Page last updated: 2024-08-23

pregnanolone and morphine

pregnanolone has been researched along with morphine in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's4 (26.67)18.2507
2000's7 (46.67)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Strassburg, CP; Tukey, RH1
Lombardo, F; Obach, RS; Waters, NJ1
Colburn, RW; Coombs, DW; DeLeo, JA; Winfree, CJ1
Meloche, R; Prys-Roberts, C1
Chapman, JM; Cooper, GM; Gray, AJ; Prys-Roberts, C; Sear, JW; Simpson, PJ1
Kulkarni, SK; Reddy, DS1
Czuchwicki, A; Ilsley, AH; Love, DR; Owen, H; Plummer, JL1
Bowen, CA; Gatto, GJ; Grant, KA1
Bachtell, RK; Ryabinin, AE; Tsivkovskaia, NO1
Gingras, M; Le Moal, M; Marinelli, M; Mayo, W; Piazza, PV; Rougé-Pont, F1
Grobin, AC; Morrow, AL; Porrino, LJ; VanDoren, MJ1
Biggio, G; Brundu, A; Concas, A; Marra, C; Porcu, P; Sogliano, C1
Gerak, LR1
Elfverson, M; Johansson, T; Nyberg, F; Zhou, Q1
Eppolito, AK; Gerak, LR; Kodeih, HR1

Reviews

2 review(s) available for pregnanolone and morphine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
Management of anesthesia in patients with hypertension or ischemic heart disease.
    International anesthesiology clinics, 1980,Winter, Volume: 18, Issue:4

    Topics: Alfaxalone Alfadolone Mixture; Analgesics; Anesthesia; Anesthesia, Conduction; Anesthesia, Local; Coronary Disease; Emergencies; Fentanyl; Fluid Therapy; Humans; Hypertension; Monitoring, Physiologic; Morphine; Narcotics; Postoperative Care; Pregnanolone; Premedication; Surgical Procedures, Operative

1980

Trials

1 trial(s) available for pregnanolone and morphine

ArticleYear
Influence of premedication with diazepam or morphine on the induction dose of eltanolone.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:5

    Topics: Adjuvants, Anesthesia; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Confidence Intervals; Diazepam; Double-Blind Method; Female; Humans; Incidence; Injections, Intramuscular; Logistic Models; Male; Middle Aged; Morphine; Movement; Placebos; Preanesthetic Medication; Pregnanolone

1998

Other Studies

12 other study(ies) available for pregnanolone and morphine

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Analgesic effects of intrathecally-administered 3 alpha-hydroxy-5 alpha-pregnan-20-one in a rat mechanical visceral pain model.
    Life sciences, 1992, Volume: 50, Issue:14

    Topics: Analgesics; Animals; Disease Models, Animal; Injections, Spinal; Male; Morphine; Pain; Pregnanolone; Rats; Spinal Cord

1992
Studies on premedication and ventilatory responses to minaxolone.
    Acta anaesthesiologica Belgica, 1981, Volume: 32, Issue:2

    Topics: Adult; Anesthetics; Atropine; Diazepam; Female; Humans; Male; Morphine; Nitrous Oxide; Oxygen; Preanesthetic Medication; Pregnanes; Pregnanolone; Respiration; Time Factors

1981
Chronic neurosteroid treatment prevents the development of morphine tolerance and attenuates abstinence behavior in mice.
    European journal of pharmacology, 1997, Oct-15, Volume: 337, Issue:1

    Topics: Analgesics, Opioid; Animals; Dehydroepiandrosterone; Drug Tolerance; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Pregnanolone; Pregnenolone; Reaction Time; Steroids; Substance Withdrawal Syndrome

1997
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
    Behavioural pharmacology, 1997, Volume: 8, Issue:4

    Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water

1997
Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2

    Topics: Aminoacetonitrile; Animals; Brain; Chlordiazepoxide; Dopamine; Ethanol; Gene Expression Regulation; Genes, fos; Haloperidol; Male; Mice; Mice, Inbred C57BL; Morphine; Norepinephrine; Pregnanolone; Protease Inhibitors; Signal Transduction; Tyrosine 3-Monooxygenase; Yohimbine

2002
The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens.
    The European journal of neuroscience, 2002, Volume: 16, Issue:1

    Topics: Analgesics, Opioid; Animals; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Injections, Intraventricular; Male; Microdialysis; Morphine; Narcotics; Nucleus Accumbens; Pregnanolone; Rats; Rats, Sprague-Dawley

2002
Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphine.
    Psychopharmacology, 2005, Volume: 179, Issue:3

    Topics: Animals; Cerebral Cortex; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Male; Morphine; Pregnanolone; Rats; Rats, Sprague-Dawley

2005
Neurosteroids in nicotine and morphine dependence.
    Psychopharmacology, 2006, Volume: 186, Issue:3

    Topics: Analgesics, Opioid; Animals; Cerebral Cortex; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Antagonists; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2006
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.
    Psychopharmacology, 2009, Volume: 204, Issue:4

    Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Ketamine; Male; Midazolam; Morphine; Pentobarbital; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reinforcement Schedule; Substance-Related Disorders

2009
Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration.
    Biochemical and biophysical research communications, 2010, Oct-29, Volume: 401, Issue:4

    Topics: Allosteric Regulation; Animals; Brain; Dehydroepiandrosterone; Male; Morphine; Neurotransmitter Agents; Opioid-Related Disorders; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2010
Using drug combinations to assess potential contributions of non-GABAA receptors in the discriminative stimulus effects of the neuroactive steroid pregnanolone in rats.
    Physiology & behavior, 2014, Volume: 137

    Topics: Animals; Biguanides; Central Nervous System Depressants; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Modulators; Male; Midazolam; Morphine; Narcotics; Phencyclidine; Pregnanolone; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists

2014