Page last updated: 2024-08-23

pregnanolone and pregnanediol

pregnanolone has been researched along with pregnanediol in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199027 (75.00)18.7374
1990's6 (16.67)18.2507
2000's2 (5.56)29.6817
2010's1 (2.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schindler, AE; Wuchter, J1
Collins, DC; Graham, CE; YoungLai, EV1
Farkas, R; Feuer, G; Kardish, R1
Beyer, C; Bondani, A; Kubli-Garfias, C; Medrano-Conde, L1
Eckstein, B; Lerner, N2
Chen, GT; Gant, NF; MacDonald, PC; Milewich, L; Schwarz, BE1
Dhont, M; Thiery, M; Vandekerchkhove, D; Vanluchene, E1
Eckstein, B; Lerner, N; Yehud, S1
Holtermann, M; Lisboa, BP2
Bokkenheuser, VD; de Leon, O; Dehazya, P; Kelly, WG; Winter, J1
Holzbauer, M1
Baillie, TA; Herz, JE; Sjövall, J1
Cadoni, C; Gee, KW1
Gee, KW; Lan, NC1
Belelli, D; Gee, KW; McCauley, L1
Anderson, RA; Axelson, M; Baillie, TA; Cronholm, T; Sjövall, J; Sjövall, K1
Belelli, D; Gee, KW1
Smith, SS; Waterhouse, BD; Woodward, DJ1
Baker, K; Bevan, BR; Jenkins, JM; Pennington, GW; Savvas, M; Taylor, NF1
Duleba, AJ; Kim, KS; Moon, YS; Yuen, BH1
Chatterton, RT; Cheesman, KL; Cheesman, SD; Cohen, MR1
Baillie, TA; Curstedt, T; Sjövall, J; Sjövall, K1
Casey, ML; MacDonald, PC1
Gilles, PA; Karavolas, HJ1
Chavatte, PM; Rossdale, PD; Tait, AD1
Carboni, E; Gee, KW; Lan, NC; Wieland, S1
Covey, DF; Heinrichs, SC; Koob, GF; Purdy, RH; Shen, W; Vallée, M; Zorumski, CF1
DE COURCY, C; SCHNEIDER, JJ1
BELL, M; VARLEY, H1
FRANCIS, FE; KATZMAN, MB; KINSELLA, RA; SHEN, NH1
CREPY, O; JAYLE, MF; LACHESE, B1
CREPY, O; JAYLE, MF; JUDAS, O1
Backstrom, T; Birzniece, V; Johansson, IM; Lundgren, P; Turkmen, S; Zingmark, E1
Gaikwad, NW; Kaddurah-Daouk, R; Kucera, HR; Motsinger-Reif, A; Nguyen, TV; Nieman, LK; Reuter, JM; Rotroff, DM; Rubinow, DR; Schmidt, PJ; Smith, CP1

Reviews

1 review(s) available for pregnanolone and pregnanediol

ArticleYear
Studies on steroids in urine of the male newborn.
    Biology of the neonate, 1975, Volume: 27, Issue:3-4

    Topics: 17-alpha-Hydroxypregnenolone; Androstanes; Arylsulfatases; Dehydroepiandrosterone; Glucuronidase; Humans; Hydrolysis; Hydroxyprogesterones; Infant, Newborn; Male; Pregnanediol; Pregnanes; Pregnanolone; Pregnenolone; Progesterone

1975

Trials

1 trial(s) available for pregnanolone and pregnanediol

ArticleYear
The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback.
    Translational psychiatry, 2017, 08-08, Volume: 7, Issue:8

    Topics: Adult; Cross-Over Studies; Desoxycorticosterone; Estradiol; Estrone; Female; Humans; Leuprolide; Metabolome; Middle Aged; Pregnanediol; Pregnanolone; Premenstrual Dysphoric Disorder; Progesterone; Young Adult

2017

Other Studies

34 other study(ies) available for pregnanolone and pregnanediol

ArticleYear
Metabolism of 4-14 C-progesterone in the adult female chimpanzee.
    Steroids, 1975, Volume: 25, Issue:4

    Topics: Aluminum; Androsterone; Animals; Carbon Radioisotopes; Chromatography; Chromatography, Paper; Glucuronidase; Pan troglodytes; Pregnanediol; Pregnanetriol; Pregnanolone; Progesterone; Silicon Dioxide; Spectrophotometry, Infrared; Sulfatases; Time Factors

1975
Differential action of progesterones on hepatic microsomal activities in the rat.
    Biochemical pharmacology, 1977, Aug-15, Volume: 26, Issue:16

    Topics: Aminopyrine N-Demethylase; Animals; Coumarins; Female; Hydroxyprogesterones; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Phospholipids; Phosphoric Monoester Hydrolases; Pregnanediol; Pregnanolone; Pregnenolone Carbonitrile; Progesterone; Rats

1977
In vitro inhibition of rat uterine contractility induced by 5 alpha and 5 beta progestins.
    Steroids, 1979, Volume: 34, Issue:6 Spec no

    Topics: 20-alpha-Dihydroprogesterone; Animals; Diestrus; Dose-Response Relationship, Drug; Female; Isomerism; Pregnancy; Pregnanediol; Pregnanediones; Pregnanes; Pregnanolone; Progesterone; Progestins; Rats; Stereoisomerism; Structure-Activity Relationship; Uterine Contraction

1979
Changes in steroidogenesis in preovulatory rat ovaries induced to ovulate with pregnant mare serum gonadotropin.
    Endocrinology, 1978, Volume: 103, Issue:4

    Topics: 20-alpha-Dihydroprogesterone; Androstane-3,17-diol; Animals; Female; Gonadotropins, Equine; Isomerism; Ovary; Ovulation; Ovulation Induction; Pregnanediol; Pregnanolone; Progesterone; Rats; Sexual Maturation

1978
Initiation of human parturition. VIII. Metabolism of progesterone by fetal membranes of early and late human gestation.
    Obstetrics and gynecology, 1977, Volume: 50, Issue:1

    Topics: Extraembryonic Membranes; Female; Gestational Age; Humans; Labor Onset; Pregnancy; Pregnanediol; Pregnanolone; Pregnenolone; Progesterone

1977
Steroid profiles in hydatidiform mole associated with theca-lutein cysts.
    Zeitschrift fur Geburtshilfe und Perinatologie, 1977, Volume: 181, Issue:4

    Topics: Adult; Chorionic Gonadotropin; Female; Humans; Hydatidiform Mole; Ovarian Cysts; Pregnancy; Pregnanediol; Pregnanes; Pregnanetriol; Pregnanolone; Theca Cells; Ultrasonography; Uterine Neoplasms; Vacuum Curettage

1977
Pre-ovulatory changes in steroidogenesis in ovaries from immature rats treated with pregnant mare serum gonadotrophin.
    The Journal of endocrinology, 1976, Volume: 70, Issue:3

    Topics: Age Factors; Androstenediol; Animals; Chromatography, Gas; Female; Gonadotropins, Equine; In Vitro Techniques; Ovary; Pregnanediol; Pregnanes; Pregnanolone; Progesterone; Rats

1976
Metabolism of progesterone in uterine tissue of non-pregnant rats in vitro.
    Acta endocrinologica, 1976, Volume: 83, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; Allyl Compounds; Animals; Female; Pregnanediol; Pregnanes; Pregnanolone; Pregnenes; Progesterone; Rats; Uterus

1976
Metabolism of 20beta-hydroxy-4-pregnen-3-one in uterine tissue of non-pregnant rats in vitro.
    Acta endocrinologica, 1976, Volume: 83, Issue:3

    Topics: 20-alpha-Dihydroprogesterone; Animals; Female; Isomerism; Pregnanediol; Pregnanes; Pregnanolone; Pregnenes; Progesterone; Rats; Uterus

1976
Formation and metabolism of tetrahydrodeoxycorticosterone by human fecal flora.
    Journal of steroid biochemistry, 1976, Volume: 7, Issue:10

    Topics: Bacteria; Desoxycorticosterone; Feces; Humans; Kinetics; Lactobacillus; Pregnanediol; Pregnanolone

1976
Physiological variations in the ovarian production of 5alpha-pregnane derivatives with sedative properties in the rat.
    Journal of steroid biochemistry, 1975, Volume: 6, Issue:9

    Topics: Anesthetics; Animals; Estrus; Female; Ovary; Pregnancy; Pregnanediol; Pregnanes; Pregnanolone; Progesterone; Rats

1975
Synthesis of specifically deuterium-labelled pregnanolone and pregnanediol sulphates for metabolic studies in humans.
    Steroids, 1975, Volume: 26, Issue:4

    Topics: Deuterium; Humans; Isotope Labeling; Mass Spectrometry; Methods; Pregnanediol; Pregnanes; Pregnanolone

1975
Identification of two 5alpha-reduced pregnanes as major metabolites of progesterone in immature rat ovaries (1000 x g supernatant) in vitro.
    Endocrinology, 1976, Volume: 98, Issue:1

    Topics: Androstane-3,17-diol; Animals; Female; Ovary; Oxidation-Reduction; Oxidoreductases; Pregnanediol; Pregnanes; Pregnanolone; Progesterone; Rats

1976
Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex.
    European journal of pharmacology, 1992, Oct-01, Volume: 227, Issue:2

    Topics: Androstanes; Animals; Azasteroids; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism

1992
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
    Molecular pharmacology, 1991, Volume: 40, Issue:6

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes

1991
Heterotropic cooperativity between putative recognition sites for progesterone metabolites and the atypical benzodiazepine Ro 5-4864.
    Journal of neurochemistry, 1990, Volume: 55, Issue:1

    Topics: Animals; Benzodiazepinones; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Convulsants; gamma-Aminobutyric Acid; Male; Pregnanediol; Pregnanolone; Progesterone; Rats; Rats, Inbred Strains

1990
Stable isotope studies on steroid metabolism and kinetics: sulfates of 3 alpha-hydroxy-5 alpha-pregnane derivatives in human pregnancy.
    Steroids, 1990, Volume: 55, Issue:10

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Deuterium; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Hydroxylation; Kinetics; Oxidation-Reduction; Pregnancy; Pregnanediol; Pregnanolone; Steroid 16-alpha-Hydroxylase; Sulfates

1990
5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes.
    European journal of pharmacology, 1989, Aug-11, Volume: 167, Issue:1

    Topics: Animals; Benzodiazepines; Bicuculline; Chlorides; Clonazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ionophores; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes

1989
Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum.
    Brain research bulletin, 1987, Volume: 18, Issue:6

    Topics: Animals; Drug Interactions; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Iontophoresis; Pregnanediol; Pregnanes; Pregnanolone; Purkinje Cells; Rats; Rats, Inbred Strains

1987
Abnormal steroid excretion in gestational trophoblastic disease complicated by ovarian theca-lutein cysts.
    Journal of clinical pathology, 1986, Volume: 39, Issue:6

    Topics: Adult; Chromatography, Gas; Female; Humans; Male; Ovarian Cysts; Pregnancy; Pregnanediol; Pregnanetriol; Pregnanolone; Steroids; Trophoblastic Neoplasms; Uterine Neoplasms

1986
Alterations of 20 alpha-hydroxysteroid dehydrogenase activity in cultured rat granulosa cells by follicle-stimulating hormone and testosterone.
    Biology of reproduction, 1985, Volume: 32, Issue:5

    Topics: 20-alpha-Dihydroprogesterone; 20-alpha-Hydroxysteroid Dehydrogenase; 20-Hydroxysteroid Dehydrogenases; Animals; Cells, Cultured; Cyanoketone; Dose-Response Relationship, Drug; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Pregnanediol; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Stereoisomerism; Testosterone

1985
Alterations in progesterone metabolism and luteal function in infertile women with endometriosis.
    Fertility and sterility, 1983, Volume: 40, Issue:5

    Topics: Adult; Biopsy; Body Temperature; Corpus Luteum; Endometriosis; Female; Humans; Infertility, Female; Laparoscopy; Luteinizing Hormone; Pregnanediol; Pregnanolone; Progesterone; Time Factors

1983
Production rates and metabolism of sulphates of 3 beta-hydroxy-5 alpha-pregnane derivatives in pregnant women.
    Journal of steroid biochemistry, 1980, Volume: 13, Issue:12

    Topics: Deuterium; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Kinetics; Pregnancy; Pregnanediol; Pregnanes; Pregnanolone; Radioisotope Dilution Technique; Structure-Activity Relationship

1980
Metabolism of deoxycorticosterone and deoxycorticosterone sulfate in men and women.
    The Journal of clinical investigation, 1982, Volume: 70, Issue:2

    Topics: Adult; Bile; Desoxycorticosterone; Female; Humans; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Menopause; Middle Aged; Pregnanediol; Pregnanolone; Progesterone; Sex Factors

1982
Effect on ovulation of 20 alpha-hydroxy-4-pregnen-3-one and its 5 alpha-reduced metabolites in immature rats treated with pregnant mare serum gonadotrophin.
    The Journal of endocrinology, 1981, Volume: 88, Issue:2

    Topics: 20-alpha-Dihydroprogesterone; Animals; Dose-Response Relationship, Drug; Female; Gonadotropins, Equine; Ovulation; Pregnanediol; Pregnanolone; Progesterone; Rats; Sexual Maturation

1981
Modulation of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) activity in the equine placenta by pregnenolone and progesterone metabolites.
    Equine veterinary journal, 1995, Volume: 27, Issue:5

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Dose-Response Relationship, Drug; Female; Horses; Placenta; Pregnancy; Pregnanediol; Pregnanes; Pregnanolone; Pregnenes; Pregnenolone; Progesterone

1995
Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety.
    Psychopharmacology, 1996, Volume: 126, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Chemical Phenomena; Chemistry; Chlordiazepoxide; Injections, Intraventricular; Male; Maze Learning; Mice; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley

1996
Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats.
    The European journal of neuroscience, 2001, Volume: 14, Issue:12

    Topics: Amnesia; Animals; Animals, Newborn; Avoidance Learning; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Male; Membrane Potentials; Memory; Muscarinic Antagonists; Neurons; Pregnanediol; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Scopolamine; Stereoisomerism

2001
Enzymatic reduction of the C-20 carbonyl group of tetrahydrocortisone and 17-hydroxypregnanolone.
    The Journal of biological chemistry, 1956, Volume: 223, Issue:2

    Topics: Cortisone; Liver; Pregnanediol; Pregnanolone; Progestins; Tetrahydrocortisone

1956
The estimation of pregnanetriol and 17-hydroxypregnanolone in urine in congenital adrenal hyperplasia.
    Clinica chimica acta; international journal of clinical chemistry, 1960, Volume: 5

    Topics: Adrenal Cortex; Adrenal Hyperplasia, Congenital; Humans; Pregnanediol; Pregnanetriol; Pregnanolone

1960
Determination of pregnanolone, pregnanediol, and pregnanetriol in urine.
    The Journal of laboratory and clinical medicine, 1963, Volume: 61

    Topics: Body Fluids; Humans; Pregnanediol; Pregnanetriol; Pregnanolone; Progestins

1963
[CHROMATOGRAPHIC SEPARATION AND DETERMINATION OF PREGNANOLONE].
    Clinica chimica acta; international journal of clinical chemistry, 1963, Volume: 8

    Topics: Body Fluids; Chromatography; Female; Humans; Pregnancy; Pregnanediol; Pregnanolone; Pregnenolone; Spectrophotometry; Urine

1963
[COMPARISON BETWEEN THE METABOLISM OF 5-ALPHA-PREGNANOLONE AND 5-BETA-PREGNANOLONE IN MAN AND THE RABBIT].
    Bulletin de la Societe de chimie biologique, 1964, Volume: 46

    Topics: Animals; Glucuronates; Lagomorpha; Metabolism; Pregnanediol; Pregnanolone; Progestins; Rabbits; Research; Sulfates

1964
3beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone.
    The European journal of neuroscience, 2004, Volume: 20, Issue:6

    Topics: Analysis of Variance; Animals; Behavior, Animal; Cerebral Cortex; Chlorides; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Learning Disabilities; Male; Maze Learning; Pregnanediol; Pregnanolone; Radioimmunoassay; Rats; Rats, Wistar; Reaction Time; Statistics, Nonparametric; Time Factors

2004