Page last updated: 2024-08-23

pregnanolone and dihydrotestosterone

pregnanolone has been researched along with dihydrotestosterone in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19904 (16.00)18.7374
1990's6 (24.00)18.2507
2000's10 (40.00)29.6817
2010's2 (8.00)24.3611
2020's3 (12.00)2.80

Authors

AuthorsStudies
Strassburg, CP; Tukey, RH1
Abraham, GE; Chang, RJ1
García-Yañez, E; Ibáñez, R; Kubli-Garfias, C; Perusquía, M1
Lambert, JG; Schoonen, WG; Van Oordt, PG1
Benson, HD; Blohm, TR; Johnston, JO; Laughlin, ME; Schatzman, GL; Weintraub, PM; Wright, CL1
Ahmed, R; Morgan, TE; Sweet, BC; Sweet, F1
Bitran, D; McLeod, M; Shiekh, M1
Celotti, F; Martini, L; Melcangi, RC1
Baulieu, EE; Corpéchot, C; Eychenne, B; Haug, M; Perché, F; Robel, P; Young, J1
Holtan, DW; Kerby, JL; Schutzer, WE1
Cavarretta, I; Ferraboschi, P; Magnaghi, V; Martini, L; Melcangi, RC1
Devaud, LL; Grobin, AC; Janis, GC; Matthews, DB; Morrow, AL; VanDoren, MJ1
Costa, E; Dong, E; Guidotti, A; Matsumoto, K; Nomura, H; Sugaya, I; Takahata, H; Uzunova, V; Watanabe, H1
Beaujean, D; Do-Régo, JL; Luu-The, V; Mathieu, M; Mensah-Nyagan, AG; Pelletier, G; Vallarino, M; Vaudry, D; Vaudry, H1
Azcoitia, I; Ciriza, I; Garcia-Segura, LM1
Chopde, CT; Hirani, K; Jain, NS1
Smith, SS; Zhou, X1
Furukawa, K; Kita, A1
Begliuomini, S; Casarosa, E; Cela, V; Cubeddu, A; Freschi, L; Genazzani, AR; Giannini, A; Lenzi, E; Luisi, S; Merlini, S; Ninni, F; Pluchino, N1
Frye, CA; Koonce, CJ; Walf, AA1
Calza, L; Caruso, D; D'Intino, G; Garcia-Segura, LM; Giatti, S; Maschi, O; Melcangi, RC; Pesaresi, M1
Fujitani, N; Ikeda-Ishihara, N; Ishida, A; Ishihara, Y; Mori-Yasumoto, K; Nehira, T; Sakurai, H; Takemoto, T; Yamazaki, T1
Biagini, G; Costa, AM; Lucchi, C; Messina, S; Rustichelli, C; Senn, L1
Ahn, JH; Ahn, SH; Bae, MA; Cho, SH; Hwang, KS; Kan, H; Kim, SS; Lee, BH; Shin, DS; Son, Y; Yang, JY1
Caputi, V; Caruso, D; Cioffi, L; Diviccaro, S; Giatti, S; Lyte, JM; Melcangi, RC; O'Mahony, SM1

Reviews

1 review(s) available for pregnanolone and dihydrotestosterone

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000

Other Studies

24 other study(ies) available for pregnanolone and dihydrotestosterone

ArticleYear
Peripheral steroid levels in a patient with congenital absence of the uterus.
    Obstetrics and gynecology, 1975, Volume: 46, Issue:3

    Topics: 17-alpha-Hydroxypregnenolone; Adolescent; Amenorrhea; Androstenedione; Dehydroepiandrosterone; Dihydrotestosterone; Estradiol; Estrone; Female; Follicular Phase; Humans; Hydrocortisone; Hydroxyprogesterones; Karyotyping; Luteal Phase; Luteinizing Hormone; Pregnanolone; Progesterone; Steroids; Testosterone; Uterus

1975
Non-genomic mechanism of action of delta-4 and 5-reduced androgens and progestins on the contractility of the isolated rat myometrium.
    Life sciences, 1990, Volume: 47, Issue:17

    Topics: Androgens; Animals; Calcimycin; Calcium; Calcium Channels; Dihydrotestosterone; Female; Lasalocid; Muscle Relaxation; Myometrium; Potassium; Pregnanediones; Pregnanolone; Progestins; Rats; Rats, Inbred Strains; Uterine Contraction

1990
Quantitative analysis of steroids and steroid glucuronides in the seminal vesicle fluid of feral spawning and feral and cultivated nonspawning African catfish, Clarias gariepinus.
    General and comparative endocrinology, 1988, Volume: 70, Issue:1

    Topics: Androstane-3,17-diol; Animals; Catfishes; Dihydrotestosterone; Etiocholanolone; Gas Chromatography-Mass Spectrometry; Glucuronates; Male; Pregnanolone; Reproduction; Semen; Steroids; Testosterone

1988
Pharmacological induction of 5 alpha-reductase deficiency in the rat: separation of testosterone-mediated and 5 alpha-dihydrotestosterone-mediated effects.
    Endocrinology, 1986, Volume: 119, Issue:3

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Dihydrotestosterone; Estradiol; Genitalia, Male; Male; Orchiectomy; Pregnanolone; Progesterone; Rats; Rats, Inbred Strains; Receptors, Androgen; Testosterone

1986
Bifunctional enzyme activity at the same active site: competitive inhibition kinetics with 3 alpha/20 beta-hydroxysteroid dehydrogenase.
    Steroids, 1980, Volume: 35, Issue:1

    Topics: 20-Hydroxysteroid Dehydrogenases; Binding, Competitive; Cortisone; Cortisone Reductase; Dihydrotestosterone; Hydroxyprogesterones; Isomerism; Kinetics; Pregnanolone; Steroids, Brominated; Streptomyces; Structure-Activity Relationship

1980
Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors.
    Journal of neuroendocrinology, 1995, Volume: 7, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Azasteroids; Brain; Cholestenone 5 alpha-Reductase; Dihydrotestosterone; Estrus; Female; Mifepristone; Ovariectomy; Ovary; Oxidoreductases; Picrotoxin; Pregnanolone; Progesterone; Rats; Receptors, GABA-A

1995
Progesterone 5-alpha-reduction in neuronal and in different types of glial cell cultures: type 1 and 2 astrocytes and oligodendrocytes.
    Brain research, 1994, Mar-14, Volume: 639, Issue:2

    Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; Animals; Astrocytes; Cells, Cultured; Dihydrotestosterone; Immunohistochemistry; Neurons; Oligodendroglia; Oxidoreductases; Pregnanolone; Rats; Rats, Sprague-Dawley

1994
Neurosteroids in the mouse brain: behavioral and pharmacological effects of a 3 beta-hydroxysteroid dehydrogenase inhibitor.
    Steroids, 1996, Volume: 61, Issue:3

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Brain; Dehydroepiandrosterone; Dihydrotestosterone; Enzyme Inhibitors; Female; Humans; Mice; Pregnanolone; Pregnenolone; Progesterone; Sexual Behavior, Animal

1996
Differential effect of trilostane on the progestin milieu in the pregnant mare.
    Journal of reproduction and fertility, 1996, Volume: 107, Issue:2

    Topics: 3-Hydroxysteroid Dehydrogenases; 5-alpha-Dihydroprogesterone; Animals; Dihydrotestosterone; Female; Horses; Male; Placenta; Pregnancy; Pregnancy, Animal; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Progestins

1996
Interactions between type 1 astrocytes and LHRH-secreting neurons (GT1-1 cells): modification of steroid metabolism and possible role of TGFbeta1.
    The Journal of steroid biochemistry and molecular biology, 1999, Volume: 71, Issue:1-2

    Topics: 20-alpha-Dihydroprogesterone; 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Astrocytes; Cells, Cultured; Coculture Techniques; Dihydrotestosterone; Etiocholanolone; Gonadotropin-Releasing Hormone; Neurons; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Steroids; Testosterone; Transforming Growth Factor beta

1999
Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Mar-01, Volume: 20, Issue:5

    Topics: Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Central Nervous System Depressants; Cerebral Cortex; Convulsants; Cyclooxygenase Inhibitors; Dihydrotestosterone; Electrophysiology; Enzyme Inhibitors; Epilepsy; Ethanol; Finasteride; Indomethacin; Male; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2000
Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-27, Volume: 98, Issue:5

    Topics: Animals; Base Sequence; Brain; Dihydrotestosterone; DNA; Male; Mice; Models, Animal; Molecular Sequence Data; Pregnanolone; Social Isolation

2001
Immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase and 5 alpha-reductase in the brain of the African lungfish Protopterus annectens.
    The Journal of comparative neurology, 2001, Sep-17, Volume: 438, Issue:2

    Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Antibody Specificity; Brain; Dihydrotestosterone; Fishes; Immunohistochemistry; Male; Pituitary Gland; Pregnanolone; Receptors, GABA-A

2001
Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo.
    Journal of neuroendocrinology, 2004, Volume: 16, Issue:1

    Topics: Animals; Cell Death; Dentate Gyrus; Dihydrotestosterone; Excitatory Amino Acid Agonists; Female; Kainic Acid; Neurons; Neuroprotective Agents; Pregnanolone; Progesterone; Rats; Rats, Wistar

2004
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time

2005
Steroid requirements for regulation of the alpha4 subunit of the GABA(A) receptor in an in vitro model.
    Neuroscience letters, 2007, Jan-03, Volume: 411, Issue:1

    Topics: Analysis of Variance; Androgen Antagonists; Azasteroids; Bicuculline; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Dihydrotestosterone; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Humans; Membrane Potentials; Nerve Growth Factor; Neuroblastoma; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; RNA, Messenger

2007
Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; GABA Antagonists; Interpersonal Relations; Male; Mice; Picrotoxin; Pregnanolone; Progesterone; Purines; Receptors, GABA-A

2008
Sexually dimorphic effects of testosterone administration on brain allopregnanolone in gonadectomized rats.
    The journal of sexual medicine, 2008, Volume: 5, Issue:12

    Topics: Animals; Brain; Dihydrotestosterone; Dose-Response Relationship, Drug; Estradiol; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Injections, Subcutaneous; Male; Orchiectomy; Ovariectomy; Parietal Lobe; Pituitary Gland, Anterior; Pregnanolone; Rats; Sex Characteristics; Signal Transduction; Testosterone

2008
Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor [beta] knockout mice.
    Neuroreport, 2009, Aug-05, Volume: 20, Issue:12

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Corticosterone; Depression; Dihydrotestosterone; Estrogen Receptor beta; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neuropsychological Tests; Pregnanolone; Radioimmunoassay; Swimming; Time Factors

2009
Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels.
    Neurochemistry international, 2010, Volume: 56, Issue:1

    Topics: 20-alpha-Dihydroprogesterone; Acute Disease; Androstane-3,17-diol; Animals; Brain; Chromatography, Liquid; Dihydrotestosterone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Male; Mass Spectrometry; Multiple Sclerosis; Neurotransmitter Agents; Pregnanolone; Progesterone; Rats; Sex Characteristics; Testosterone

2010
Effects of sex steroid hormones and their metabolites on neuronal injury caused by oxygen-glucose deprivation/reoxygenation in organotypic hippocampal slice cultures.
    Steroids, 2016, Volume: 113

    Topics: Animals; Cell Death; Dihydrotestosterone; Estradiol; Finasteride; Glucose; Hippocampus; Hypoxia; In Vitro Techniques; Neuroprotective Agents; Oxygen; Pregnanolone; Progesterone; Rats; Receptors, Androgen; Testosterone; Tetrahydronaphthalenes

2016
Augmentation of endogenous neurosteroid synthesis alters experimental status epilepticus dynamics.
    Epilepsia, 2020, Volume: 61, Issue:9

    Topics: 5-alpha-Dihydroprogesterone; Animals; Brain; Chromatography, Liquid; Dihydrotestosterone; Electrocorticography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Neocortex; Neurosteroids; Pregnanolone; Pregnenolone; Progesterone; Rats; Receptors, GABA-A; Status Epilepticus; Tandem Mass Spectrometry; Time Factors

2020
Neurochemical Effects of 4-(2Chloro-4-Fluorobenzyl)-3-(2-Thienyl)-1,2,4-Oxadiazol-5(4H)-One in the Pentylenetetrazole (PTZ)-Induced Epileptic Seizure Zebrafish Model.
    International journal of molecular sciences, 2021, Jan-28, Volume: 22, Issue:3

    Topics: Animals; Anticonvulsants; Antioxidants; Brain; Brain Chemistry; Dihydrotestosterone; Disease Models, Animal; Estradiol; gamma-Aminobutyric Acid; Hydrocortisone; Male; Neuroprotective Agents; Normetanephrine; Oxadiazoles; Oxidative Stress; Pentylenetetrazole; Pregnanolone; Progesterone; Reactive Oxygen Species; Seizures; Serotonin; Zebrafish

2021
Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals.
    International journal of molecular sciences, 2021, Nov-21, Volume: 22, Issue:22

    Topics: Androstane-3,17-diol; Animals; Brain; Chromatography; Dihydrotestosterone; Gastrointestinal Microbiome; Germ Cells; Gonadal Steroid Hormones; Male; Mice; Microbiota; Neurosteroids; Pregnanolone; Tandem Mass Spectrometry; Testosterone

2021