pregnanolone has been researched along with pk 11195 in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bender, AS; Norenberg, MD | 1 |
| Bitran, D; Dugan, M; Ellis, R; Foley, M; Renda, P | 1 |
| Audette, D; Bitran, D; Foley, M; Frye, CA; Leslie, N | 1 |
| Breton, JD; Keller, AF; Poisbeau, P; Schlichter, R | 1 |
| Akwa, Y; Eychenne, B; Gillardin, JM; Ladurelle, N; Liere, P; Pianos, A; Schumacher, M; Verleye, M | 1 |
| Ahboucha, S; Butterworth, RF | 1 |
| Gillardin, JM; Heulard, I; Verleye, M | 1 |
| Frye, CA; Paris, JJ; Rhodes, ME | 1 |
| Kondo, D; Kurihara, T; Saegusa, H; Takasaki, I; Tanabe, T; Yabe, R; Zong, S | 1 |
| Boyd, KN; Kumar, S; Morrow, AL; O'Buckley, TK; Porcu, P | 1 |
| do Rego, JL; Vaudry, D; Vaudry, H | 1 |
| Chen, JS; Chen, Y; He, JL; Lai, S; Li, MS; Li, Y; Liu, X; Ma, JC; Qiu, ZK; Shen, YG; Wu, HW; Zeng, J; Zhang, GH | 1 |
| Chen, HX; Chen, XF; Li, YF; Qiu, ZK; Xue, R; Yang, RF; Zhang, LM; Zhang, YZ; Zhao, N | 1 |
| Gao, ZW; Huang, JB; Liang, YJ; Lin, Q; Luo, M; Qin, Q; Zhou, L | 1 |
| Fu, Q; Guo, WZ; Jiao, LB; Liu, N; Ma, L; Ma, YQ; Mi, WD; Wang, PQ; Zhang, H | 1 |
| Lin, F; Lin, QF; Lu, C; Mao, WD; Shen, D; Xu, JN | 1 |
| Covey, DF; Ishikawa, M; Izumi, Y; Yoshitomi, T; Zorumski, CF | 1 |
| Chen, JS; He, JL; Liu, X; Nie, H; Qiu, ZK; Shen, YG; Zeng, J; Zhang, GH | 1 |
| Gong, J; Guo, Y; Jiang, XY; Li, L; Li, YF; Sun, LJ; Sun, SZ; Wang, HL; Wang, W; Zhang, LM; Zhang, YZ | 1 |
1 review(s) available for pregnanolone and pk 11195
| Article | Year |
|---|---|
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Isoquinolines; Manganese; Pregnanolone; Receptors, GABA-A; Synaptic Transmission | 2007 |
18 other study(ies) available for pregnanolone and pk 11195
| Article | Year |
|---|---|
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Chloride Channels; Dose-Response Relationship, Drug; Electroshock; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Hippocampus; Isoquinolines; Male; Microinjections; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Septum of Brain | 1999 |
Activation of peripheral mitochondrial benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic-like effects in the rat.
Topics: Analysis of Variance; Animals; Anxiety; GABA Antagonists; Hippocampus; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Picrotoxin; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A | 2000 |
Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA(A) miniature IPSCs in lamina II of the spinal cord.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Age Factors; Animals; Diazepam; Enzyme Inhibitors; Finasteride; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Posterior Horn Cells; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Steroids | 2004 |
The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain.
Topics: Animals; Anti-Anxiety Agents; Brain; Isoquinolines; Male; Oxazines; Pregnanolone; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Steroids | 2005 |
Investigation of the anticonvulsive effect of acute immobilization stress in anxious Balb/cByJ mice using GABA A-related mechanistic probes.
Topics: Allosteric Regulation; Animals; Anxiety; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Convulsants; Drug Interactions; Finasteride; Isoquinolines; Male; Mice; Mice, Inbred BALB C; Oxazines; Picrotoxin; Pregnanolone; Progesterone; Receptors, GABA-A; Restraint, Physical; Seizures; Stress, Psychological | 2008 |
Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.
Topics: Animals; Anxiety; Behavior, Animal; Exploratory Behavior; Female; Indoleacetic Acids; Indomethacin; Isoquinolines; Pregnanolone; Rats; Rats, Long-Evans; Sexual Behavior, Animal; Social Behavior; Ventral Tegmental Area | 2009 |
Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.
Topics: Analgesics; Animals; Behavior, Animal; Desoxycorticosterone; DNA, Complementary; GABA-A Receptor Antagonists; Immunohistochemistry; Injections, Spinal; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Pain; Peripheral Nervous System Diseases; Pregnanolone; Progesterone; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Spinal Nerves | 2009 |
Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Brain; Central Nervous System Depressants; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Ethanol; GABA Agents; Gene Expression Regulation; Glucocorticoids; Hypophysectomy; Imidazoles; Immunoglobulin G; Immunoprecipitation; Isoquinolines; Male; Melphalan; Phosphoproteins; Pregnanolone; Pregnenolone; Protein Synthesis Inhibitors; Pyridines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Steroids | 2010 |
The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis.
Topics: 17-alpha-Hydroxypregnenolone; 20-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Bicuculline; Complex Mixtures; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression; Hypothalamus; Isoquinolines; Male; Neuropeptides; Oxazines; Peptide Fragments; Pregnanolone; Progesterone; Rana esculenta; Receptors, GABA-A; Tissue Culture Techniques | 2015 |
Translocator protein mediates the anxiolytic and antidepressant effects of midazolam.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Carrier Proteins; Dose-Response Relationship, Drug; Hippocampus; Isoquinolines; Male; Midazolam; Prefrontal Cortex; Pregnanolone; Rats; Receptors, GABA-A | 2015 |
Involvement of allopregnanolone in the anti-PTSD-like effects of AC-5216.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Fear; Hippocampus; Isoquinolines; Male; Motor Activity; Prefrontal Cortex; Pregnanolone; Purines; Rats; Rats, Sprague-Dawley; Stress Disorders, Post-Traumatic | 2016 |
The effects of PK11195 on meningioma was associated with allopregnanolone biosynthesis, which was mediated by translocator protein 18 KDa.
Topics: Antineoplastic Agents; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Isoquinolines; Meningioma; Pregnanolone; Receptors, GABA | 2016 |
TSPO ligand PK11195 alleviates neuroinflammation and beta-amyloid generation induced by systemic LPS administration.
Topics: Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Aspartic Acid Endopeptidases; Brain-Derived Neurotrophic Factor; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Gene Expression Regulation; Hippocampus; Isoquinolines; Lipopolysaccharides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Pregnanolone; Progesterone; Receptors, GABA | 2016 |
The effects of PK11195 on the MCF-7 and T47D were associated with the allopregnanolone biosynthesis, which was mediated by Translocator Protein 18 KDa.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression; Humans; Isoquinolines; MCF-7 Cells; Pregnanolone; Receptors, GABA; RNA, Messenger | 2016 |
TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model.
Topics: 5-alpha Reductase Inhibitors; Animals; Carrier Proteins; Cholestenone 5 alpha-Reductase; Disease Models, Animal; Dutasteride; Glaucoma; In Vitro Techniques; Isoquinolines; Male; Pregnanolone; Pressure; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Retina; Retinal Ganglion Cells; Up-Regulation | 2016 |
The antidepressant-like activity of AC-5216, a ligand for 18KDa translocator protein (TSPO), in an animal model of diabetes mellitus.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Carrier Proteins; Depression; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Hippocampus; Isoquinolines; Ligands; Male; Molecular Weight; Prefrontal Cortex; Pregnanolone; Purines; Rats, Sprague-Dawley; Receptors, GABA-A | 2016 |
Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety; Dentate Gyrus; Depression; Finasteride; Genetic Vectors; Isoquinolines; Lentivirus; Male; Mice, Inbred ICR; Motor Activity; Pregnanolone; Psychotropic Drugs; Receptors, GABA | 2017 |