pregnanolone has been researched along with pregnenolone in 179 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (8.38) | 18.7374 |
| 1990's | 48 (26.82) | 18.2507 |
| 2000's | 69 (38.55) | 29.6817 |
| 2010's | 34 (18.99) | 24.3611 |
| 2020's | 13 (7.26) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Bolstad, ES; Bridges, RJ; Carrigan, CN; Cox, HD; Gerdes, JM; Patel, SA; Smith, WE; Thompson, CM | 1 |
| Bell, JB | 1 |
| Schindler, AE; Wuchter, J | 1 |
| Mickan, H; Zander, J | 3 |
| Chen, GT; Gant, NF; MacDonald, PC; Milewich, L; Schwarz, BE | 1 |
| Laumas, KR; Verma, U | 1 |
| Barnard, EA; Darlison, MG; Harvey, RJ; Shingai, R; Zaman, SH | 1 |
| Allen, PM; Melchior, CL | 1 |
| Majewska, MD; Vaupel, DB | 1 |
| Liu, ZH; Wu, JT | 1 |
| Hawkins, RA; Kelly, RW; Miller, WR; Scott, WN | 1 |
| Canario, AV; Scott, AP | 1 |
| Kohara, H; Shimizu, K; Yamaga, N | 1 |
| Duleba, AJ; Kim, KS; Moon, YS; Yuen, BH | 1 |
| Birmingham, MK; De Nicola, AF; Holzbauer, M; Oliver, JT | 1 |
| Eechaute, W; Vandekerckhove, D; Vanluchene, E | 1 |
| Isobe, M; Kanai, M; Ozawa, N; Watabe, T | 1 |
| Albert, DH; Lieberman, S; Ponticorvo, L | 1 |
| Dartois, E; Fillion, G; Haour, F; Moyse, E; Vincens, M | 1 |
| Baulieu, EE; Mahé, V; Monnet, FP; Robel, P | 1 |
| Moore, FL; Murray, TF; Orchinik, M | 1 |
| Costa, E; Ducić, I; Puia, G; Vicini, S | 1 |
| Holsboer, F; Parlow, F; Vedder, H; Zieglgänsberger, W | 1 |
| Baulieu, EE; Cherkaoui, J; Dellu, F; Le Moal, M; Mayo, W; Robel, P; Simon, H | 1 |
| Cheney, DL; Guidotti, A; Uzunov, D | 1 |
| Devaud, LL; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Hauser, CA; Holsboer, F; Rupprecht, R; Wetzel, CH | 1 |
| Chavatte, PM; Rossdale, PD; Tait, AD | 1 |
| Holtan, DW; Schutzer, WE | 1 |
| Bãckström, T; Purdy, RH; Seippel, L; Wang, M | 1 |
| Anderson, WR; Bodor, N; Brewster, ME; Huang, MJ; Loftsson, T; Pop, E | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Bondoux, D; Chapouthier, G; Clément, Y; Launay, JM; Martin, B; Robel, P; Venault, P; Young, J | 1 |
| Baulieu, EE; Corpéchot, C; Eychenne, B; Haug, M; Perché, F; Robel, P; Young, J | 1 |
| Holtan, DW; Kerby, JL; Schutzer, WE | 1 |
| Bäckström, T; Wahlström, G; Wang, MD | 1 |
| Bäckström, T; Landgren, S; Wang, MD | 1 |
| Gillies, GE; Murray, HE | 1 |
| Feltz, P; Poisbeau, P; Schlichter, R | 1 |
| Gower, DB; Kraevskaya, MA; Kwan, TK; Makin, HL; Trafford, DJ | 1 |
| Carter, RB; Edgar, DM; Field, G; Gee, KW; Hawkinson, JE; Lan, NC; Seidel, WF; Wieland, S; Wood, PL; Xia, H | 1 |
| Kulkarni, SK; Reddy, DS | 2 |
| Farb, DH; Gibbs, TT; Malayev, AA; Park-Chung, M; Purdy, RH; Wu, FS | 1 |
| Akwa, Y; Baulieu, EE; El-Etr, M; Robel, P | 1 |
| Fry, J; Honour, J | 1 |
| Lübbert, H | 1 |
| Covey, DF; Nilsson, KR; Zorumski, CF | 1 |
| di Michele, F; Hermann, B; Holsboer, F; Pasini, A; Romeo, E; Rupprecht, R; Spalletta, G; Ströhle, A | 1 |
| Arancibia, S; Belmar, J; Cuellar, C; Kusch, C; Llona, I; Pérez, H; Pinter, A; Tapia-Arancibia, L | 1 |
| Wang, L; Wang, Q; Wardwell-Swanson, J | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Budziszewska, B; Coenen, AM; Lasoń, W; Leśkiewicz, M; Van Luijtelaar, G | 1 |
| Farb, DH; Gibbs, TT; Malayev, A; Park-Chung, M; Purdy, RH | 1 |
| Bouyer, JJ; Darnaudéry, M; Le Moal, M; Mayo, W; Pallarés, M | 1 |
| Holsboer, F; Rupprecht, R | 1 |
| Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H | 1 |
| Carter, RB; Edgar, DM; Fick, DB; Gee, KW; Hogenkamp, DJ; Lan, NC; Seidel, WF; Vanover, KE | 1 |
| Baumann, N; Eychenne, B; Lachapelle, F; Le Goascogne, C; Robel, P; Tonon, MC | 1 |
| Akwa, Y; Britton, KT; Koob, GF; Purdy, RH | 1 |
| Baulieu, E; Blair-West, J; Denton, D; Eychenne, B; Ladurelle, N; Robel, P; Schumacher, M | 1 |
| Biggio, G; Concas, A; Porcu, P; Purdy, RH; Serra, M; Sogliano, C | 1 |
| Biggio, G; Littera, M; Papi, G; Pisu, MG; Purdy, RH; Sanna, E; Serra, M; Tuveri, F; Usala, L | 1 |
| Beekman, M; Carter, RB; Dijkstra, D; Gasior, M; Ungard, JT; Witkin, JM | 1 |
| Barbaccia, ML; Foddi, C; Ghezzi, P; Mennini, T; Sacco, S; Santo, ED | 1 |
| Bicíková, M; Hill, M; Stárka, L; Számel, I; Tallová, J | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Barbosa, AD; Morato, GS | 2 |
| Jhangri, GS; Le Mellédo, JM; Semeniuk, T | 1 |
| Bicíková, M; Hill, M; Putz, Z; Tallová, J; Tomandl, J; Vañuga, A | 1 |
| Peeke, HV; Snyder, MJ | 1 |
| Simmonds, MA; Sooksawate, T | 1 |
| Bertram, EH; Kapur, J; Mtchedlishvili, Z | 1 |
| Covey, DF; Heinrichs, SC; Koob, GF; Purdy, RH; Shen, W; Vallée, M; Zorumski, CF | 1 |
| Farb, DH; Gibbs, TT; Malayev, A | 1 |
| Biggio, F; Biggio, G; Cinus, M; Concas, A; Follesa, P; Mancuso, L; Mostallino, MC; Paoletti, AM; Porcu, P; Purdy, RH; Sogliano, C | 1 |
| Bicíková, M; Calda, P; Hampl, R; Hill, M; Klak, J; Zizka, Z | 1 |
| Heydari, B; Le Mellédo, JM | 1 |
| Akwa, Y; Baulieu, EE; David, JP; Delacourte, A; Eychenne, B; Liere, P; Pianos, A; Sazdovitch, V; Schumacher, M; Weill-Engerer, S | 1 |
| Billiards, SS; Canny, BJ; Hirst, JJ; Walker, DW | 1 |
| Cascio, C; De Leo, G; Guarneri, M; Guarneri, P; Guarneri, R; Piccoli, F; Russo, D | 1 |
| Pearson Murphy, BE | 1 |
| Harrison, MB; Kapur, J; Mtchedlishvili, Z; Sun, CS | 1 |
| Anzini, M; Biggio, G; Cappelli, A; Concas, A; Donati, A; Fresta, M; Gallelli, A; Giuliani, G; Maciocco, E; Pericot Mohr, Gl; Porcu, P; Vomero, S | 1 |
| Auchus, RJ; Flück, CE; Miller, WL | 1 |
| CREPY, O; JAYLE, MF; LACHESE, B | 1 |
| Alomary, AA; Fitzgerald, RL; Koob, GF; O'Dell, LE; Purdy, RH; Vallée, M | 1 |
| Bicíková, M; Budesínský, M; Cerný, I; Hampl, R; Hill, M; Pouzar, V | 1 |
| Boyd, SK; Goetz, FW; Hollis, DM; Roberts, SB | 1 |
| Biggio, G; Brambilla, F; Gerra, G; Pisu, MG; Purdy, RH; Serra, M; Zaimovich, A | 1 |
| Bernardi, F; Casarosa, E; Genazzani, AR; Liut, M; Lombardi, I; Luisi, S; Monteleone, P; Palumbo, M; Petraglia, F; Quirici, B | 1 |
| Gong, W; Griffin, LD; Mellon, SH; Verot, L | 1 |
| Hirst, JJ; Nguyen, PN; Ross Young, I; Walker, DW | 1 |
| Castillo-Melendez, M; Hirst, JJ; Nguyen, PN; Walker, DW; Yan, EB | 1 |
| Akwa, Y; Caldeira, JC; Engen, JR; Li, PK; Mameli, M; Purdy, RH; Savage, DD; Valenzuela, CF; Wu, Y | 1 |
| Bäckström, T; Haage, D; Johansson, S | 1 |
| Holtan, DW; Stormshak, F; Waite, AL | 1 |
| Cerný, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Popov, P; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Martín-García, E; Pallarès, M | 3 |
| Biggio, G; Brundu, A; Concas, A; Marra, C; Porcu, P; Sogliano, C | 1 |
| Frändberg, PA; Johansson, T; Le Grevès, P; Nyberg, F | 1 |
| Gilbert Evans, SE; Purdy, RH; Romach, MK; Ross, LE; Sellers, EM | 1 |
| Cambourg, A; De Nicola, AF; Eychenne, B; Gonzalez, S; Guennoun, R; Labombarda, F; Liere, P; Pianos, A; Schumacher, M | 1 |
| George, O; Le Moal, M; Mayo, W; Vallée, M | 1 |
| Hou, YN; Wang, N; Wu, HH | 1 |
| Ahboucha, S; Butterworth, RF; Mamer, O; Pomier-Layrargues, G | 1 |
| Citraro, R; De Sarro, G; Di Paola, ED; Gratteri, S; Ibbadu, GF; Marra, R; Russo, E | 1 |
| Cerny, I; Havlíková, H; Hill, M; Kancheva, L; Kancheva, R; Pouzar, V; Stárka, L; Vrbíková, J | 1 |
| Bradford, DW; Butterfield, MI; Grobin, AC; Khisti, RT; Lieberman, JA; Madison, RD; Marx, CE; Massing, MW; Morrow, AL; Shampine, LJ; Trost, WT | 1 |
| Blazer, DG; Butterfield, MI; Ervin, JF; Hulette, CM; Lieberman, JA; Marx, CE; Massing, MW; Shampine, LJ; Steffens, DC; Stevens, RD; Trost, WT | 1 |
| Akk, G; Evers, AS; Li, P; Manion, BD; Steinbach, JH | 1 |
| Gentile, L; Hall, A; Hall, J; Knight, L; Morgan, A; Stoll, L; Van Buren, N; Van Deusen, H; Zuger, S | 1 |
| Darbra, S; Martin-García, E; Pallarès, M | 2 |
| Hamann, M; Richter, A; Richter, F | 1 |
| Mellon, SH | 1 |
| Bishnoi, M; Chopra, K; Kulkarni, SK | 1 |
| Basta-Kaim, A; Budziszewska, B; Jagla, G; Jantas, D; Jaworska-Feil, L; Kubera, M; Lason, W; Leskiewicz, M; Nowak, W; Regulska, M | 1 |
| Kilts, JD; Madison, RD; Manji, HK; Marx, CE; Shampine, LJ; Yuan, P | 1 |
| Biggio, G; Concas, A; Marotto, MF; Marra, C; Marrosu, F; Melis, GB; Orrù, M; Paoletti, AM; Sogliano, C; Tuveri, A; Zedda, P | 1 |
| Ahboucha, S; Baker, GB; Butterworth, RF; Chatauret, N; Jiang, W; Mamer, O | 1 |
| Elfverson, M; Johansson, T; Le Grevès, P; Linde, AM; Nyberg, F; Zhou, Q | 1 |
| Akk, G; Bracamontes, J; Covey, DF; Li, P; Reichert, DE; Steinbach, JH | 1 |
| Budziszewska, B; Jantas, D; Lason, W; Leskiewicz, M | 1 |
| Bradford, DW; Buchanan, RW; Dunn, L; Hamer, RM; Keefe, RS; Kilts, JD; Leimone, LA; Lieberman, JA; Marx, CE; Morrow, AL; Naylor, JC; Payne, VM; Porcu, P; Savitz, AJ; Shampine, LJ; Strauss, JL | 1 |
| Boyd, KN; Kumar, S; Morrow, AL; O'Buckley, TK; Porcu, P | 1 |
| Alward, SE; de Wit, H; Grant, KA; Leslie Morrow, A; O'Buckley, TK; Porcu, P; Song, SC | 1 |
| Elfverson, M; Johansson, T; Nyberg, F; Zhou, Q | 1 |
| Darbra, S; Pallarès, M | 1 |
| Besheer, J; Hodge, CW; Lindsay, TG; Morrow, AL; O'Buckley, TK | 1 |
| Gupta, RC; Singh, SK; Suryawanshi, S | 1 |
| Elfverson, M; Johansson, T; Le Grevès, P; Nyberg, F; Zhou, Q | 1 |
| Darbra, S; Mòdol, L; Pallarès, M | 2 |
| Agustí, A; Cauli, O; Felipo, V; González-Usano, A | 1 |
| Bartle, E; Borkowski, B; Cameron, K; Fanelli, D; Gentile, L; Kahlson, M; Kangala, M; Kim, J; Pham, M; Pollard, B; Rhoads, S; Roark, R; Rocha, M | 1 |
| Darbra, S; Modol, L; Pallarès, M; Vallée, M | 1 |
| Ho, SS; King, AP; Liberzon, I; Marx, CE; Rampton, JC; Sripada, RK | 1 |
| Gao, H; Qiao, MQ; Xia, T | 1 |
| Deligiannidis, KM; Frederick, B; Kopoyan, A; Kosma, CA; Moore, CM; Rothschild, AJ; Shaffer, SA; Sikoglu, EM; Svenson, AE | 1 |
| Lucchi, C; Pinetti, D; Puia, G; Ravazzini, F; Rustichelli, C | 1 |
| Brown, ES; Davila, D; Gardner, C; Holmes, T; Hynan, LS; Lo, A; Marx, CE; Nakamura, A; Park, J; Sunderajan, P | 1 |
| Allen, TB; Bradford, DW; Brancu, M; Brunca, M; Hamer, RM; Kilts, JD; Marx, CE; Naylor, JC; Shampine, LJ; Strauss, JL; Szabo, ST; Youssef, NA | 1 |
| Dury, AY; Gonthier, R; Isabelle, M; Ke, Y; Labrie, F; Simard, JN | 1 |
| Ben Dor, R; Marx, CE; Rubinow, DR; Schmidt, PJ; Shampine, LJ | 1 |
| Cintron, D; Khine, KK; Koziol, DE; Martinez, PE; Morrow, AL; Nieman, LK; Rubinow, DR; Schiller, CE; Schmidt, PJ; Thompson, KD | 1 |
| Ball, BA; Berger, T; Conley, AJ; Legacki, EL; Scholtz, EL; Stanley, SD | 1 |
| Chung, BC; Weng, JH | 1 |
| Bues, B; Calignano, A; Carotenuto, A; Cerillo, I; Mangone, G; Orefice, G; Orefice, N; Rehm, R; Saccà, F | 1 |
| Gonthier, R; Ke, Y; Labrie, F | 1 |
| Bertini, ES; Biagini, G; Cusmai, R; Gecz, J; Giannone, G; Lucchi, C; Rustichelli, C; Specchio, N; Terracciano, A; Trivisano, M; Ubertini, GM; Vigevano, F | 1 |
| Brown, ES; Filbey, F; Marx, CE; Mason, BL; Nakamura, A; Park, J; Sunderajan, P; Van Enkevort, E | 1 |
| Cai, H; Dougherty, GG; Haas, GL; Keshavan, M; Montrose, DM; Reddy, RD; Yao, JK; Zhou, X | 1 |
| Baulieu, EE; Froger, N; Lanfumey, L; Schverer, M; Villey, I | 1 |
| Bedin, R; Biagini, G; Giovannini, G; Lucchi, C; Meletti, S; Monti, G; Rustichelli, C; Trenti, T | 1 |
| Brunton, PJ; Gill, AC; Sze, Y | 1 |
| Aurelian, L; Balan, I; Beattie, MC; Morrow, AL; O'Buckley, TK | 1 |
| Tomaselli, G; Vallée, M | 1 |
| Allen, TB; Cuffe, BT; Dunn, CE; Kilts, JD; Marx, CE; Naylor, JC; O'Loughlin, SH; Parke, GJ; Shampine, LJ; Smith, KD; Szabo, ST; Telford-Marx, EG; Wagner, HR | 1 |
| Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y | 1 |
| Akk, G; Evers, AS; Germann, AL; Pierce, SR; Steinbach, JH; Sugasawa, Y | 1 |
| Biagini, G; Costa, AM; Lucchi, C; Messina, S; Rustichelli, C; Senn, L | 1 |
| Avallone, R; Biagini, G; Codeluppi, A; Filaferro, M; Lucchi, C; Puja, G; Rustichelli, C; Vitale, G | 1 |
| Pinna, G | 1 |
| Aurelian, L; Balan, I; Boero, G; Morrow, AL; O'Buckley, T; Schleicher, R | 1 |
| Baraldi, C; Bellei, E; Bergamini, S; Ferrari, A; Lo Castro, F; Monari, E; Rustichelli, C; Tomasi, A | 1 |
| Ackerman, MG; Blakemore, JK; Jacobson, MH; Kannan, K; Liu, M; Long, SE; Pinna, G; Romay-Tallon, R; Stein, CR; Trasande, L; Zhu, H | 1 |
| Lin, YC; Papadopoulos, V | 1 |
| Caruso, D; Cioffi, L; Cotter, PD; Crispie, F; Diviccaro, S; Falvo, E; FitzGerald, JA; Giatti, S; Melcangi, RC; O'Mahony, SM | 1 |
| Caruso, D; Cioffi, L; Diviccaro, S; Falvo, E; Giatti, S; Herian, M; Melcangi, RC | 1 |
| Brivio, P; Calabrese, F; Caruso, D; Cioffi, L; Diviccaro, S; Falvo, E; Giatti, S; Herian, M; Melcangi, RC; Piazza, R | 1 |
10 review(s) available for pregnanolone and pregnenolone
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Studies on steroids in urine of the male newborn.
Topics: 17-alpha-Hydroxypregnenolone; Androstanes; Arylsulfatases; Dehydroepiandrosterone; Glucuronidase; Humans; Hydrolysis; Hydroxyprogesterones; Infant, Newborn; Male; Pregnanediol; Pregnanes; Pregnanolone; Pregnenolone; Progesterone | 1975 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Male; Menstruation; Pregnancy; Pregnanolone; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1995 |
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.
Topics: Dehydroepiandrosterone; Desoxycorticosterone; Estradiol; Humans; Neuroprotective Agents; Neurosecretory Systems; Pregnanolone; Pregnenolone; Progesterone; Steroids | 1999 |
Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes.
Topics: Acetylcholine; Aging; Animals; Brain Stem; Dehydroepiandrosterone Sulfate; Humans; Memory; Memory Disorders; Pregnanolone; Pregnenolone; Prosencephalon; Sleep; Sleep Wake Disorders | 2006 |
Neurosteroid regulation of central nervous system development.
Topics: Animals; Central Nervous System; Dehydroepiandrosterone; Humans; Pregnanolone; Pregnenolone; Progesterone; Steroids; Synaptic Transmission | 2007 |
Nongenomic actions of neurosteroid pregnenolone and its metabolites.
Topics: 17-alpha-Hydroxypregnenolone; Animals; Depression; Humans; Microtubules; Neurodegenerative Diseases; Neurotransmitter Agents; Pregnanolone; Pregnenolone | 2016 |
Neurosteroids: non-genomic pathways in neuroplasticity and involvement in neurological diseases.
Topics: Animals; Dehydroepiandrosterone; Humans; Nervous System Diseases; Neurogenesis; Neuronal Plasticity; Neurotransmitter Agents; Pregnanolone; Pregnenolone | 2018 |
Stress and drug abuse-related disorders: The promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway.
Topics: Alcoholism; Animals; Marijuana Use; Neurosteroids; Pregnanolone; Pregnenolone; Progesterone; Signal Transduction; Stress, Psychological | 2019 |
Neurosteroidogenic enzymes: CYP11A1 in the central nervous system.
Topics: Animals; Brain; Central Nervous System; Cholesterol Side-Chain Cleavage Enzyme; Female; Humans; Pregnanolone; Pregnenolone | 2021 |
8 trial(s) available for pregnanolone and pregnenolone
| Article | Year |
|---|---|
Effects of antidepressant treatment on neuroactive steroids in major depression.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Female; Fluoxetine; Follow-Up Studies; Hospitalization; Humans; Male; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Receptors, GABA; Steroids; Treatment Outcome | 1998 |
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Topics: Adult; Aged; Brain; Brain Chemistry; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Placebos; Pregnanolone; Pregnenolone; Schizophrenia; Treatment Outcome; Up-Regulation | 2009 |
Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits.
Topics: Administration, Oral; Adolescent; Adult; Attention; Brain; Brain Mapping; Case-Control Studies; Emotions; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Oxygen; Pattern Recognition, Visual; Photic Stimulation; Pregnanolone; Pregnenolone; Reaction Time; Time Factors; Young Adult | 2013 |
A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Bipolar Disorder; Double-Blind Method; Female; Humans; Male; Middle Aged; Pregnanolone; Pregnenolone; Psychiatric Status Rating Scales; Treatment Outcome; Young Adult | 2014 |
DHEA metabolism to the neurosteroid androsterone: a possible mechanism of DHEA's antidepressant action.
Topics: Androsterone; Antidepressive Agents; Cross-Over Studies; Dehydroepiandrosterone; Depressive Disorder; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Sex Factors; Treatment Outcome | 2015 |
5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder.
Topics: 5-alpha Reductase Inhibitors; Adult; Androsterone; Cholestenone 5 alpha-Reductase; Double-Blind Method; Dutasteride; Female; Humans; Luteal Phase; Middle Aged; Pregnanolone; Pregnenolone; Premenstrual Dysphoric Disorder; Severity of Illness Index; Single-Blind Method | 2016 |
Neurosteroid Levels in Patients With Bipolar Disorder and a History of Cannabis Use Disorders.
Topics: Adult; Androsterone; Bipolar Disorder; Depressive Disorder, Major; Diagnosis, Dual (Psychiatry); Female; Humans; Male; Marijuana Abuse; Middle Aged; Pregnanolone; Pregnenolone | 2017 |
Effect of Pregnenolone vs Placebo on Self-reported Chronic Low Back Pain Among US Military Veterans: A Randomized Clinical Trial.
Topics: Adult; Afghan Campaign 2001-; Chronic Pain; Double-Blind Method; Female; Gas Chromatography-Mass Spectrometry; Humans; Iraq War, 2003-2011; Least-Squares Analysis; Low Back Pain; Male; Middle Aged; Pain Measurement; Pregnanolone; Pregnenolone; Self Report; Tandem Mass Spectrometry; United States; Veterans | 2020 |
161 other study(ies) available for pregnanolone and pregnenolone
| Article | Year |
|---|---|
The development of benzo- and naphtho-fused quinoline-2,4-dicarboxylic acids as vesicular glutamate transporter (VGLUT) inhibitors reveals a possible role for neuroactive steroids.
Topics: Binding, Competitive; Cyclization; Dicarboxylic Acids; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Naphthols; Neurotransmitter Agents; Pregnanolone; Quinolines; Reference Standards; Vesicular Glutamate Transport Proteins | 2014 |
Studies of in vitro steroid metabolism by testis tissue from 'complete' and 'incomplete' forms of testicular feminization.
Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Adult; Androgen-Insensitivity Syndrome; Androstane-3,17-diol; Androstenediols; Androstenedione; Dehydroepiandrosterone; Humans; Hydroxyprogesterones; In Vitro Techniques; Kinetics; Male; Pregnanolone; Pregnenolone; Progesterone; Testis; Testosterone | 1975 |
Pregnanolones and pregnenolone in human myometrium at term of pregnancy.
Topics: Chromatography, Gas; Chromatography, Gel; Female; Humans; Myometrium; Pregnancy; Pregnancy Trimester, Third; Pregnanes; Pregnanolone; Pregnenolone; Stereoisomerism; Uterus | 1979 |
Pregnanolones, pregnenolone and progesterone in the human feto-placental circulation at term of pregnancy.
Topics: Chromatography, Gas; Female; Fetal Blood; Humans; Hydroxysteroids; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy Trimester, Third; Pregnanes; Pregnanolone; Pregnenolone; Progesterone | 1979 |
Pregnanolones, pregnenolone and progesterone in the human fetal tissues of early and midtrimester pregnancy.
Topics: Female; Fetus; Humans; Hydroxysteroids; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnanes; Pregnanolone; Pregnenolone; Progesterone; Tissue Distribution | 1979 |
Initiation of human parturition. VIII. Metabolism of progesterone by fetal membranes of early and late human gestation.
Topics: Extraembryonic Membranes; Female; Gestational Age; Humans; Labor Onset; Pregnancy; Pregnanediol; Pregnanolone; Pregnenolone; Progesterone | 1977 |
Effect of oestradiol-17beta and progesterone on the metabolism of [1,2(-3)H] progesterone by the rabbit endometrium and myometrium.
Topics: Animals; Endometrium; Estradiol; Female; In Vitro Techniques; Myometrium; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Rabbits; Subcellular Fractions; Time Factors; Uterus | 1976 |
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.
Topics: Animals; Base Sequence; DNA; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Molecular Sequence Data; Oocytes; Polymerase Chain Reaction; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1992 |
Interaction of pregnanolone and pregnenolone sulfate with ethanol and pentobarbital.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pentobarbital; Pregnanolone; Pregnenolone; Seizures; Sleep; Time Factors | 1992 |
Steroid control of uterine motility via gamma-aminobutyric acidA receptors in the rabbit: a novel mechanism?
Topics: Animals; Female; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Progesterone; Progestins; Rabbits; Receptors, GABA-A; Stimulation, Chemical; Uterine Contraction | 1991 |
Conversion of pregnenolone to progesterone by mouse morulae and blastocysts.
Topics: 5-alpha-Dihydroprogesterone; Animals; Blastocyst; Cleavage Stage, Ovum; Female; Mice; Mice, Inbred Strains; Morula; Pregnancy; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone | 1990 |
Steroid hormones in breast cyst fluids.
Topics: Androgens; Chromatography, Gas; Exudates and Transudates; Female; Fibrocystic Breast Disease; Gas Chromatography-Mass Spectrometry; Humans; Pregnanes; Pregnanolone; Pregnenolone; Radioimmunoassay | 1990 |
Synthesis of 20 alpha-hydroxylated steroids by ovaries of the dab (Limanda limanda).
Topics: 17-alpha-Hydroxyprogesterone; 20-Hydroxysteroid Dehydrogenases; Animals; Female; Fishes; Hydroxyprogesterones; Male; Ovary; Pregnanes; Pregnanetriol; Pregnanolone; Pregnenolone; Radioimmunoassay | 1989 |
Conversion of 5 alpha-pregnane-3,20-dione, 3 alpha-hydroxy-5 alpha-pregnan-20-one and 3 beta-hydroxy-5 alpha-pregnan-20-one to delta 16-C19 steroids by the reconstituted delta 16-C19-steroid synthetase system.
Topics: 5-alpha-Dihydroprogesterone; Androstadienes; Animals; Male; Microsomes; Oxidoreductases; Pregnanediones; Pregnanes; Pregnanolone; Pregnenolone; Progesterone; Steroid 17-alpha-Hydroxylase; Steroids; Substrate Specificity; Swine; Testis | 1989 |
Alterations of 20 alpha-hydroxysteroid dehydrogenase activity in cultured rat granulosa cells by follicle-stimulating hormone and testosterone.
Topics: 20-alpha-Dihydroprogesterone; 20-alpha-Hydroxysteroid Dehydrogenase; 20-Hydroxysteroid Dehydrogenases; Animals; Cells, Cultured; Cyanoketone; Dose-Response Relationship, Drug; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Pregnanediol; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Stereoisomerism; Testosterone | 1985 |
In vivo secretion of 3 alpha-hydroxy-5 alpha-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat.
Topics: Adrenal Glands; Animals; Desoxycorticosterone; Female; Kinetics; Pregnanes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains | 1985 |
Conversion of free 3 beta-hydroxy-5-ene-steroids by incubation with Helix pomatia.
Topics: 17-alpha-Hydroxypregnenolone; Animals; Chromatography, Gas; Helix, Snails; Hydroxycorticosteroids; Pregnanolone; Pregnenolone | 1982 |
Hepatic microsomal conversion of pregnenolone to 3 beta,5,6 beta-trihydroxy-5 alpha-pregnan-20-one via pregnenolone alpha- and beta-epoxides.
Topics: Animals; Cattle; Cholesterol; Chromatography, High Pressure Liquid; Epoxide Hydrolases; Gas Chromatography-Mass Spectrometry; Lipid Peroxides; Microsomes, Liver; Pregnanes; Pregnanetriol; Pregnanolone; Pregnenolone; Structure-Activity Relationship | 1980 |
Identification of fatty acid esters of pregnenolone and allopregnanolone from bovine corpora lutea.
Topics: Animals; Cattle; Chromatography, Gas; Corpus Luteum; Female; Isomerism; Lipids; Mass Spectrometry; Pregnanes; Pregnanolone; Pregnenolone | 1980 |
An autoradiographic study comparing the interactions of 3 alpha-OH-5 alpha-pregnan-20-one, pregnenolone sulfate and pentobarbital with [3S]-TBPS binding sites and their modulation by GABA in different structures of the rat brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mesencephalon; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Female; Guanidines; Haloperidol; Hippocampus; Kinetics; N-Methylaspartate; Norepinephrine; Ovariectomy; Pertussis Toxin; Piperazines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Stereotaxic Techniques; Virulence Factors, Bordetella | 1995 |
Steroid modulation of GABAA receptors in an amphibian brain.
Topics: Animals; Autoradiography; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chlorides; Convulsants; Corticosterone; Flunitrazepam; Kinetics; Male; Mammals; Neurons; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Salamandridae; Species Specificity; Steroids; Sulfur Radioisotopes; Synaptosomes; Tritium | 1994 |
Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?
Topics: Allosteric Regulation; Animals; Cell Line; Cells, Cultured; Cerebral Cortex; Chlorides; Electrophysiology; Humans; Pregnanolone; Pregnenolone; Protein Conformation; Rats; Receptors, GABA-A; Recombinant Proteins | 1993 |
Neurosteroids do not regulate proopiomelanocortin-gene expression in pituitary cells.
Topics: Animals; Blotting, Northern; Brain Chemistry; Cells, Cultured; Corticosterone; Dehydroepiandrosterone; Gene Expression; Mice; Pituitary Gland; Pregnanolone; Pregnenolone; Pro-Opiomelanocortin; RNA, Messenger; Steroids | 1993 |
Infusion of neurosteroids into the nucleus basalis magnocellularis affects cognitive processes in the rat.
Topics: Animals; Basal Ganglia; Cognition; Conditioning, Operant; Exploratory Behavior; GABA-A Receptor Antagonists; Injections; Male; Memory; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 1993 |
Pregnenolone sulfate antagonizes dizocilpine amnesia: role for allopregnanolone.
Topics: Amnesia; Animals; Anti-Anxiety Agents; Brain; Cognition; Dizocilpine Maleate; Dose-Response Relationship, Drug; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Reaction Time | 1995 |
Sex steroids and memory.
Topics: Animals; Clinical Trials as Topic; GABA Modulators; Gonadal Steroid Hormones; Humans; Memory; Pregnanolone; Pregnenolone; Progesterone; Steroids | 1995 |
Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.
Topics: Animals; Anti-Anxiety Agents; Cell Line; Cell Membrane; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypothalamus; Kinetics; Membrane Potentials; Molecular Sequence Data; Muscimol; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1996 |
Modulation of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) activity in the equine placenta by pregnenolone and progesterone metabolites.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Dose-Response Relationship, Drug; Female; Horses; Placenta; Pregnancy; Pregnanediol; Pregnanes; Pregnanolone; Pregnenes; Pregnenolone; Progesterone | 1995 |
Steroid transformations in pregnant mares: metabolism of exogenous progestins and unusual metabolic activity in vivo and in vitro.
Topics: 5-alpha-Dihydroprogesterone; Animals; Biotransformation; Deuterium; Endometrium; Female; Horses; In Vitro Techniques; Infusions, Intravenous; Liver; Organ Specificity; Pharmaceutical Vehicles; Placenta; Pregnancy; Pregnancy, Animal; Pregnanediones; Pregnanolone; Pregnenolone; Progestins | 1996 |
Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one.
Topics: 5-alpha-Dihydroprogesterone; Adult; Female; Hormones; Humans; Luteal Phase; Menstrual Cycle; Osmolar Concentration; Pregnanediones; Pregnanolone; Pregnenolone; Premenstrual Syndrome | 1996 |
Preparation, characterization, and anesthetic properties of 2-hydroxypropyl-beta-cyclodextrin complexes of pregnanolone and pregnenolone in rat and mouse.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Oral; Anesthetics; Animals; beta-Cyclodextrins; Chemistry, Pharmaceutical; Cyclodextrins; Female; Male; Mice; Mice, Inbred ICR; Pharmaceutical Vehicles; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Solubility | 1995 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
A mouse mutant strain highly resistant to methyl beta-carboline-3-carboxylate-induced seizures.
Topics: Animals; Brain Chemistry; Carbolines; Convulsants; Drug Resistance; Evaluation Studies as Topic; Female; Male; Mice; Mice, Mutant Strains; Pentylenetetrazole; Pregnanolone; Pregnenolone; Radioligand Assay; Receptors, GABA-A; Seizures | 1996 |
Neurosteroids in the mouse brain: behavioral and pharmacological effects of a 3 beta-hydroxysteroid dehydrogenase inhibitor.
Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Brain; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Female; Humans; Mice; Pregnanolone; Pregnenolone; Progesterone; Sexual Behavior, Animal | 1996 |
Differential effect of trilostane on the progestin milieu in the pregnant mare.
Topics: 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Animals; Dihydrotestosterone; Female; Horses; Male; Placenta; Pregnancy; Pregnancy, Animal; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Progestins | 1996 |
Pregnenolone sulphate and pregnenolone do not interact with 5 beta-pregnanolone- and hexobarbitone-induced anaesthesia in the rat.
Topics: Albumins; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Hexobarbital; Male; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley | 1997 |
The effects of allopregnanolone, pregnenolone sulphate and pregnenolone on the CA1 population spike of the rat hippocampus after 17 beta-oestradiol priming.
Topics: Animals; Estradiol; Evoked Potentials; GABA Modulators; Male; Pregnanolone; Pregnenolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1997 |
Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures.
Topics: Animals; Bicuculline; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dopamine; Drug Synergism; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Pregnanolone; Pregnenolone; Rats; Somatostatin | 1997 |
Modulation of GABAA receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model.
Topics: Animals; Animals, Newborn; Cells, Cultured; Electrophysiology; Female; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypothalamo-Hypophyseal System; Membrane Potentials; Pentobarbital; Pregnancy; Pregnanes; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
Use of gas chromatographic-mass spectrometric techniques in studies of androst-16-ene and androgen biosynthesis in human testis; cytosolic specific binding of 5alpha-androst-16-en-3-one.
Topics: 5-alpha-Dihydroprogesterone; Adult; Aged; Androgens; Androstenes; Androstenols; Chromatography, Gas; Cytosol; Humans; Male; Mass Spectrometry; Middle Aged; Pregnanediones; Pregnanolone; Pregnenolone; Testis; Testosterone | 1997 |
CCD-3693: an orally bioavailable analog of the endogenous neuroactive steroid, pregnanolone, demonstrates potent sedative hypnotic actions in the rat.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Body Temperature; Hypnotics and Sedatives; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sleep | 1997 |
Chronic neurosteroid treatment prevents the development of morphine tolerance and attenuates abstinence behavior in mice.
Topics: Analgesics, Opioid; Animals; Dehydroepiandrosterone; Drug Tolerance; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pregnanolone; Pregnenolone; Reaction Time; Steroids; Substance Withdrawal Syndrome | 1997 |
Distinct sites for inverse modulation of N-methyl-D-aspartate receptors by sulfated steroids.
Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cells, Cultured; Chick Embryo; Hippocampus; N-Methylaspartate; Neurons; Oxidation-Reduction; Polyamines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Structure-Activity Relationship; Xenopus laevis | 1997 |
Opposing effects of different steroid sulfates on GABAA receptor-mediated chloride uptake.
Topics: Animals; Biological Transport; Cerebral Cortex; Chlorides; Dehydroepiandrosterone Sulfate; GABA Agonists; GABA Modulators; GABA-A Receptor Agonists; In Vitro Techniques; Ionophores; Male; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Synaptosomes | 1998 |
Understanding premenstrual syndrome.
Topics: Female; GABA Modulators; Humans; Isomerism; Pregnanolone; Pregnenolone; Premenstrual Syndrome | 1998 |
Understanding premenstrual syndrome.
Topics: Female; GABA Modulators; Humans; Isomerism; Pregnanolone; Pregnenolone; Premenstrual Syndrome | 1998 |
Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.
Topics: Animals; Cells, Cultured; Dehydroepiandrosterone Sulfate; GABA Modulators; Hippocampus; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Stereoisomerism | 1998 |
The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice.
Topics: Animals; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Eating; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Mitochondria; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1998 |
Allopregnanolone-induced modification of presynaptic basal and K+-induced [3H]-norepinephrine efflux from rat cortical slices during the estrous cycle.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Cerebral Cortex; Drug Interactions; Estrus; Female; Frontal Lobe; Isomerism; Norepinephrine; Potassium; Pregnanolone; Pregnenolone; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Tritium; Yohimbine | 1998 |
Modulation of cloned human neuronal voltage-gated potassium channels (hKv1.1 and hKv2.1) by neurosteroids.
Topics: Animals; CHO Cells; Cloning, Molecular; Cricetinae; Electric Conductivity; Gene Expression; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Potassium Channels; Pregnanolone; Pregnenolone; Steroids | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors | 1998 |
Effects of neurosteroids on spike-wave discharges in the genetic epileptic WAG/Rij rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy, Absence; GABA Modulators; Male; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 1999 |
Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites.
Topics: Animals; Cells, Cultured; Chick Embryo; Dehydroepiandrosterone Sulfate; GABA Modulators; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Steroids; Sulfuric Acid Esters; Xenopus laevis | 1999 |
Infusion of neurosteroids into the rat nucleus basalis affects paradoxical sleep in accordance with their memory modulating properties.
Topics: Animals; GABA Modulators; Male; Memory; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Sleep; Sleep, REM; Substantia Innominata; Wakefulness | 1999 |
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 1999 |
Response-rate suppression in operant paradigm as predictor of soporific potency in rats and identification of three novel sedative-hypnotic neuroactive steroids.
Topics: Animals; Conditioning, Operant; Depression, Chemical; Dose-Response Relationship, Drug; Electroencephalography; Hypnotics and Sedatives; Male; Pentobarbital; Postural Balance; Pregnanolone; Pregnenolone; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Steroids; Triazolam; Zolpidem | 1999 |
Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice.
Topics: 5-alpha-Dihydroprogesterone; Adrenal Cortex; Animals; Brain; Brain Chemistry; Corticosterone; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Demyelinating Diseases; Diazepam Binding Inhibitor; Immunohistochemistry; Leydig Cells; Male; Mice; Mice, Inbred Strains; Mice, Jimpy; Mice, Neurologic Mutants; Neuropeptides; Organ Specificity; Peptide Fragments; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Radioimmunoassay; Receptors, Cytoplasmic and Nuclear; Up-Regulation | 2000 |
The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Conflict, Psychological; Dehydroepiandrosterone Sulfate; Female; Injections; Injections, Intraventricular; Ovariectomy; Pregnanolone; Pregnenolone; Punishment; Rats; Rats, Wistar | 1999 |
Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse.
Topics: 5-alpha-Dihydroprogesterone; Animals; Behavior, Animal; Cognition; Infusion Pumps, Implantable; Injections, Intraventricular; Male; Maze Learning; Memory; Mice; Neuroprotective Agents; Pregnanediones; Pregnanolone; Pregnenolone; Prosencephalon; Space Perception | 2000 |
Caffeine-induced increases in the brain and plasma concentrations of neuroactive steroids in the rat.
Topics: Animals; Caffeine; Cerebral Cortex; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal System; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley | 2000 |
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.
Topics: Animals; Anxiety; Brain; Cerebral Cortex; Conflict, Psychological; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Electroshock; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Oocytes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Social Isolation; Steroids; Synaptosomes; Time Factors; Xenopus laevis | 2000 |
Modification of behavioral effects of drugs in mice by neuroactive steroids.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Convulsants; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Pregnenolone; Psychotropic Drugs; Steroids; Synaptic Transmission | 2000 |
Neurosteroid levels are increased in vivo after LPS treatment and negatively regulate LPS-induced TNF production.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Dehydroepiandrosterone Sulfate; Hippocampus; Kinetics; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Pregnanolone; Pregnenolone; Progesterone; Tumor Necrosis Factor-alpha | 2000 |
Allopregnanolone, pregnenolone sulfate, and epitestosterone in breast cyst fluid.
Topics: Adult; Epitestosterone; Exudates and Transudates; Female; Fibrocystic Breast Disease; Humans; Luteal Phase; Middle Aged; Pregnanolone; Pregnenolone; Reference Values | 2001 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Effect of epipregnanolone and pregnenolone sulfate on chronic tolerance to ethanol.
Topics: Animals; Central Nervous System Depressants; Drug Tolerance; Ethanol; Male; Mice; Motor Skills; Pregnanolone; Pregnenolone | 2000 |
Neuroactive steroid levels in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Dehydroepiandrosterone; Female; gamma-Aminobutyric Acid; Humans; Male; Pregnanolone; Pregnenolone; Receptors, GABA-A | 2001 |
Effect of treatment of hypothyroidism on the plasma concentrations of neuroactive steroids and homocysteine.
Topics: Adjuvants, Immunologic; Adult; Aged; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Homocysteine; Humans; Hypothyroidism; Male; Microsomes; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Thyrotropin; Thyroxine; Time Factors; Triiodothyronine | 2001 |
Neuroactive steroids modulate crustacean locomotor activity.
Topics: Animals; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Gonadal Steroid Hormones; Male; Motor Activity; Nephropidae; Pregnanolone; Pregnenolone | 2001 |
Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.
Topics: Animals; Cell Membrane; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Pregnenolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A | 2001 |
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Pyridines; Rats; Receptors, GABA-A; Zinc; Zolpidem | 2001 |
Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.
Topics: Amnesia; Animals; Animals, Newborn; Avoidance Learning; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Male; Membrane Potentials; Memory; Muscarinic Antagonists; Neurons; Pregnanediol; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Scopolamine; Stereoisomerism | 2001 |
Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Models, Biological; Oocytes; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 2002 |
Changes in GABAA receptor gamma 2 subunit gene expression induced by long-term administration of oral contraceptives in rats.
Topics: Adult; Analysis of Variance; Animals; Cerebral Cortex; Contraceptives, Oral, Synthetic; Female; Gene Expression Regulation; Humans; Injections, Subcutaneous; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 2002 |
Two neuroactive steroids in midpregnancy as measured in maternal and fetal sera and in amniotic fluid.
Topics: Amniotic Fluid; Female; Fetal Blood; Gonadal Steroid Hormones; History, 16th Century; Humans; Pregnancy; Pregnancy Trimester, Second; Pregnanolone; Pregnenolone; Sensitivity and Specificity | 2002 |
Low pregnenolone sulphate plasma concentrations in patients with generalized social phobia.
Topics: Adult; Arousal; Dehydroepiandrosterone; Humans; Male; Middle Aged; Phobic Disorders; Pilot Projects; Pregnanolone; Pregnenolone; Reference Values | 2002 |
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Brain Chemistry; Cerebellum; Corpus Striatum; Dehydroepiandrosterone Sulfate; Female; Frontal Lobe; Gas Chromatography-Mass Spectrometry; Hippocampus; Humans; Hypothalamus; Male; Pregnanolone; Pregnenolone; Progesterone; Protein Structure, Secondary; Steroids; tau Proteins | 2002 |
Endotoxin increases sleep and brain allopregnanolone concentrations in newborn lambs.
Topics: Animals; Animals, Newborn; Bacterial Infections; Brain; Disease Models, Animal; Humans; Hydrocortisone; Infant; Lipopolysaccharides; Pregnanolone; Pregnenolone; Progesterone; Risk Factors; Sheep; Sleep; Sudden Infant Death | 2002 |
A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-specific caspase-2 activation in the retinal cell death.
Topics: Animals; Apoptosis; Caspase 2; Caspase 3; Caspases; Cytochrome c Group; Enzyme Activation; Enzyme Inhibitors; Estradiol; In Situ Nick-End Labeling; In Vitro Techniques; Male; Neuroprotective Agents; Neurotoxins; Oxidation-Reduction; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retina; Signal Transduction | 2002 |
Neuroactive steroid levels in patients with panic disorder.
Topics: Adult; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Menstrual Cycle; Panic Disorder; Paroxetine; Postmenopause; Pregnanolone; Pregnenolone; Progesterone; Radioimmunoassay; Research Design | 2003 |
Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Dentate Gyrus; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Male; Membrane Potentials; Neural Inhibition; Neurons; Pregnanolone; Pregnenolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Steroids; Up-Regulation | 2003 |
Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands.
Topics: Amides; Animals; Boranes; Cerebral Cortex; In Vitro Techniques; Ligands; Pregnanolone; Pregnenolone; Progesterone; Quinolines; Radioligand Assay; Radiopharmaceuticals; Rats; Receptors, GABA-A; Structure-Activity Relationship | 2003 |
The 17, 20-lyase activity of cytochrome p450c17 from human fetal testis favors the delta5 steroidogenic pathway.
Topics: 17-alpha-Hydroxyprogesterone; Adult; Catalysis; Dehydroepiandrosterone; Female; Humans; Kinetics; Leydig Cells; Male; Microsomes; Multienzyme Complexes; Pregnancy; Pregnanolone; Pregnenolone; Progesterone; Progesterone Reductase; Steroid 17-alpha-Hydroxylase; Steroid Isomerases; Steroids; Testis | 2003 |
[CHROMATOGRAPHIC SEPARATION AND DETERMINATION OF PREGNANOLONE].
Topics: Body Fluids; Chromatography; Female; Humans; Pregnancy; Pregnanediol; Pregnanolone; Pregnenolone; Spectrophotometry; Urine | 1963 |
Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.
Topics: Adrenalectomy; Animals; Brain; Desoxycorticosterone; Ethanol; Male; Orchiectomy; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 2004 |
Synthesis of [19- 2H3]-analogs of dehydroepiandrosterone and pregnenolone and their sulfates.
Topics: Androstanes; Combinatorial Chemistry Techniques; Dehydroepiandrosterone; Deuterium; Molecular Structure; Pregnanolone; Pregnenolone | 2004 |
Acute neurosteroid modulation and subunit isolation of the gamma-aminobutyric acidA receptor in the bullfrog, Rana catesbeiana.
Topics: Amino Acid Sequence; Anesthetics; Animals; Brain; Cell Membrane; Cloning, Molecular; GABA Agonists; Male; Molecular Sequence Data; Muscimol; Pregnanolone; Pregnenolone; Protein Isoforms; Protein Subunits; Radioligand Assay; Rana catesbeiana; Receptors, GABA-A; Sequence Alignment; Tritium | 2004 |
Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.
Topics: Adult; Anxiety; Desoxycorticosterone; Humans; Male; Pregnanolone; Pregnenolone; Progesterone; Psychiatric Status Rating Scales; Reference Values | 2004 |
Adrenal response to adrenocorticotropic hormone stimulation in patients with premenstrual syndrome.
Topics: Adolescent; Adrenal Cortex; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Adult; Androstenedione; Case-Control Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dexamethasone; Estradiol; Female; Follicular Phase; Humans; Hydrocortisone; Luteal Phase; Pregnanolone; Pregnenolone; Premenstrual Syndrome; Progesterone; Testosterone | 2004 |
Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone.
Topics: 20-alpha-Hydroxysteroid Dehydrogenase; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); Animals; Brain; Mice; Niemann-Pick Diseases; Pregnanolone; Pregnenolone; Rats | 2004 |
Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep.
Topics: Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Brain Chemistry; Cholesterol Side-Chain Cleavage Enzyme; Female; Fetus; Gestational Age; Hydrocortisone; Hypophysectomy; Immunoblotting; Pituitary Gland; Pregnancy; Pregnanolone; Pregnenolone; Progesterone; Radioimmunoassay; Sheep | 2004 |
Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion.
Topics: Animals; Blood Pressure; Brain; Cholestenone 5 alpha-Reductase; Cholesterol Side-Chain Cleavage Enzyme; Constriction; Extracellular Fluid; Fetal Blood; Fetus; Gases; Heart Rate, Fetal; Hydrogen-Ion Concentration; Isoenzymes; Microdialysis; Osmolar Concentration; Pregnanolone; Pregnenolone; Sheep; Umbilical Cord | 2004 |
Fetal alcohol exposure alters neurosteroid levels in the developing rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Brain; Brain Chemistry; Central Nervous System Depressants; Ethanol; Feeding Behavior; Female; Gas Chromatography-Mass Spectrometry; Liver; Male; Models, Neurological; Placenta; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Exposure Delayed Effects; Radioimmunoassay; Rats; Steroids; Testosterone; Tyramine | 2004 |
Interaction between allopregnanolone and pregnenolone sulfate in modulating GABA-mediated synaptic currents in neurons from the rat medial preoptic nucleus.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Preoptic Area; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2005 |
Changes in bovine luteal progesterone metabolism in response to exogenous prostaglandin F(2alpha).
Topics: Animals; Cattle; Corpus Luteum; Dinoprost; Female; Gas Chromatography-Mass Spectrometry; Hydroxyprogesterones; Pregnanolone; Pregnenolone; Progesterone; Radioimmunoassay; Random Allocation | 2005 |
Altered profiles of serum neuroactive steroids in premenopausal women treated for alcohol addiction.
Topics: Alcoholism; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Estradiol; Female; Gas Chromatography-Mass Spectrometry; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Progesterone; Radioimmunoassay; Stereoisomerism; Steroids; Time Factors | 2005 |
Intrahippocampal nicotine and neurosteroids effects on the anxiety-like behaviour in voluntary and chronic alcohol-drinking rats.
Topics: Administration, Oral; Alcohol Drinking; Animals; Anti-Anxiety Agents; Anxiety; Drug Interactions; Ethanol; Exploratory Behavior; GABA Agents; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; Male; Microinjections; Motor Activity; Nicotine; Nicotinic Agonists; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Self Medication | 2005 |
Neurosteroids in nicotine and morphine dependence.
Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Antagonists; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2006 |
Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex.
Topics: Animals; Binding, Competitive; Dose-Response Relationship, Drug; Frontal Lobe; Male; Piperidines; Pregnanolone; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tritium | 2005 |
Effects of intrahippocampal nicotine and neurosteroid administration on withdrawal in voluntary and chronic alcohol-drinking rats.
Topics: Animals; Body Weight; Ethanol; Hippocampus; Male; Motor Activity; Nicotine; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome | 2005 |
The intrahippocampal administration of the neurosteroid allopregnanolone blocks the audiogenic seizures induced by nicotine.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Cholinergic Fibers; Dose-Response Relationship, Drug; Epilepsy, Reflex; Hippocampus; Male; Microinjections; Nicotine; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Wistar; Receptors, GABA-A; Statistics, Nonparametric | 2005 |
3alpha-reduced neuroactive steroids and their precursors during pregnancy and the postpartum period.
Topics: 5-alpha-Dihydroprogesterone; Adult; Delivery, Obstetric; Depression, Postpartum; Female; Gas Chromatography-Mass Spectrometry; Gestational Age; Humans; Labor Onset; Parity; Postpartum Period; Pregnancy; Pregnanolone; Pregnenolone; Progesterone | 2005 |
Injury elicited increase in spinal cord neurosteroid content analyzed by gas chromatography mass spectrometry.
Topics: 17-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Animals; Cholesterol Side-Chain Cleavage Enzyme; Gas Chromatography-Mass Spectrometry; Male; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Spinal Cord Injuries | 2006 |
[Effects of morphine dependence on the levels of neurosteroids in rat brain].
Topics: Amygdala; Animals; Brain; Conditioning, Operant; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Hypothalamus; Male; Morphine Dependence; Nucleus Accumbens; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley | 2005 |
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; In Vitro Techniques; Liver Cirrhosis; Male; Membranes; Middle Aged; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards | 2006 |
Effects of some neurosteroids injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epilepsy, Absence; Male; Microinjections; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Time Factors | 2006 |
Serum profiles of free and conjugated neuroactive pregnanolone isomers in nonpregnant women of fertile age.
Topics: Adult; Aging; Dehydroepiandrosterone; Estradiol; Female; Follicular Phase; Gas Chromatography-Mass Spectrometry; Humans; Isomerism; Luteal Phase; Pregnanolone; Pregnenolone; Progesterone; Receptors, GABA-A | 2006 |
Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Gas Chromatography-Mass Spectrometry; Hippocampus; Male; Olanzapine; Pregnanolone; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2006 |
The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Disease Progression; Gas Chromatography-Mass Spectrometry; Humans; Male; Prefrontal Cortex; Pregnanolone; Pregnenolone | 2006 |
Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone with the alpha1beta2gamma2L GABAA receptor.
Topics: Animals; Behavior, Animal; Binding Sites; Dose-Response Relationship, Drug; Estradiol; Ethanol; Female; Kinetics; Larva; Pregnanolone; Pregnenolone; Protein Binding; Protein Subunits; Receptors, GABA-A | 2007 |
Differential regulation of ionotropic glutamate receptors.
Topics: Binding Sites; Ligands; Models, Molecular; Pregnanolone; Pregnenolone; Protein Structure, Tertiary; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Zinc | 2007 |
Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats.
Topics: Alcohol Drinking; Alcohols; Anesthetics; Animals; Behavior, Animal; Choice Behavior; Conditioning, Operant; Dose-Response Relationship, Drug; Drinking Behavior; Food Deprivation; Glucose; Hippocampus; Linear Models; Male; Pregnanolone; Pregnenolone; Rats; Rats, Wistar | 2007 |
Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.
Topics: Animals; Animals, Genetically Modified; Cricetinae; Dehydroepiandrosterone; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Mesocricetus; Pregnanolone; Pregnenolone | 2007 |
Modulatory effect of neurosteroids in haloperidol-induced vacuous chewing movements and related behaviors.
Topics: Animals; Behavior, Animal; Catalase; Corpus Striatum; Dehydroepiandrosterone Sulfate; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Haloperidol; Homovanillic Acid; Injections, Intraperitoneal; Lipid Peroxidation; Male; Mastication; Norepinephrine; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Wistar; Serotonin; Superoxide Dismutase; Superoxides | 2008 |
Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells.
Topics: Apoptosis; Brain; Cell Line, Tumor; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Humans; Hydrogen Peroxide; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Nerve Degeneration; Neuroblastoma; Neurons; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Pregnanolone; Pregnenolone; Staurosporine; Steroids | 2008 |
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.
Topics: Analysis of Variance; Anesthetics; Animals; Body Temperature; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone | 2007 |
Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice.
Topics: Affect; Animals; Antimanic Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; DNA; Gas Chromatography-Mass Spectrometry; Genes, bcl-2; Lithium Chloride; Male; Mice; Mice, Knockout; Neuronal Plasticity; Prefrontal Cortex; Pregnanolone; Pregnenolone; Rats; Rats, Inbred WKY; Reverse Transcriptase Polymerase Chain Reaction; Valproic Acid | 2008 |
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.
Topics: Adult; Anticonvulsants; Body Mass Index; Dehydroepiandrosterone; Desoxycorticosterone; Electroencephalography; Epilepsy; Estradiol; Female; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Premenstrual Syndrome; Progesterone; Receptors, GABA | 2008 |
Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Brain; Brain Chemistry; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Indomethacin; Male; Molecular Structure; Motor Activity; Portacaval Shunt, Surgical; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 2008 |
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A.
Topics: Allosteric Regulation; Animals; CHO Cells; Cricetinae; Cricetulus; Hippocampus; Ion Channels; Male; Piperidines; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins | 2008 |
Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration.
Topics: Animals; Animals, Newborn; Anxiety; Avoidance Learning; Enzyme Inhibitors; Finasteride; Gonadal Steroid Hormones; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 2008 |
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
Topics: Amino Acid Substitution; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutant Proteins; Mutation; Piperidines; Pregnanetriol; Pregnanolone; Pregnenolone; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Serine; Steroids; Tryptophan | 2008 |
Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Cell Death; Cerebral Cortex; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Enzyme Inhibitors; Excitatory Amino Acids; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Neurotransmitter Agents; Phosphoinositide-3 Kinase Inhibitors; Pregnanolone; Pregnenolone; Reactive Oxygen Species; Staurosporine; Steroids | 2008 |
Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Brain; Central Nervous System Depressants; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Ethanol; GABA Agents; Gene Expression Regulation; Glucocorticoids; Hypophysectomy; Imidazoles; Immunoglobulin G; Immunoprecipitation; Isoquinolines; Male; Melphalan; Phosphoproteins; Pregnanolone; Pregnenolone; Protein Synthesis Inhibitors; Pyridines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Steroids | 2010 |
Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.
Topics: Adult; Androstane-3,17-diol; Androsterone; Animals; Central Nervous System Depressants; Desoxycorticosterone; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Young Adult | 2010 |
Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration.
Topics: Allosteric Regulation; Animals; Brain; Dehydroepiandrosterone; Male; Morphine; Neurotransmitter Agents; Opioid-Related Disorders; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Interaction between early postnatal neurosteroid manipulations and adult infusion of neurosteroids into CA1 hippocampal region on the open field behaviour.
Topics: 5-alpha Reductase Inhibitors; Adaptation, Physiological; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Exploratory Behavior; Finasteride; Male; Microinjections; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Spatial Behavior | 2011 |
Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats.
Topics: Alcoholism; Animals; Cerebral Cortex; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Ethanol; Male; Motor Activity; Pregnanolone; Pregnenolone; Rats; Rats, Inbred Strains; Self Administration | 2010 |
Preclinical pharmacokinetics, dose proportionality, gender difference and protein binding study of 16-dehydropregnenolone, an antihyperlipidemic agent, in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Hypolipidemic Agents; Injections, Intravenous; Male; Pregnanolone; Pregnenolone; Protein Binding; Rats; Rats, Sprague-Dawley; Sex Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tissue Distribution | 2011 |
Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors.
Topics: Allosteric Regulation; Anabolic Agents; Androgens; Animals; Dehydroepiandrosterone Sulfate; Frontal Lobe; Kinetics; Male; Nandrolone; Nandrolone Decanoate; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2011 |
Neurosteroids infusion into the CA1 hippocampal region on exploration, anxiety-like behaviour and aversive learning.
Topics: Animals; Anxiety; Avoidance Learning; Body Weight; CA1 Region, Hippocampal; Disease Models, Animal; Exploratory Behavior; Male; Maze Learning; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Statistics, Nonparametric | 2011 |
Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo.
Topics: Animals; Cerebellum; Cyclic GMP; Dehydroepiandrosterone; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2011 |
Allopregnanolone infused into the dorsal (CA1) hippocampus increases prepulse inhibition of startle response in Wistar rats.
Topics: Animals; CA1 Region, Hippocampal; Male; Microinjections; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Sensory Gating | 2012 |
Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors.
Topics: Binding Sites; Cloning, Molecular; Models, Molecular; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Receptors, Ionotropic Glutamate; Spectrometry, Fluorescence | 2012 |
Neonatal neurosteroid levels are determinant in shaping adult prepulse inhibition response to hippocampal allopregnanolone in rats.
Topics: 5-alpha Reductase Inhibitors; Age Factors; Animals; Animals, Newborn; Exploratory Behavior; Finasteride; Hippocampus; Male; Microinjections; Motor Activity; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Reflex, Startle; Sensory Gating | 2013 |
[Correlation between neurotransmitters and neurosteroids and premenstrual syndrome patients of Gan-yang ascending syndrome and Gan-qi stagnation syndrome].
Topics: Adult; Case-Control Studies; Dehydroepiandrosterone; Estradiol; Female; Follicular Phase; Humans; Luteal Phase; Medicine, Chinese Traditional; Middle Aged; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Premenstrual Syndrome; Progesterone; Young Adult | 2012 |
GABAergic neuroactive steroids and resting-state functional connectivity in postpartum depression: a preliminary study.
Topics: Adult; Amygdala; Depression, Postpartum; Female; Gyrus Cinguli; Hippocampus; Humans; Magnetic Resonance Imaging; Nerve Net; Pilot Projects; Postpartum Period; Prefrontal Cortex; Pregnancy; Pregnanolone; Pregnenolone | 2013 |
Simultaneous determination of pregnenolone sulphate, dehydroepiandrosterone and allopregnanolone in rat brain areas by liquid chromatography-electrospray tandem mass spectrometry.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Hippocampus; Male; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2013 |
Exploratory investigation of biomarker candidates for suicide in schizophrenia and bipolar disorder.
Topics: Adult; Aged; Autopsy; Biomarkers; Bipolar Disorder; Brain; Case-Control Studies; Chromatography, High Pressure Liquid; Dehydroepiandrosterone; Female; Gas Chromatography-Mass Spectrometry; Gyrus Cinguli; Humans; Male; Middle Aged; Parietal Lobe; Pilot Projects; Pregnanolone; Pregnenolone; Schizophrenia; Suicide; Young Adult | 2015 |
Validated LC-MS/MS simultaneous assay of five sex steroid/neurosteroid-related sulfates in human serum.
Topics: Androsterone; Chromatography, Liquid; Dehydroepiandrosterone Sulfate; Estrone; Humans; Limit of Detection; Pregnanolone; Pregnenolone; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
The dynamic steroid landscape of equine pregnancy mapped by mass spectrometry.
Topics: 20-alpha-Dihydroprogesterone; Animals; Biomarkers; Chromatography, Liquid; Corpus Luteum; Female; Horses; Placenta; Pregnancy; Pregnancy, Animal; Pregnanolone; Pregnenolone; Progesterone; Steroids; Tandem Mass Spectrometry | 2016 |
Assessment of neuroactive steroids in cerebrospinal fluid comparing acute relapse and stable disease in relapsing-remitting multiple sclerosis.
Topics: Adult; Biomarkers; Brain; Dehydroepiandrosterone; Female; Humans; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Pregnanolone; Pregnenolone; Recurrence | 2016 |
A sensitive and accurate LC-MS/MS assay with the derivatization of 1-Amino-4-methylpiperazine applied to serum allopregnanolone, pregnenolone and androsterone in pre- and postmenopausal women.
Topics: Androsterone; Biological Assay; Chromatography, Liquid; Female; Humans; Molecular Structure; Piperazines; Postmenopause; Pregnanolone; Pregnenolone; Premenopause; Reproducibility of Results; Tandem Mass Spectrometry | 2017 |
Reduced steroidogenesis in patients with PCDH19-female limited epilepsy.
Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adrenocorticotropic Hormone; Adrenogenital Syndrome; Cadherins; Case-Control Studies; Child; Child, Preschool; DNA Mutational Analysis; Epilepsy; Estradiol; Female; Genetic Diseases, X-Linked; Gonadal Steroid Hormones; Humans; Hydrocortisone; Intellectual Disability; Pregnanolone; Pregnenolone; Progesterone; Prospective Studies; Protocadherins; Puberty, Precocious; Reference Values | 2017 |
Pregnenolone-progesterone-allopregnanolone pathway as a potential therapeutic target in first-episode antipsychotic-naïve patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Biomarkers, Pharmacological; Case-Control Studies; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Female; Humans; Hydrocortisone; Male; Metabolic Networks and Pathways; Pregnanolone; Pregnenolone; Progesterone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2018 |
Low levels of progesterone and derivatives in cerebrospinal fluid of patients affected by status epilepticus.
Topics: 5-alpha-Dihydroprogesterone; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Retrospective Studies; Status Epilepticus; Steroids; Tandem Mass Spectrometry; Young Adult | 2018 |
Sex-dependent changes in neuroactive steroid concentrations in the rat brain following acute swim stress.
Topics: Animals; Brain; Corticosterone; Female; Male; Pregnanolone; Pregnenolone; Progesterone; Rats, Sprague-Dawley; Sex Characteristics; Steroids; Stress, Psychological; Swimming; Testosterone | 2018 |
Endogenous Neurosteroid (3α,5α)3-Hydroxypregnan-20-one Inhibits Toll-like-4 Receptor Activation and Pro-inflammatory Signaling in Macrophages and Brain.
Topics: Animals; Inflammation; Lipopolysaccharides; Male; Mice; Neurosteroids; Pregnanolone; Pregnenolone; Protein Interaction Maps; Rats; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptor 4; Ventral Tegmental Area | 2019 |
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry | 2020 |
Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA
Topics: Allosteric Regulation; Binding Sites; GABA-A Receptor Agonists; HEK293 Cells; Humans; Multiprotein Complexes; Muscimol; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; Steroids; Tritium | 2020 |
Augmentation of endogenous neurosteroid synthesis alters experimental status epilepticus dynamics.
Topics: 5-alpha-Dihydroprogesterone; Animals; Brain; Chromatography, Liquid; Dihydrotestosterone; Electrocorticography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neocortex; Neurosteroids; Pregnanolone; Pregnenolone; Progesterone; Rats; Receptors, GABA-A; Status Epilepticus; Tandem Mass Spectrometry; Time Factors | 2020 |
BV-2 Microglial Cells Respond to Rotenone Toxic Insult by Modifying Pregnenolone, 5α-Dihydroprogesterone and Pregnanolone Levels.
Topics: 5-alpha-Dihydroprogesterone; Animals; Cell Line, Transformed; Cell Survival; Chromatography, Liquid; Mice; Microglia; Pregnanolone; Pregnenolone; Reactive Oxygen Species; Rotenone; Signal Transduction; Tandem Mass Spectrometry | 2020 |
Sex and COVID-19: A Protective Role for Reproductive Steroids.
Topics: Age Factors; Animals; COVID-19; Estradiol; Estrogens; Female; Humans; Immune System; Inflammation; Male; Pregnanolone; Pregnenolone; Progesterone; Sex Factors; Signal Transduction | 2021 |
Neurosteroid allopregnanolone (3α,5α-THP) inhibits inflammatory signals induced by activated MyD88-dependent toll-like receptors.
Topics: Animals; Ethanol; Mice; Myeloid Differentiation Factor 88; Neurosteroids; Pregnanolone; Pregnenolone; Rats | 2021 |
Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study.
Topics: Aged; Estradiol; Female; Humans; Migraine Disorders; Pregnanolone; Pregnenolone | 2021 |
Prenatal Exposure to Bisphenols and Phthalates and Postpartum Depression: The Role of Neurosteroid Hormone Disruption.
Topics: Adult; Benzhydryl Compounds; Depression, Postpartum; Endocrine Disruptors; Female; Humans; Maternal Exposure; Neurosteroids; Phenols; Phthalic Acids; Postpartum Period; Pregnancy; Pregnancy Trimesters; Pregnanolone; Pregnenolone; Progesterone; Prospective Studies; Psychiatric Status Rating Scales | 2021 |
Gut Steroids and Microbiota: Effect of Gonadectomy and Sex.
Topics: Animals; Castration; Female; Gas Chromatography-Mass Spectrometry; Male; Microbiota; Pregnanolone; Pregnenolone; Progesterone; Rats; RNA, Ribosomal, 16S | 2022 |
Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats.
Topics: Animals; Finasteride; Inflammation; Male; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A | 2022 |
Gut microbiota composition is altered in a preclinical model of type 1 diabetes mellitus: Influence on gut steroids, permeability, and cognitive abilities.
Topics: Animals; Claudin-1; Cognition; Diabetes Mellitus, Type 1; Dysbiosis; Female; Gastrointestinal Microbiome; Gonadal Steroid Hormones; Neurosteroids; Permeability; Pregnanolone; Pregnenolone; Rats | 2023 |