pregnanolone has been researched along with diazepam in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.13) | 18.7374 |
| 1990's | 24 (37.50) | 18.2507 |
| 2000's | 20 (31.25) | 29.6817 |
| 2010's | 13 (20.31) | 24.3611 |
| 2020's | 5 (7.81) | 2.80 |
| Authors | Studies |
|---|---|
| Acosta-Burruel, M; Alauddin, M; Bolger, MB; Gee, KW; Hawkinson, JE; Hogenkamp, DJ; Kimbrough, CL; Lan, NC; Tahir, SH; Upasani, RB; Whittemore, ER; Woodward, RM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Briggs, LP; Clarke, RS; Dundee, JW; McNeill, HG | 1 |
| Gee, KW; Lan, NC | 1 |
| Blakeman, DP; Im, WB | 1 |
| Chapman, JM; Cooper, GM; Gray, AJ; Prys-Roberts, C; Sear, JW; Simpson, PJ | 1 |
| Felzenberg, E; McCarthy, MM; Pfaff, DW; Robbins, A; Schwartz-Giblin, S | 1 |
| Ator, NA; Grant, KA; Griffiths, RR; Paul, SM; Purdy, RH | 1 |
| Gallo, MA; Smith, SS | 1 |
| Akaike, N; Harata, N; Shimura, M; Tamai, M | 1 |
| Akaike, N; Harata, N; Wu, J | 1 |
| Akaike, N; Imanishi, T; Xu, TL | 1 |
| Vanover, KE | 1 |
| Barros, HM; Manitiu, A; Miczek, KA; Vivian, JA | 1 |
| Firestone, LL; Homanics, GE; Korpi, ER; Mäkelä, R; Quinlan, JJ; Uusi-Oukari, M; Wisden, W | 1 |
| Johnson, NJ; Rodgers, RJ | 1 |
| Czuchwicki, A; Ilsley, AH; Love, DR; Owen, H; Plummer, JL | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P | 1 |
| Kellogg, CK; Olson, VG; Pleger, GL | 1 |
| Biggio, G; Concas, A; Floris, S; Follesa, P; Mostallino, MC; Tuligi, G | 1 |
| Bowen, CA; Grant, KA | 1 |
| Bowen, CA; Gatto, GJ; Grant, KA | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Carter, RB; Gee, KW; Huber, M; Lan, NC; Robledo, S; Suruki, M; Vanover, KE; Wieland, S; Wood, PL | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Alkana, RL; Bolger, MB; Brinton, RD; Davies, DL; Finn, DA | 1 |
| Chistina Grobin, A; Devaud, LL; Inglefield, JR; Morrow, AL; Schwartz-Bloom, RD | 1 |
| Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM | 1 |
| Sapp, DW; Yeh, HH | 1 |
| Reddy, DS; Rogawski, MA | 3 |
| Dekermendjian, K; Hartvig, L; Liljefors, T; Lükensmejer, B | 1 |
| Bertram, EH; Kapur, J; Mtchedlishvili, Z | 1 |
| France, CP; McMahon, LR | 1 |
| Altobelli, D; Cannizzaro, C; Martire, M; Maurizi, S; Preziosi, P | 1 |
| Delgado, G; Gomez, C; Rodriguez, R; Saldivar-Gonzalez, A | 1 |
| Dillon, GH; Huang, RQ | 1 |
| Breton, JD; Keller, AF; Poisbeau, P; Schlichter, R | 1 |
| Keller, AF; Leroy, C; Nehlig, A; Poisbeau, P | 1 |
| Chopde, CT; Hirani, K; Jain, NS | 1 |
| France, CP; Gerak, LR; McMahon, LR | 1 |
| France, CP; Javors, MA; McMahon, LR | 1 |
| Pericić, D; Strac, DS; Vlainić, J | 1 |
| Furukawa, K; Kita, A | 1 |
| Akk, G; Bracamontes, J; Li, P; Steinbach, JH | 1 |
| Dandekar, MP; Deo, GS; Kokare, DM; Subhedar, NK; Upadhya, MA | 1 |
| Angioni, MM; Biggio, G; Calza, A; Concas, A; Marra, C; Mostallino, MC; Santoru, F; Sogliano, C | 1 |
| Gangisetty, O; Reddy, DS | 1 |
| Coyne, L; Halliwell, RF; Hirakawa, R; Przyborski, SA; Shan, M | 1 |
| Gangisetty, O; Gould, J; Reddy, DS | 1 |
| Cao, Z; Hammock, BD; Lein, PJ; McCoy, M; Pessah, IN; Rogawski, MA | 1 |
| Lossin, C; Loya, CM; Reddy, K; Rogawski, MA; Zolkowska, D | 1 |
| Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP | 1 |
| Austin, AT; Bruun, DA; Cao, Z; Hammock, BD; Hulsizer, S; Inceoglu, B; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Vito, ST | 1 |
| Crawley, JN; Hagerman, RJ; Kazdoba, TM; Rogawski, MA; Zolkowska, D | 1 |
| André, E; de Sousa Pinto, ÍA; Gavioli, EC; Lovick, T; Santos, RO; Soares-Rachetti, Vde P | 1 |
| Higashi, T; Nakashima, K; Okumura, A; Sato, T; Yoshizawa, K | 1 |
| Barker-Haliski, M; DiCamillo, A; Gruner, JA; Hinchliffe, R; Saporito, MS; White, HS | 1 |
| Benz, A; Lambert, PM; Mennerick, S; Ni, R; Rensing, NR; Wong, M; Zorumski, CF | 1 |
| Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J | 1 |
| Bernal-Morales, B; Cueto-Escobedo, J; Flores-Aguilar, LÁ; Olmos-Vázquez, OJ; Puga-Olguín, A; Rodríguez-Landa, JF; Rosas-Sánchez, GU | 1 |
| Bäckström, T; Bixo, M; Möller, A; Sandström, A; Turkmen, S | 1 |
| Graham, BM; Pestana, JE | 1 |
1 review(s) available for pregnanolone and diazepam
| Article | Year |
|---|---|
Neuroactive steroids for the treatment of status epilepticus.
Topics: Anesthetics; Animals; Benzodiazepines; Diazepam; Humans; Neurotransmitter Agents; Pregnanolone; Status Epilepticus | 2013 |
1 trial(s) available for pregnanolone and diazepam
| Article | Year |
|---|---|
Influence of premedication with diazepam or morphine on the induction dose of eltanolone.
Topics: Adjuvants, Anesthesia; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Confidence Intervals; Diazepam; Double-Blind Method; Female; Humans; Incidence; Injections, Intramuscular; Logistic Models; Male; Middle Aged; Morphine; Movement; Placebos; Preanesthetic Medication; Pregnanolone | 1998 |
62 other study(ies) available for pregnanolone and diazepam
| Article | Year |
|---|---|
Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.
Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Desoxycorticosterone; Electrophysiology; Female; In Vitro Techniques; Models, Molecular; Oocytes; Rats; Receptors, GABA-A; Xenopus | 1997 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
The influence of dosage and premedication on induction of anesthesia with minaxolone.
Topics: Adult; Anesthesia, Intravenous; Anesthetics; Blood Pressure; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Movement; Narcotics; Preanesthetic Medication; Pregnanes; Pregnanolone; Respiration | 1979 |
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes | 1991 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Studies on premedication and ventilatory responses to minaxolone.
Topics: Adult; Anesthetics; Atropine; Diazepam; Female; Humans; Male; Morphine; Nitrous Oxide; Oxygen; Preanesthetic Medication; Pregnanes; Pregnanolone; Respiration; Time Factors | 1981 |
Infusions of diazepam and allopregnanolone into the midbrain central gray facilitate open-field behavior and sexual receptivity in female rats.
Topics: Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Female; GABA Modulators; Mesencephalon; Ovariectomy; Pregnanolone; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Time Factors | 1995 |
Drug discrimination analysis of endogenous neuroactive steroids in rats.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Discrimination Learning; Ethanol; Generalization, Stimulus; Lorazepam; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A | 1993 |
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Electroshock; Estradiol; Female; Indomethacin; Pregnanolone; Premenstrual Syndrome; Progesterone; Rats; Substance Withdrawal Syndrome | 1993 |
Allosteric modulation of GABAA receptors in acutely dissociated neurons of the suprachiasmatic nucleus.
Topics: Allosteric Regulation; Animals; Bicuculline; Chlorides; Diazepam; Electric Conductivity; Female; GABA Antagonists; GABA-A Receptor Agonists; Intracellular Membranes; Male; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Suprachiasmatic Nucleus | 1996 |
Potentiation by sevoflurane of the gamma-aminobutyric acid-induced chloride current in acutely dissociated CA1 pyramidal neurones from rat hippocampus.
Topics: Animals; Chloride Channels; Diazepam; Drug Synergism; Ethers; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channel Gating; Methyl Ethers; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Sevoflurane | 1996 |
Modulation of the GABAA response in rat ventromedial hypothalamic neurons by pregnanolone.
Topics: Animals; Chloride Channels; Chlorides; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Transport; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Ventromedial Hypothalamic Nucleus | 1997 |
Discriminative stimulus effects of the endogenous neuroactive steroid pregnanolone.
Topics: Animals; Behavior, Animal; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Male; Pentobarbital; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1997 |
Ultrasonic vocalizations in rat pups: modulation at the gamma-aminobutyric acidA receptor complex and the neurosteroid recognition site.
Topics: Alprazolam; Animals; Diazepam; Female; Male; Muscimol; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Vocalization, Animal | 1997 |
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mutation; Pregnanolone; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Tritium; Zinc | 1997 |
Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Male; Maze Learning; Mice; Mice, Inbred DBA; Pregnanediones; Pregnanolone; Steroids | 1998 |
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Neurosteroid action at the GABAA receptor in fetal rat forebrain.
Topics: Androsterone; Animals; Chlorides; Diazepam; Female; Fetus; GABA Modulators; gamma-Aminobutyric Acid; Male; Pregnancy; Pregnanolone; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors; Synaptosomes | 1998 |
Molecular and functional adaptation of the GABA(A) receptor complex during pregnancy and after delivery in the rat brain.
Topics: Allosteric Regulation; Alternative Splicing; Animals; Brain Chemistry; Cerebral Cortex; Chlorides; Diazepam; Female; Hippocampus; Isotopes; Muscimol; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1998 |
Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using a three-choice ethanol-dizocilpine-water discrimination.
Topics: Animals; Diazepam; Discrimination, Psychological; Dizocilpine Maleate; Ethanol; GABA Modulators; Indoles; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists; Water | 1998 |
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water | 1997 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol.
Topics: Allosteric Regulation; Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; GABA-A Receptor Agonists; Male; Mice; Motor Activity; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Triazolam | 1999 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors | 1998 |
In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Diazepam; Ethanol; Flunitrazepam; GABA Modulators; Hyperbaric Oxygenation; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Pregnanolone; Receptors, GABA-A | 1999 |
Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.
Topics: Animals; Central Nervous System Depressants; Chlorides; Diazepam; DNA Primers; Ethanol; Flunitrazepam; Fluorescent Dyes; GABA Agonists; GABA Modulators; Gene Expression; Mice; Muscimol; Neoplastic Stem Cells; Neuroglia; Pentobarbital; Pregnanolone; Quinolinium Compounds; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 1999 |
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Seizures; Stereotypic Movement Disorder; Valproic Acid | 2000 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid | 2000 |
Two conserved arginines in the extracellular N-terminal domain of the GABA(A) receptor alpha(5) subunit are crucial for receptor function.
Topics: Amino Acid Substitution; Animals; Arginine; Chlorides; CHO Cells; Cricetinae; Diazepam; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Ion Channel Gating; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Structure, Tertiary; Receptors, GABA-A; Sequence Alignment; Steroids; Structure-Activity Relationship; Transfection | 2000 |
Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Female; Motor Activity; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2000 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Pyridines; Rats; Receptors, GABA-A; Zinc; Zolpidem | 2001 |
Daily treatment with diazepam differentially modifies sensitivity to the effects of gamma-aminobutyric acid(A) modulators on schedule-controlled responding in rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Electroshock; Food; GABA Agonists; GABA Antagonists; GABA Modulators; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule; Triazolam | 2002 |
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
Topics: Allosteric Regulation; Animals; Baclofen; Bicuculline; Diazepam; Female; Fetal Proteins; GABA Agonists; GABA Antagonists; Hippocampus; Male; Mental Disorders; Nerve Tissue Proteins; Norepinephrine; Picrotoxin; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2002 |
Rapid anxiolytic activity of progesterone and pregnanolone in male rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Motor Activity; Pregnanolone; Progesterone; Rats; Rats, Wistar | 2002 |
Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.
Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Carbolines; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Diuretics; Female; Furosemide; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem | 2002 |
Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA(A) miniature IPSCs in lamina II of the spinal cord.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Age Factors; Animals; Diazepam; Enzyme Inhibitors; Finasteride; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Posterior Horn Cells; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Steroids | 2004 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; Lithium; Male; Neural Inhibition; Patch-Clamp Techniques; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Synapses | 2004 |
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time | 2005 |
Efficacy and the discriminative stimulus effects of negative GABAA modulators, or inverse agonists, in diazepam-treated rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2006 |
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2007 |
Interaction of diazepam and swim stress.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Mice; Picrotoxin; Pregnanolone; Reaction Time; Seizures; Stress, Psychological; Swimming | 2007 |
Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; GABA Antagonists; Interpersonal Relations; Male; Mice; Picrotoxin; Pregnanolone; Progesterone; Purines; Receptors, GABA-A | 2008 |
Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.
Topics: Binding Sites; Cell Line; Diazepam; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutation; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Multimerization; Protein Subunits; Receptors, GABA-A | 2009 |
Neuropeptide Y Y1 receptors in the central nucleus of amygdala mediate the anxiolytic-like effect of allopregnanolone in mice: Behavioral and immunocytochemical evidences.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Arcuate Nucleus of Hypothalamus; Arginine; Central Nervous System Agents; Diazepam; Dose-Response Relationship, Drug; Electroshock; Immunohistochemistry; Male; Mice; Neuropeptide Y; Neuropsychological Tests; Nucleus Accumbens; Pregnanolone; Receptors, Neuropeptide Y; Septal Nuclei | 2010 |
Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Diazepam; Estradiol; Female; Immunoblotting; Motor Activity; Neurotransmitter Agents; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 2010 |
Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway.
Topics: Animals; Diazepam; Drug Administration Schedule; Early Growth Response Protein 3; Female; Flumazenil; Gene Expression Regulation; Hippocampus; Kindling, Neurologic; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotransmitter Agents; Oligodeoxyribonucleotides, Antisense; Pregnanolone; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Signal Transduction; Up-Regulation | 2010 |
Neuropharmacological properties of neurons derived from human stem cells.
Topics: Cell Differentiation; Chlordiazepoxide; Diazepam; gamma-Aminobutyric Acid; Glycine; Humans; Immunohistochemistry; Ion Channel Gating; Ligands; Mefenamic Acid; Neurons; Pentobarbital; Pregnanolone; Stem Cells; Tetraethylammonium; Tetrodotoxin | 2011 |
A mouse kindling model of perimenstrual catamenial epilepsy.
Topics: 5-alpha Reductase Inhibitors; Animals; Diazepam; Disease Models, Animal; Epilepsy; Female; Finasteride; Gonadotropins; Hippocampus; Kindling, Neurologic; Menstrual Cycle; Mice; Mice, Inbred C57BL; Pregnanolone; Progesterone; Rats; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome | 2012 |
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; High-Throughput Screening Assays; Hippocampus; Mice; Mice, Inbred C57BL; Microelectrodes; Neurons; Picrotoxin; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors | 2012 |
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Hypnotics and Sedatives; Pregnanolone; Psychiatric Status Rating Scales; Receptors, GABA-A; Saccades; Stress Disorders, Post-Traumatic; Young Adult | 2016 |
Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.
Topics: Animals; Anticonvulsants; Bridged-Ring Compounds; Calcium; Cells, Cultured; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hippocampus; Male; Mice; Neuroimmunomodulation; Neurons; Pregnanolone; Seizures | 2015 |
Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.
Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Behavior, Animal; Diazepam; Female; GABA Modulators; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pregnanolone; Receptors, GABA-A; Social Behavior | 2016 |
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Diazepam; Estrous Cycle; Estrus; Female; Fluoxetine; gamma-Aminobutyric Acid; Locomotion; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Serotonin | 2016 |
Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety Disorders; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Freezing Reaction, Cataleptic; Male; Mice, Inbred C57BL; Muscle Relaxants, Central; Muscle Strength; Muscle Tonus; Pregnanediones; Pregnanolone; Restraint, Physical; Stress, Psychological | 2017 |
Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone.
Topics: Administration, Intravenous; Anesthetics; Animals; Anticonvulsants; Diazepam; Drug Resistant Epilepsy; Electroencephalography; Lithium; Male; Muscarinic Agonists; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2019 |
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators.
Topics: Animals; Antidepressive Agents; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Humans; Ketamine; Mice; Neurosteroids; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnanolone; Pyrrolidonecarboxylic Acid; Rodentia; Spasm; Spasms, Infantile | 2023 |
Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause.
Topics: Animals; Diazepam; Female; Flavonoids; Menopause; Pregnanolone; Rats; Rats, Wistar | 2023 |
Altered GABA
Topics: Diazepam; Endometriosis; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Pelvic Pain; Pregnanolone; Receptors, GABA-A | 2023 |
Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Extinction, Psychological; Fear; Female; Fluoxetine; Humans; Pregnancy; Pregnanolone; Progesterone; Rats | 2023 |