Page last updated: 2024-08-23

pregnanolone and fluoxetine

pregnanolone has been researched along with fluoxetine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (14.29)	18.2507
2000's	19 (54.29)	29.6817
2010's	8 (22.86)	24.3611
2020's	3 (8.57)	2.80

Authors

Authors	Studies
Cooper, TB; Costa, E; Guidotti, A; Uzunov, DP	1
Costa, E; Davis, JM; Guidotti, A; Rasmusson, A; Sheline, Y; Uzunov, DP; Uzunova, V	1
di Michele, F; Hermann, B; Holsboer, F; Pasini, A; Romeo, E; Rupprecht, R; Spalletta, G; Ströhle, A	1
Costa, E; Guidotti, A; Matsumoto, K; Mienville, JM; Pinna, G; Taki, K; Uzunov, DP; Uzunova, V; Watanabe, H	1
Griffin, LD; Mellon, SH	1
Chopde, CT; Jain, SP; Khisti, RT	1
Casarosa, E; Florio, P; Genazzani, AD; Genazzani, AR; Lombardi, I; Luisi, M; Petraglia, F; Quirici, B	1
Biggio, G; Dazzi, L; Pisul, MG; Purdy, RH; Serra, M	1
Jiang, A; LoGrasso, PV; Stearns, BA; Trauger, JW	1
Costa, E; Dong, E; Guidotti, A; Matsumoto, K; Pinna, G	1
Bernardi, G; di Michele, F; Pace, M; Pasinib, A; Pompili, E; Romeo, E; Rupprecht, R	1
Funae, Y; Hiroi, T; Igarashi, T; Imaoka, S; Kishimoto, W; Kominami, S; Osada, M; Shiraishi, M	1
Chopde, CT; Hirani, K; Mittal, N; Ugale, RR	1
Costa, E; Guidotti, A; Pinna, G	2
Costa, E; Guidotti, A; Matsumoto, K	1
Carboni, G; Nelson, M; Pibiri, F; Pinna, G	1
Bradford, DW; Butterfield, MI; Grobin, AC; Khisti, RT; Lieberman, JA; Madison, RD; Marx, CE; Massing, MW; Morrow, AL; Shampine, LJ; Trost, WT	1
Daniels, RN; Lindsley, CW	1
Costa, E; Guidotti, A; Nelson, M; Pibiri, F; Pinna, G	1
Agis-Balboa, RC; Costa, E; Guidotti, A; Nelson, M; Pibiri, F; Pinna, G	1
Agis-Balboa, RC; Nelson, M; Pibiri, F; Pinna, G	1
J M, V; N S, J; P V, D; S N, U	1
Jaramillo, MT; Molina-Hernández, M; Olivera-Lopez, JI; Téllez-Alcántara, NP	1
Frye, CA; Rhodes, ME	1
Pinna, G	1
Nelson, M; Pinna, G	1
Pinna, G; Rasmusson, AM	1
Lovick, T	1
Cockcroft, S; Devall, AJ; Fry, JP; Honour, JW; Li, KY; Lovick, TA	1
Brandão, ML; Devall, AJ; Fry, JP; Honour, JW; Lovick, TA; Santos, JM	1
André, E; de Sousa Pinto, ÍA; Gavioli, EC; Lovick, T; Santos, RO; Soares-Rachetti, Vde P	1
Chen, J; Hu, L; Peng, H; Yang, K; Zeng, X; Zhu, W	1
Brandão, ML; de Rezende, MG; Del-Ben, CM; Graeff, FG; Guapo, VG; Lovick, T; Maranho, MCMF; Vieira, CS	1
Graham, BM; Pestana, JE	1

Reviews

5 review(s) available for pregnanolone and fluoxetine

Article	Year
[Stress and sleep/emotional disorder: possible involvement of neurosteroid allopregnanolone]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2005, Volume: 126, Issue:2 Topics: Affective Symptoms; Animals; Brain Chemistry; Female; Fluoxetine; Mice; Pregnanolone; Rats; Sleep Wake Disorders; Stress, Psychological	2005
Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochemical research, 2008, Volume: 33, Issue:10 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aggression; Anabolic Agents; Androstanes; Animals; Behavior, Animal; Down-Regulation; Fear; Female; Fluoxetine; Frontal Lobe; Male; Mice; Muscle, Skeletal; Nandrolone; Organ Size; Pregnanolone; Receptors, GABA-A; RNA, Messenger; Social Isolation; Stanozolol; Stereotyped Behavior; Synaptic Transmission; Testosterone Propionate	2008
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Current opinion in pharmacology, 2009, Volume: 9, Issue:1 Topics: Animals; Brain; Fluoxetine; gamma-Aminobutyric Acid; Humans; Mental Disorders; Mood Disorders; Pregnanolone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Social Isolation; Synaptic Transmission	2009
In a mouse model relevant for post-traumatic stress disorder, selective brain steroidogenic stimulants (SBSS) improve behavioral deficits by normalizing allopregnanolone biosynthesis. Behavioural pharmacology, 2010, Volume: 21, Issue:5-6 Topics: Animals; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Fluoxetine; Humans; Mice; Pregnanolone; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress Disorders, Post-Traumatic	2010
Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder. Journal of neuroendocrinology, 2012, Volume: 24, Issue:1 Topics: Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Fluoxetine; Mice; Neurotransmitter Agents; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Stress Disorders, Post-Traumatic; Up-Regulation	2012

Trials

3 trial(s) available for pregnanolone and fluoxetine

Article	Year
Effects of antidepressant treatment on neuroactive steroids in major depression. The American journal of psychiatry, 1998, Volume: 155, Issue:7 Topics: Adult; Ambulatory Care; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Female; Fluoxetine; Follow-Up Studies; Hospitalization; Humans; Male; Middle Aged; Pregnanolone; Pregnenolone; Progesterone; Receptors, GABA; Steroids; Treatment Outcome	1998
Effects of fluoxetine, indomethacine and placebo on 3 alpha, 5 alpha tetrahydroprogesterone (THP) plasma levels in uncomplicated alcohol withdrawal. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2000, Volume: 1, Issue:2 Topics: Adult; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Ethanol; Fluoxetine; gamma-Aminobutyric Acid; Humans; Indomethacin; Male; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome	2000
Low doses of fluoxetine for the treatment of emotional premenstrual syndrome: a randomized double-blind, placebo-controlled, pilot study. Psychoneuroendocrinology, 2023, Volume: 157 Topics: Adult; Double-Blind Method; Female; Fluoxetine; Humans; Menstrual Cycle; Pilot Projects; Pregnanolone; Premenstrual Syndrome; Progesterone; Young Adult	2023

Other Studies

27 other study(ies) available for pregnanolone and fluoxetine

Article	Year
Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proceedings of the National Academy of Sciences of the United States of America, 1996, Oct-29, Volume: 93, Issue:22 Topics: 20-alpha-Dihydroprogesterone; Adrenalectomy; Animals; Brain; Castration; Fluoxetine; GABA Modulators; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Imipramine; Male; Paroxetine; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley	1996
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proceedings of the National Academy of Sciences of the United States of America, 1998, Mar-17, Volume: 95, Issue:6 Topics: Adult; Depressive Disorder, Major; Female; Fluoxetine; Fluvoxamine; Humans; Male; Middle Aged; Pregnanolone; Psychometrics; Selective Serotonin Reuptake Inhibitors; Stereoisomerism	1998
Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology, 1999, Volume: 38, Issue:7 Topics: 5-alpha Reductase Inhibitors; Animals; Fluoxetine; Male; Mice; Pentobarbital; Prefrontal Cortex; Pregnanolone; Reflex, Abnormal; Selective Serotonin Reuptake Inhibitors	1999
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes. Proceedings of the National Academy of Sciences of the United States of America, 1999, Nov-09, Volume: 96, Issue:23 Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Amino Acid Sequence; Animals; Base Sequence; Brain; Cholestenone 5 alpha-Reductase; COS Cells; DNA, Complementary; Fluoxetine; Humans; Molecular Sequence Data; Oxidoreductases; Paroxetine; Pregnanolone; Progesterone; Rats; RNA, Messenger; Selective Serotonin Reuptake Inhibitors	1999
Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:1 Topics: Animals; Antidepressive Agents; Benzodiazepinones; Bicuculline; Fluoxetine; Indoleacetic Acids; Male; Mice; Pregnanolone; Receptors, GABA-A; Swimming; Time Factors	2000
Neuroendocrine effects of raloxifene hydrochloride in postmenopausal women. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2001, Volume: 15, Issue:5 Topics: Adrenergic alpha-Agonists; Aged; beta-Endorphin; Clonidine; Drug Interactions; Female; Fluoxetine; Humans; Middle Aged; Naloxone; Narcotic Antagonists; Neurosecretory Systems; Postmenopause; Pregnanolone; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Selective Serotonin Reuptake Inhibitors	2001
Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine. Journal of psychopharmacology (Oxford, England), 2002, Volume: 16, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Second-Generation; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Desoxycorticosterone; Electroshock; Fluoxetine; Male; Mianserin; Mirtazapine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Stress, Psychological	2002
Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type III (AKR1C2). Biochemistry, 2002, Nov-12, Volume: 41, Issue:45 Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Carbamazepine; Catalysis; Clozapine; Enzyme Activation; Enzyme Inhibitors; Fluoxetine; Flurbiprofen; Humans; Hydroxysteroid Dehydrogenases; Kinetics; Oxidation-Reduction; Pregnanediones; Pregnanolone; Recombinant Fusion Proteins; Selective Serotonin Reuptake Inhibitors; Substrate Specificity; Ursodeoxycholic Acid	2002
In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proceedings of the National Academy of Sciences of the United States of America, 2003, Feb-18, Volume: 100, Issue:4 Topics: Aggression; Animals; Brain; Down-Regulation; Female; Fluoxetine; Male; Mice; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stereoisomerism	2003
Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. Endocrinology, 2004, Volume: 145, Issue:2 Topics: 17-alpha-Hydroxyprogesterone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Brain; Brain Chemistry; Cytochrome P-450 CYP2D6; Fluoxetine; Humans; Hydroxylation; Male; Microsomes; Mixed Function Oxygenases; Pregnanolone; Progesterone; Rats; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Steroid 21-Hydroxylase; Substrate Specificity; Tissue Distribution	2004
Essentiality of central GABAergic neuroactive steroid allopregnanolone for anticonvulsant action of fluoxetine against pentylenetetrazole-induced seizures in mice. Brain research, 2004, Oct-08, Volume: 1023, Issue:1 Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; gamma-Aminobutyric Acid; Male; Mice; Pentylenetetrazole; Pregnanolone; Seizures	2004
Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior. Proceedings of the National Academy of Sciences of the United States of America, 2005, Feb-08, Volume: 102, Issue:6 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Aggression; Animals; Behavior; Brain; Estrogens; Female; Fluoxetine; Humans; Male; Mice; Motor Activity; Orchiectomy; Ovariectomy; Pregnanolone; Progesterone; Receptors, GABA-A; Testosterone	2005
Neurosteroids regulate mouse aggression induced by anabolic androgenic steroids. Neuroreport, 2006, Oct-02, Volume: 17, Issue:14 Topics: Aggression; Androgens; Anesthetics; Animals; Behavior, Animal; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Drug Interactions; Female; Fluoxetine; Gene Expression Regulation; Male; Mice; Motor Activity; Pregnanolone; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin; Sex Factors; Social Isolation; Testosterone; Time Factors	2006
Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions. Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:4 Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Gas Chromatography-Mass Spectrometry; Hippocampus; Male; Olanzapine; Pregnanolone; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors	2006
A new, non-SSRI mechanism of action for Prozac. Current topics in medicinal chemistry, 2007, Volume: 7, Issue:10 Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Fluoxetine; Humans; Mice; Pregnanolone; Serotonin	2007
Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America, 2008, Apr-08, Volume: 105, Issue:14 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Brain Chemistry; Cerebral Cortex; Fear; Fluoxetine; Gene Expression Regulation; Limbic System; Mice; Models, Animal; Pregnanolone; RNA, Messenger; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress Disorders, Post-Traumatic	2008
Enhanced fear responses in mice treated with anabolic androgenic steroids. Neuroreport, 2009, Apr-22, Volume: 20, Issue:6 Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Amygdala; Anabolic Agents; Androgens; Animals; Conditioning, Psychological; Fear; Female; Fluoxetine; Gene Expression; Glutamic Acid; Hippocampus; Mice; Neurons; Prefrontal Cortex; Pregnanolone; RNA, Messenger; Steroids; Testosterone Propionate	2009
Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder. Progress in neuro-psychopharmacology & biological psychiatry, 2009, Oct-01, Volume: 33, Issue:7 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Dehydroepiandrosterone Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Fluoxetine; Injections, Intraventricular; Male; Maze Learning; Mice; Motor Activity; Obsessive-Compulsive Disorder; Pregnanolone; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Social Isolation; Stress, Physiological	2009
Olanzapine plus 17-beta estradiol produce antidepressant-like actions in rats forced to swim. Pharmacology, biochemistry, and behavior, 2009, Volume: 93, Issue:4 Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Female; Fluoxetine; Male; Motor Activity; Olanzapine; Ovariectomy; Pregnanolone; Progesterone; Rats; Selective Serotonin Reuptake Inhibitors; Swimming	2009
Fluoxetine-induced decrements in sexual responses of female rats and hamsters are reversed by 3α,5α-THP. The journal of sexual medicine, 2010, Volume: 7, Issue:8 Topics: Aggression; Animals; Antidepressive Agents, Second-Generation; Brain Mapping; Cricetinae; Female; Fluoxetine; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Pregnanolone; Rats; Sexual Behavior, Animal; Ventral Tegmental Area	2010
S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice. Neuropharmacology, 2011, Volume: 60, Issue:7-8 Topics: Aggression; Amygdala; Animals; Behavior, Animal; Corpus Striatum; Fluoxetine; Locomotion; Male; Mice; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Social Isolation	2011
SSRIs and the female brain--potential for utilizing steroid-stimulating properties to treat menstrual cycle-linked dysphorias. Journal of psychopharmacology (Oxford, England), 2013, Volume: 27, Issue:12 Topics: Animals; Brain; Dose-Response Relationship, Drug; Epilepsy; Female; Fluoxetine; GABAergic Neurons; Humans; Menstrual Cycle; Neurons; Pregnanolone; Premenstrual Syndrome; Progesterone; Rats; Selective Serotonin Reuptake Inhibitors	2013
Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase. British journal of pharmacology, 2014, Volume: 171, Issue:24 Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 5-alpha-Dihydroprogesterone; Aldehyde Reductase; Aldo-Keto Reductases; Animals; Brain; Female; Fluoxetine; HEK293 Cells; Humans; Male; Pregnanolone; Progesterone; Rats; Selective Serotonin Reuptake Inhibitors	2014
Elevation of brain allopregnanolone rather than 5-HT release by short term, low dose fluoxetine treatment prevents the estrous cycle-linked increase in stress sensitivity in female rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, Volume: 25, Issue:1 Topics: Analysis of Variance; Animals; Antidepressive Agents, Second-Generation; Arabidopsis Proteins; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Electric Stimulation; Escape Reaction; Estrous Cycle; Female; Fluoxetine; Freezing Reaction, Cataleptic; Hyperalgesia; Nuclear Proteins; Periaqueductal Gray; Pregnanolone; Rats; Rats, Wistar; Serotonin; Stress, Psychological	2015
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats. Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:10 Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Diazepam; Estrous Cycle; Estrus; Female; Fluoxetine; gamma-Aminobutyric Acid; Locomotion; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Serotonin	2016
Paeoniflorin exhibits antidepressant activity in rats with postpartum depression via the TSPO and BDNF‑mTOR pathways. Acta neurobiologiae experimentalis, 2022, Volume: 82, Issue:3 Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Carrier Proteins; Corticosterone; Depression; Depression, Postpartum; Disease Models, Animal; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Fluoxetine; Glucosides; Hippocampus; Humans; Monoterpenes; Pregnancy; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Stress, Psychological; Sucrose; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha	2022
Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats. Psychopharmacology, 2023, Volume: 240, Issue:12 Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Extinction, Psychological; Fear; Female; Fluoxetine; Humans; Pregnancy; Pregnanolone; Progesterone; Rats	2023