Page last updated: 2024-08-23

pregnanolone and valproic acid

pregnanolone has been researched along with valproic acid in 10 studies

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (80.00)	29.6817
2010's	1 (10.00)	24.3611
2020's	1 (10.00)	2.80

Authors

Authors	Studies
Strassburg, CP; Tukey, RH	1
Lombardo, F; Obach, RS; Waters, NJ	1
Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM	1
Reddy, DS; Rogawski, MA	2
Abou-Khalil, BW; Blum, D; Data, JL; Laxer, K; Lee, DA; Monaghan, EP; Morrell, MJ	1
Agis-Balboa, RC; Costa, E; Doueiri, MS; Guidotti, A; Pinna, G	1
Kilts, JD; Madison, RD; Manji, HK; Marx, CE; Shampine, LJ; Yuan, P	1
Balestri, P; Barlocco, EG; Casarosa, E; Grosso, S; Luisi, S; Matera, M; Mostardini, R; Petraglia, F	1
Higashi, T; Nakashima, K; Nakatake, Y; Okumura, A; Tabuchi, M; Tsuneoka, Y; Yamada, M; Yoshizawa, K	1

Reviews

2 review(s) available for pregnanolone and valproic acid

Article	Year
Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annual review of pharmacology and toxicology, 2000, Volume: 40 Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic	2000
Brain neurosteroids in gender-related aggression induced by social isolation. Critical reviews in neurobiology, 2004, Volume: 16, Issue:1-2 Topics: Aggression; Animals; Female; GABA Agents; Gonadal Steroid Hormones; Male; Methionine; Mice; Neurotransmitter Agents; Pregnanolone; Reelin Protein; Sex Characteristics; Social Isolation; Steroids; Valproic Acid	2004

Trials

1 trial(s) available for pregnanolone and valproic acid

Article	Year
Assessment of ganaxolone's anticonvulsant activity using a randomized, double-blind, presurgical trial design. Ganaxolone Presurgical Study Group. Epilepsia, 2000, Volume: 41, Issue:9 Topics: Adolescent; Adult; Anticonvulsants; Double-Blind Method; Female; Humans; Male; Middle Aged; Placebos; Pregnanolone; Treatment Outcome; Valproic Acid	2000

Other Studies

7 other study(ies) available for pregnanolone and valproic acid

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate. Neuropharmacology, 2000, Apr-27, Volume: 39, Issue:7 Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Seizures; Stereotypic Movement Disorder; Valproic Acid	2000
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3 Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid	2000
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. Epilepsia, 2001, Volume: 42, Issue:3 Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid	2001
Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. The international journal of neuropsychopharmacology, 2008, Volume: 11, Issue:4 Topics: Affect; Animals; Antimanic Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; DNA; Gas Chromatography-Mass Spectrometry; Genes, bcl-2; Lithium Chloride; Male; Mice; Mice, Knockout; Neuronal Plasticity; Prefrontal Cortex; Pregnanolone; Pregnenolone; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid	2008
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy. Neuroendocrinology, 2011, Volume: 93, Issue:3 Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Immunoassay; Leptin; Male; Obesity; Pregnanolone; Valproic Acid; Weight Gain	2011
Benzothiazepines, diltiazem and JTV-519, exert an anxiolytic-like effect via neurosteroid biosynthesis in mice. Journal of pharmacological sciences, 2020, Volume: 143, Issue:3 Topics: 5-alpha Reductase Inhibitors; Animals; Anti-Anxiety Agents; Behavior, Animal; Carbamazepine; Diltiazem; Dose-Response Relationship, Drug; Finasteride; Male; Mice, Inbred C57BL; Neurosteroids; Pregnanolone; Thiazepines; Valproic Acid	2020