reproductive biology, 1990, Volume: 37, Issue:2

    Topics: Androstenediol; Cells, Cultured; Chorionic Gonadotropin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Estradiol; Female; Granulosa Cells; Humans; In Vitro Techniques; Pregnenolone; Progesterone

1990
Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain.
    Steroids, 1989, Volume: 54, Issue:3

    Topics: Animals; Brain Chemistry; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Esters; Estrus; Fatty Acids; Female; Male; Orchiectomy; Pregnenolone; Radioimmunoassay; Rats; Rats, Inbred Strains

1989
Changes in steroid pattern following acute and chronic adrenocorticotropin administration in premature adrenarche.
    Journal of steroid biochemistry, 1989, Volume: 32, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Androstenedione; Child; Cortodoxone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Hydroxyprogesterones; Male; Pregnenolone; Puberty, Precocious

1989
Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia.
    The New England journal of medicine, 1985, Nov-07, Volume: 313, Issue:19

    Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; 18-Hydroxycorticosterone; 18-Hydroxydesoxycorticosterone; Adrenal Hyperplasia, Congenital; Aldehyde-Lyases; Aldosterone; Androstenedione; Corticosterone; Cortodoxone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dihydrotestosterone; Disorders of Sex Development; Humans; Hydrocortisone; Infant; Male; Mixed Function Oxygenases; Pregnenolone; Progesterone; Steroid Hydroxylases; Testosterone

1985
The effect of dehydroepiandrosterone sulfate on de novo and low-density lipoprotein-stimulated progesterone secretion by human choriocarcinoma JEG-3 cells.
    American journal of obstetrics and gynecology, 1986, Volume: 154, Issue:5

    Topics: Cell Line; Cells, Cultured; Choriocarcinoma; Culture Media; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; In Vitro Techniques; Lipoproteins, LDL; Pregnancy; Pregnenolone; Progesterone; Trophoblasts; Uterine Neoplasms

1986
Concentrations of steroid hormones, and of prolactin, in washings of the human uterus during the menstrual cycle.
    Journal of reproduction and fertility, 1986, Volume: 78, Issue:1

    Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Gonadal Steroid Hormones; Humans; Menstrual Cycle; Pregnenolone; Prolactin; Proteins; Uterus

1986
Blood and tissue steroid levels and their interrelationship in men with pathological conditions of the reproductive organs.
    International journal of andrology, 1986, Volume: 9, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Arteries; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Epididymis; Genital Diseases, Male; Humans; Male; Middle Aged; Pregnenolone; Steroids; Testis; Testosterone; Vas Deferens; Veins

1986
Chronobiologic dynamics of delta 5-3 beta-hydroxysteroids and glucocorticoids in rat brain and plasma and human plasma.
    Progress in clinical and biological research, 1987, Volume: 227A

    Topics: Animals; Brain Chemistry; Circadian Rhythm; Corticosterone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Glucocorticoids; Humans; Hydrocortisone; Hydroxysteroids; Male; Pregnenolone; Rats; Rats, Inbred Strains

1987
Progesterone and estradiol production by normal and preeclamptic placentas.
    Obstetrics and gynecology, 1988, Volume: 71, Issue:2

    Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Humans; In Vitro Techniques; Placenta; Pre-Eclampsia; Pregnancy; Pregnenolone; Progesterone

1988
Enhanced 17 alpha-hydroxylation of pregnenolone and increased androgen production by rabbit adrenocortical cells stimulated chronically with corticotropin.
    Journal of steroid biochemistry, 1986, Volume: 24, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex; Adrenocorticotropic Hormone; Androgens; Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hydroxylation; In Vitro Techniques; Male; Pregnenolone; Rabbits; Stimulation, Chemical

1986
Normal ovarian function in a mild form of late-onset 3 beta-hydroxysteroid dehydrogenase deficiency.
    Fertility and sterility, 1986, Volume: 46, Issue:6

    Topics: 3-Hydroxysteroid Dehydrogenases; Adrenocorticotropic Hormone; Adult; Age Factors; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Estradiol; Female; Follicle Stimulating Hormone; Hirsutism; Humans; Luteinizing Hormone; Menstrual Cycle; Ovary; Ovulation; Polycystic Ovary Syndrome; Pregnenolone; Progesterone; Prolactin; Testosterone

1986
The role of calmodulin antagonists on steroidogenesis by fetal zone cells of the human fetal adrenal gland.
    Endocrinology, 1987, Volume: 120, Issue:3

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Bucladesine; Calmodulin; Cells, Cultured; Chlorpromazine; Cyclic AMP; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Embryo, Mammalian; Fetus; Humans; Hydrocortisone; Imidazoles; Kinetics; Pregnenolone; Trifluoperazine

1987
Chronic treatment with corticotropin increases the capacity of rabbit adrenocortical cells to convert pregnenolone into androgens.
    Journal of steroid biochemistry, 1987, Volume: 26, Issue:2

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Androgens; Androstenedione; Animals; Cosyntropin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; In Vitro Techniques; Kinetics; Pregnenolone; Rabbits; Testosterone

1987
Pattern of plasma levels of cortisol, dehydroepiandrosterone and pregnenolone sulphate in normal subjects and in patients with homozygous familial hypercholesterolaemia during ACTH infusion.
    Clinical endocrinology, 1986, Volume: 25, Issue:4

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Hyperlipoproteinemia Type II; Male; Pregnenolone

1986
Response of serum testosterone and its precursor steroids, SHBG and CBG to anabolic steroid and testosterone self-administration in man.
    Journal of steroid biochemistry, 1985, Volume: 23, Issue:1

    Topics: 17-alpha-Hydroxypregnenolone; Anabolic Agents; Androgens; Androstenediol; Androstenedione; Carrier Proteins; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Kinetics; Male; Pregnenolone; Progesterone; Sex Hormone-Binding Globulin; Sports; Testosterone

1985
[Changes in plasma concentrations of adrenal androgens in patients with chronic renal insufficiency].
    Bollettino della Societa italiana di biologia sperimentale, 1983, Dec-30, Volume: 59, Issue:12

    Topics: Adrenal Glands; Adult; Androgens; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Kidney Failure, Chronic; Male; Middle Aged; Pregnenolone

1983
Umbilical artery concentrations of androstenedione increased in early labour in the leading twin fetus.
    British journal of obstetrics and gynaecology, 1984, Volume: 91, Issue:8

    Topics: Androstenedione; Cesarean Section; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Fetal Blood; Humans; Labor Stage, First; Labor Stage, Second; Labor, Obstetric; Pregnancy; Pregnenolone; Progesterone; Twins

1984
[Fetal hormonology by direct sampling of fetal blood during the 2d trimester of pregnancy. Study of fetal and maternal 5-ene steroid sulfates].
    Pathologie-biologie, 1984, Volume: 32, Issue:8

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Blood Specimen Collection; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Fetal Blood; Humans; Male; Pregnancy; Pregnancy Trimester, Second; Pregnenolone; Prenatal Diagnosis

1984
Enhancement of human amniotic phospholipase A2 activity by steroid-sulphate derived from the foeto-placental unit.
    Acta endocrinologica, 1984, Volume: 107, Issue:3

    Topics: Amnion; Arachidonic Acid; Arachidonic Acids; Cholesterol Esters; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Estrone; Female; Humans; Hydrocortisone; Hydrogen-Ion Concentration; Phosphatidylcholines; Phospholipases; Phospholipases A; Phospholipases A2; Pregnancy; Pregnenolone; Progesterone

1984
Impaired pregnenolone secretion after combined cyproterone acetate and ethynyl estradiol therapy in hirsute patients.
    Gynecologic and obstetric investigation, 1982, Volume: 14, Issue:2

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Androstenedione; Cyproterone; Cyproterone Acetate; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Drug Therapy, Combination; Ethinyl Estradiol; Female; Hirsutism; Humans; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone; Testosterone

1982
Steroidogenesis in dispersed cells of human fetal adrenal.
    The Journal of clinical endocrinology and metabolism, 1983, Volume: 56, Issue:5

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Cyanoketone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Pituitary Hormones; Pregnenolone; Steroid 17-alpha-Hydroxylase; Tetrahydronaphthalenes

1983
Pattern of plasma pregnenolone sulfate levels in humans from birth to adulthood.
    The Journal of clinical endocrinology and metabolism, 1983, Volume: 57, Issue:3

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aging; Child; Child, Preschool; Chorionic Gonadotropin; Circadian Rhythm; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Female; Fetal Blood; Humans; Infant; Infant, Newborn; Male; Metyrapone; Middle Aged; Pregnenolone

1983
Effect of prostaglandins on steroid secretion by human fetal adrenal tissue.
    Steroids, 1983, Volume: 41, Issue:5

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Estradiol; Female; Fetus; Humans; Hydrocortisone; In Vitro Techniques; Pregnancy; Pregnenolone; Prostaglandins E; Prostaglandins F; Radioimmunoassay

1983
Excitatory effect of dehydroepiandrosterone, its sulphate ester and pregnenolone sulphate, applied by iontophoresis and pressure, on single neurones in the septo-preoptic area of the guinea pig.
    Neuroscience letters, 1984, Mar-23, Volume: 45, Issue:2

    Topics: Animals; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Guinea Pigs; Membrane Potentials; Neurons; Pregnenolone; Preoptic Area; Septum Pellucidum; Synaptic Transmission

1984
Neuroactive steroids modulate in vivo the Mg2+/Ca(2+)-ATPase activity in rat cortical and cerebellar synaptosomal membranes.
    Biochemical and biophysical research communications, 1995, Jul-06, Volume: 212, Issue:1

    Topics: Animals; Ca(2+) Mg(2+)-ATPase; Calmodulin; Cell Membrane; Cerebellum; Cerebral Cortex; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Pregnenolone; Rats; Rats, Wistar; Reference Values; Synaptosomes

1995
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Apr-25, Volume: 92, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Guanidines; Haloperidol; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ovariectomy; Pertussis Toxin; Piperazines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereotaxic Techniques; Virulence Factors, Bordetella

1995
Key role for pregnenolone in combination therapy that promotes recovery after spinal cord injury.
    Proceedings of the National Academy of Sciences of the United States of America, 1994, Dec-06, Volume: 91, Issue:25

    Topics: Analysis of Variance; Animals; Aspirin; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Double-Blind Method; Drug Therapy, Combination; Female; Indomethacin; Lipopolysaccharides; Motor Activity; Pregnenolone; Rats; Rats, Sprague-Dawley; Salmonella enteritidis; Spinal Cord; Spinal Cord Injuries

1994
Tetrapropylammonium perruthenate as a mild and efficient oxidant for sensitive steroidal alcohols.
    Steroids, 1993, Volume: 58, Issue:5

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Alcohols; Androstenedione; Cyclic N-Oxides; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hydroxyprogesterones; Ketones; Morpholines; Organometallic Compounds; Oxidants; Oxidation-Reduction; Pregnenediones; Pregnenolone; Quaternary Ammonium Compounds; Ruthenium; Steroids

1993
Inhibition of estrone sulfatase and 17 beta-hydroxysteroid dehydrogenase by antiestrogens.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 45, Issue:5

    Topics: 17-Hydroxysteroid Dehydrogenases; Animals; Binding, Competitive; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Kinetics; Mammary Neoplasms, Experimental; Polyunsaturated Alkamides; Pregnenolone; Rats; Rats, Sprague-Dawley; Sulfatases; Tamoxifen

1993
A glucocorticoid receptor-independent mechanism for neurosteroid inhibition of tumor necrosis factor production.
    European journal of pharmacology, 1996, Mar-28, Volume: 299, Issue:1-3

    Topics: Animals; Brain; Cell Line; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Escherichia coli; Hormone Antagonists; Lipopolysaccharides; Male; Mice; Mifepristone; Pregnenolone; Receptors, Glucocorticoid; RNA, Messenger; Tumor Necrosis Factor-alpha

1996
Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to sigma 1 receptors in the mouse forebrain.
    Journal of neuroscience research, 1996, Dec-15, Volume: 46, Issue:6

    Topics: Animals; Antipsychotic Agents; Binding, Competitive; Cerebral Cortex; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Gonadal Steroid Hormones; Hippocampus; Male; Mice; Phenazocine; Pregnancy; Pregnenolone; Progesterone; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, sigma; Tritium

1996
Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures.
    Journal of neuroendocrinology, 1997, Volume: 9, Issue:4

    Topics: Animals; Bicuculline; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dopamine; Drug Synergism; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Pregnanolone; Pregnenolone; Rats; Somatostatin

1997
The neurosteroid pregnenolone sulphate enhances NMDA-induced phasic firing of vasopressin neurones in the rat supraoptic nucleus.
    Neuroscience letters, 1997, Apr-25, Volume: 226, Issue:2

    Topics: Animals; Dehydroepiandrosterone Sulfate; Drug Synergism; Evoked Potentials; Female; Hypothalamus; In Vitro Techniques; N-Methylaspartate; Neurons; Picrotoxin; Pregnenolone; Rats; Rats, Wistar; Supraoptic Nucleus; Time Factors; Vasopressins

1997
Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:8

    Topics: 17-Hydroxysteroid Dehydrogenases; Adult; Aged; Aged, 80 and over; Aging; Androgens; Androstenediol; Androstenedione; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dihydrotestosterone; Female; Gonadal Steroid Hormones; Humans; Male; Middle Aged; Pregnenolone; Protein Precursors; Reference Values

1997
Proconvulsant effects of neurosteroids pregnenolone sulfate and dehydroepiandrosterone sulfate in mice.
    European journal of pharmacology, 1998, Mar-12, Volume: 345, Issue:1

    Topics: Animals; Body Weight; Convulsants; Dehydroepiandrosterone Sulfate; Injections, Subcutaneous; Male; Mice; Neurotoxins; Pentylenetetrazole; Pregnenolone; Progesterone

1998
The effects of neurosteroids on acquisition and retention of a modified passive-avoidance learning task in mice.
    Brain research, 1998, Apr-27, Volume: 791, Issue:1-2

    Topics: Animals; Avoidance Learning; Dehydroepiandrosterone Sulfate; Dopamine Antagonists; Haloperidol; Male; Mice; Pregnenolone; Receptors, sigma; Reproducibility of Results; Retention, Psychology

1998
Opposing effects of different steroid sulfates on GABAA receptor-mediated chloride uptake.
    Brain research, 1998, Apr-20, Volume: 790, Issue:1-2

    Topics: Animals; Biological Transport; Cerebral Cortex; Chlorides; Dehydroepiandrosterone Sulfate; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; In Vitro Techniques; Ionophores; Male; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes

1998
Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.
    Journal of medicinal chemistry, 1998, Jul-02, Volume: 41, Issue:14

    Topics: Animals; Cells, Cultured; Dehydroepiandrosterone Sulfate; GABA Modulators; Hippocampus; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Stereoisomerism

1998
The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with sigma1 (sigma1) receptors.
    Brain research, 1998, Jul-13, Volume: 799, Issue:1

    Topics: Animals; Anisoles; Dehydroepiandrosterone Sulfate; Learning Disabilities; Male; Maze Learning; Mice; Muscarinic Antagonists; Pregnenolone; Progesterone; Propylamines; Receptors, sigma; Scopolamine; Swimming

1998
Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment.
    Brain research, 1998, Jul-20, Volume: 799, Issue:2

    Topics: Aging; Amnesia; Animals; Avoidance Learning; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Enzyme Inhibitors; Learning Disabilities; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nootropic Agents; Pregnenolone

1998
The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice.
    Psychopharmacology, 1998, Volume: 137, Issue:4

    Topics: Animals; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Eating; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Mitochondria; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate

1998
Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test.
    Neuroreport, 1998, Sep-14, Volume: 9, Issue:13

    Topics: Animals; Anisoles; Antidepressive Agents; Behavior, Animal; Dehydroepiandrosterone Sulfate; Female; Hypokinesia; Immobilization; Injections, Intraperitoneal; Injections, Subcutaneous; Ligands; Male; Mice; Mice, Inbred Strains; Pregnenolone; Progesterone; Propylamines; Rats; Rats, Wistar; Receptors, sigma; Stress, Physiological; Swimming; Time Factors

1998
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
    Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5

    Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation

1998
Prevention of co-elution of steroid sulfates with serum proteins from pre-column in column-switching HPLC system.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:11

    Topics: Blood Proteins; Chromatography, High Pressure Liquid; Dehydroepiandrosterone Sulfate; Estriol; Humans; Pregnenolone; Quaternary Ammonium Compounds

1998
Immunocytochemical localization and biological activity of hydroxysteroid sulfotransferase in the frog brain.
    Journal of neurochemistry, 1999, Volume: 72, Issue:2

    Topics: Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Dehydroepiandrosterone Sulfate; Immunohistochemistry; Male; Phosphoadenosine Phosphosulfate; Pregnenolone; Rabbits; Rana ridibunda; Sulfotransferases; Sulfur Radioisotopes; Tritium

1999
Short-time effects of neuroactive steroids on rat cortical Ca2+-ATPase activity.
    Biochimica et biophysica acta, 1999, Feb-25, Volume: 1437, Issue:2

    Topics: Animals; Brain; Calcium-Transporting ATPases; Calmodulin; Cells, Cultured; Dehydroepiandrosterone Sulfate; Enzyme Activation; Estradiol; Pregnenolone; Rats; Rats, Wistar; Synaptosomes; Testosterone; Up-Regulation

1999
Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors.
    Neuropharmacology, 1999, Volume: 38, Issue:2

    Topics: Animals; Chloride Channels; Dehydroepiandrosterone Sulfate; Female; gamma-Aminobutyric Acid; Macromolecular Substances; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis

1999
Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites.
    Brain research, 1999, May-29, Volume: 830, Issue:1

    Topics: Animals; Cells, Cultured; Chick Embryo; Dehydroepiandrosterone Sulfate; GABA Modulators; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Steroids; Sulfuric Acid Esters; Xenopus laevis

1999
Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally administered dehydroepiandrosterone sulfate but not pregnenolone sulfate.
    Psychoneuroendocrinology, 1999, Volume: 24, Issue:8

    Topics: Animals; Arylsulfatases; Avoidance Learning; Brain Mapping; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrone; Hippocampus; Injections; Male; Maze Learning; Mice; Pregnenolone; Retention, Psychology; Steryl-Sulfatase

1999
Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice.
    Glia, 2000, Jan-01, Volume: 29, Issue:1

    Topics: 5-alpha-Dihydroprogesterone; Adrenal Cortex; Animals; Brain; Brain Chemistry; Corticosterone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Demyelinating Diseases; Diazepam Binding Inhibitor; Immunohistochemistry; Leydig Cells; Male; Mice; Mice, Inbred Strains; Mice, Jimpy; Mice, Neurologic Mutants; Neuropeptides; Organ Specificity; Peptide Fragments; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Up-Regulation

2000
The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat.
    Behavioural brain research, 1999, Volume: 106, Issue:1-2

    Topics: Amygdala; Animals; Anti-Anxiety Agents; Conflict, Psychological; Dehydroepiandrosterone Sulfate; Female; Injections; Injections, Intraventricular; Ovariectomy; Pregnanolone; Pregnenolone; Punishment; Rats; Rats, Wistar

1999
Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.
    Clinical chemistry, 2000, Volume: 46, Issue:4

    Topics: Adult; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Pregnenolone; Thyroid Hormones

2000
Pregnenolone sulfate, a naturally occurring excitotoxin involved in delayed retinal cell death.
    Journal of neurochemistry, 2000, Volume: 74, Issue:6

    Topics: Adjuvants, Immunologic; Animals; Apoptosis; Cycloheximide; Dehydroepiandrosterone Sulfate; DNA Fragmentation; Estradiol; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Lipid Peroxidation; Male; Neurotoxins; Pregnenolone; Progesterone; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Retina; Superoxide Dismutase; Superoxides; Thiobarbituric Acid Reactive Substances

2000
Effects of sigma(1) receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Animals; Anisoles; Antipsychotic Agents; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory; Nootropic Agents; Piperazines; Pregnenolone; Progesterone; Propylamines; Psychomotor Performance; Rats; Rats, Wistar; Receptors, sigma; Steroids; Time Factors

2000
Neurosteroids ameliorate conditioned fear stress: an association with sigma receptors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:3

    Topics: Animals; Antipsychotic Agents; Conditioning, Psychological; Dehydroepiandrosterone Sulfate; Electroshock; Fear; Male; Mice; Phenazocine; Pregnenolone; Receptors, sigma; Sigma-1 Receptor; Steroids; Stress, Psychological

2000
Neurosteroid levels are increased in vivo after LPS treatment and negatively regulate LPS-induced TNF production.
    European cytokine network, 2000, Volume: 11, Issue:3

    Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dehydroepiandrosterone Sulfate; Hippocampus; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Pregnanolone; Pregnenolone; Progesterone; Tumor Necrosis Factor-alpha

2000
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2

    Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids

2000
Subunit-specific modulation of glycine receptors by neurosteroids.
    Neuropharmacology, 2001, Volume: 41, Issue:3

    Topics: Androstanes; Animals; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Humans; Isomerism; Neurotransmitter Agents; Oocytes; Pregnenes; Pregnenolone; Receptors, Glycine; Recombinant Proteins; Stereoisomerism; Steroids; Structure-Activity Relationship; Xenopus laevis

2001
Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism.
    Endocrine journal, 2001, Volume: 48, Issue:3

    Topics: Adult; Androstenediol; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Pregnenolone; Sex Characteristics; Sex Hormone-Binding Globulin; Thyroxine

2001
Effect of treatment of hypothyroidism on the plasma concentrations of neuroactive steroids and homocysteine.
    Clinical chemistry and laboratory medicine, 2001, Volume: 39, Issue:8

    Topics: Adjuvants, Immunologic; Adult; Aged; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Homocysteine; Humans; Hypothyroidism; Male; Microsomes; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Thyrotropin; Thyroxine; Time Factors; Triiodothyronine

2001
Identification of ST2A1 as a rat brain neurosteroid sulfotransferase mRNA.
    Brain research, 2001, Nov-30, Volume: 920, Issue:1-2

    Topics: Animals; Blotting, Western; Brain; Corticosterone; Cytosol; Dehydroepiandrosterone Sulfate; Female; Isoenzymes; Liver; Male; Phosphoadenosine Phosphosulfate; Pregnenolone; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfotransferases

2001
Influence of neurosteroids on the development of rapid tolerance to ethanol in mice.
    European journal of pharmacology, 2001, Nov-16, Volume: 431, Issue:2

    Topics: Animals; Dehydroepiandrosterone Sulfate; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Ethanol; Male; Mice; Motor Activity; Muscimol; Pregnenolone; Steroids

2001
Gender differences in steroid modulation of angiotensin II-induced protein kinase C activity in anterior pituitary of the rat.
    Biochemical and biophysical research communications, 2002, May-31, Volume: 294, Issue:1

    Topics: Angiotensin II; Animals; Dehydroepiandrosterone Sulfate; Estradiol; Female; Male; Ovariectomy; Phosphorylation; Pituitary Gland, Anterior; Pregnenolone; Progesterone; Protein Kinase C; Rats; Rats, Wistar; Sex Factors; Synapsins

2002
Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol.
    Brain research bulletin, 2002, Volume: 58, Issue:1

    Topics: Alcoholism; Animals; Body Temperature; Central Nervous System Depressants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Pregnenolone

2002
Accumulation of 4- and 5-ene steroid sulfates in human breast cyst fluids.
    The Journal of steroid biochemistry and molecular biology, 2002, Volume: 81, Issue:3

    Topics: Adult; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Exudates and Transudates; Female; Fibrocystic Breast Disease; Humans; Middle Aged; Pregnenolone

2002
Detection of oestrogenic activity of steroids present during mammalian gestation using oestrogen receptor alpha- and oestrogen receptor beta-specific in vitro assays.
    The Journal of endocrinology, 2002, Volume: 174, Issue:3

    Topics: Androgens; Animals; Cell Line; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Gestational Age; Hormones; Humans; Kidney; Mice; Pregnenolone; Protein Binding; Protein Precursors; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transfection

2002
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
    The Journal of clinical endocrinology and metabolism, 2002, Volume: 87, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Brain Chemistry; Cerebellum; Corpus Striatum; Dehydroepiandrosterone Sulfate; Female; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Hippocampus; Humans; Hypothalamus; Male; Pregnanolone; Pregnenolone; Progesterone; Protein Structure, Secondary; Steroids; tau Proteins

2002
Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones.
    The Journal of rheumatology, 2003, Volume: 30, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adult; Aged; Androstenedione; Arthritis, Rheumatoid; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Lupus Erythematosus, Systemic; Male; Middle Aged; Pregnenolone; Progesterone

2003
DHEA, PREG and their sulphate derivatives on plasma and brain after CRH and ACTH administration.
    Neurochemical research, 2003, Volume: 28, Issue:8

    Topics: Adrenocorticotropic Hormone; Animals; Blood; Brain; Corticotropin-Releasing Hormone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Male; Pregnenolone; Rats; Rats, Wistar

2003
SYNTHESIS OF PREGNENOLONE SULFATE, DEHYDROISOANDROSTERONE SULFATE, 17-ALPHA-HYDROXYPREGNENOLONE SULFATE AND DELTA-5-PREGNENETRIOL SULFATE BY THE NORMAL HUMAN ADRENAL GLAND.
    The Journal of clinical endocrinology and metabolism, 1965, Volume: 25

    Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Chromatography; Crystallization; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Metabolism; Pregnanediol; Pregnanetriol; Pregnenes; Pregnenolone; Sulfates; Tritium

1965
Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part B: Reduced serum androgen levels in healthy premenopausal women with complaints of sexual dysfunction.
    International journal of impotence research, 2004, Volume: 16, Issue:2

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Age Factors; Androgens; Androstenedione; Case-Control Studies; Dehydroepiandrosterone Sulfate; Female; Humans; Libido; Middle Aged; Ovary; Pregnenolone; Premenopause; Progesterone; Reference Values; Sexual Dysfunctions, Psychological; Surveys and Questionnaires; Testosterone

2004
Adrenal response to adrenocorticotropic hormone stimulation in patients with premenstrual syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2004, Volume: 18, Issue:2

    Topics: Adolescent; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Adult; Androstenedione; Case-Control Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Estradiol; Female; Follicular Phase; Humans; Hydrocortisone; Luteal Phase; Pregnanolone; Pregnenolone; Premenstrual Syndrome; Progesterone; Testosterone

2004
Plasma levels of 7-hydroxylated dehydroepiandrosterone (DHEA) metabolites and selected amino-thiols as discriminatory tools of Alzheimer's disease and vascular dementia.
    Clinical chemistry and laboratory medicine, 2004, Volume: 42, Issue:5

    Topics: 17-alpha-Hydroxypregnenolone; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Cysteine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dementia, Vascular; Dipeptides; Female; Glutathione; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Predictive Value of Tests; Pregnenolone; Radioimmunoassay; Sensitivity and Specificity; Sex Factors; Statistics, Nonparametric; Sulfhydryl Compounds

2004
Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain.
    Journal of lipid research, 2004, Volume: 45, Issue:12

    Topics: Animals; Brain; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Gas Chromatography-Mass Spectrometry; Male; Pregnenolone; Rats; Rats, Sprague-Dawley

2004
Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:10

    Topics: Animals; Brain; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Male; Morphine Dependence; Pregnenolone; Progesterone; Random Allocation; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2004
Testicular and blood steroid levels in aged men.
    Reproductive biology, 2004, Volume: 4, Issue:3

    Topics: Aged; Aged, 80 and over; Aging; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Middle Aged; Pregnenolone; Progesterone; Reference Values; Sex Hormone-Binding Globulin; Steroids; Testis; Testosterone

2004
The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2005, Volume: 15, Issue:3

    Topics: Adrenocorticotropic Hormone; Animals; Brain; Brain Chemistry; Cytosol; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depression; Electroshock; Hydrocortisone; Liver; Male; Nerve Tissue Proteins; Pregnenolone; Rats; Rats, Inbred Strains; Sulfotransferases

2005
Novel type of Gq/11 protein-coupled neurosteroid receptor sensitive to endocrine disrupting chemicals in mast cell line (RBL-2H3).
    British journal of pharmacology, 2005, Volume: 145, Issue:4

    Topics: Animals; Behavior, Animal; beta-N-Acetylhexosaminidases; Binding, Competitive; Cattle; Cell Line, Tumor; Cell Membrane; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Estradiol; Estrenes; Fluorescein-5-isothiocyanate; GTP-Binding Protein alpha Subunits, Gi-Go; Leukemia, Basophilic, Acute; Macrocyclic Compounds; Male; Mast Cells; Mice; Nociceptors; Oligonucleotides, Antisense; Oxazoles; Pain; Pertussis Toxin; Phenols; Phosphodiesterase Inhibitors; Pregnenolone; Pyrrolidinones; Receptors, Steroid; Serum Albumin, Bovine; Type C Phospholipases

2005
Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction.
    Steroids, 2005, Volume: 70, Issue:8

    Topics: Alcoholism; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Progesterone; Radioimmunoassay; Stereoisomerism; Steroids; Time Factors

2005
Involvement of GABAA receptor modulating neuroactive steroids in patients with social phobia.
    Psychiatry research, 2005, Nov-15, Volume: 137, Issue:1-2

    Topics: Adult; Aged; Allosteric Regulation; Blood Platelets; Brain; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; GABA-A Receptor Antagonists; Humans; Hydrocortisone; Male; Middle Aged; Phobic Disorders; Pregnenolone; Receptors, GABA-A; Reference Values; Statistics as Topic

2005
Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:5

    Topics: Affect; Animals; Biogenic Monoamines; Brain Chemistry; Chromatography, High Pressure Liquid; Cocaine-Related Disorders; Conditioning, Operant; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dopamine; Dose-Response Relationship, Drug; Male; Nerve Tissue Proteins; Pregnenolone; Rats; Rats, Sprague-Dawley; Reward; Self Administration; Serotonin

2006
[Effects of morphine dependence on the levels of neurosteroids in rat brain].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2005, Volume: 40, Issue:11

    Topics: Amygdala; Animals; Brain; Conditioning, Operant; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hypothalamus; Male; Morphine Dependence; Nucleus Accumbens; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley

2005
Modification of OATP2B1-mediated transport by steroid hormones.
    Molecular pharmacology, 2006, Volume: 70, Issue:5

    Topics: Animals; Biological Transport; Dehydroepiandrosterone Sulfate; Dogs; Estrone; Gene Expression; Humans; Isotope Labeling; Kinetics; Mifepristone; Organic Anion Transporters; Pregnenolone; Progesterone; Steroids; Testosterone

2006
The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues.
    Molecular pharmacology, 2007, Volume: 72, Issue:5

    Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Caenorhabditis elegans Proteins; Cells, Cultured; Dehydroepiandrosterone Sulfate; GABA Antagonists; GABA-A Receptor Antagonists; Molecular Sequence Data; Mutation; Oocytes; Pregnenolone; Receptors, GABA-A; Xenopus

2007
Modulatory effect of neurosteroids in haloperidol-induced vacuous chewing movements and related behaviors.
    Psychopharmacology, 2008, Volume: 196, Issue:2

    Topics: Animals; Behavior, Animal; Catalase; Corpus Striatum; Dehydroepiandrosterone Sulfate; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Haloperidol; Homovanillic Acid; Injections, Intraperitoneal; Lipid Peroxidation; Male; Mastication; Norepinephrine; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Wistar; Serotonin; Superoxide Dismutase; Superoxides

2008
Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells.
    Journal of neuroscience research, 2008, May-01, Volume: 86, Issue:6

    Topics: Apoptosis; Brain; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; Neurons; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Pregnanolone; Pregnenolone; Staurosporine; Steroids

2008
Adrenal steroid concentrations in children seven to seventeen years of age.
    Journal of pediatric endocrinology & metabolism : JPEM, 2007, Volume: 20, Issue:12

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adolescent; Adrenal Glands; Age Factors; Analysis of Variance; Androstenedione; Child; Chromatography, High Pressure Liquid; Cortodoxone; Dehydroepiandrosterone Sulfate; Female; Humans; Immunoassay; Male; Pregnenolone; Puberty; Sex Factors; Sexual Maturation; Steroids; Tandem Mass Spectrometry; Testosterone

2007
Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2008, Volume: 59, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Death; Cerebral Cortex; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Excitatory Amino Acids; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phosphoinositide-3 Kinase Inhibitors; Pregnanolone; Pregnenolone; Reactive Oxygen Species; Staurosporine; Steroids

2008
Neurosteroid transport by the organic solute transporter OSTα-OSTβ.
    Journal of neurochemistry, 2010, Volume: 115, Issue:1

    Topics: Adrenal Glands; Animals; Biological Transport, Active; Brain Chemistry; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Humans; Immunohistochemistry; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdissection; Neurotransmitter Agents; Oocytes; Pregnenolone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroids; Xenopus laevis

2010
Sulphates of 3beta-hydroxy-5-ene steroids in women with epilepsy.
    Prague medical report, 2010, Volume: 111, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Dehydroepiandrosterone Sulfate; Epilepsy; Female; Follicular Phase; Humans; Luteal Phase; Middle Aged; Pregnenolone; Young Adult

2010
Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors.
    Neuropharmacology, 2011, Volume: 61, Issue:7

    Topics: Allosteric Regulation; Anabolic Agents; Androgens; Animals; Dehydroepiandrosterone Sulfate; Frontal Lobe; Kinetics; Male; Nandrolone; Nandrolone Decanoate; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor

2011
Correction of steroidopenia as a new method of hypercholesterolemia treatment.
    Neuro endocrinology letters, 2011, Volume: 32, Issue:1

    Topics: Cholecalciferol; Cholesterol, HDL; Cholesterol, LDL; Dehydroepiandrosterone Sulfate; Estrogens; Female; Hormone Replacement Therapy; Hormones; Humans; Hydrocortisone; Hypercholesterolemia; Hypogonadism; Lipase; Male; Middle Aged; Pregnenolone; Progesterone; Retrospective Studies; Testosterone

2011
Psychomotor and rewarding properties of the neurosteroids dehydroepiandrosterone sulphate and androsterone: effects on monoamine and steroid metabolism.
    Acta neurobiologiae experimentalis, 2012, Volume: 72, Issue:1

    Topics: Androsterone; Animals; Basal Ganglia; Biogenic Amines; Dehydroepiandrosterone Sulfate; Dopamine; Hippocampus; Male; Pregnenolone; Psychomotor Performance; Rats; Rats, Wistar; Reward; Serotonin; Steroids

2012
Naturally occurring steroids in Xenopus oocyte during meiotic maturation. Unexpected presence and role of steroid sulfates.
    Molecular and cellular endocrinology, 2012, Oct-15, Volume: 362, Issue:1-2

    Topics: Animals; Dehydroepiandrosterone Sulfate; Female; Gonadal Hormones; Luteinizing Hormone; Meiosis; Oocytes; Ovary; Ovulation; Pregnenolone; Steryl-Sulfatase; Sulfonic Acids; Xenopus laevis

2012
Inhibition by pregnenolone sulphate, a metabolite of the neurosteroid pregnenolone, of voltage-gated sodium channels expressed in Xenopus oocytes.
    Journal of pharmacological sciences, 2012, Volume: 120, Issue:1

    Topics: Animals; Cells, Cultured; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; NAV1.2 Voltage-Gated Sodium Channel; Oocytes; Pregnenolone; Sodium Channel Blockers; Xenopus laevis

2012
Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus.
    Endocrinology, 2013, Volume: 154, Issue:6

    Topics: Amino Acid Sequence; Animals; Cell Line; Dehydroepiandrosterone Sulfate; Diencephalon; Gene Expression Profiling; Gonadotropin-Releasing Hormone; Hypothalamus; In Situ Hybridization; Male; Microscopy, Confocal; Molecular Sequence Data; Neurons; Pituitary Gland; Pregnenolone; Protein Isoforms; Ranidae; Receptors, LHRH; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sulfotransferases

2013
Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ₂₅₋₃₅ peptide-induced toxicity in vitro and in vivo in mice.
    Psychopharmacology, 2014, Volume: 231, Issue:17

    Topics: Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Cell Line, Tumor; Cell Survival; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Lipid Peroxidation; Male; Mice; Neurites; Neuroprotective Agents; Peptide Fragments; Pregnenolone; Rats

2014
Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Adrenodoxin; Animals; Biosynthetic Pathways; Cattle; Cholesterol; Cholesterol Oxidase; Cholesterol Side-Chain Cleavage Enzyme; Dehydroepiandrosterone Sulfate; Ferredoxin-NADP Reductase; Humans; Kinetics; Pregnenolone; Progesterone

2014
Effects of electroconvulsive therapy on plasma levels of neuroactive steroids in inpatients with major depression.
    International journal of psychiatry in clinical practice, 2014, Volume: 18, Issue:4

    Topics: Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depressive Disorder, Treatment-Resistant; Electroconvulsive Therapy; Estradiol; Female; Humans; Inpatients; Male; Neurotransmitter Agents; Pregnenolone; Progesterone; Prospective Studies; Testosterone; Young Adult

2014
Validated LC-MS/MS simultaneous assay of five sex steroid/neurosteroid-related sulfates in human serum.
    The Journal of steroid biochemistry and molecular biology, 2015, Volume: 149

    Topics: Androsterone; Chromatography, Liquid; Dehydroepiandrosterone Sulfate; Estrone; Humans; Limit of Detection; Pregnanolone; Pregnenolone; Reproducibility of Results; Tandem Mass Spectrometry

2015
Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate.
    Journal of molecular neuroscience : MN, 2015, Volume: 56, Issue:4

    Topics: Allosteric Regulation; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Dehydroepiandrosterone Sulfate; GABA-A Receptor Antagonists; HEK293 Cells; Humans; Molecular Sequence Data; Pregnenolone; Protein Binding; Receptors, GABA-A

2015
Peripheral neurosteroids enhance P2X receptor-induced mechanical allodynia via a sigma-1 receptor-mediated mechanism.
    Brain research bulletin, 2016, Volume: 121

    Topics: Adenosine Triphosphate; Animals; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethylenediamines; Hyperalgesia; Male; Pain Measurement; Pregnenolone; Purinergic P2X Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X; Receptors, sigma; Time Factors

2016
Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate.
    The Journal of clinical endocrinology and metabolism, 2016, Volume: 101, Issue:12

    Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adrenal Glands; Adult; Age Factors; Androstenediol; Cell Culture Techniques; Child; Child, Preschool; Cytochromes b5; Dehydroepiandrosterone Sulfate; Female; Human Development; Humans; Infant; Male; Pregnenolone; Progesterone Reductase; Young Adult

2016
Serum DHEA-S concentration correlates with clinical symptoms and neurocognitive function in patients with bipolar II disorder: A case-controlled study.
    Progress in neuro-psychopharmacology & biological psychiatry, 2017, 03-06, Volume: 74

    Topics: Adolescent; Adult; Bipolar Disorder; Case-Control Studies; Cognition; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Pregnenolone; Psychiatric Status Rating Scales; Young Adult

2017
Gender differences in susceptibility to schizophrenia: Potential implication of neurosteroids.
    Psychoneuroendocrinology, 2017, Volume: 84

    Topics: Adult; Case-Control Studies; China; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Disease Susceptibility; Female; Humans; Hydrocortisone; Male; Middle Aged; Neurotransmitter Agents; Pregnenolone; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Sex Factors

2017
Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro.
    The Journal of clinical endocrinology and metabolism, 2018, 01-01, Volume: 103, Issue:1

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aged; Case-Control Studies; Cells, Cultured; Dehydroepiandrosterone Sulfate; Female; Follow-Up Studies; Humans; Hyperaldosteronism; Male; Middle Aged; Pregnenolone; Prognosis

2018
Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia.
    Psychoneuroendocrinology, 2018, Volume: 90

    Topics: Adult; Antipsychotic Agents; Biomarkers, Pharmacological; Case-Control Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Male; Metabolic Networks and Pathways; Pregnanolone; Pregnenolone; Progesterone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome

2018
Plasma concentrations of steroid precursors, steroids, neuroactive steroids, and neurosteroids in healthy neonatal foals from birth to 7 days of age.
    Journal of veterinary internal medicine, 2019, Volume: 33, Issue:5

    Topics: Animals; Animals, Newborn; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Female; Horses; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Pregnenolone; Progesterone; Prospective Studies

2019
Impact of Gestational and Postmenstrual Age on Excretion of Fetal Zone Steroids in Preterm Infants Determined by Gas Chromatography-Mass Spectrometry.
    The Journal of clinical endocrinology and metabolism, 2021, 08-18, Volume: 106, Issue:9

    Topics: 17-alpha-Hydroxypregnenolone; Adult; Aging; Amniotic Fluid; Cohort Studies; Dehydroepiandrosterone Sulfate; Female; Fetus; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Infant, Extremely Premature; Infant, Newborn; Infant, Premature; Male; Pregnancy; Pregnenolone; Sex Characteristics; Steroids

2021
Dehydroepiandrosterone sulfate, dehydroepiandrosterone, 5α-dihydroprogesterone and pregnenolone in women with migraine: Analysis of serum levels and correlation with age, migraine years and frequency.
    Journal of pharmaceutical and biomedical analysis, 2021, Nov-30, Volume: 206

    Topics: 20-alpha-Dihydroprogesterone; Adult; Chromatography, Liquid; Dehydroepiandrosterone Sulfate; Female; Humans; Migraine Disorders; Pregnenolone; Tandem Mass Spectrometry

2021
The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the
    Molecular pharmacology, 2022, Volume: 101, Issue:2

    Topics: Animals; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; GABA Antagonists; Humans; Neurosteroids; Pregnenolone; Protein Stability; Receptors, GABA-A; Xenopus laevis

2022
COVID-19 patients with altered steroid hormone levels are more likely to have higher disease severity.
    Endocrine, 2022, Volume: 78, Issue:2

    Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Aldosterone; Androstenedione; Androsterone; Chromatography, Liquid; Corticosterone; Cortodoxone; COVID-19; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dihydrotestosterone; Estradiol; Estrone; Humans; Hydrocortisone; Pregnenolone; Progesterone; Severity of Illness Index; Tandem Mass Spectrometry

2022