Page last updated: 2024-08-23

pregnanolone and diazepam

pregnanolone has been researched along with diazepam in 64 studies

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-19902 (3.13)18.7374
1990's24 (37.50)18.2507
2000's20 (31.25)29.6817
2010's13 (20.31)24.3611
2020's5 (7.81)2.80

Authors

AuthorsStudies
Acosta-Burruel, M; Alauddin, M; Bolger, MB; Gee, KW; Hawkinson, JE; Hogenkamp, DJ; Kimbrough, CL; Lan, NC; Tahir, SH; Upasani, RB; Whittemore, ER; Woodward, RM1
Lombardo, F; Obach, RS; Waters, NJ1
Briggs, LP; Clarke, RS; Dundee, JW; McNeill, HG1
Gee, KW; Lan, NC1
Blakeman, DP; Im, WB1
Chapman, JM; Cooper, GM; Gray, AJ; Prys-Roberts, C; Sear, JW; Simpson, PJ1
Felzenberg, E; McCarthy, MM; Pfaff, DW; Robbins, A; Schwartz-Giblin, S1
Ator, NA; Grant, KA; Griffiths, RR; Paul, SM; Purdy, RH1
Gallo, MA; Smith, SS1
Akaike, N; Harata, N; Shimura, M; Tamai, M1
Akaike, N; Harata, N; Wu, J1
Akaike, N; Imanishi, T; Xu, TL1
Vanover, KE1
Barros, HM; Manitiu, A; Miczek, KA; Vivian, JA1
Firestone, LL; Homanics, GE; Korpi, ER; Mäkelä, R; Quinlan, JJ; Uusi-Oukari, M; Wisden, W1
Johnson, NJ; Rodgers, RJ1
Czuchwicki, A; Ilsley, AH; Love, DR; Owen, H; Plummer, JL1
Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P1
Kellogg, CK; Olson, VG; Pleger, GL1
Biggio, G; Concas, A; Floris, S; Follesa, P; Mostallino, MC; Tuligi, G1
Bowen, CA; Grant, KA1
Bowen, CA; Gatto, GJ; Grant, KA1
Bender, AS; Norenberg, MD1
Carter, RB; Gee, KW; Huber, M; Lan, NC; Robledo, S; Suruki, M; Vanover, KE; Wieland, S; Wood, PL1
Akhondzadeh, S; Stone, TW1
Alkana, RL; Bolger, MB; Brinton, RD; Davies, DL; Finn, DA1
Chistina Grobin, A; Devaud, LL; Inglefield, JR; Morrow, AL; Schwartz-Bloom, RD1
Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM1
Sapp, DW; Yeh, HH1
Reddy, DS; Rogawski, MA3
Dekermendjian, K; Hartvig, L; Liljefors, T; Lükensmejer, B1
Bertram, EH; Kapur, J; Mtchedlishvili, Z1
France, CP; McMahon, LR1
Altobelli, D; Cannizzaro, C; Martire, M; Maurizi, S; Preziosi, P1
Delgado, G; Gomez, C; Rodriguez, R; Saldivar-Gonzalez, A1
Dillon, GH; Huang, RQ1
Breton, JD; Keller, AF; Poisbeau, P; Schlichter, R1
Keller, AF; Leroy, C; Nehlig, A; Poisbeau, P1
Chopde, CT; Hirani, K; Jain, NS1
France, CP; Gerak, LR; McMahon, LR1
France, CP; Javors, MA; McMahon, LR1
Pericić, D; Strac, DS; Vlainić, J1
Furukawa, K; Kita, A1
Akk, G; Bracamontes, J; Li, P; Steinbach, JH1
Dandekar, MP; Deo, GS; Kokare, DM; Subhedar, NK; Upadhya, MA1
Angioni, MM; Biggio, G; Calza, A; Concas, A; Marra, C; Mostallino, MC; Santoru, F; Sogliano, C1
Gangisetty, O; Reddy, DS1
Coyne, L; Halliwell, RF; Hirakawa, R; Przyborski, SA; Shan, M1
Gangisetty, O; Gould, J; Reddy, DS1
Cao, Z; Hammock, BD; Lein, PJ; McCoy, M; Pessah, IN; Rogawski, MA1
Lossin, C; Loya, CM; Reddy, K; Rogawski, MA; Zolkowska, D1
Bäckström, T; Helström, L; Möller, AT; Nyberg, S; Söndergaard, HP1
Austin, AT; Bruun, DA; Cao, Z; Hammock, BD; Hulsizer, S; Inceoglu, B; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Vito, ST1
Crawley, JN; Hagerman, RJ; Kazdoba, TM; Rogawski, MA; Zolkowska, D1
André, E; de Sousa Pinto, ÍA; Gavioli, EC; Lovick, T; Santos, RO; Soares-Rachetti, Vde P1
Higashi, T; Nakashima, K; Okumura, A; Sato, T; Yoshizawa, K1
Barker-Haliski, M; DiCamillo, A; Gruner, JA; Hinchliffe, R; Saporito, MS; White, HS1
Benz, A; Lambert, PM; Mennerick, S; Ni, R; Rensing, NR; Wong, M; Zorumski, CF1
Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J1
Bernal-Morales, B; Cueto-Escobedo, J; Flores-Aguilar, LÁ; Olmos-Vázquez, OJ; Puga-Olguín, A; Rodríguez-Landa, JF; Rosas-Sánchez, GU1
Bäckström, T; Bixo, M; Möller, A; Sandström, A; Turkmen, S1
Graham, BM; Pestana, JE1

Reviews

1 review(s) available for pregnanolone and diazepam

ArticleYear
Neuroactive steroids for the treatment of status epilepticus.
    Epilepsia, 2013, Volume: 54 Suppl 6

    Topics: Anesthetics; Animals; Benzodiazepines; Diazepam; Humans; Neurotransmitter Agents; Pregnanolone; Status Epilepticus

2013

Trials

1 trial(s) available for pregnanolone and diazepam

ArticleYear
Influence of premedication with diazepam or morphine on the induction dose of eltanolone.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:5

    Topics: Adjuvants, Anesthesia; Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Confidence Intervals; Diazepam; Double-Blind Method; Female; Humans; Incidence; Injections, Intramuscular; Logistic Models; Male; Middle Aged; Morphine; Movement; Placebos; Preanesthetic Medication; Pregnanolone

1998

Other Studies

62 other study(ies) available for pregnanolone and diazepam

ArticleYear
Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.
    Journal of medicinal chemistry, 1997, Jan-03, Volume: 40, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Desoxycorticosterone; Electrophysiology; Female; In Vitro Techniques; Models, Molecular; Oocytes; Rats; Receptors, GABA-A; Xenopus

1997
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
The influence of dosage and premedication on induction of anesthesia with minaxolone.
    Acta anaesthesiologica Belgica, 1979, Volume: 30 Suppl

    Topics: Adult; Anesthesia, Intravenous; Anesthetics; Blood Pressure; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Movement; Narcotics; Preanesthetic Medication; Pregnanes; Pregnanolone; Respiration

1979
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
    Molecular pharmacology, 1991, Volume: 40, Issue:6

    Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes

1991
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
    Molecular pharmacology, 1991, Volume: 39, Issue:3

    Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes

1991
Studies on premedication and ventilatory responses to minaxolone.
    Acta anaesthesiologica Belgica, 1981, Volume: 32, Issue:2

    Topics: Adult; Anesthetics; Atropine; Diazepam; Female; Humans; Male; Morphine; Nitrous Oxide; Oxygen; Preanesthetic Medication; Pregnanes; Pregnanolone; Respiration; Time Factors

1981
Infusions of diazepam and allopregnanolone into the midbrain central gray facilitate open-field behavior and sexual receptivity in female rats.
    Hormones and behavior, 1995, Volume: 29, Issue:3

    Topics: Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Female; GABA Modulators; Mesencephalon; Ovariectomy; Pregnanolone; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal; Time Factors

1995
Drug discrimination analysis of endogenous neuroactive steroids in rats.
    European journal of pharmacology, 1993, Sep-14, Volume: 241, Issue:2-3

    Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Discrimination Learning; Ethanol; Generalization, Stimulus; Lorazepam; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A

1993
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Electroshock; Estradiol; Female; Indomethacin; Pregnanolone; Premenstrual Syndrome; Progesterone; Rats; Substance Withdrawal Syndrome

1993
Allosteric modulation of GABAA receptors in acutely dissociated neurons of the suprachiasmatic nucleus.
    The American journal of physiology, 1996, Volume: 270, Issue:6 Pt 1

    Topics: Allosteric Regulation; Animals; Bicuculline; Chlorides; Diazepam; Electric Conductivity; Female; GABA Antagonists; GABA-A Receptor Agonists; Intracellular Membranes; Male; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Suprachiasmatic Nucleus

1996
Potentiation by sevoflurane of the gamma-aminobutyric acid-induced chloride current in acutely dissociated CA1 pyramidal neurones from rat hippocampus.
    British journal of pharmacology, 1996, Volume: 119, Issue:5

    Topics: Animals; Chloride Channels; Diazepam; Drug Synergism; Ethers; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ion Channel Gating; Methyl Ethers; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Sevoflurane

1996
Modulation of the GABAA response in rat ventromedial hypothalamic neurons by pregnanolone.
    Comparative biochemistry and physiology. Part A, Physiology, 1997, Volume: 117, Issue:2

    Topics: Animals; Chloride Channels; Chlorides; Diazepam; Drug Interactions; gamma-Aminobutyric Acid; In Vitro Techniques; Ion Transport; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Stereoisomerism; Structure-Activity Relationship; Ventromedial Hypothalamic Nucleus

1997
Discriminative stimulus effects of the endogenous neuroactive steroid pregnanolone.
    European journal of pharmacology, 1997, May-30, Volume: 327, Issue:2-3

    Topics: Animals; Behavior, Animal; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Male; Pentobarbital; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

1997
Ultrasonic vocalizations in rat pups: modulation at the gamma-aminobutyric acidA receptor complex and the neurosteroid recognition site.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:1

    Topics: Alprazolam; Animals; Diazepam; Female; Male; Muscimol; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Vocalization, Animal

1997
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
    Molecular pharmacology, 1997, Volume: 52, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mutation; Pregnanolone; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Tritium; Zinc

1997
Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:1

    Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Male; Maze Learning; Mice; Mice, Inbred DBA; Pregnanediones; Pregnanolone; Steroids

1998
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
    Neuroscience, 1998, Volume: 85, Issue:3

    Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium

1998
Neurosteroid action at the GABAA receptor in fetal rat forebrain.
    Brain research. Developmental brain research, 1998, Jun-15, Volume: 108, Issue:1-2

    Topics: Androsterone; Animals; Chlorides; Diazepam; Female; Fetus; GABA Modulators; gamma-Aminobutyric Acid; Male; Pregnancy; Pregnanolone; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors; Synaptosomes

1998
Molecular and functional adaptation of the GABA(A) receptor complex during pregnancy and after delivery in the rat brain.
    The European journal of neuroscience, 1998, Volume: 10, Issue:9

    Topics: Allosteric Regulation; Alternative Splicing; Animals; Brain Chemistry; Cerebral Cortex; Chlorides; Diazepam; Female; Hippocampus; Isotopes; Muscimol; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger

1998
Pharmacological analysis of the heterogeneous discriminative stimulus effects of ethanol in rats using a three-choice ethanol-dizocilpine-water discrimination.
    Psychopharmacology, 1998, Volume: 139, Issue:1-2

    Topics: Animals; Diazepam; Discrimination, Psychological; Dizocilpine Maleate; Ethanol; GABA Modulators; Indoles; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists; Water

1998
Assessment of the multiple discriminative stimulus effects of ethanol using an ethanol-pentobarbital-water discrimination in rats.
    Behavioural pharmacology, 1997, Volume: 8, Issue:4

    Topics: Animals; Central Nervous System Depressants; Diazepam; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; GABA Modulators; Hypnotics and Sedatives; Indoles; Male; Midazolam; Morphine; N-Methylaspartate; Narcotics; Pentobarbital; Phencyclidine; Pregnanolone; Quinoxalines; Rats; Rats, Long-Evans; Serotonin Receptor Agonists; Water

1997
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
    Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5

    Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation

1998
Positive allosteric modulators of the GABA(A) receptor: differential interaction of benzodiazepines and neuroactive steroids with ethanol.
    Psychopharmacology, 1999, Volume: 141, Issue:1

    Topics: Allosteric Regulation; Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; GABA-A Receptor Agonists; Male; Mice; Motor Activity; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sleep; Triazolam

1999
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
    Pharmacological research, 1998, Volume: 38, Issue:6

    Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Synergism; Hippocampus; In Vitro Techniques; Male; Muscimol; Pentobarbital; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Time Factors

1998
In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol.
    Psychopharmacology, 1999, Volume: 141, Issue:4

    Topics: Allosteric Regulation; Analysis of Variance; Animals; Diazepam; Ethanol; Flunitrazepam; GABA Modulators; Hyperbaric Oxygenation; Isoxazoles; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Pregnanolone; Receptors, GABA-A

1999
Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.
    Brain research, 1999, May-08, Volume: 827, Issue:1-2

    Topics: Animals; Central Nervous System Depressants; Chlorides; Diazepam; DNA Primers; Ethanol; Flunitrazepam; Fluorescent Dyes; GABA Agonists; GABA Modulators; Gene Expression; Mice; Muscimol; Neoplastic Stem Cells; Neuroglia; Pentobarbital; Pregnanolone; Quinolinium Compounds; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium

1999
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate.
    Neuropharmacology, 2000, Apr-27, Volume: 39, Issue:7

    Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; Mice; Motor Activity; Pentylenetetrazole; Pregnanolone; Seizures; Stereotypic Movement Disorder; Valproic Acid

2000
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
    Journal of neuroscience research, 2000, May-15, Volume: 60, Issue:4

    Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc

2000
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Finasteride; Menstruation; Oxidoreductases; Pentylenetetrazole; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Seizures; Steroids; Valproic Acid

2000
Two conserved arginines in the extracellular N-terminal domain of the GABA(A) receptor alpha(5) subunit are crucial for receptor function.
    Journal of neurochemistry, 2000, Volume: 75, Issue:4

    Topics: Amino Acid Substitution; Animals; Arginine; Chlorides; CHO Cells; Cricetinae; Diazepam; GABA Modulators; gamma-Aminobutyric Acid; Gene Expression; Humans; Ion Channel Gating; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Structure, Tertiary; Receptors, GABA-A; Sequence Alignment; Steroids; Structure-Activity Relationship; Transfection

2000
Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Female; Motor Activity; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2000
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid

2001
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
    The Journal of physiology, 2001, Dec-01, Volume: 537, Issue:Pt 2

    Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Pregnanolone; Pregnenolone; Pyridines; Rats; Receptors, GABA-A; Zinc; Zolpidem

2001
Daily treatment with diazepam differentially modifies sensitivity to the effects of gamma-aminobutyric acid(A) modulators on schedule-controlled responding in rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:3

    Topics: Animals; Azides; Benzodiazepines; Carbolines; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Electroshock; Food; GABA Agonists; GABA Antagonists; GABA Modulators; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule; Triazolam

2002
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
    Developmental neuroscience, 2002, Volume: 24, Issue:1

    Topics: Allosteric Regulation; Animals; Baclofen; Bicuculline; Diazepam; Female; Fetal Proteins; GABA Agonists; GABA Antagonists; Hippocampus; Male; Mental Disorders; Nerve Tissue Proteins; Norepinephrine; Picrotoxin; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes

2002
Rapid anxiolytic activity of progesterone and pregnanolone in male rats.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 72, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Motor Activity; Pregnanolone; Progesterone; Rats; Rats, Wistar

2002
Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice.
    Journal of neurophysiology, 2002, Volume: 88, Issue:4

    Topics: Anesthetics; Animals; Animals, Newborn; Anticonvulsants; Carbolines; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Diuretics; Female; Furosemide; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Hypothalamus; Male; Membrane Potentials; Organ Culture Techniques; Patch-Clamp Techniques; Picrotoxin; Pregnanolone; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Triazoles; Zinc; Zolpidem

2002
Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA(A) miniature IPSCs in lamina II of the spinal cord.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jan-28, Volume: 24, Issue:4

    Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Age Factors; Animals; Diazepam; Enzyme Inhibitors; Finasteride; GABA Modulators; GABA-A Receptor Antagonists; In Vitro Techniques; Isoquinolines; Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Posterior Horn Cells; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Steroids

2004
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
    The Journal of physiology, 2004, Jun-01, Volume: 557, Issue:Pt 2

    Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Epilepsy, Temporal Lobe; Flumazenil; GABA Modulators; Lithium; Male; Neural Inhibition; Patch-Clamp Techniques; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Synapses

2004
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
    Neuropharmacology, 2005, Volume: 48, Issue:5

    Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time

2005
Efficacy and the discriminative stimulus effects of negative GABAA modulators, or inverse agonists, in diazepam-treated rhesus monkeys.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 318, Issue:2

    Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A

2006
Changes in relative potency among positive GABA(A) receptor modulators upon discontinuation of chronic benzodiazepine treatment in rhesus monkeys.
    Psychopharmacology, 2007, Volume: 192, Issue:1

    Topics: Animals; Behavior, Animal; Benzodiazepines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Lorazepam; Macaca mulatta; Male; Midazolam; Pentobarbital; Pregnanediones; Pregnanolone; Receptors, GABA-A; Substance Withdrawal Syndrome

2007
Interaction of diazepam and swim stress.
    Brain research, 2007, Dec-12, Volume: 1184

    Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Combinations; Mice; Picrotoxin; Pregnanolone; Reaction Time; Seizures; Stress, Psychological; Swimming

2007
Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice.
    Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Finasteride; GABA Antagonists; Interpersonal Relations; Male; Mice; Picrotoxin; Pregnanolone; Progesterone; Purines; Receptors, GABA-A

2008
Activation and modulation of concatemeric GABA-A receptors expressed in human embryonic kidney cells.
    Molecular pharmacology, 2009, Volume: 75, Issue:6

    Topics: Binding Sites; Cell Line; Diazepam; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutation; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Multimerization; Protein Subunits; Receptors, GABA-A

2009
Neuropeptide Y Y1 receptors in the central nucleus of amygdala mediate the anxiolytic-like effect of allopregnanolone in mice: Behavioral and immunocytochemical evidences.
    Brain research, 2010, Mar-08, Volume: 1318

    Topics: Amygdala; Animals; Anti-Anxiety Agents; Arcuate Nucleus of Hypothalamus; Arginine; Central Nervous System Agents; Diazepam; Dose-Response Relationship, Drug; Electroshock; Immunohistochemistry; Male; Mice; Neuropeptide Y; Neuropsychological Tests; Nucleus Accumbens; Pregnanolone; Receptors, Neuropeptide Y; Septal Nuclei

2010
Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs.
    Journal of neurochemistry, 2010, Volume: 113, Issue:5

    Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Diazepam; Estradiol; Female; Immunoblotting; Motor Activity; Neurotransmitter Agents; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids

2010
Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway.
    Neuroscience, 2010, Oct-27, Volume: 170, Issue:3

    Topics: Animals; Diazepam; Drug Administration Schedule; Early Growth Response Protein 3; Female; Flumazenil; Gene Expression Regulation; Hippocampus; Kindling, Neurologic; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotransmitter Agents; Oligodeoxyribonucleotides, Antisense; Pregnanolone; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Signal Transduction; Up-Regulation

2010
Neuropharmacological properties of neurons derived from human stem cells.
    Neurochemistry international, 2011, Volume: 59, Issue:3

    Topics: Cell Differentiation; Chlordiazepoxide; Diazepam; gamma-Aminobutyric Acid; Glycine; Humans; Immunohistochemistry; Ion Channel Gating; Ligands; Mefenamic Acid; Neurons; Pentobarbital; Pregnanolone; Stem Cells; Tetraethylammonium; Tetrodotoxin

2011
A mouse kindling model of perimenstrual catamenial epilepsy.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Animals; Diazepam; Disease Models, Animal; Epilepsy; Female; Finasteride; Gonadotropins; Hippocampus; Kindling, Neurologic; Menstrual Cycle; Mice; Mice, Inbred C57BL; Pregnanolone; Progesterone; Rats; Real-Time Polymerase Chain Reaction; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome

2012
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.
    Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 130, Issue:2

    Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; High-Throughput Screening Assays; Hippocampus; Mice; Mice, Inbred C57BL; Microelectrodes; Neurons; Picrotoxin; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors

2012
Women with PTSD have a changed sensitivity to GABA-A receptor active substances.
    Psychopharmacology, 2016, Volume: 233, Issue:11

    Topics: Adolescent; Adult; Anxiety; Diagnostic and Statistical Manual of Mental Disorders; Diazepam; Female; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Hypnotics and Sedatives; Pregnanolone; Psychiatric Status Rating Scales; Receptors, GABA-A; Saccades; Stress Disorders, Post-Traumatic; Young Adult

2016
Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.
    Neuropharmacology, 2015, Volume: 95

    Topics: Animals; Anticonvulsants; Bridged-Ring Compounds; Calcium; Cells, Cultured; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hippocampus; Male; Mice; Neuroimmunomodulation; Neurons; Pregnanolone; Seizures

2015
Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism.
    Psychopharmacology, 2016, Volume: 233, Issue:2

    Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Behavior, Animal; Diazepam; Female; GABA Modulators; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pregnanolone; Receptors, GABA-A; Social Behavior

2016
Short term, low dose fluoxetine blocks estrous cycle-linked changes in responsiveness to diazepam in female rats.
    Journal of psychopharmacology (Oxford, England), 2016, Volume: 30, Issue:10

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Diazepam; Estrous Cycle; Estrus; Female; Fluoxetine; gamma-Aminobutyric Acid; Locomotion; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Selective Serotonin Reuptake Inhibitors; Serotonin

2016
Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice.
    Synapse (New York, N.Y.), 2017, Volume: 71, Issue:8

    Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety Disorders; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Finasteride; Freezing Reaction, Cataleptic; Male; Mice, Inbred C57BL; Muscle Relaxants, Central; Muscle Strength; Muscle Tonus; Pregnanediones; Pregnanolone; Restraint, Physical; Stress, Psychological

2017
Intravenously Administered Ganaxolone Blocks Diazepam-Resistant Lithium-Pilocarpine-Induced Status Epilepticus in Rats: Comparison with Allopregnanolone.
    The Journal of pharmacology and experimental therapeutics, 2019, Volume: 368, Issue:3

    Topics: Administration, Intravenous; Anesthetics; Animals; Anticonvulsants; Diazepam; Drug Resistant Epilepsy; Electroencephalography; Lithium; Male; Muscarinic Agonists; Pilocarpine; Pregnanolone; Rats; Rats, Sprague-Dawley; Status Epilepticus

2019
Non-sedative cortical EEG signatures of allopregnanolone and functional comparators.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2023, Volume: 48, Issue:2

    Topics: Animals; Antidepressive Agents; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Humans; Ketamine; Mice; Neurosteroids; Pentobarbital; Pregnanolone; Receptors, GABA-A

2023
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
    Pharmacological reports : PR, 2023, Volume: 75, Issue:1

    Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnanolone; Pyrrolidonecarboxylic Acid; Rodentia; Spasm; Spasms, Infantile

2023
Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause.
    Molecules (Basel, Switzerland), 2023, Jan-06, Volume: 28, Issue:2

    Topics: Animals; Diazepam; Female; Flavonoids; Menopause; Pregnanolone; Rats; Rats, Wistar

2023
Altered GABA
    Acta obstetricia et gynecologica Scandinavica, 2023, Volume: 102, Issue:10

    Topics: Diazepam; Endometriosis; Female; gamma-Aminobutyric Acid; Gonadal Steroid Hormones; Humans; Pelvic Pain; Pregnanolone; Receptors, GABA-A

2023
Reproductive experience alters the effects of diazepam and fluoxetine on anxiety-like behaviour, fear extinction, and corticosterone levels in female rats.
    Psychopharmacology, 2023, Volume: 240, Issue:12

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Corticosterone; Diazepam; Estradiol; Extinction, Psychological; Fear; Female; Fluoxetine; Humans; Pregnancy; Pregnanolone; Progesterone; Rats

2023