Page last updated: 2024-08-23

pregnanolone and pk 11195

pregnanolone has been researched along with pk 11195 in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's7 (36.84)29.6817
2010's10 (52.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bender, AS; Norenberg, MD1
Bitran, D; Dugan, M; Ellis, R; Foley, M; Renda, P1
Audette, D; Bitran, D; Foley, M; Frye, CA; Leslie, N1
Breton, JD; Keller, AF; Poisbeau, P; Schlichter, R1
Akwa, Y; Eychenne, B; Gillardin, JM; Ladurelle, N; Liere, P; Pianos, A; Schumacher, M; Verleye, M1
Ahboucha, S; Butterworth, RF1
Gillardin, JM; Heulard, I; Verleye, M1
Frye, CA; Paris, JJ; Rhodes, ME1
Kondo, D; Kurihara, T; Saegusa, H; Takasaki, I; Tanabe, T; Yabe, R; Zong, S1
Boyd, KN; Kumar, S; Morrow, AL; O'Buckley, TK; Porcu, P1
do Rego, JL; Vaudry, D; Vaudry, H1
Chen, JS; Chen, Y; He, JL; Lai, S; Li, MS; Li, Y; Liu, X; Ma, JC; Qiu, ZK; Shen, YG; Wu, HW; Zeng, J; Zhang, GH1
Chen, HX; Chen, XF; Li, YF; Qiu, ZK; Xue, R; Yang, RF; Zhang, LM; Zhang, YZ; Zhao, N1
Gao, ZW; Huang, JB; Liang, YJ; Lin, Q; Luo, M; Qin, Q; Zhou, L1
Fu, Q; Guo, WZ; Jiao, LB; Liu, N; Ma, L; Ma, YQ; Mi, WD; Wang, PQ; Zhang, H1
Lin, F; Lin, QF; Lu, C; Mao, WD; Shen, D; Xu, JN1
Covey, DF; Ishikawa, M; Izumi, Y; Yoshitomi, T; Zorumski, CF1
Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Shen, YG; Zeng, J; Zhang, GH1
Gong, J; Guo, Y; Jiang, XY; Li, L; Li, YF; Sun, LJ; Sun, SZ; Wang, HL; Wang, W; Zhang, LM; Zhang, YZ1

Reviews

1 review(s) available for pregnanolone and pk 11195

ArticleYear
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
    Metabolic brain disease, 2007, Volume: 22, Issue:3-4

    Topics: Ammonia; Animals; Brain; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Isoquinolines; Manganese; Pregnanolone; Receptors, GABA-A; Synaptic Transmission

2007

Other Studies

18 other study(ies) available for pregnanolone and pk 11195

ArticleYear
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
    Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5

    Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation

1998
Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
    Brain research, 1999, Dec-11, Volume: 850, Issue:1-2

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chloride Channels; Dose-Response Relationship, Drug; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Isoquinolines; Male; Microinjections; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Septum of Brain

1999
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
    Psychopharmacology, 2000, Volume: 151, Issue:1

    Topics: Analysis of Variance; Animals; Anxiety; GABA Antagonists; Hippocampus; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A

2000
Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA(A) miniature IPSCs in lamina II of the spinal cord.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jan-28, Volume: 24, Issue:4

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Age Factors; Animals; Diazepam; Enzyme Inhibitors; Finasteride; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Posterior Horn Cells; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Steroids

2004
The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Brain; Isoquinolines; Male; Oxazines; Pregnanolone; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Steroids

2005
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
    Psychopharmacology, 2008, Volume: 197, Issue:4

    Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological

2008
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
    Reproduction (Cambridge, England), 2009, Volume: 137, Issue:1

    Topics: Animals; Anxiety; Behavior, Animal; Exploratory Behavior; Female; Indoleacetic Acids; Indomethacin; Isoquinolines; Pregnanolone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area

2009
Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.
    Journal of pharmacological sciences, 2009, Volume: 110, Issue:1

    Topics: Analgesics; Animals; Behavior, Animal; Desoxycorticosterone; DNA, Complementary; GABA-A Receptor Antagonists; Immunohistochemistry; Injections, Spinal; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Pain; Peripheral Nervous System Diseases; Pregnanolone; Progesterone; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Spinal Nerves

2009
Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.
    Journal of neurochemistry, 2010, Volume: 112, Issue:3

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Brain; Central Nervous System Depressants; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Ethanol; GABA Agents; Gene Expression Regulation; Glucocorticoids; Hypophysectomy; Imidazoles; Immunoglobulin G; Immunoprecipitation; Isoquinolines; Male; Melphalan; Phosphoproteins; Pregnanolone; Pregnenolone; Protein Synthesis Inhibitors; Pyridines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Steroids

2010
The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; 20-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Bicuculline; Complex Mixtures; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression; Hypothalamus; Isoquinolines; Male; Neuropeptides; Oxazines; Peptide Fragments; Pregnanolone; Progesterone; Rana esculenta; Receptors, GABA-A; Tissue Culture Techniques

2015
Translocator protein mediates the anxiolytic and antidepressant effects of midazolam.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 139, Issue:Pt A

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Carrier Proteins; Dose-Response Relationship, Drug; Hippocampus; Isoquinolines; Male; Midazolam; Prefrontal Cortex; Pregnanolone; Rats; Receptors, GABA-A

2015
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:5

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Isoquinolines; Male; Motor Activity; Prefrontal Cortex; Pregnanolone; Purines; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic

2016
The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa.
    Cancer biomarkers : section A of Disease markers, 2016, Volume: 16, Issue:1

    Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Isoquinolines; Meningioma; Pregnanolone; Receptors, GABA

2016
TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration.
    Brain research bulletin, 2016, Volume: 121

    Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Aspartic Acid Endopeptidases; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Gene Expression Regulation; Hippocampus; Isoquinolines; Lipopolysaccharides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Pregnanolone; Progesterone; Receptors, GABA

2016
The effects of PK11195 on the MCF-7 and T47D were associated with the allopregnanolone biosynthesis, which was mediated by Translocator Protein 18 KDa.
    Cancer biomarkers : section A of Disease markers, 2016, Apr-01, Volume: 17, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression; Humans; Isoquinolines; MCF-7 Cells; Pregnanolone; Receptors, GABA; RNA, Messenger

2016
TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model.
    Neuropharmacology, 2016, Volume: 111

    Topics: 5-alpha Reductase Inhibitors; Animals; Carrier Proteins; Cholestenone 5 alpha-Reductase; Disease Models, Animal; Dutasteride; Glaucoma; In Vitro Techniques; Isoquinolines; Male; Pregnanolone; Pressure; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Retina; Retinal Ganglion Cells; Up-Regulation

2016
The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.
    Scientific reports, 2016, 11-25, Volume: 6

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Carrier Proteins; Depression; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hippocampus; Isoquinolines; Ligands; Male; Molecular Weight; Prefrontal Cortex; Pregnanolone; Purines; Rats, Sprague-Dawley; Receptors, GABA-A

2016
Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects.
    Neuropharmacology, 2017, Volume: 125

    Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Dentate Gyrus; Depression; Finasteride; Genetic Vectors; Isoquinolines; Lentivirus; Male; Mice, Inbred ICR; Motor Activity; Pregnanolone; Psychotropic Drugs; Receptors, GABA

2017