pregnenolone has been researched along with abiraterone in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balk, SP; Bubley, GJ; Cai, C; Chen, S; Marck, B; Matsumoto, AM; Mostaghel, EA; Nelson, PS; Ng, P; Simon, NI; Wang, H | 1 |
| Chen, HL; Du, JJ; Li, YC | 1 |
| DeVore, NM; Petrunak, EM; Porubsky, PR; Scott, EE | 1 |
| Chang, CY; Chen, WT; Chiou, YS; Chou, FP; Hsu, WC; Huang, SC; Lyu, JW; Tsai, CT; Wu, TK | 1 |
| Chapman, JG; Guengerich, FP; McCarty, KD; Tateishi, Y | 1 |
1 review(s) available for pregnenolone and abiraterone
| Article | Year |
|---|---|
[Advances in the study of steroidal inhibitors of cytochrome P45017alpha].
Topics: Androstenedione; Androstenes; Androstenols; Animals; Antineoplastic Agents; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Humans; Male; Molecular Structure; Pregnenolone; Progesterone; Prostatic Neoplasms; Steroid 17-alpha-Hydroxylase; Testosterone | 2013 |
4 other study(ies) available for pregnenolone and abiraterone
| Article | Year |
|---|---|
Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.
Topics: Androstenedione; Androstenes; Androstenols; Animals; Antineoplastic Agents, Hormonal; Carcinoma; Cell Line, Tumor; Dehydroepiandrosterone; Female; Humans; Indomethacin; Male; Mice; Orchiectomy; Pregnenolone; Progesterone; Prostatic Neoplasms; Receptors, Androgen; Steroid 17-alpha-Hydroxylase; Up-Regulation | 2011 |
Structures of human steroidogenic cytochrome P450 17A1 with substrates.
Topics: 17-alpha-Hydroxyprogesterone; Androstenes; Androstenols; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Dehydroepiandrosterone; Estrogens; Heme; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Molecular Structure; Mutation; Oxidation-Reduction; Pregnenolone; Progesterone; Protein Binding; Protein Structure, Secondary; Steroid 17-alpha-Hydroxylase; Steroids; Substrate Specificity; Testosterone | 2014 |
Pregnenolonyl-α-glucoside exhibits marked anti-cancer and CYP17A1 enzymatic inhibitory activities.
Topics: Androstenes; Antineoplastic Agents; Bacteria; Catalytic Domain; Cell Line, Tumor; Cytochrome P-450 Enzyme Inhibitors; Glucosides; Glycosylation; HEK293 Cells; Humans; Molecular Docking Simulation; Pregnenolone; Protein Binding | 2020 |
Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis.
Topics: Androgens; Androstenes; Antineoplastic Agents, Hormonal; Catalytic Domain; Cytochrome P-450 CYP3A; Enzyme Inhibitors; Humans; Imidazoles; Ketoconazole; Kinetics; Male; Naphthalenes; Pregnenolone; Progesterone; Prostatic Neoplasms; Steroid 17-alpha-Hydroxylase | 2021 |