pregnanolone has been researched along with gamma-aminobutyric acid in 192 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.56) | 18.7374 |
| 1990's | 63 (32.81) | 18.2507 |
| 2000's | 69 (35.94) | 29.6817 |
| 2010's | 33 (17.19) | 24.3611 |
| 2020's | 24 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Covey, DF; Hu, Y; Isenberg, KE; Rodgers-Neame, NT; Zorumski, CF | 1 |
| Prince, RJ; Simmonds, MA | 1 |
| Hill-Venning, C; Lambert, JJ; Peters, JA | 1 |
| Barnard, EA; Darlison, MG; Harvey, RJ; Shingai, R; Zaman, SH | 1 |
| Cadoni, C; Gee, KW | 1 |
| Macdonald, RL; Twyman, RE | 1 |
| Gee, KW; Lan, NC | 1 |
| Majewska, MD; Vaupel, DB | 1 |
| Blakeman, DP; Im, WB | 1 |
| Belelli, D; Gee, KW; McCauley, L | 1 |
| Ayer, DE; Blakeman, DP; Davis, JP; Im, WB | 1 |
| Costa, E; Paul, SM; Pritchett, DB; Puia, G; Purdy, RH; Santi, MR; Seeburg, PH; Vicini, S | 1 |
| Belelli, D; Gee, KW | 1 |
| Smith, SS; Waterhouse, BD; Woodward, DJ | 1 |
| Callachan, H; Cottrell, GA; Hather, NY; Lambert, JJ; Nooney, JM; Peters, JA | 1 |
| Costa, AM; ffrench-Mullen, JM; Smith, SS; Spence, KT | 1 |
| Covey, DF; Han, M; Hu, Y; Zorumski, CF | 1 |
| Brailowsky, S; Calixto, E; Lemini, C; Montiel, T | 1 |
| Dartois, E; Fillion, G; Haour, F; Moyse, E; Vincens, M | 1 |
| Ticku, MK; Yu, R | 1 |
| Jackson, MB; Zhang, SJ | 1 |
| Bähring, R; Grantyn, R; Martelli, EA; Standhardt, H | 1 |
| Berger, TW; Grace, AA; Nisenbaum, ES | 1 |
| Gjerstad, L; Ottersen, OP; Taubøll, E | 1 |
| Bain, CJ; Kemp, JA; McKernan, RM; Quirk, K; Wafford, KA; Whiting, PJ; Wingrove, PB | 1 |
| Finn, DA; Gee, KW | 1 |
| Hauser, CA; Holsboer, F; Rupprecht, R; Wetzel, CH | 1 |
| Bain, C; Garrett, EM; Hadingham, KL; Heavens, RP; Sirinathsinghji, DJ; Wafford, KA; Whiting, PJ | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Hosie, AM; Sattelle, DB | 1 |
| Cooper, TB; Costa, E; Guidotti, A; Uzunov, DP | 1 |
| Akaike, N; Harata, N; Wu, J | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Franks, NP; Lieb, WR | 1 |
| de las Heras, MA; Perez, LJ; Valcarcel, A | 1 |
| Barbaccia, ML; Biggio, G; Concas, A; Mostallino, MC; Purdy, RH; Roscetti, G; Trabucchi, M | 1 |
| Biscardi, R; Wilson, MA | 1 |
| Davies, PA; Hales, TG; Kirkness, EF | 1 |
| Gillies, GE; Murray, HE | 1 |
| Feltz, P; Poisbeau, P; Schlichter, R | 1 |
| Akaike, N; Imanishi, T; Xu, TL | 1 |
| Fries, U; Iglauer, F; Kunze, K; Stuerenburg, HJ | 1 |
| Fiszer de Plazas, S; Viapiano, MS | 2 |
| Firestone, LL; Homanics, GE; Korpi, ER; Mäkelä, R; Quinlan, JJ; Uusi-Oukari, M; Wisden, W | 1 |
| Castel, H; Cazin, L; Le Foll, F; Louiset, E; Vaudry, H | 1 |
| Castel, H; Cazin, L; Le Foll, F; Soriani, O; Vaudry, H | 1 |
| Heesch, CM; Laiprasert, JD; Rogers, RC | 1 |
| ffrench-Mullen, JM; Gong, QH; Hsu, FC; Li, X; Markowitz, RS; Smith, SS | 1 |
| de Novara, AM; de Plazas, SF; Viapiano, MS | 1 |
| Covey, DF; Mennerick, SJ; Zorumski, CF | 1 |
| Kellogg, CK; Olson, VG; Pleger, GL | 1 |
| Simmonds, MA; Sooksawate, T | 2 |
| de Novara, AM; Fiszer de Plazas, S; Gravielle, MC | 1 |
| Bailey, CD; Brien, JF; Reynolds, JN | 1 |
| Maitra, R; Reynolds, JN | 2 |
| Brussaard, AB; Devay, P; Kits, KS; Leyting-Vermeulen, JL | 1 |
| Bayon, LE; Frye, CA | 1 |
| Belelli, D; Lambert, JJ; Peters, JA; Pistis, M | 1 |
| Haage, D; Johansson, S | 1 |
| Amin, J; Moorefield, CN; Morris, KD | 1 |
| Fiszer de Plazas, S; Mitridate de Novara, AM; Rodríguez Gil, DJ; Viapiano, MS | 1 |
| George-Friedman, KP; Rackow, SH; Zimmerberg, B | 1 |
| Reith, CA; Sillar, KT | 1 |
| Chong, A; Hassid, S; Jackson-Friedman, C; Lyden, P; Macdonald, RL; Shin, C | 1 |
| Bargas, J; Brailowsky, S; Calixto, E; Casasola, C; López-Colomé, AM; Montiel, T | 1 |
| Sapp, DW; Yeh, HH | 1 |
| Chopde, CT; Khisti, RT | 1 |
| Beart, PM; Crossley, KJ; Hirst, JJ; Walker, DW | 1 |
| Biggio, G; Littera, M; Papi, G; Pisu, MG; Purdy, RH; Sanna, E; Serra, M; Tuveri, F; Usala, L | 1 |
| Beekman, M; Carter, RB; Dijkstra, D; Gasior, M; Ungard, JT; Witkin, JM | 1 |
| Dekermendjian, K; Hartvig, L; Liljefors, T; Lükensmejer, B | 1 |
| Murphy, DD; Segal, M | 1 |
| Fiszer de Plazas, S; Rodríguez Gil, DJ; Viapiano, MS | 1 |
| Fiszer de Plazas, S; Pignataro, L | 1 |
| di Michele, F; Furnari, C; Guidotti, A; Korpi, ER; Mäkelä, R; Romeo, E; Rosenberg, PH; Sarviharju, M; Uusi-Oukari, M; Xu, M | 1 |
| Adkins, CE; Bonnert, TP; Gonzalez, JE; Haldon, C; Kerby, J; McKernan, RM; Oades, K; Pillai, GV; Simpson, PB; Whiting, PJ | 1 |
| Jhangri, GS; Le Mellédo, JM; Semeniuk, T | 1 |
| Bertram, EH; Kapur, J; Mtchedlishvili, Z | 1 |
| Bäckström, T; Birzniece, V; Johansson, IM; Lindblad, C; Olsson, T | 1 |
| Chigr, F; M'hamed, SB; Najimi, M | 1 |
| Sheng, MP; Xu, XH; Yu, R | 1 |
| Barker, JL; Chang, YH; Liu, QY; Schaffner, AE; Smith, SV | 1 |
| Epperson, CN; Gueorguieva, R; Haga, K; Krystal, JH; Mason, GF; Rothman, DL; Sellers, E; Weiss, E; Zhang, W | 1 |
| Dillon, GH; Huang, RQ | 1 |
| De Almeida, RM; De Bold, JF; Fish, EW; Miczek, KA | 1 |
| Akaike, N; Kakazu, Y; Mizoguchi, Y; Nabekura, J; Noda, E; Uchida, S | 1 |
| Druzin, M; Haage, D; Johansson, S | 1 |
| Duncan, GE; Lieberman, JA; Marx, CE; Morrow, AL; VanDoren, MJ | 1 |
| Costa, E; Guidotti, A; Matsumoto, K; Mienville, JM; Puia, G; Takahata, H; Watanabe, H | 1 |
| Akk, G; Bracamontes, JR; Covey, DF; Darbandi-Tonkabon, R; Evers, AS; Hastings, WR; Manion, BD; Mennerick, SJ; Steinbach, JH; Zeng, CM | 1 |
| Brussaard, AB; Koksma, JJ; Lüddens, H; Rosahl, TW; Smit, AB; van Kesteren, RE; Zwart, R | 1 |
| Bernardi, G; di Michele, F; Pace, M; Pasinib, A; Pompili, E; Romeo, E; Rupprecht, R | 1 |
| Faber, DS; Hsu, FC; Smith, SS; Waldeck, R | 1 |
| Grobin, AC; Heenan, EJ; Lieberman, JA; Morrow, AL | 1 |
| Harrison, MB; Kapur, J; Mtchedlishvili, Z; Sun, CS | 1 |
| Khisti, RT; Morrow, AL; O'Buckley, T; VanDoren, MJ | 1 |
| Fjalland, B; Hansen, SL; Jackson, MB | 1 |
| Bäckström, T; Lundgren, P; Strömberg, J; Wang, M | 1 |
| Moenter, SM; Sullivan, SD | 1 |
| Calvo, DJ; Goutman, JD | 1 |
| Chopde, CT; Hirani, K; Morelli, M; Ugale, RR | 1 |
| Frye, CA; Sumida, K; Walf, AA | 1 |
| Backstrom, T; Birzniece, V; Johansson, IM; Lundgren, P; Turkmen, S; Zingmark, E | 1 |
| Chopde, CT; Hirani, K; Mittal, N; Ugale, RR | 1 |
| Avellana-Adalid, V; Baron-Van Evercooren, A; Cadepond, F; El-Etr, M; Gago, N; Samuel, D; Sananès, N; Schumacher, M | 1 |
| Bitran, D; Smith, SS | 1 |
| Bäckström, T; Haage, D; Johansson, S | 1 |
| France, CP; McMahon, LR | 1 |
| Bäckström, T; Lundgren, P; Strömberg, J | 1 |
| Bíró, T; Maksay, G | 1 |
| Dudek, BC; Frye, CA; Harney, JP; Lydon, JP; O'Malley, BW; Pfaff, DW; Rhodes, ME; Sumida, K | 1 |
| Aptel, H; Bancel, F; Dayanithi, G; Méchaly, I; Puech, S; Valmier, J; Viéro, C | 1 |
| Bäckström, T; Haage, D; Lundgren, P; Strömberg, J; Taube, M | 1 |
| Smith, SS; Zhou, X | 1 |
| Marx, CE; Moore, SD; Morrow, AL; Wang, C; Wilson, WA | 1 |
| Miura, Y | 1 |
| Akk, G; Covey, DF; Eisenman, LN; Evers, AS; Kress, GJ; Manion, BD; Mennerick, S; Shu, HJ; Steinbach, JH; Wang, C; Zorumski, CF | 1 |
| Aoki, C; Dattilo, M; Gong, QH; Ruderman, Y; Shen, H; Smith, SS; Williams, K; Yuan, M | 1 |
| Akk, G; Covey, DF; Li, P; Mennerick, S; Shu, HJ; Steinbach, JH; Wang, C; Zorumski, CF | 1 |
| Bishnoi, M; Chopra, K; Kulkarni, SK | 1 |
| Erisir, A; Kapur, J; Mtchedlishvili, Z; Sun, C | 1 |
| Caruso, D; Melcangi, RC; Nobbio, L; Roglio, I; Schenone, A; Scurati, S | 1 |
| Lovick, TA | 1 |
| Dall'olio, R; Gandolfi, O; Locchi, F; Rimondini, R | 1 |
| Akk, G; Bracamontes, J; Covey, DF; Li, P; Reichert, DE; Steinbach, JH | 1 |
| De Sarro, G; Dore, R; Maciocco, E; Mostallino, MC; Mura, ML; Pisu, MG; Russo, E; Serra, M | 1 |
| Begliuomini, S; Casarosa, E; Cela, V; Cubeddu, A; Freschi, L; Genazzani, AR; Giannini, A; Lenzi, E; Luisi, S; Merlini, S; Ninni, F; Pluchino, N | 1 |
| Costa, E; Guidotti, A; Pinna, G | 1 |
| Akk, G; Bracamontes, J; Li, P; Steinbach, JH | 1 |
| Bandyopadhyaya, AK; Benz, A; Chisari, M; Covey, DF; Eisenman, LN; Krishnan, K; Mennerick, S; Taylor, A; Wang, C; Zorumski, CF | 1 |
| Ballabio, M; Bonanno, G; Frasca, A; Fumagalli, F; Magnaghi, V; Parducz, A; Procacci, P; Racagni, G | 1 |
| Fleming, RL; Manis, PB; Morrow, AL | 1 |
| Finn, DA; Kaufman, KR; Strong, MN; Tanchuck, MA | 1 |
| Bell, SV; Jenkins, A; Williams, CA | 1 |
| Chang, JL; Chen, MJ; Lin, TB; Lu, HT; Pan, SF; Peng, HY; Wu, HC | 1 |
| Ashenhurst, JR; Hutchison, KE; Morrow, AL; Ray, LA | 1 |
| Joshi, S; Kapur, J; Mtchedlishvilli, Z; Rajasekaran, K; Sun, C | 1 |
| Amato, RJ; He, H; Lewis, PB; Winsauer, PJ | 1 |
| Andreen, L; Backstrom, T; Johansson, IM; Turkmen, S; Wahlstrom, G | 1 |
| Coyne, L; Halliwell, RF; Hirakawa, R; Przyborski, SA; Shan, M | 1 |
| Cho, CH; Han, SK; Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Lee, SK; Lee, SY; Pandit, S; Park, JB; Ryu, PD; Stern, JE | 1 |
| Ballabio, M; Di Cairano, ES; Magnaghi, V; Perego, C | 1 |
| Agustí, A; Cauli, O; Felipo, V; González-Usano, A | 1 |
| Akk, G; Bracamontes, JR; Li, P; Steinbach, JH | 1 |
| Bell-Carter, D; Hacker, Y; Isang, M; Omole, F; Patterson, E | 1 |
| Bazzocchini, V; Cabrera, R; Casas, S; Escudero, C; Giuliani, FA; Laconi, MR; Yunes, R | 1 |
| Harada, K; Inoue, M; Matsuoka, H; Nakamura, J | 1 |
| Aitta-Aho, T; den Hollander, B; Korpi, ER; Manner, AK; Uusi-Oukari, M; Vashchinkina, E; Vekovischeva, O | 1 |
| Baker, GB; Branton, WG; Lu, JQ; Paul, AM; Polyak, MJ; Power, C; Walsh, JG | 1 |
| Gao, H; Ma, YX; Qiao, MQ; Shang, YZ; Xia, T; Zhang, HY | 1 |
| Alkana, RL; Asatryan, L; Davies, DL; Homanics, GE; Muchhala, KH; Naito, A; Perkins, DI; Trudell, JR | 1 |
| Aoki, C; Gong, QH; Kuver, A; Molla, J; Sabaliauskas, N; Shen, H; Smith, SS | 1 |
| Belelli, D; Brown, AR; Herd, MB; Lambert, JJ | 1 |
| Ackley, MA; Corbin, JG; Doherty, JJ; Huntsman, MM; Loya, CM; Martin, BS; Martinez-Botella, G; Robichaud, AJ; Salituro, FG | 1 |
| André, E; de Sousa Pinto, ÍA; Gavioli, EC; Lovick, T; Santos, RO; Soares-Rachetti, Vde P | 1 |
| Barton, BA; Deligiannidis, KM; Hall, JE; Jaitly, N; Kroll-Desrosiers, AR; Mo, S; Nguyen, HP; Rothschild, AJ; Shaffer, SA; Svenson, A | 1 |
| Beattie, MC; Hasirci, AS; Maldonado-Devincci, AM; Morrow, AL; O'Buckley, TK | 1 |
| Ackley, MA; Althaus, AL; Doherty, JJ; Hammond, RS; Maciag, C; Martinez Botella, G; Robichaud, AJ; Salituro, FG | 1 |
| Bäckström, T; Bixo, M; Holmberg, E; Jaukkuri, L; Johansson, M; Löfgren, M; Lundqvist, A; Malinina, E; Ragagnin, G; Sjöstedt, J; Turkmen, S | 1 |
| Caruso, D; Cilurzo, F; Gennari, CG; Magnaghi, V; Minghetti, P; Mitro, N | 1 |
| Jin, YH; Kim, S; Kim, SM; Oh, B; Tak, J; Yang, E | 1 |
| Carrillo, NR; Giulivi, C; Hagerman, RJ; Napoli, E; Rogawski, M; Schneider, A; Tassone, F; Trivedi, A; Wang, JY | 1 |
| Deligiannidis, KM; Edden, RA; Fales, CL; Frederick, BB; Hall, JE; Kroll-Desrosiers, AR; Moore, CM; Rothschild, AJ; Shaffer, SA; Sikoglu, EM; Tan, Y; Villamarin, V | 1 |
| Naguy, A | 1 |
| Ding, ZC; Fang, XX; Guo, Y; Jiang, XY; Li, YF; Ran, YH; Shang, C; Sun, LJ; Wang, HL; Yao, JQ; Zhang, LM | 1 |
| Aspesi, D; Gatta, E; Grayson, DR; Guidotti, A; Pandey, SC; Pinna, G; Saudagar, V | 1 |
| Akk, G; Evers, AS; Germann, AL; Pierce, SR; Steinbach, JH | 1 |
| Antkowiak, B; Drexler, B; Grasshoff, C; Grenz, J | 1 |
| Ahn, JH; Ahn, SH; Bae, MA; Cho, SH; Hwang, KS; Kan, H; Kim, SS; Lee, BH; Shin, DS; Son, Y; Yang, JY | 1 |
| Harada, K; Inoue, M; Matsuoka, H; Toyohira, Y; Yanagawa, Y | 1 |
| Almeida, FB; Barros, HMT; Pinna, G | 1 |
| Bäckström, T; Bixo, M; Das, R | 1 |
| Akk, G; Covey, DF; Evers, AS; Wang, L | 1 |
| Gallo, AT; Hulse, GK | 1 |
| Bäckström, T; Blackburn, TP; Doverskog, M; Felipo, V; Gimenez-Garzo, C; Hällgren, A; Izquierdo-Altarejos, P; Llansola, M; Martinez-Garcia, M; Mincheva, G | 1 |
| Bukanova, JV; Kondratenko, RV; Solntseva, EI | 1 |
| Benz, A; Lambert, PM; Mennerick, S; Ni, R; Rensing, NR; Wong, M; Zorumski, CF | 1 |
| Brunner, LM; Kufner, M; Nothdurfter, C; Pradhan, AK; Puig, X; Rammes, G; Rupprecht, C; Rupprecht, R; Schwarzbach, J; Wein, S | 1 |
| Besheer, J; Boero, G; Morrow, AL; O'Buckley, TK; Ornelas, LC; Van Voorhies, K | 1 |
| Benz, A; Lambert, P; Lu, X; Mennerick, SJ; Zorumski, CF | 1 |
| Antonoudiou, P; Barros, L; Dargan, T; DiLeo, A; Evans-Strong, A; Gabby, J; Howard, S; Kong, D; Maguire, JL; Paracha, R; Sánchez, EJ; Walton, NL; Weiss, GL | 1 |
| Akk, G; Amtashar, F; Bracamontes, J; Chen, Z; Chintala, SM; Covey, DF; Evers, AS; Germann, AL; Pierce, SR; Tateiwa, H; Wang, L | 1 |
| Bäckström, T; Bixo, M; Möller, A; Sandström, A; Turkmen, S | 1 |
| Abramova, V; Balik, A; Bartunek, P; Bozikova, P; Cerny, J; Chodounska, H; Ciz, D; Dittert, I; Fili, K; Hill, M; Hrcka Krausova, B; Korinek, M; Kudova, E; Kysilov, B; Leal Alvarado, V; Maly, M; Martinovic, J; Smejkalova, T; Vales, K; Vyklicky, L; Vyklicky, V | 1 |
| Bäckström, T; Blackburn, TP; Das, R; Doverskog, M; Turkmen, S | 1 |
| Rubinow, DR; Sikes-Keilp, C | 1 |
| Fan, C; Hibbs, RE; Howard, RJ; Legesse, DH; Lindahl, E; Noviello, CM; Teng, J; Zhuang, Y | 1 |
| Gao, D; Gao, M; Liu, H; Qiao, M; Sun, C; Sun, Y; Wang, J; Zhang, H; Zhang, Y; Zhang, Z | 1 |
10 review(s) available for pregnanolone and gamma-aminobutyric acid
| Article | Year |
|---|---|
Social and neural determinants of aggressive behavior: pharmacotherapeutic targets at serotonin, dopamine and gamma-aminobutyric acid systems.
Topics: Adaptation, Psychological; Aggression; Animals; Brain; Dopamine; Ethanol; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Oxazolidinones; Piperidines; Pregnanolone; Pyridines; Receptors, Dopamine; Receptors, GABA; Receptors, Serotonin; Reinforcement Schedule; Serotonin; Serotonin Receptor Agonists; Social Environment; Tryptamines | 2002 |
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Lacosamide; Levetiracetam; Phenylenediamines; Piracetam; Pregabalin; Pregnanolone; Pyrrolidinones; Triazoles | 2007 |
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake.
Topics: Animals; Brain; Fluoxetine; gamma-Aminobutyric Acid; Humans; Mental Disorders; Mood Disorders; Pregnanolone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Social Isolation; Synaptic Transmission | 2009 |
Tolerance to allopregnanolone with focus on the GABA-A receptor.
Topics: Animals; Drug Tolerance; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Pregnancy; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; RNA, Messenger; Stress, Psychological; Substance Withdrawal Syndrome; Time Factors | 2011 |
Allopregnanolone involvement in feeding regulation, overeating and obesity.
Topics: Animals; Female; gamma-Aminobutyric Acid; Humans; Hyperphagia; Obesity; Polycystic Ovary Syndrome; Pregnancy; Pregnanolone; Receptors, GABA-A | 2018 |
The Role of HPA Axis and Allopregnanolone on the Neurobiology of Major Depressive Disorders and PTSD.
Topics: Adaptation, Physiological; Animals; Antidepressive Agents; Chronic Disease; Corticosterone; Depressive Disorder, Major; Feedback, Physiological; Female; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Male; Models, Biological; Pituitary-Adrenal System; Pregnanolone; Receptors, GABA-A; Sex Characteristics; Stress Disorders, Post-Traumatic; Stress, Physiological; Stress, Psychological | 2021 |
Positive GABA
Topics: Animals; Anti-Anxiety Agents; Clinical Trials, Phase II as Topic; Female; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Pregnanolone; Premenstrual Dysphoric Disorder; Rats; Receptors, GABA-A | 2022 |
Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options.
Topics: Anti-Anxiety Agents; Benzodiazepines; Carrier Proteins; Cognition; Depression; Depression, Postpartum; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Humans; Ligands; Neuronal Plasticity; Neurosteroids; Neurotransmitter Agents; Pregnanolone; Receptors, GABA; Receptors, GABA-A | 2023 |
The GABA system, a new target for medications against cognitive impairment-Associated with neuroactive steroids.
Topics: Aged; Alzheimer Disease; Animals; Cognitive Dysfunction; gamma-Aminobutyric Acid; Humans; Neurosteroids; Pregnanolone; Receptors, GABA-A | 2023 |
GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder.
Topics: Female; GABA Modulators; gamma-Aminobutyric Acid; Humans; Luteal Phase; Menstrual Cycle; Pregnanolone; Premenstrual Dysphoric Disorder; Premenstrual Syndrome; Quality of Life | 2023 |
3 trial(s) available for pregnanolone and gamma-aminobutyric acid
| Article | Year |
|---|---|
Effects of fluoxetine, indomethacine and placebo on 3 alpha, 5 alpha tetrahydroprogesterone (THP) plasma levels in uncomplicated alcohol withdrawal.
Topics: Adult; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Ethanol; Fluoxetine; gamma-Aminobutyric Acid; Humans; Indomethacin; Male; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome | 2000 |
Naltrexone selectively elevates GABAergic neuroactive steroid levels in heavy drinkers with the Asp40 allele of the OPRM1 gene: a pilot investigation.
Topics: Adult; Alcohol Drinking; Alcoholism; Alleles; Amino Acid Substitution; Aspartic Acid; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Naltrexone; Pilot Projects; Polymorphism, Single Nucleotide; Pregnanolone; Receptors, Opioid, mu; Young Adult | 2010 |
Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study.
Topics: Aged; Anxiety; Ataxia; Depression; Energy Metabolism; Fragile X Syndrome; gamma-Aminobutyric Acid; Humans; Male; Metabolomics; Middle Aged; Mitochondria; Ornithine; Oxidative Stress; Pilot Projects; Pregnanolone; Tremor | 2019 |
179 other study(ies) available for pregnanolone and gamma-aminobutyric acid
| Article | Year |
|---|---|
Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons.
Topics: Animals; Cells, Cultured; Chloride Channels; Chlorides; gamma-Aminobutyric Acid; Hippocampus; Indenes; Ion Channel Gating; Ion Channels; Isomerism; Membrane Proteins; Molecular Structure; Neurons; Pregnanolone; Rats | 1992 |
5 beta-pregnan-3 beta-ol-20-one, a specific antagonist at the neurosteroid site of the GABAA receptor-complex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Flunitrazepam; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pentobarbital; Pregnanolone; Rats; Rats, Inbred Strains | 1992 |
The interaction of steroids with inhibitory and excitatory amino acid receptors.
Topics: Anesthetics; Animals; Cattle; Cells, Cultured; gamma-Aminobutyric Acid; Mice; Neurons; Pregnanediones; Pregnanolone; Receptors, Amino Acid; Receptors, Cell Surface; Steroids | 1992 |
Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.
Topics: Animals; Base Sequence; DNA; gamma-Aminobutyric Acid; Humans; Macromolecular Substances; Molecular Sequence Data; Oocytes; Polymerase Chain Reaction; Pregnanolone; Pregnenolone; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1992 |
Complex interactions between the steroid derivative RU 5135 and the GABAA-receptor complex.
Topics: Androstanes; Animals; Azasteroids; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanediol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism | 1992 |
Neurosteroid regulation of GABAA receptor single-channel kinetic properties of mouse spinal cord neurons in culture.
Topics: Androsterone; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; gamma-Aminobutyric Acid; Ion Channel Gating; Kinetics; Mice; Neurons; Pregnanolone; Receptors, GABA-A | 1992 |
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes | 1991 |
Steroid control of uterine motility via gamma-aminobutyric acidA receptors in the rabbit: a novel mechanism?
Topics: Animals; Female; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Progesterone; Progestins; Rabbits; Receptors, GABA-A; Stimulation, Chemical; Uterine Contraction | 1991 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Heterotropic cooperativity between putative recognition sites for progesterone metabolites and the atypical benzodiazepine Ro 5-4864.
Topics: Animals; Benzodiazepinones; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Convulsants; gamma-Aminobutyric Acid; Male; Pregnanediol; Pregnanolone; Progesterone; Rats; Rats, Inbred Strains | 1990 |
Studies on the mechanism of interactions between anesthetic steroids and gamma-aminobutyric acidA receptors.
Topics: Anesthetics; Animals; Chlorides; Desoxycorticosterone; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Nipecotic Acids; Pentobarbital; Pregnanolone; Progesterone; Proline; Rats; Receptors, GABA-A; Synaptic Membranes | 1990 |
Neurosteroids act on recombinant human GABAA receptors.
Topics: Benzodiazepines; Cell Line, Transformed; Cell Membrane Permeability; Chlorides; Desoxycorticosterone; Electric Conductivity; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Pentobarbital; Pregnanolone; Receptors, GABA-A; Recombinant Proteins; Transfection | 1990 |
5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes.
Topics: Animals; Benzodiazepines; Bicuculline; Chlorides; Clonazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ionophores; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1989 |
Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum.
Topics: Animals; Drug Interactions; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Iontophoresis; Pregnanediol; Pregnanes; Pregnanolone; Purkinje Cells; Rats; Rats, Inbred Strains | 1987 |
Modulation of the GABAA receptor by progesterone metabolites.
Topics: Adrenal Medulla; Animals; Cattle; Cells, Cultured; gamma-Aminobutyric Acid; Kinetics; Membrane Potentials; Phenobarbital; Pregnanediones; Pregnanes; Pregnanolone; Receptors, GABA-A | 1987 |
Withdrawal from the endogenous steroid progesterone results in GABAA currents insensitive to benzodiazepine modulation in rat CA1 hippocampus.
Topics: Animals; Benzodiazepines; Brain Chemistry; Chloride Channels; Electrophysiology; Female; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Ion Channel Gating; Lorazepam; Picrotoxin; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome | 1995 |
Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5 beta-configuration.
Topics: Animals; Chloride Channels; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Indenes; Membrane Potentials; Molecular Structure; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Receptors, GABA | 1995 |
Allopregnanolone potentiates a GABA-withdrawal syndrome in the rat cerebral cortex.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Disease Models, Animal; Drug Synergism; Electroencephalography; Epilepsies, Partial; gamma-Aminobutyric Acid; Male; Neurons; Pregnanolone; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 1995 |
An autoradiographic study comparing the interactions of 3 alpha-OH-5 alpha-pregnan-20-one, pregnenolone sulfate and pentobarbital with [3S]-TBPS binding sites and their modulation by GABA in different structures of the rat brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mesencephalon; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Chronic neurosteroid treatment produces functional heterologous uncoupling at the gamma-aminobutyric acid type A/benzodiazepine receptor complex in mammalian cortical neurons.
Topics: Androstanes; Animals; Azasteroids; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chlorides; Chlorine; Convulsants; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Inbred C57BL; Neurons; Pregnanolone; Radioisotopes; Radioligand Assay; Receptors, GABA-A; Sulfur Radioisotopes; Time Factors; Tritium | 1995 |
Neuroactive steroids modulate GABAA receptors in peptidergic nerve terminals.
Topics: Animals; Chloride Channels; Drug Synergism; Electric Conductivity; Estradiol; gamma-Aminobutyric Acid; Ion Channel Gating; Nerve Endings; Neuropeptides; Pituitary Gland, Posterior; Pregnanediones; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1994 |
GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons?
Topics: Acetylcarnitine; Acetylcholine; Action Potentials; Animals; Bicuculline; Chloride Channels; Clonazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Potassium Chloride; Pregnanolone; Quinoxalines; Retina; Retinal Ganglion Cells; Strychnine; Substrate Specificity; Tetrodotoxin; Zinc | 1994 |
Depression of glutamatergic and GABAergic synaptic responses in striatal spiny neurons by stimulation of presynaptic GABAB receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Corpus Striatum; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Lidocaine; Male; Neurons; Pregnanolone; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Sodium Channel Blockers; Synapses | 1993 |
The progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one reduces K(+)-induced GABA and glutamate release from identified nerve terminals in rat hippocampus: a semiquantitative immunocytochemical study.
Topics: Animals; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hippocampus; Immunohistochemistry; Nerve Endings; Potassium; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley | 1993 |
A novel allosteric modulatory site on the GABAA receptor beta subunit.
Topics: Allosteric Site; Animals; Anticonvulsants; Cells, Cultured; Chlorides; Drug Synergism; Electric Conductivity; Electrophysiology; Female; gamma-Aminobutyric Acid; Gene Expression; Humans; Pentobarbital; Pregnanolone; Rats; Receptors, GABA; Transfection; Triazoles; Xenopus | 1994 |
The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; gamma-Aminobutyric Acid; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors | 1993 |
Allopregnanolone acts as an inhibitory modulator on alpha1- and alpha6-containing GABA-A receptors.
Topics: Animals; Anti-Anxiety Agents; Cell Line; Cell Membrane; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Hypothalamus; Kinetics; Membrane Potentials; Molecular Sequence Data; Muscimol; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1996 |
Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.
Topics: Amino Acid Sequence; Animals; Antisense Elements (Genetics); Autoradiography; Base Sequence; Cerebellar Cortex; Cloning, Molecular; DNA Primers; DNA, Complementary; Female; Flunitrazepam; gamma-Aminobutyric Acid; Humans; In Situ Hybridization; Kinetics; L Cells; Ligands; Macromolecular Substances; Membrane Potentials; Mice; Molecular Sequence Data; Oocytes; Pentobarbital; Polymerase Chain Reaction; Pregnanolone; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Transfection; Xenopus laevis | 1996 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster.
Topics: Allosteric Regulation; Animals; Chloride Channels; Dose-Response Relationship, Drug; Drosophila melanogaster; GABA Modulators; gamma-Aminobutyric Acid; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA; Triazoles; Xenopus | 1996 |
Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography.
Topics: 20-alpha-Dihydroprogesterone; Adrenalectomy; Animals; Brain; Castration; Fluoxetine; GABA Modulators; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Imipramine; Male; Paroxetine; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley | 1996 |
Potentiation by sevoflurane of the gamma-aminobutyric acid-induced chloride current in acutely dissociated CA1 pyramidal neurones from rat hippocampus.
Topics: Animals; Chloride Channels; Diazepam; Drug Synergism; Ethers; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channel Gating; Methyl Ethers; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Sevoflurane | 1996 |
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship | 1997 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Selectivity of general anesthetics: a new dimension.
Topics: Anesthetics, General; Chloride Channels; Drug Interactions; Electric Conductivity; gamma-Aminobutyric Acid; Humans; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A | 1997 |
In vitro capacitating effect of gamma-aminobutyric acid in ram spermatozoa.
Topics: Acrosome; Analysis of Variance; Animals; Baclofen; Calcimycin; Chlortetracycline; Dose-Response Relationship, Drug; Exocytosis; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscimol; Neuroprotective Agents; Pregnanolone; Prostate-Specific Antigen; Receptors, GABA-A; Receptors, GABA-B; Sheep; Sperm Capacitation; Spermatozoa | 1997 |
The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations.
Topics: Adrenalectomy; Animals; Carbolines; Cerebral Cortex; Corticosterone; GABA Antagonists; gamma-Aminobutyric Acid; Isoniazid; Male; Orchiectomy; Pregnanolone; Rats; Rats, Sprague-Dawley; Stress, Physiological | 1997 |
Influence of gender and brain region on neurosteroid modulation of GABA responses in rats.
Topics: Amygdala; Androgens; Androsterone; Animals; Brain; Cerebellum; Cerebral Cortex; Chlorides; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Pregnanolone; Rats; Sex Characteristics | 1997 |
Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells.
Topics: Anesthetics, General; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Transformed; gamma-Aminobutyric Acid; Humans; Pentobarbital; Pregnanolone; Propofol; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Sulfur Radioisotopes | 1997 |
Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures.
Topics: Animals; Bicuculline; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dopamine; Drug Synergism; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Pregnanolone; Pregnenolone; Rats; Somatostatin | 1997 |
Modulation of GABAA receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model.
Topics: Animals; Animals, Newborn; Cells, Cultured; Electrophysiology; Female; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hypothalamo-Hypophyseal System; Membrane Potentials; Pentobarbital; Pregnancy; Pregnanes; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
Modulation of the GABAA response in rat ventromedial hypothalamic neurons by pregnanolone.
Topics: Animals; Chloride Channels; Chlorides; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Transport; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Ventromedial Hypothalamic Nucleus | 1997 |
Effect of age on synthesis of the GABAergic steroids 5-alpha-pregnane-3,20-dione and 5-alpha-pregnane-3-alpha-ol-20-one in rat cortex in vitro.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Aging; Animals; Buffers; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Male; Oxidoreductases; Pregnanediones; Pregnanolone; Rats; Rats, Inbred Strains | 1997 |
3 beta-OH-5 beta-pregnan-20-one enhances [3H]GABA binding in developing chick optic lobe.
Topics: Animals; Chick Embryo; Drug Synergism; gamma-Aminobutyric Acid; Optic Lobe, Nonmammalian; Pregnanolone; Receptors, GABA; Signal Transduction | 1997 |
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mutation; Pregnanolone; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Tritium; Zinc | 1997 |
Multiple modulatory effects of the neuroactive steroid pregnanolone on GABAA receptor in frog pituitary melanotrophs.
Topics: Action Potentials; Animals; Cells, Cultured; Evoked Potentials; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Isonicotinic Acids; Male; Membrane Potentials; Patch-Clamp Techniques; Pituitary Gland; Pregnanolone; Protein Conformation; Rana ridibunda; Receptors, GABA-A | 1997 |
Comparative modulation by 3 alpha,5 alpha and 3 beta,5 beta neurosteroids of GABA binding sites during avian central nervous system development.
Topics: Animals; Binding Sites; Central Nervous System; Chick Embryo; gamma-Aminobutyric Acid; Isomerism; Optic Lobe, Nonmammalian; Pregnanolone; Receptors, GABA; Synaptic Membranes | 1998 |
Gramicidin-perforated patch revealed depolarizing effect of GABA in cultured frog melanotrophs.
Topics: Animals; Cells, Cultured; Electrophysiology; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gramicidin; Male; Melanocyte-Stimulating Hormones; Membrane Potentials; Patch-Clamp Techniques; Pituitary Gland; Pregnanolone; Rana ridibunda | 1998 |
Neurosteroid modulation of arterial baroreflex-sensitive neurons in rat rostral ventrolateral medulla.
Topics: Animals; Arteries; Baroreflex; Blood Pressure; Differential Threshold; Female; gamma-Aminobutyric Acid; Medulla Oblongata; Neurons; Osmolar Concentration; Pregnanolone; Rats; Rats, Sprague-Dawley; Spinal Cord; Sympathetic Nervous System; Synaptic Transmission | 1998 |
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Carbolines; Female; gamma-Aminobutyric Acid; Hippocampus; Indomethacin; Lorazepam; Oligonucleotides, Antisense; Patch-Clamp Techniques; Pregnanolone; Premenstrual Syndrome; Progesterone; Pyramidal Cells; Rats; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic | 1998 |
Neurosteroid modulation of GABA binding sites in developing avian central nervous system.
Topics: Animals; Binding, Competitive; Central Nervous System; Chick Embryo; Chickens; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Pregnanolone; Protein Binding; Receptors, GABA | 1998 |
Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures.
Topics: Androstanols; Animals; Cells, Cultured; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Hippocampus; Indenes; Ion Channels; Membrane Potentials; Neurons; Nitriles; Patch-Clamp Techniques; Pregnanolone; Rats; Stereoisomerism; Synaptic Membranes; Synaptic Transmission | 1998 |
Neurosteroid action at the GABAA receptor in fetal rat forebrain.
Topics: Androsterone; Animals; Chlorides; Diazepam; Female; Fetus; GABA Modulators; gamma-Aminobutyric Acid; Male; Pregnancy; Pregnanolone; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors; Synaptosomes | 1998 |
Increased membrane cholesterol reduces the potentiation of GABA(A) currents by neurosteroids in dissociated hippocampal neurones.
Topics: Animals; Cholesterol; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hippocampus; Liposomes; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Synapses; Synaptic Membranes | 1998 |
GABA-stimulated chloride uptake during avian CNS development: modulation by neurosteroids.
Topics: Animals; Biological Transport; Brain Chemistry; Chick Embryo; Chloride Channels; Chlorides; GABA Modulators; gamma-Aminobutyric Acid; Optic Lobe, Nonmammalian; Pregnanolone; Receptors, GABA-A | 1998 |
Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex.
Topics: Animals; Benzodiazepines; Binding, Competitive; Brain Chemistry; Cerebral Cortex; Female; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Guinea Pigs; Hypnotics and Sedatives; Male; Muscimol; Organ Size; Pregnanolone; Pyridines; Radioligand Assay; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms.
Topics: Animals; Dose-Response Relationship, Drug; Female; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pregnanediones; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; Steroids; Xenopus laevis | 1998 |
Subunit dependent modulation of GABAA receptor function by neuroactive steroids.
Topics: Animals; Drug Synergism; Female; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; In Vitro Techniques; Membrane Potentials; Microinjections; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1999 |
Changes in properties and neurosteroid regulation of GABAergic synapses in the supraoptic nucleus during the mammalian female reproductive cycle.
Topics: Actins; Animals; Excitatory Postsynaptic Potentials; Female; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Labor, Obstetric; Lactation; Neurotransmitter Agents; Oxytocin; Patch-Clamp Techniques; Pregnancy; Pregnanolone; Rats; Receptors, GABA-A; Reproduction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Supraoptic Nucleus; Synapses | 1999 |
Prenatal stress reduces the effectiveness of the neurosteroid 3 alpha,5 alpha-THP to block kainic-acid-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Corticosterone; Female; gamma-Aminobutyric Acid; Hippocampus; Immobilization; Kainic Acid; Male; Maze Learning; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Radioimmunoassay; Rats; Rats, Long-Evans; Seizures; Sex Characteristics; Stress, Psychological | 1999 |
The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors.
Topics: Anesthetics; Animals; Drug Interactions; Electric Conductivity; Etomidate; Female; gamma-Aminobutyric Acid; Glycine; Mutagenesis, Site-Directed; Oocytes; Pentobarbital; Pregnanolone; Propofol; Receptors, GABA-A; Receptors, Glycine; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 1999 |
Neurosteroid modulation of synaptic and GABA-evoked currents in neurons from the rat medial preoptic nucleus.
Topics: Animals; Drug Synergism; Evoked Potentials; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Nerve Endings; Neurons; Patch-Clamp Techniques; Pregnanolone; Preoptic Area; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Tetrodotoxin | 1999 |
Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Inflammatory Agents; Desoxycorticosterone; gamma-Aminobutyric Acid; Humans; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Receptors, GABA; Receptors, Purinergic P1; Xenopus laevis | 1999 |
Synaptic membrane freezing affects modulatory sites in avian central nervous system GABA(A) receptor.
Topics: Animals; Binding Sites; Chickens; Drug Synergism; Freezing; GABA Modulators; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Pentobarbital; Picrotoxin; Pregnanolone; Receptors, GABA-A; Sesterterpenes; Synaptic Membranes; Tectum Mesencephali; Tritium | 1999 |
Sex-dependent behavioral effects of the neurosteroid allopregnanolone (3alpha,5alpha-THP) in neonatal and adult rats after postnatal stress.
Topics: Animals; Anti-Anxiety Agents; Behavior; Female; gamma-Aminobutyric Acid; Grooming; Male; Maternal Deprivation; Pituitary-Adrenal System; Pregnanolone; Rats; Rats, Long-Evans; Sex Characteristics; Stress, Physiological; Swimming | 1999 |
Development and role of GABA(A) receptor-mediated synaptic potentials during swimming in postembryonic Xenopus laevis tadpoles.
Topics: Animals; Bicuculline; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine Agents; Larva; Neurons; Nipecotic Acids; Pregnanolone; Proline; Receptors, GABA-A; Rhombencephalon; Spinal Cord; Strychnine; Swimming; Synapses; Xenopus laevis | 1999 |
Effect of ganaxolone in a rodent model of cerebral hematoma.
Topics: Animals; Anticonvulsants; Cerebral Hemorrhage; Collagenases; gamma-Aminobutyric Acid; Injections, Intravenous; Male; Pregnanolone; Rats; Rats, Sprague-Dawley | 2000 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex; Pregnanolone; Progesterone; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; Synaptic Transmission | 2000 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc | 2000 |
Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Depression; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; Pregnanolone; Serotonin Agents | 2000 |
Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone.
Topics: Aging; Animals; Animals, Newborn; Binding, Competitive; Brain; Brain Stem; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Female; Fetus; Frontal Lobe; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Picrotoxin; Pregnancy; Pregnanolone; Receptors, GABA-A; Sheep; Sulfur Radioisotopes | 2000 |
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.
Topics: Animals; Anxiety; Brain; Cerebral Cortex; Conflict, Psychological; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Electroshock; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Oocytes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Social Isolation; Steroids; Synaptosomes; Time Factors; Xenopus laevis | 2000 |
Modification of behavioral effects of drugs in mice by neuroactive steroids.
Topics: Animals; Anticonvulsants; Behavior, Animal; Central Nervous System Stimulants; Cocaine; Convulsants; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Pregnenolone; Psychotropic Drugs; Steroids; Synaptic Transmission | 2000 |
Two conserved arginines in the extracellular N-terminal domain of the GABA(A) receptor alpha(5) subunit are crucial for receptor function.
Topics: Amino Acid Substitution; Animals; Arginine; Chlorides; CHO Cells; Cricetinae; Diazepam; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Ion Channel Gating; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Structure, Tertiary; Receptors, GABA-A; Sequence Alignment; Steroids; Structure-Activity Relationship; Transfection | 2000 |
Progesterone prevents estradiol-induced dendritic spine formation in cultured hippocampal neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Size; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dendrites; Drug Interactions; Estradiol; Fetus; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Indomethacin; Microscopy, Electron; Mifepristone; Neuronal Plasticity; Patch-Clamp Techniques; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Signal Transduction | 2000 |
Acute hypoxic hypoxia transiently reduces GABA(A) binding site number in developing chick optic lobe.
Topics: Acute Disease; Allosteric Regulation; Animals; Binding Sites; Chick Embryo; GABA Modulators; gamma-Aminobutyric Acid; Hypoxia; Optic Lobe, Nonmammalian; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors | 2000 |
In ovo chronic neurosteroid treatment affects the function and allosteric interactions of GABA(A) receptor modulatory sites.
Topics: Allosteric Regulation; Animals; Chick Embryo; Chloride Channels; Chlorides; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; Ion Transport; Nerve Tissue Proteins; Optic Lobe, Nonmammalian; Pregnanolone; Receptors, GABA-A; Signal Transduction; Specific Pathogen-Free Organisms; Synaptic Membranes; Synaptic Transmission | 2001 |
Increased behavioral neurosteroid sensitivity in a rat line selectively bred for high alcohol sensitivity.
Topics: Animals; Behavior, Animal; Brain; Breeding; Dose-Response Relationship, Drug; Ethanol; Female; gamma-Aminobutyric Acid; Male; Motor Activity; Pregnanolone; Rats; Receptors, GABA-A | 2001 |
alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential.
Topics: Animals; Benzodiazepines; Cell Line; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Membrane Potentials; Mice; Models, Biological; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Protein Binding; Protein Conformation; Receptors, GABA-A; Spectrometry, Fluorescence; Time Factors; Transfection | 2001 |
Neuroactive steroid levels in patients with generalized anxiety disorder.
Topics: Adult; Anxiety Disorders; Dehydroepiandrosterone; Female; gamma-Aminobutyric Acid; Humans; Male; Pregnanolone; Pregnenolone; Receptors, GABA-A | 2001 |
Influence of membrane cholesterol on modulation of the GABA(A) receptor by neuroactive steroids and other potentiators.
Topics: Animals; Cell Membrane; Cholesterol; Dose-Response Relationship, Drug; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Pregnenolone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A | 2001 |
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Pyridines; Rats; Receptors, GABA-A; Zinc; Zolpidem | 2001 |
Allopregnanolone inhibits learning in the Morris water maze.
Topics: Anesthetics; Animals; Brain; Corticosterone; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hippocampus; Learning Disabilities; Male; Maze Learning; Memory Disorders; Neural Inhibition; Neurons; Orientation; Pregnanolone; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Space Perception; Swimming; Synaptic Transmission | 2002 |
Modulation Of [35S]-tert-butylbicyclophosphorothionate binding by somatostatin in rat hypothalamus.
Topics: Animals; Bicuculline; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Muscimol; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Somatostatin; Sulfur Radioisotopes | 2002 |
Differential effects of allopregnanolone and GABA on kainate-induced lactate dehydrogenase release in cultured rat cerebral cortical cells.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Kainic Acid; L-Lactate Dehydrogenase; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley | 2002 |
Allopregnanolone activates GABA(A) receptor/Cl(-) channels in a multiphasic manner in embryonic rat hippocampal neurons.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cells, Cultured; Chloride Channels; Chlorides; Dose-Response Relationship, Drug; Drug Synergism; Electric Conductivity; Embryo, Mammalian; gamma-Aminobutyric Acid; Hippocampus; Neurons; Pertussis Toxin; Pregnanolone; Rats; Reaction Time; Receptors, GABA-A; Steroids; Virulence Factors, Bordetella | 2002 |
Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study.
Topics: Adult; Cerebral Cortex; Estradiol; Female; Follicular Phase; gamma-Aminobutyric Acid; Humans; Luteal Phase; Magnetic Resonance Spectroscopy; Menstrual Cycle; Occipital Lobe; Pregnanolone; Premenstrual Syndrome; Progesterone | 2002 |
Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.
Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Carbolines; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Diuretics; Female; Furosemide; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 2002 |
Allopregnanolone enhancement of GABAergic transmission in rat medial preoptic area neurons.
Topics: Animals; Bumetanide; Calcium; Cell Separation; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Pregnanolone; Preoptic Area; Presynaptic Terminals; Rats; Rats, Wistar; Sodium; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Synaptic Transmission | 2002 |
Allopregnanolone modulates spontaneous GABA release via presynaptic Cl- permeability in rat preoptic nerve terminals.
Topics: Action Potentials; Animals; Chlorides; gamma-Aminobutyric Acid; Male; Permeability; Pregnanolone; Preoptic Area; Presynaptic Terminals; Rats; Rats, Sprague-Dawley | 2002 |
Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.
Topics: Adrenalectomy; Animals; Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Clozapine; Corticosterone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Haloperidol; Male; Olanzapine; Pirenzepine; Pregnanolone; Progesterone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Risperidone | 2003 |
On the putative physiological role of allopregnanolone on GABA(A) receptor function.
Topics: 5-alpha Reductase Inhibitors; Allosteric Regulation; Androstanes; Animals; Chloride Channels; GABA Agents; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Neocortex; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A | 2003 |
Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.
Topics: Affinity Labels; Animals; Aziridines; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Membrane; Female; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Muscimol; Oocytes; Porins; Pregnanolone; Rats; Recombinant Proteins; Steroids; Telencephalon; Transfection; Voltage-Dependent Anion Channel 1; Voltage-Dependent Anion Channels; Xenopus laevis | 2003 |
Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition.
Topics: Animals; Animals, Newborn; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Female; gamma-Aminobutyric Acid; Humans; Kidney; Ligands; Male; Mice; Mice, Knockout; Mice, Transgenic; Oocytes; Oxytocin; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Pregnancy; Pregnanolone; Protein Kinase C; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Supraoptic Nucleus; Transfection; Xenopus | 2003 |
Neurosteroid effects on GABAergic synaptic plasticity in hippocampus.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Female; gamma-Aminobutyric Acid; Hippocampus; Neural Inhibition; Neuronal Plasticity; Oligonucleotides, Antisense; Organ Culture Techniques; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA; Synaptic Transmission | 2003 |
Perinatal neurosteroid levels influence GABAergic interneuron localization in adult rat prefrontal cortex.
Topics: Animals; Animals, Newborn; Antigens, Differentiation; Binding, Competitive; Cell Count; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Interneurons; Male; Parvalbumins; Prefrontal Cortex; Pregnanolone; Rats; Rats, Sprague-Dawley; Steroids | 2003 |
Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Cell Membrane; Cells, Cultured; Dentate Gyrus; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Male; Membrane Potentials; Neural Inhibition; Neurons; Pregnanolone; Pregnenolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Steroids; Up-Regulation | 2003 |
Neuroactive steroid 3 alpha-hydroxy-5 alpha-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats.
Topics: Adrenalectomy; Animals; Cerebral Cortex; Ethanol; gamma-Aminobutyric Acid; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Reflex | 2003 |
Modulation of GABAA receptors and neuropeptide secretion by the neurosteroid allopregnanolone in posterior and intermediate pituitary.
Topics: alpha-MSH; Animals; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; gamma-Aminobutyric Acid; Male; Nerve Endings; Neuropeptides; Patch-Clamp Techniques; Picrotoxin; Pituitary Gland; Pituitary Gland, Posterior; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Time Factors; Vasopressins | 2003 |
Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnan-20-one (isoallopregnanolone).
Topics: Animals; Cerebral Cortex; Chlorides; Flunitrazepam; GABA Modulators; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Osmolar Concentration; Pentobarbital; Pregnanolone; Rats; Rats, Wistar | 2003 |
Neurosteroids alter gamma-aminobutyric acid postsynaptic currents in gonadotropin-releasing hormone neurons: a possible mechanism for direct steroidal control.
Topics: Animals; Dehydroepiandrosterone Sulfate; Electric Conductivity; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; In Vitro Techniques; Mice; Neurons; Patch-Clamp Techniques; Pregnanolone; Pressure; Synapses; Synaptic Transmission | 2003 |
Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor.
Topics: Animals; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Kinetics; Oocytes; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Quercetin; Receptors, GABA-B; Recombinant Proteins; Xenopus laevis | 2004 |
Role of neuroactive steroid allopregnanolone in antipsychotic-like action of olanzapine in rodents.
Topics: Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Behavior, Animal; Benzodiazepines; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Haloperidol; Injections, Intraventricular; Male; Motor Activity; Neurotransmitter Agents; Olanzapine; Pregnanolone; Rats; Rats, Sprague-Dawley; Risperidone; Social Isolation | 2004 |
Progestins' actions in the VTA to facilitate lordosis involve dopamine-like type 1 and 2 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Female; gamma-Aminobutyric Acid; Mifepristone; Posture; Pregnanolone; Quinpirole; Rats; Rats, Long-Evans; Receptors, Dopamine D1; Receptors, Dopamine D2; Sexual Behavior, Animal; Sulpiride; Ventral Tegmental Area | 2004 |
3beta-20beta-dihydroxy-5alpha-pregnane (UC1011) antagonism of the GABA potentiation and the learning impairment induced in rats by allopregnanolone.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cerebral Cortex; Chlorides; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Synergism; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Learning Disabilities; Male; Maze Learning; Pregnanediol; Pregnanolone; Radioimmunoassay; Rats; Rats, Wistar; Reaction Time; Statistics, Nonparametric; Time Factors | 2004 |
Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Pregnanolone; Seizures | 2004 |
3alpha,5alpha-Tetrahydroprogesterone (allopregnanolone) and gamma-aminobutyric acid: autocrine/paracrine interactions in the control of neonatal PSA-NCAM+ progenitor proliferation.
Topics: Animals; Animals, Newborn; Base Sequence; Cell Division; Cell Survival; Cells, Cultured; DNA Primers; DNA Replication; gamma-Aminobutyric Acid; Neural Cell Adhesion Molecules; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialic Acids; Stem Cells | 2004 |
Termination of pseudopregnancy in the rat produces an anxiogenic-like response that is associated with an increase in benzodiazepine receptor binding density and a decrease in GABA-stimulated chloride influx in the hippocampus.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anxiety; Cerebral Cortex; Chlorides; Female; gamma-Aminobutyric Acid; Gonadotropins; Gonadotropins, Equine; Hippocampus; Humans; Isotopes; Maze Learning; Ovariectomy; Pregnanolone; Pseudopregnancy; Radioimmunoassay; Radioligand Assay; Rats; Receptors, GABA-A; Steroids; Time Factors | 2005 |
Interaction between allopregnanolone and pregnenolone sulfate in modulating GABA-mediated synaptic currents in neurons from the rat medial preoptic nucleus.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Pregnenolone; Preoptic Area; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2005 |
Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Ethanol; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Injections, Subcutaneous; Isoxazoles; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanolone; Receptors, GABA-A; Time Factors; Triazolam; Women | 2005 |
Rapid non-genomic effect of glucocorticoid metabolites and neurosteroids on the gamma-aminobutyric acid-A receptor.
Topics: Animals; Cerebral Cortex; Chlorides; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Glucocorticoids; Male; Neurons; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2005 |
High affinity, heterogeneous displacement of [3H]EBOB binding to cerebellar GABA A receptors by neurosteroids and GABA agonists.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Male; Pregnanolone; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A | 2005 |
Progesterone's effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors.
Topics: Aging; Animals; Anxiety; Behavior, Animal; Conflict, Psychological; gamma-Aminobutyric Acid; Hippocampus; Mice; Mice, Knockout; Motor Activity; Motor Skills; Pregnanolone; Progesterone; Receptors, Progesterone | 2006 |
Rapid inhibition of Ca2+ influx by neurosteroids in murine embryonic sensory neurones.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chelating Agents; Embryo, Mammalian; Fluorescent Dyes; Fura-2; GABA Agonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Membrane Proteins; Mice; Muscimol; Neurons, Afferent; Potassium Channel Blockers; Pregnanolone; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Sodium Channel Blockers | 2006 |
Neurosteroid modulation of allopregnanolone and GABA effect on the GABA-A receptor.
Topics: Analysis of Variance; Animals; Brain; Cells, Cultured; Chloride Channels; Chlorides; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Steroids | 2006 |
Steroid requirements for regulation of the alpha4 subunit of the GABA(A) receptor in an in vitro model.
Topics: Analysis of Variance; Androgen Antagonists; Azasteroids; Bicuculline; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Dihydrotestosterone; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Humans; Membrane Potentials; Nerve Growth Factor; Neuroblastoma; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; RNA, Messenger | 2007 |
Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors.
Topics: Amygdala; Analysis of Variance; Anesthetics; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.
Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Cell Line, Transformed; Fluorescein; gamma-Aminobutyric Acid; Hippocampus; Humans; Larva; Light; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Swimming; Transfection | 2007 |
Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty.
Topics: Animals; Anxiety; Arginine; Cell Line; Drug Interactions; Female; gamma-Aminobutyric Acid; Hippocampus; Humans; In Vitro Techniques; Ion Channel Gating; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Patch-Clamp Techniques; Pregnanolone; Pyramidal Cells; Radioimmunoassay; Receptors, GABA-A; Stress, Psychological; Transfection | 2007 |
Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; GABA Agents; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Kinetics; Pregnanolone; Protein Subunits; Rats; Receptors, GABA-A | 2007 |
Progesterone attenuates neuroleptic-induced orofacial dyskinesia via the activity of its metabolite, allopregnanolone, a positive GABA(A) modulating neurosteroid.
Topics: Animals; Antipsychotic Agents; Brain Diseases; Control Groups; Disease Models, Animal; Dopamine; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Haloperidol; Male; Movement Disorders; Neuroprotective Agents; Oxidative Stress; Pregnanolone; Progesterone; Rats; Rats, Inbred ACI; Receptors, GABA-A | 2008 |
Diminished neurosteroid sensitivity of synaptic inhibition and altered location of the alpha4 subunit of GABA(A) receptors in an animal model of epilepsy.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Drug Resistance; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Hippocampus; Male; Neural Inhibition; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Synapses; Synaptic Transmission | 2007 |
Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy.
Topics: Animals; Animals, Genetically Modified; Axons; Charcot-Marie-Tooth Disease; Chromatography, Liquid; Disease Models, Animal; Down-Regulation; Female; gamma-Aminobutyric Acid; Male; Mass Spectrometry; Mutation; Myelin Proteins; Peripheral Nerves; Pregnanolone; Rats; Receptors, GABA-A; Sciatic Nerve; Sex Characteristics; Steroids | 2008 |
GABA in the female brain -- oestrous cycle-related changes in GABAergic function in the periaqueductal grey matter.
Topics: Animals; Brain Chemistry; Dose-Response Relationship, Drug; Environment; Estrous Cycle; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Immunohistochemistry; Male; Periaqueductal Gray; Pregnanolone; Progesterone; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Receptors, GABA-A; Sex Characteristics; Steroids | 2008 |
Olanzapine counteracts stress-induced anxiety-like behavior in rats.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety Disorders; Benzodiazepines; Brain; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Finasteride; gamma-Aminobutyric Acid; Male; Maze Learning; Olanzapine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Restraint, Physical; Stress, Psychological | 2008 |
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
Topics: Amino Acid Substitution; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutant Proteins; Mutation; Piperidines; Pregnanetriol; Pregnanolone; Pregnenolone; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Serine; Steroids; Tryptophan | 2008 |
Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy.
Topics: Aging; Animals; Animals, Genetically Modified; Brain; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Disease Models, Animal; Down-Regulation; Epilepsy, Absence; gamma-Aminobutyric Acid; Male; Neuronal Plasticity; Pregnanolone; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Stress, Psychological; Synapses; Synaptic Transmission; Thalamus; Up-Regulation | 2008 |
Sexually dimorphic effects of testosterone administration on brain allopregnanolone in gonadectomized rats.
Topics: Animals; Brain; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Injections, Subcutaneous; Male; Orchiectomy; Ovariectomy; Parietal Lobe; Pituitary Gland, Anterior; Pregnanolone; Rats; Sex Characteristics; Signal Transduction; Testosterone | 2008 |
Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.
Topics: Binding Sites; Cell Line; Diazepam; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutation; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Multimerization; Protein Subunits; Receptors, GABA-A | 2009 |
The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.
Topics: Animals; Cell Membrane; Cells, Cultured; Computer Simulation; Fluorescence; gamma-Aminobutyric Acid; gamma-Cyclodextrins; Hippocampus; Hydrophobic and Hydrophilic Interactions; Kinetics; Membrane Potentials; Models, Neurological; Neurons; Oxadiazoles; Pregnanolone; Rats; Receptors, GABA-A; Steroids; Xenopus laevis | 2009 |
GABA synthesis in Schwann cells is induced by the neuroactive steroid allopregnanolone.
Topics: Anesthetics; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Colforsin; Computational Biology; CREB-Binding Protein; Cyclic AMP; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Phosphorylation; Pregnanolone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schwann Cells; Sciatic Nerve; Signal Transduction; Time Factors; Up-Regulation | 2010 |
The effects of acute and chronic ethanol exposure on presynaptic and postsynaptic gamma-aminobutyric acid (GABA) neurotransmission in cultured cortical and hippocampal neurons.
Topics: Animals; Benzodiazepinones; Cells, Cultured; Cerebral Cortex; Drug Tolerance; Ethanol; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Pregnanolone; Rats; Receptors, GABA-A; Synaptic Transmission | 2009 |
Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Acute Disease; Alcohol-Induced Disorders, Nervous System; Animals; Castration; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Female; Finasteride; gamma-Aminobutyric Acid; Male; Mice; Neural Inhibition; Neurotransmitter Agents; Pregnanolone; Progesterone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2010 |
A residue in loop 9 of the beta2-subunit stabilizes the closed state of the GABAA receptor.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Anesthetics; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pregnanolone; Propofol; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Sequence Alignment | 2010 |
Acute neurosteroids inhibit the spinal reflex potentiation via GABAergic neurotransmission.
Topics: Action Potentials; Animals; Bicuculline; Desoxycorticosterone; Electric Stimulation; Electromyography; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Spinal; Neuronal Plasticity; Neurotransmitter Agents; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Spinal Nerves; Synaptic Transmission; Time Factors; Urethra | 2010 |
Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals.
Topics: Action Potentials; Affinity Labels; Animals; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Electric Stimulation; Electrophysiology; Epilepsy, Temporal Lobe; gamma-Aminobutyric Acid; Hippocampus; Immunoprecipitation; Male; Neural Inhibition; Neurons; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2010 |
Effects of positive and negative modulators of the γ-aminobutyric acid A receptor complex on responding under a differential-reinforcement-of-low-rate schedule of reinforcement in rats.
Topics: Adjuvants, Immunologic; Analysis of Variance; Anesthetics; Animals; Carbolines; Conditioning, Operant; Dehydroepiandrosterone; Dose-Response Relationship, Drug; GABA Agents; gamma-Aminobutyric Acid; Male; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Reinforcement Schedule | 2010 |
Neuropharmacological properties of neurons derived from human stem cells.
Topics: Cell Differentiation; Chlordiazepoxide; Diazepam; gamma-Aminobutyric Acid; Glycine; Humans; Immunohistochemistry; Ion Channel Gating; Ligands; Mefenamic Acid; Neurons; Pentobarbital; Pregnanolone; Stem Cells; Tetraethylammonium; Tetrodotoxin | 2011 |
Neurosteroid modulation of benzodiazepine-sensitive GABAA tonic inhibition in supraoptic magnocellular neurons.
Topics: Animals; Benzodiazepines; Desoxycorticosterone; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Postsynaptic Potentials; Male; Models, Animal; Neurons; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Supraoptic Nucleus | 2011 |
Neurosteroid allopregnanolone regulates EAAC1-mediated glutamate uptake and triggers actin changes in Schwann cells.
Topics: Actins; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Biological Transport, Active; Excitatory Amino Acid Transporter 3; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Models, Neurological; Pregnanolone; Rats; RNA, Messenger; Schwann Cells; Up-Regulation | 2012 |
Differential modulation of the glutamate-nitric oxide-cyclic GMP pathway by distinct neurosteroids in cerebellum in vivo.
Topics: Animals; Cerebellum; Cyclic GMP; Dehydroepiandrosterone; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2011 |
A neurosteroid potentiation site can be moved among GABAA receptor subunits.
Topics: Action Potentials; Amino Acid Sequence; Anesthetics; Animals; Binding Sites; gamma-Aminobutyric Acid; Glutamic Acid; HEK293 Cells; Humans; Molecular Sequence Data; Mutation, Missense; Pregnanolone; Protein Subunits; Rats; Receptors, GABA-A | 2012 |
Easing the burden of premenstrual dysphoric disorder.
Topics: Contraceptives, Oral, Hormonal; Diagnostic and Statistical Manual of Mental Disorders; Diet; Dietary Supplements; Down-Regulation; Exercise; Female; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Humans; Hypothalamo-Hypophyseal System; Interpersonal Relations; Phytotherapy; Pituitary-Adrenal System; Pregnanolone; Premenstrual Syndrome; Quality of Life; Selective Serotonin Reuptake Inhibitors; Serotonin | 2013 |
Allopregnanolone and puberty: modulatory effect on glutamate and GABA release and expression of 3α-hydroxysteroid oxidoreductase in the hypothalamus of female rats.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); Animals; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hypothalamus; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sexual Maturation | 2013 |
Regulation of α3-containing GABAA receptors in guinea-pig adrenal medullary cells by adrenal steroids.
Topics: Abortifacient Agents, Steroidal; Action Potentials; Adrenal Medulla; Anesthetics; Animals; Carrier Proteins; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Guinea Pigs; Male; Membrane Proteins; Mifepristone; Patch-Clamp Techniques; PC12 Cells; Pregnanolone; Rats; Receptors, GABA-A; Steroids; Zinc | 2013 |
Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons.
Topics: Action Potentials; Animals; Dopamine; Dopaminergic Neurons; Excitatory Amino Acid Agents; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Neurotransmitter Agents; Picrotoxin; Pregnanolone; Receptors, GABA-A; Ventral Tegmental Area | 2014 |
GABA transport and neuroinflammation are coupled in multiple sclerosis: regulation of the GABA transporter-2 by ganaxolone.
Topics: Animals; Astrocytes; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Female; Frontal Lobe; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Interferon-gamma; Macrophages; Mice, Inbred C57BL; Microglia; Multiple Sclerosis; Neuroimmunomodulation; Neuroprotective Agents; Pregnanolone; RNA, Messenger; Spinal Cord; T-Lymphocytes; White Matter | 2014 |
The correlation between neurosteroids and neurotransmitters with liver yang rising and liver qi stagnation types of premenstrual syndrome.
Topics: Adult; Dehydroepiandrosterone; Dopamine; Female; gamma-Aminobutyric Acid; Humans; Liver; Medicine, Chinese Traditional; Middle Aged; Neurotransmitter Agents; Pregnanolone; Premenstrual Syndrome; Progesterone; Qi; Serotonin; Testosterone; Yin-Yang; Young Adult | 2014 |
Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research.
Topics: Animals; Brain; Ethanol; Female; gamma-Aminobutyric Acid; Models, Molecular; Pregnanolone; Receptors, GABA-A; Receptors, Glycine; Structure-Activity Relationship; Xenopus laevis | 2014 |
Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse.
Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Dendritic Spines; Electric Stimulation; Estradiol; Estrous Cycle; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone; Pyramidal Cells; Receptors, GABA-A; Spatial Learning | 2015 |
Developmentally regulated neurosteroid synthesis enhances GABAergic neurotransmission in mouse thalamocortical neurones.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 5-alpha-Dihydroprogesterone; Aging; Animals; gamma-Aminobutyric Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pregnanolone; Receptors, GABA-A; Synaptic Transmission; Thalamus | 2015 |
Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator.
Topics: Amygdala; Animals; Animals, Newborn; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Fragile X Mental Retardation Protein; Fragile X Syndrome; GABA Agents; GABA Modulators; gamma-Aminobutyric Acid; Heterocyclic Compounds, 2-Ring; In Vitro Techniques; Membrane Potentials; Mice; Mice, Knockout; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Transfection | 2016 |
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Diazepam; Estrous Cycle; Estrus; Female; Fluoxetine; gamma-Aminobutyric Acid; Locomotion; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Serotonin | 2016 |
Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
Topics: 20-alpha-Dihydroprogesterone; Adult; Case-Control Studies; Depression, Postpartum; Desoxycorticosterone; Female; gamma-Aminobutyric Acid; Humans; Longitudinal Studies; Peripartum Period; Pregnancy; Pregnanolone; Progesterone; Receptors, GABA-A; Risk Factors; Steroids | 2016 |
Cellular GABAergic Neuroactive Steroid (3α,5α)-3-Hydroxy-Pregnan-20-One (3α,5α-THP) Immunostaining Levels Are Increased in the Ventral Tegmental Area of Human Alcohol Use Disorder Patients: A Postmortem Study.
Topics: Alcohol-Related Disorders; Alcoholism; Autopsy; Female; gamma-Aminobutyric Acid; Hepatitis, Alcoholic; Humans; Immunohistochemistry; Male; Middle Aged; Pregnanolone; Sex Characteristics; Substantia Nigra; Ventral Tegmental Area | 2017 |
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models.
Topics: Action Potentials; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Fragile X Mental Retardation Protein; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Male; Mice; Mice, Knockout; Pentylenetetrazole; Piperidines; Potassium Channel Blockers; Pregnanolone; Rats; Rats, Sprague-Dawley; Seizures | 2017 |
In vitro and in vivo evaluation of silk fibroin functionalized with GABA and allopregnanolone for Schwann cell and neuron survival.
Topics: Animals; Biocompatible Materials; Bombyx; Fibroins; gamma-Aminobutyric Acid; Materials Testing; Nerve Regeneration; Neurons; Pregnanolone; Rats; Rats, Sprague-Dawley; Schwann Cells; Silk; Tissue Engineering | 2018 |
Allopregnanolone Effects on Transmission in the Brain Stem Solitary Tract Nucleus (NTS).
Topics: Animals; Bicuculline; Central Nervous System Agents; Female; gamma-Aminobutyric Acid; Neurons, Afferent; Patch-Clamp Techniques; Pregnanolone; Pyridazines; Rats, Sprague-Dawley; Receptors, GABA-A; Solitary Nucleus; Synaptic Transmission; Tissue Culture Techniques | 2018 |
Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study.
Topics: Adult; Cerebral Cortex; Connectome; Creatine; Depression, Postpartum; Female; gamma-Aminobutyric Acid; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Neurosteroids; Pregnanolone; Proton Magnetic Resonance Spectroscopy; Young Adult | 2019 |
Brexanolone and postpartum depression: what does it have to do with GABA?
Topics: beta-Cyclodextrins; Depression, Postpartum; Drug Combinations; Female; GABA Modulators; gamma-Aminobutyric Acid; Humans; Pregnanolone | 2019 |
Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: Emphasis on brain GABA, neurosteroids and HPA axis function.
Topics: Animals; Behavior, Animal; Carrier Proteins; Corticosterone; Disease Models, Animal; gamma-Aminobutyric Acid; Hippocampus; Hypothalamo-Hypophyseal System; Imidazoles; Male; Prefrontal Cortex; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Sertraline; Stress Disorders, Post-Traumatic | 2020 |
Epigenetic Regulation of GABAergic Neurotransmission and Neurosteroid Biosynthesis in Alcohol Use Disorder.
Topics: Adult; Alcoholism; Autopsy; Cerebellum; Cohort Studies; DNA Methylation; Epigenesis, Genetic; gamma-Aminobutyric Acid; Humans; Male; Neurosteroids; Prefrontal Cortex; Pregnanolone; Protein Biosynthesis; Receptors, GABA-A; Synaptic Transmission | 2021 |
Reduced Activation of the Synaptic-Type GABA
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Oocytes; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Recombinant Proteins; Synaptic Potentials; Time Factors; Xenopus laevis | 2020 |
Allopregnanolone Enhances GABAergic Inhibition in Spinal Motor Networks.
Topics: Action Potentials; Animals; Cells, Cultured; gamma-Aminobutyric Acid; Mice; Motor Neurons; Neuromuscular Junction; Pregnanolone; Propofol; Receptors, GABA-A; Spinal Cord | 2020 |
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model.
Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, Animal; Estradiol; gamma-Aminobutyric Acid; Hydrocortisone; Male; Neuroprotective Agents; Normetanephrine; Oxadiazoles; Oxidative Stress; Pentylenetetrazole; Pregnanolone; Progesterone; Reactive Oxygen Species; Seizures; Serotonin; Zebrafish | 2021 |
Mechanisms for establishment of GABA signaling in adrenal medullary chromaffin cells.
Topics: Adrenal Medulla; Animals; Cattle; Chloride Channels; Chromaffin Cells; Cricetinae; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Guinea Pigs; Hydrocortisone; Immunohistochemistry; Male; Mesocricetus; Mice; Mice, Inbred C57BL; Paracrine Communication; PC12 Cells; Pregnanolone; Rats; Receptors, GABA-A; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide | 2021 |
Neurosteroid Modulation of GABA
Topics: Animals; Binding Sites; gamma-Aminobutyric Acid; Humans; Mammals; Neurosteroids; Pregnanolone; Receptors, GABA-A | 2022 |
A theory of the anxiolytic action of flumazenil in anxiety disorders.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Flumazenil; gamma-Aminobutyric Acid; Humans; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Pregnanolone; Receptors, GABA-A | 2022 |
Golexanolone, a GABA
Topics: Animals; Cognition; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutaminase; Hyperammonemia; Inflammation; Interleukin-10; Neuroinflammatory Diseases; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Tumor Necrosis Factor, Type I; Symporters; Tumor Necrosis Factor-alpha | 2022 |
Positive allosteric modulators of GABA
Topics: Animals; Chlorides; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ligands; Pregnanolone; Rats; Receptors, GABA-A | 2022 |
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators.
Topics: Animals; Antidepressive Agents; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Humans; Ketamine; Mice; Neurosteroids; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2023 |
Pharmacological administration of 3α,5α-THP into the nucleus accumbens core increases 3α,5α-THP expression and reduces alcohol self-administration.
Topics: Animals; Brain; Ethanol; Female; gamma-Aminobutyric Acid; Humans; Male; Neurosteroids; Nucleus Accumbens; Pregnanolone; Rats | 2023 |
Allopregnanolone Effects on Inhibition in Hippocampal Parvalbumin Interneurons.
Topics: Animals; Female; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Male; Mice; Parvalbumins; Pregnanolone; Receptors, GABA-A | 2023 |
Impaired Endogenous Neurosteroid Signaling Contributes to Behavioral Deficits Associated With Chronic Stress.
Topics: Animals; gamma-Aminobutyric Acid; Mice; Neurosteroids; Pregnanolone; Receptors, GABA-A; Signal Transduction | 2023 |
The Mechanism of Enantioselective Neurosteroid Actions on GABA
Topics: gamma-Aminobutyric Acid; Neurosteroids; Pregnanolone; Receptors, GABA-A; Stereoisomerism | 2023 |
Altered GABA
Topics: Diazepam; Endometriosis; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Pelvic Pain; Pregnanolone; Receptors, GABA-A | 2023 |
Effects of Pregnanolone Glutamate and Its Metabolites on GABA
Topics: Animals; Esters; gamma-Aminobutyric Acid; Glutamic Acid; Pregnanolone; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Zebrafish | 2023 |
Structural insights into opposing actions of neurosteroids on GABA
Topics: Binding Sites; Female; gamma-Aminobutyric Acid; Humans; Neurosteroids; Pregnanolone; Receptors, GABA-A; Sulfates | 2023 |
Shuyu capsule alleviates premenstrual depression via allopregnanolone metabolic pathway targeting GABA (A) receptors δ subunit in the hippocampus.
Topics: Animals; Female; gamma-Aminobutyric Acid; Hippocampus; Metabolic Networks and Pathways; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2023 |