pregnenolone has been researched along with 16-dehydropregnenolone in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 14 (53.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gower, DB; Kwan, TK; Taylor, NF; Watson, D | 1 |
| Forgó, P; Sweet, F; Szendi, Z | 1 |
| Kobayashi, Y; Saiki, K; Tagawa, N; Watanabe, F | 1 |
| Kobayashi, Y; Kusuda, S; Nakata, Y; Tagawa, N; Watanabe, F | 1 |
| Gower, DB; Kraevskaya, MA; Kwan, TK; Makin, HL; Trafford, DJ | 1 |
| Kobayashi, Y; Kusuda, S; Tagawa, N | 1 |
| Kobayashi, Y; Saiki, K; Tagawa, N | 1 |
| Gupta, RC; Mehrotra, N; Sabarinath, S; Singh, SK | 1 |
| Chowdhury, P; Das, AM; Goswami, P | 1 |
| Gupta, RC; Singh, SK; Suryawanshi, S | 2 |
| Bi, KS; Fu, WW; Ren, J; Sun, LX; Wang, MW; Xu, L | 1 |
| Bratoeff, E; Cabeza, M; Heuze, I; Pérez-Ornelas, V; Recillas, S | 1 |
| Khan, MF; Kumar, M; Maurya, R; Rawat, AK; Rawat, P; Srivastava, AK | 1 |
| Cao, H; Li, JC; Li, YC; Ma, EL; Sun, LX; Zhao, DM; Zhao, QY | 1 |
| Gautam, N; Kushwaha, HN; Misra, A; Pratap, R; Singh, B; Singh, SK; Verma, PC | 1 |
| Cui, Y; Deng, Z; Qin, Z; Sun, L; Sun, Y; Wang, F; Wang, X | 1 |
| Bratoeff, E; Cabeza, M; Heuze, Y; Ramírez-Apan, T; Sánchez, A; Silva-Ortiz, AV; Soriano, J | 1 |
| Frank, É; Gyovai, A; Kovács, F; Mótyán, G; Wölfling, J; Zupkó, I | 1 |
| Bhateria, M; Bhatta, RS; Ramakrishna, R; Singh, R | 1 |
| Jia, L; Mao, M; Sun, L; Sun, Y; Wang, X; Wei, L; Zhou, H | 1 |
| Kiełczewska, U; Morzycki, JW; Ratkiewicz, A; Siergiejczyk, L; Uścinowicz, P; Wojtkielewicz, A | 1 |
| Bautista, L; Bratoeff, E; Bravo, M; Cabeza, M; Heuze, Y; Moreno, I; Ramírez-Apan, T; Silva-Ortiz, AV; Soriano, J | 1 |
| Bhateria, M; Bhatta, RS; Gaikwad, AN; Kumar, D; Ramakrishna, R | 1 |
| Edina Herman, B; Gömöry, Á; Kollár, L; Maksó, L; Mikle, G; Skoda-Földes, R; Szánti-Pintér, E; Szécsi, M; Wouters, J | 1 |
| Ostrowska, P; Panek, A; Świzdor, A | 1 |
26 other study(ies) available for pregnenolone and 16-dehydropregnenolone
| Article | Year |
|---|---|
Identification of 16-dehydropregnenolone as an intermediate in 16-androstene biosynthesis in neonatal porcine testicular microsomes.
Topics: 17-alpha-Hydroxypregnenolone; Androstenes; Animals; Chromatography, Gas; Gas Chromatography-Mass Spectrometry; Male; Microsomes; Pregnenolone; Testis | 1984 |
Complete 1H and 13C NMR spectra of pregnenolone.
Topics: Carbon Isotopes; Hydrogen; Magnetic Resonance Spectroscopy; Pregnenolone | 1995 |
Studies on steroids in fetuses and neonates: identification of 16-dehydropregnenolone in the circulation of pre-term neonates.
Topics: Arylsulfatases; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Hydrogen-Ion Concentration; Hydrolysis; Infant, Newborn; Infant, Premature; Methylene Chloride; Pregnenolone; Spectroscopy, Fourier Transform Infrared | 1994 |
Serum levels of 16-dehydropregnenolone sulfate during the early neonatal period.
Topics: Adult; Age Factors; Aged; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Middle Aged; Pregnenolone; Sulfates | 1997 |
Use of gas chromatographic-mass spectrometric techniques in studies of androst-16-ene and androgen biosynthesis in human testis; cytosolic specific binding of 5alpha-androst-16-en-3-one.
Topics: 5-alpha-Dihydroprogesterone; Adult; Aged; Androgens; Androstenes; Androstenols; Chromatography, Gas; Cytosol; Humans; Male; Mass Spectrometry; Middle Aged; Pregnanediones; Pregnanolone; Pregnenolone; Testis; Testosterone | 1997 |
16-Dehydropregnenolone 3-sulfate, its source and metabolism in the feto-placental unit.
Topics: Adult; Aged; Female; Fetus; Humans; Infant, Newborn; Male; Middle Aged; Placenta; Pregnancy; Pregnenolone; Steroids; Umbilical Arteries; Umbilical Veins | 1999 |
Development of an enzyme immunoassay for serum 16-dehydropregnenolone.
Topics: Adult; Alkaline Phosphatase; Antibody Specificity; Chromatography, High Pressure Liquid; Female; Fetal Blood; Gas Chromatography-Mass Spectrometry; Humans; Immunoenzyme Techniques; Infant, Newborn; Pregnancy; Pregnenolone; Serum Albumin, Bovine | 2001 |
HPLC-UV method development and validation for 16-dehydropregnenolone, a novel oral hypolipidaemic agent, in rat biological matrices for application to pharmacokinetic studies.
Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Extracellular Matrix; Hypolipidemic Agents; Male; Pregnenolone; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 2003 |
Synthesis of some new steroidal [16alpha,17alpha-d]-isoxazolines.
Topics: Anti-Inflammatory Agents; Chloramines; Ethanol; Heterocyclic Compounds; Isoxazoles; Mass Spectrometry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oximes; Pregnanes; Pregnenolone; Steroids; Structure-Activity Relationship; Tosyl Compounds | 2005 |
A sensitive and selective HPLC/ESI-MS/MS assay for the simultaneous quantification of 16-dehydropregnenolone and its major metabolites in rabbit plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Pregnenolone; Rabbits; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2006 |
Cytotoxic constituents from Solanum lyratum.
Topics: Animals; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; HeLa Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Pregnenolone; Solanum | 2006 |
In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5alpha-reductase inhibitors.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Azasteroids; Cricetinae; Cricetulus; Dihydrotestosterone; Dutasteride; Enzyme Inhibitors; Finasteride; Humans; Male; Molecular Structure; Nandrolone; Pregnadienes; Pregnenolone; Prostate; Rats; Testosterone; Testosterone Congeners | 2008 |
Preclinical pharmacokinetics, dose proportionality, gender difference and protein binding study of 16-dehydropregnenolone, an antihyperlipidemic agent, in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Hypolipidemic Agents; Injections, Intravenous; Male; Pregnanolone; Pregnenolone; Protein Binding; Rats; Rats, Sprague-Dawley; Sex Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution | 2011 |
Aza-annulation on the 16-dehydropregnenolone, via tandem intermolecular aldol process and intramolecular Michael addition.
Topics: Aldehydes; Amines; Aza Compounds; Cyclization; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Pregnenolone | 2011 |
Activation of ATM-Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosis in HeLa cells.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Caspase 3; Caspase 9; Cell Cycle Proteins; Checkpoint Kinase 2; DNA-Binding Proteins; G1 Phase; HeLa Cells; Humans; Mitochondria; Molecular Structure; Pregnenolone; Protein Serine-Threonine Kinases; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2012 |
Bioanalytical LC-MS/MS method development and validation of novel antidiabetic candidate S007-1261 in rat plasma and its application to pharmacokinetic and oral bioavailability studies.
Topics: Administration, Oral; Animals; Biological Availability; Calibration; Half-Life; Hypoglycemic Agents; Injections, Intravenous; Male; Oximes; Pregnenes; Pregnenolone; Quality Control; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results | 2014 |
Pharmacokinetics and tissue distribution study of 16-dehydropregnenolone liposome in female mice after intravenous administration.
Topics: Administration, Intravenous; Animals; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Injections, Intravenous; Liposomes; Mice; Mice, Nude; Pharmaceutical Solutions; Pregnenolone; Tissue Distribution | 2016 |
Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5α-reductase and on cancer cell line SK-LU-1.
Topics: 5-alpha Reductase Inhibitors; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cholestenone 5 alpha-Reductase; Humans; Male; Mesocricetus; Neoplasms; Pregnenolone; Rats | 2015 |
Microwave-assisted stereoselective approach to novel steroidal ring D-fused 2-pyrazolines and an evaluation of their cell-growth inhibitory effects in vitro.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Hydrazines; Hydrazones; Microwaves; Pregnenolone; Stereoisomerism; Steroids | 2016 |
Evaluation of the impact of 16-dehydropregnenolone on the activity and expression of rat hepatic cytochrome P450 enzymes.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Dapsone; Dextromethorphan; Gene Expression Regulation; Hypolipidemic Agents; Liver; Male; Microsomes, Liver; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Tolbutamide | 2016 |
Pharmacokinetics of 16-dehydropregnenolone hydroxypropyl-β-cyclodextrin inclusion complex following peroral administration.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Oral; Animals; beta-Cyclodextrins; Biological Availability; Drug Carriers; Drug Liberation; Female; Mice; Pregnenolone; Rats; Rats, Sprague-Dawley; Solubility; Tissue Distribution | 2017 |
A study on the reaction of 16-dehydropregnenolone acetate with 2-aminobenzimidazole.
Topics: Benzimidazoles; Cyclization; Models, Molecular; Molecular Structure; Pregnenolone; Steroids | 2017 |
Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5α-reductase 2 and with cytotoxic activity in cancer cells.
Topics: 5-alpha Reductase Inhibitors; Animals; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line, Tumor; Cholestenone 5 alpha-Reductase; Humans; Mass Spectrometry; Mice; Pregnenolone; Proton Magnetic Resonance Spectroscopy; Rats | 2017 |
16-Dehydropregnenolone lowers serum cholesterol by up-regulation of CYP7A1 in hyperlipidemic male hamsters.
Topics: Animals; Bile Acids and Salts; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Cholesterol, LDL; Cricetinae; Feces; Hep G2 Cells; Humans; Hyperlipidemias; Liver X Receptors; Male; Mesocricetus; PPAR alpha; Pregnenolone; Time Factors; Triglycerides; Up-Regulation | 2017 |
Synthesis of 16α-amino-pregnenolone derivatives via ionic liquid-catalyzed aza-Michael addition and their evaluation as C
Topics: Animals; Catalysis; Chemistry Techniques, Synthetic; Enzyme Inhibitors; Ionic Liquids; Lyases; Models, Molecular; Molecular Conformation; Pregnenolone; Rats | 2017 |
Metabolic fate of pregnene-based steroids in the lactonization pathway of multifunctional strain Penicillium lanosocoeruleum.
Topics: Biotransformation; Catalysis; Epoxy Compounds; Lactones; Metabolic Networks and Pathways; Molecular Structure; Oxidation-Reduction; Penicillium; Pregnenes; Pregnenolone; Progesterone; Steroids | 2018 |