pregnanolone has been researched along with midazolam in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 12 (38.71) | 24.3611 |
| 2020's | 3 (9.68) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Dundee, JW | 1 |
| Desmonts, JM | 1 |
| Carl, P; Høgskilde, S; Sørensen, MB; Wagner, J | 1 |
| Biggio, G; Cagetti, E; Concas, A; Dazzi, L; Sanna, A | 1 |
| Bowen, CA; Gatto, GJ; Grant, KA | 1 |
| Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H | 1 |
| Azarov, AV; Grant, KA; Green, KL; Purdy, RH; Szeliga, KT | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Bidziński, A; Członkowska, AI; Kostowski, W; Krzaścik, P; Maciejak, P; Plaznik, A; Szyndler, J; Walkowiak, J | 1 |
| Grant, KA; Porcu, P | 1 |
| France, CP; McMahon, LR | 2 |
| France, CP; Javors, MA; McMahon, LR | 1 |
| Gerak, LR | 1 |
| Darbra, S; Pallarès, M | 3 |
| Bai, X; Gerak, LR | 1 |
| Izumi, Y; O'Dell, KA; Tokuda, K; Zorumski, CF | 1 |
| France, CP; Gerak, LR | 2 |
| France, CP; Gerak, LR; Yoon, SS; Zanettini, C | 1 |
| Eppolito, AK; Gerak, LR; Kodeih, HR | 1 |
| Chen, JS; Chen, Y; He, JL; Lai, S; Li, MS; Li, Y; Liu, X; Ma, JC; Qiu, ZK; Shen, YG; Wu, HW; Zeng, J; Zhang, GH | 1 |
| Carver, CM; Reddy, DS | 1 |
| Gerak, LR; Ibarra, MH; Pressly, JD; Smith, KR; Zanettini, C | 1 |
| Chesnoy-Marchais, D | 1 |
| Chuang, SH; Reddy, DS | 1 |
| Bruun, DA; Calsbeek, J; Dhir, A; González, E; Guignet, M; Harvey, DJ; Lein, PJ; Rogawski, MA; Saito, N; Tancredi, DJ; Tsai, YH; Vu, J | 1 |
| Aleman, M; Bruun, DA; Chen, YJ; Lein, PJ; Ma, B; Rogawski, MA; Smiley-Jewell, SM; Wu, CY; Zolkowska, D | 1 |
31 other study(ies) available for pregnanolone and midazolam
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
New i.v. anaesthetics.
Topics: Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; Etomidate; Humans; Kinetics; Midazolam; Phenols; Pregnanolone; Propofol | 1979 |
[Intravenous anesthetics: what future?].
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Animals; Benzodiazepines; Etomidate; Humans; Midazolam; Phenols; Polyethylene Glycols; Pregnanolone; Propofol | 1985 |
Anaesthetic properties of pregnanolone emulsion. A comparison with alphaxolone/alphadolone, propofol, thiopentone and midazolam in a rat model.
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Anesthetics; Animals; Drug Evaluation, Preclinical; Emulsions; Female; Male; Midazolam; Phenols; Pregnanes; Pregnanolone; Propofol; Rats; Rats, Inbred Lew; Thiopental | 1987 |
Inhibition by the neurosteroid allopregnanolone of basal and stress-induced acetylcholine release in the brain of freely moving rats.
Topics: Acetylcholine; Animals; Cerebral Cortex; Electroshock; Foot; GABA Modulators; Hippocampus; Male; Midazolam; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Reference Values; Stress, Physiological | 1996 |
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water | 1997 |
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 1999 |
The influence of menstrual cycle phase on sensitivity to ethanol-like discriminative stimulus effects of GABA(A)-positive modulators.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Discrimination, Psychological; Dose-Response Relationship, Drug; Ethanol; Female; GABA Modulators; Macaca fascicularis; Menstrual Cycle; Midazolam; Pregnanolone; Receptors, GABA-A | 1999 |
Tolerance to the anticonvulsant activity of midazolam and allopregnanolone in a model of picrotoxin seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Drug Combinations; Drug Tolerance; Male; Mice; Midazolam; Muscle, Skeletal; Picrotoxin; Pregnanolone; Receptors, GABA-A; Seizures | 2001 |
Antagonism of picrotoxin-induced changes in dopamine and serotonin metabolism by allopregnanolone and midazolam.
Topics: Amino Acids; Animals; Convulsants; Dopamine; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; Injections, Intraventricular; Male; Mice; Microinjections; Midazolam; Picrotoxin; Pregnanolone; Seizures; Serotonin | 2002 |
Discriminative stimulus effects of ethanol in rats using a three-choice ethanol-midazolam-water discrimination.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Discrimination Learning; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Hypnotics and Sedatives; Indoles; Midazolam; Pentobarbital; Phencyclidine; Piperazines; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1B; Serotonin Receptor Agonists | 2004 |
Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Isoxazoles; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors; Triazolam; Women | 2005 |
Negative GABA(A) modulators attenuate the discriminative stimulus effects of benzodiazepines and the neuroactive steroid pregnanolone in rhesus monkeys.
Topics: Animals; Benzodiazepines; Carbolines; Discrimination Learning; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Serotonin Antagonists; Serotonin Receptor Agonists | 2005 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2007 |
Selective changes in sensitivity to benzodiazepines, and not other positive GABA(A) modulators, in rats receiving flunitrazepam chronically.
Topics: Animals; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; Ketamine; Male; Midazolam; Morphine; Pentobarbital; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reinforcement Schedule; Substance-Related Disorders | 2009 |
Neonatal allopregnanolone increases novelty-directed locomotion and disrupts behavioural responses to GABA(A) receptor modulators in adulthood.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Exploratory Behavior; Flumazenil; GABA Modulators; Isoxazoles; Lorazepam; Male; Maze Learning; Midazolam; Motor Activity; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2009 |
Alterations in neonatal neurosteroids affect exploration during adolescence and prepulse inhibition in adulthood.
Topics: 5-alpha Reductase Inhibitors; Aging; Animals; Animals, Newborn; Anti-Anxiety Agents; Brain; Enzyme Inhibitors; Exploratory Behavior; Female; Finasteride; Male; Midazolam; Neural Inhibition; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Reflex, Startle; Sexual Maturation | 2010 |
Comparing the discriminative stimuli produced by either the neuroactive steroid pregnanolone or the benzodiazepine midazolam in rats.
Topics: Animals; Behavior, Animal; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; Male; Midazolam; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2011 |
Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis.
Topics: Androstenols; Animals; Avoidance Learning; Carrier Proteins; Clonazepam; Excitatory Postsynaptic Potentials; Finasteride; Hippocampus; Indoleacetic Acids; Long-Term Potentiation; Male; Midazolam; Neurons; Neurotransmitter Agents; Pregnanolone; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2010 |
Effects of early postnatal allopregnanolone administration on elevated plus maze anxiety scores in adult male Wistar rats.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Male; Midazolam; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2012 |
Quantitative analyses of antagonism: combinations of midazolam and either flunitrazepam or pregnanolone in rhesus monkeys discriminating midazolam.
Topics: Animals; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; Flunitrazepam; Macaca mulatta; Midazolam; Pregnanolone; Receptors, GABA-A | 2012 |
Acute tolerance to chlordiazepoxide qualitatively changes the interaction between flumazenil and pregnanolone and not the interaction between flumazenil and midazolam in rhesus monkeys discriminating midazolam.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Female; Flumazenil; GABA Modulators; Macaca mulatta; Midazolam; Pregnanolone | 2013 |
Discriminative stimulus effects of pregnanolone in rhesus monkeys.
Topics: Animals; Conditioning, Operant; Data Interpretation, Statistical; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flumazenil; Flunitrazepam; GABA Modulators; Gonadal Steroid Hormones; Hypnotics and Sedatives; Isoxazoles; Macaca mulatta; Male; Midazolam; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule | 2014 |
Using drug combinations to assess potential contributions of non-GABAA receptors in the discriminative stimulus effects of the neuroactive steroid pregnanolone in rats.
Topics: Animals; Biguanides; Central Nervous System Depressants; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Modulators; Male; Midazolam; Morphine; Narcotics; Phencyclidine; Pregnanolone; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists | 2014 |
Translocator protein mediates the anxiolytic and antidepressant effects of midazolam.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Carrier Proteins; Dose-Response Relationship, Drug; Hippocampus; Isoquinolines; Male; Midazolam; Prefrontal Cortex; Pregnanolone; Rats; Receptors, GABA-A | 2015 |
Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors.
Topics: Animals; Anticonvulsants; Dentate Gyrus; GABA Agonists; GABA Modulators; In Vitro Techniques; Interneurons; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Neurons; Neurotransmitter Agents; Pregnanes; Pregnanolone; Receptors, GABA-A; Seizures; Structure-Activity Relationship | 2016 |
Comparing the discriminative stimulus effects of modulators of GABAA receptors containing α4-δ subunits with those of gaboxadol in rats.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA Agonists; GABA Modulators; Isoxazoles; Male; Midazolam; Pregnanolone; Protein Subunits; Rats; Receptors, GABA-A | 2016 |
Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons.
Topics: Animals; beta-Alanine; Bicuculline; Brain Stem; Central Nervous System Agents; Chlorine; GABA Agents; Hypoglossal Nerve; Midazolam; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pentobarbital; Phosphinic Acids; Pregnanolone; Pyridazines; Pyridines; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Strychnine; Taurine; Tissue Culture Techniques | 2016 |
Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam.
Topics: Animals; Anticonvulsants; beta-Cyclodextrins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Midazolam; Neurosteroids; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Seizures; Tiagabine | 2020 |
Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Animals; Behavior, Animal; Drug Therapy, Combination; Electroencephalography; Isoflurophate; Male; Midazolam; Nitriles; Pregnanolone; Pyridones; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2020 |
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs.
Topics: Administration, Intravenous; Animals; Dogs; Midazolam; Pregnanolone; Status Epilepticus | 2023 |