pregnanolone has been researched along with desoxycorticosterone in 107 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (6.54) | 18.7374 |
| 1990's | 36 (33.64) | 18.2507 |
| 2000's | 45 (42.06) | 29.6817 |
| 2010's | 17 (15.89) | 24.3611 |
| 2020's | 2 (1.87) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Bokkenheuser, VD; Winter, J | 1 |
| Connolly, TM; Kohl, KH; Lichtwald, K; Vecsei, P | 1 |
| Bokkenheuser, VD; Kelly, WG; Polovsky, SB; Suzuki, JB; Winter, J | 1 |
| Bokkenheuser, VD; de Leon, O; Dehazya, P; Kelly, WG; Winter, J | 1 |
| Moore, PH; Morrow, AL; Paul, SM; Purdy, RH | 2 |
| Gee, KW; Lan, NC | 1 |
| Gee, KW; Lan, NC; Mirasedeghi, S; Wieland, S | 1 |
| Morrow, AL; Pace, JR; Paul, SM; Purdy, RH | 1 |
| Blakeman, DP; Im, WB | 1 |
| Hales, TG; Lambert, JJ; Peters, JA; Sturgess, NC | 1 |
| Majewska, MD | 1 |
| Ayer, DE; Blakeman, DP; Davis, JP; Im, WB | 1 |
| Blinn, JR; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Costa, E; Paul, SM; Pritchett, DB; Puia, G; Purdy, RH; Santi, MR; Seeburg, PH; Vicini, S | 1 |
| Birmingham, MK; De Nicola, AF; Holzbauer, M; Oliver, JT | 1 |
| Andrews, AW; Ayengar, NK; Bokkenheuser, VD; Lebherz, WB; McSherry, CK; Mosbach, EH; Mosenthal, AC; Pienta, RJ; Wallenstein, S; Winter, J | 1 |
| Casey, ML; MacDonald, PC | 1 |
| Backstrom, T; de Lignieres, B; Dennerstein, L | 1 |
| Jussofie, A; Kalff, R; Reinhardt, V | 1 |
| Ator, NA; Grant, KA; Griffiths, RR; Paul, SM; Purdy, RH | 1 |
| Jussofie, A | 3 |
| DeBold, JF; Frye, CA | 1 |
| Finn, DA; Gee, KW | 1 |
| Damm, K; Holsboer, F; Reul, JM; Rupprecht, R; Trapp, T; van Steensel, B; Wetzel, C; Zieglgänsberger, W | 1 |
| Dehennin, L; Jondet, M; Nahoul, K; Roger, M | 1 |
| André, M; Arancibia, S; Belmar, J; Tapia-Arancibia, L | 1 |
| Devaud, LL; Morrow, AL; Paul, SM; Purdy, RH | 1 |
| Acosta-Burruel, M; Goodnough, DB; Hawkinson, JE; Kimbrough, CL; Wood, PL | 1 |
| Fiszer de Plazas, S; Gravielle, MC; Pignataro, L | 1 |
| Zimmerberg, B | 1 |
| Biscardi, R; Wilson, MA | 1 |
| Johnson, NJ; Rodgers, RJ | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P | 1 |
| Burg, M; Heinemann, U; Schmitz, D | 1 |
| Barbaccia, ML; Biggio, G; Concas, A; Follesa, P; Grisenti, P; Mostallino, MC; Porcu, P; Purdy, RH; Trabucchi, M | 1 |
| Bender, AS; Norenberg, MD | 1 |
| Holsboer, F; Rupprecht, R | 1 |
| Bidziński, A; Członkowska, AI; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H | 1 |
| Amin, J; Moorefield, CN; Morris, KD | 1 |
| Grant, KA; Janak, PH; Janis, GC; Matthews, DB; Morrow, AL; Samson, HH; VanDoren, MJ | 1 |
| Biggio, G; Littera, M; Papi, G; Pisu, MG; Purdy, RH; Sanna, E; Serra, M; Tuveri, F; Usala, L | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Reddy, DS; Rogawski, MA | 1 |
| Barbaccia, ML; Biggio, G; Purdy, RH; Serra, M | 1 |
| Biggio, G; Eva, C; Ferrara, G; Panzica, GC; Pisu, MG; Serra, M; Zammaretti, F | 1 |
| Grobin, AC; Morrow, AL | 1 |
| Lancel, M; Müller-Preuss, P; Rupprecht, R | 1 |
| Affricano, D; Barbaccia, ML; Carai, MA; Colombo, G; Gessa, GL; Melis, S; Purdy, RH; Vacca, G | 1 |
| Biggio, G; Dazzi, L; Pisu, MG; Reho, A; Seu, E; Trapani, G | 1 |
| Biggio, G; Dazzi, L; Pisul, MG; Purdy, RH; Serra, M | 1 |
| Biggio, G; Eva, C; Oberto, A; Pisu, MG; Serra, M | 1 |
| Reddy, DS | 1 |
| Ferguson, C; Grobin, AC; Homanics, GE; Kralic, JE; Morrow, AL; O'Buckley, TK; Renzi, K; Wheeler, M | 1 |
| Alomary, AA; Fitzgerald, RL; Koob, GF; O'Dell, LE; Purdy, RH; Vallée, M | 1 |
| Biggio, G; Concas, A; Fratta, S; Lello, S; Melis, GB; Orrù, M; Paoletti, AM; Ranuzzi, F; Sogliano, C | 1 |
| Minami, K; Toyohira, Y; Tsutsui, M; Ueno, S; Yanagihara, N | 1 |
| Biggio, G; Brambilla, F; Gerra, G; Pisu, MG; Purdy, RH; Serra, M; Zaimovich, A | 1 |
| Biggio, G; Fabrazzo, M; Maj, M; Monteleone, P; Pisu, MG; Serra, M; Tortorella, A | 1 |
| Bäckström, T; Lundgren, P; Strömberg, J | 1 |
| Bíró, T; Maksay, G | 1 |
| Gavrilovici, C; McIntyre, DC; Poulter, MO; Schwabe, K | 1 |
| Alciati, A; Biggio, G; Brambilla, F; Mellado, C; Perini, G; Pisu, MG; Purdy, RH; Serra, M; Zanone, S | 1 |
| Haugvicová, R; Kasal, A; Mares, P | 1 |
| Mares, P | 1 |
| Biggio, G; Concas, A; Contu, R; Lello, S; Marotto, MF; Melis, GB; Orrù, MM; Paoletti, AM; Romagnino, S; Zedda, P | 1 |
| Basta-Kaim, A; Budziszewska, B; Lasoń, W; Leśkiewicz, M | 1 |
| Ahboucha, S; Butterworth, RF; Mamer, O; Pomier-Layrargues, G | 1 |
| Biggio, G; Carta, MG; Contu, P; Hardoy, MC; Pisu, MG; Serra, M | 1 |
| Biggio, F; Caria, S; Follesa, P; Gorini, G; Mostallino, MC; Murru, L; Sanna, E | 1 |
| Agís-Balboa, RC; Costa, E; Guidotti, A; Maloku, E; Pinna, G; Veldic, M; Zhubi, A | 1 |
| Bradford, DW; Butterfield, MI; Grobin, AC; Khisti, RT; Lieberman, JA; Madison, RD; Marx, CE; Massing, MW; Morrow, AL; Shampine, LJ; Trost, WT | 1 |
| da Silva, HM; Hosie, AM; Smart, TG; Wilkins, ME | 1 |
| Hamann, M; Richter, A; Richter, F | 1 |
| Dieni, C; Dutia, MB; Frondaroli, A; Grassi, S; Pettorossi, VE | 1 |
| Belelli, D; Dempster, J; Gentet, LJ; Mitchell, EA | 1 |
| Ahboucha, S; Butterworth, RF | 1 |
| Barbosa, AD; Morato, GS | 1 |
| Biggio, G; Concas, A; Marotto, MF; Marra, C; Marrosu, F; Melis, GB; Orrù, M; Paoletti, AM; Sogliano, C; Tuveri, A; Zedda, P | 1 |
| Ahboucha, S; Baker, GB; Butterworth, RF; Chatauret, N; Jiang, W; Mamer, O | 1 |
| De Sarro, G; Dore, R; Maciocco, E; Mostallino, MC; Mura, ML; Pisu, MG; Russo, E; Serra, M | 1 |
| Higashi, T; Mukai, Y; Nagura, Y; Shimada, K | 1 |
| Clarke, L; da Silva, H; Hosie, AM; Smart, TG | 1 |
| Kondo, D; Kurihara, T; Saegusa, H; Takasaki, I; Tanabe, T; Yabe, R; Zong, S | 1 |
| Codocedo, JF; Huidobro-Toro, JP; Rodríguez, FE | 1 |
| Biggio, G; Morgan, ML; Pisu, MG; Rapkin, AJ; Rasgon, N; Serra, M | 1 |
| Finn, DA; Kaufman, KR; Strong, MN; Tanchuck, MA | 1 |
| Alward, SE; de Wit, H; Grant, KA; Leslie Morrow, A; O'Buckley, TK; Porcu, P; Song, SC | 1 |
| Chang, JL; Chen, MJ; Lin, TB; Lu, HT; Pan, SF; Peng, HY; Wu, HC | 1 |
| Fodor, L; Maksay, G | 1 |
| Barbaccia, ML; Bortolato, M; Cuomo, V; Devoto, P; Flore, G; Frau, R; Marrosu, F; Pisanu, S; Pistritto, G; Ristaldi, MS; Roncada, P; Saba, P; Soggiu, A; Tattoli, M; Zappala, A | 1 |
| Cho, CH; Han, SK; Jeon, BH; Jeong, JA; Jo, JY; Kim, HW; Lee, SK; Lee, SY; Pandit, S; Park, JB; Ryu, PD; Stern, JE | 1 |
| Carver, CM; Reddy, DS | 1 |
| Akk, G; Covey, DF; Eaton, MM; Lim, YB | 1 |
| Dhungana, S; Goeders, NE; Guerin, GF; Runyon, SP; Schmoutz, CD | 1 |
| Agusti, A; Bäckström, T; Doverskog, M; Felipo, V; Johansson, M; Llansola, M; Malinina, E; Montoliu, C; Ragagnin, G; Strömberg, J | 1 |
| Ahmadiani, A; Dargahi, L; Ghasemi, R; Haeri, A; Rahmani, B | 1 |
| Bäckström, T; Doverskog, M; Johansson, M; Ragagnin, G; Strömberg, J | 1 |
| Butterworth, RF | 1 |
| Barton, BA; Deligiannidis, KM; Hall, JE; Jaitly, N; Kroll-Desrosiers, AR; Mo, S; Nguyen, HP; Rothschild, AJ; Shaffer, SA; Svenson, A | 1 |
| Gaikwad, NW; Kaddurah-Daouk, R; Kucera, HR; Motsinger-Reif, A; Nguyen, TV; Nieman, LK; Reuter, JM; Rotroff, DM; Rubinow, DR; Schmidt, PJ; Smith, CP | 1 |
| Bayramov, R; Filiz, AK; Karabulut, S; Korkmaz Bayramov, K; Ozdemir, E; Taskiran, AS | 1 |
| Akk, G; Burbridge, AB; Evers, AS; Germann, AL; Pierce, SR; Reichert, DE; Steinbach, JH | 1 |
| Deligiannidis, KM; Dubuke, ML; Kroll-Desrosiers, AR; Shaffer, SA; Tan, Y | 1 |
12 review(s) available for pregnanolone and desoxycorticosterone
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Steroid regulation of the GABAA receptor: ligand binding, chloride transport and behaviour.
Topics: Animals; Biological Transport; Central Nervous System; Chlorides; Desoxycorticosterone; Ligands; Mice; Pregnanolone; Rats; Receptors, GABA-A; Steroids | 1990 |
Neuroactive steroid modulators of the stress response.
Topics: Adrenalectomy; Alcoholism; Animals; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; Flunitrazepam; Hypothalamo-Hypophyseal System; Male; Menstruation; Pregnancy; Pregnanolone; Pregnenolone; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Stress, Physiological | 1995 |
Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives.
Topics: Dehydroepiandrosterone; Desoxycorticosterone; Estradiol; Humans; Neuroprotective Agents; Neurosecretory Systems; Pregnanolone; Pregnenolone; Progesterone; Steroids | 1999 |
Stress and neuroactive steroids.
Topics: Animals; Brain Chemistry; Desoxycorticosterone; Humans; Pregnanolone; Receptors, GABA-A; Stress, Physiological | 2001 |
The clinical potentials of endogenous neurosteroids.
Topics: Animals; Brain; Desoxycorticosterone; Humans; Pregnanolone; Receptors, GABA-A; Seizures; Stress, Psychological | 2002 |
[The role of neurosteroids in the central nervous system function].
Topics: Central Nervous System; Desoxycorticosterone; Humans; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate | 2005 |
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy.
Topics: Ammonia; Animals; Brain; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Isoquinolines; Manganese; Pregnanolone; Receptors, GABA-A; Synaptic Transmission | 2007 |
Neurosteroid interactions with synaptic and extrasynaptic GABA(A) receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability.
Topics: Allosteric Regulation; Androstane-3,17-diol; Animals; Brain; Desoxycorticosterone; Humans; Nerve Net; Neural Inhibition; Neuronal Plasticity; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A | 2013 |
Neurosteroids; potential underpinning roles in maintaining homeostasis.
Topics: Brain; Desoxycorticosterone; Homeostasis; Humans; Hypothalamo-Hypophyseal System; Neurotransmitter Agents; Pituitary-Adrenal System; Pregnanolone; Synaptic Transmission | 2016 |
GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo.
Topics: Animals; Desoxycorticosterone; Evoked Potentials; GABA-A Receptor Antagonists; Humans; Learning; Memory; Pregnanolone; Receptors, GABA-A; Saccades | 2016 |
Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities.
Topics: Animals; Brain; Desoxycorticosterone; Drug Discovery; Hepatic Encephalopathy; Humans; Liver; Molecular Targeted Therapy; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A | 2016 |
5 trial(s) available for pregnanolone and desoxycorticosterone
| Article | Year |
|---|---|
Influence of route of administration on progesterone metabolism.
Topics: 20-alpha-Dihydroprogesterone; Administration, Intravaginal; Administration, Oral; Cross-Over Studies; Desoxycorticosterone; Female; Humans; Pregnanolone; Progesterone | 1995 |
Psychological effect of the oral contraceptive formulation containing 3 mg of drospirenone plus 30 microg of ethinyl estradiol.
Topics: Adult; Androstenes; Anxiety; Contraceptives, Oral, Combined; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Follicular Phase; Humans; Luteal Phase; Phobic Disorders; Pregnanolone; Progesterone; Psychometrics | 2004 |
Observational study on the stability of the psychological status during normal pregnancy and increased blood levels of neuroactive steroids with GABA-A receptor agonist activity.
Topics: Adult; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Female; Follow-Up Studies; GABA-A Receptor Agonists; Humans; Hydrocortisone; Menstrual Cycle; Neuropsychological Tests; Pregnancy; Pregnanes; Pregnanolone; Progesterone; Prospective Studies; Psychiatric Status Rating Scales; Psychometrics; Receptors, GABA-A; Reference Values; Stress, Psychological | 2006 |
Neuroactive steroids after estrogen exposure in depressed postmenopausal women treated with sertraline and asymptomatic postmenopausal women.
Topics: Brain; Dehydroepiandrosterone; Depressive Disorder, Major; Desoxycorticosterone; Estrogens; Female; Humans; Middle Aged; Postmenopause; Pregnanolone; Selective Serotonin Reuptake Inhibitors; Sertraline | 2010 |
The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback.
Topics: Adult; Cross-Over Studies; Desoxycorticosterone; Estradiol; Estrone; Female; Humans; Leuprolide; Metabolome; Middle Aged; Pregnanediol; Pregnanolone; Premenstrual Dysphoric Disorder; Progesterone; Young Adult | 2017 |
90 other study(ies) available for pregnanolone and desoxycorticosterone
| Article | Year |
|---|---|
21-dehydroxylation of corticoids by anaerobic bacteria isolated from human fecal flora.
Topics: Arginine; Clostridium; Desoxycorticosterone; Enterobacteriaceae; Escherichia coli; Eubacterium; Feces; Humans; Hydrogen-Ion Concentration; Hydroxycorticosteroids; Oxidoreductases; Pregnanolone | 1978 |
Compounds in the urinary pH 1 extract reacting with corticosteroid and tetrahydrocorticosteroid antisera. Separation of a nonpolar substance with affinity to a tetrahydroaldosterone antiserum.
Topics: Adrenal Cortex Hormones; Aldosterone; Antibodies; Cortisone; Cortodoxone; Desoxycorticosterone; Female; Glucuronates; Humans; Hydrogen-Ion Concentration; Pregnancy; Pregnanolone; Radioimmunoassay; Tetrahydrocortisol | 1978 |
Metabolism of deoxycorticosterone by human fecal flora.
Topics: Aerobiosis; Anaerobiosis; Bacteria; Bacteroides; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Culture Media; Desoxycorticosterone; Diet; Escherichia coli; Feces; Humans; Hydrogen-Ion Concentration; Klebsiella; Lactobacillus; Pregnanolone; Proteus mirabilis; Species Specificity; Spectrophotometry, Infrared; Streptococcus; Tritium | 1975 |
Formation and metabolism of tetrahydrodeoxycorticosterone by human fecal flora.
Topics: Bacteria; Desoxycorticosterone; Feces; Humans; Kinetics; Lactobacillus; Pregnanediol; Pregnanolone | 1976 |
Neurosteroids and GABAA receptor function.
Topics: Adrenalectomy; Animals; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Male; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Steroids; Stress, Psychological | 1992 |
Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Desoxycorticosterone; Diazepam; gamma-Aminobutyric Acid; Ionophores; Male; Pentobarbital; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Spinal Cord; Steroids; Sulfur Radioisotopes | 1991 |
Anxiolytic activity of the progesterone metabolite 5 alpha-pregnan-3 alpha-o1-20-one.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Darkness; Desoxycorticosterone; Exploratory Behavior; Light; Male; Mice; Pregnanolone; Progesterone; Pyrazoles; Stereoisomerism | 1991 |
Characterization of steroid interactions with gamma-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites.
Topics: 20-alpha-Dihydroprogesterone; Animals; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; In Vitro Techniques; Ion Channel Gating; Ion Channels; Membrane Proteins; Pregnanolone; Rats; Receptors, GABA-A; Steroids; Structure-Activity Relationship; Synaptosomes | 1990 |
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.
Topics: Adrenalectomy; Animals; Brain; Cerebral Cortex; Desoxycorticosterone; Hypothalamus; Male; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Stress, Physiological; Swimming | 1991 |
Steroid modulation of the GABAA receptor complex: electrophysiological studies.
Topics: Anesthetics; Animals; Cattle; Chromaffin System; Desoxycorticosterone; Electrophysiology; Hippocampus; Membrane Proteins; Pregnanediones; Pregnanolone; Rats; Receptors, GABA-A; Steroids | 1990 |
Studies on the mechanism of interactions between anesthetic steroids and gamma-aminobutyric acidA receptors.
Topics: Anesthetics; Animals; Chlorides; Desoxycorticosterone; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Nipecotic Acids; Pentobarbital; Pregnanolone; Progesterone; Proline; Rats; Receptors, GABA-A; Synaptic Membranes | 1990 |
Synthesis, metabolism, and pharmacological activity of 3 alpha-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes.
Topics: Acetates; Animals; Cerebral Cortex; Chlorides; Desoxycorticosterone; Drug Synergism; Isomerism; Male; Molecular Conformation; Muscimol; Pregnanes; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes | 1990 |
Neurosteroids act on recombinant human GABAA receptors.
Topics: Benzodiazepines; Cell Line, Transformed; Cell Membrane Permeability; Chlorides; Desoxycorticosterone; Electric Conductivity; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Kidney; Membrane Potentials; Pentobarbital; Pregnanolone; Receptors, GABA-A; Recombinant Proteins; Transfection | 1990 |
In vivo secretion of 3 alpha-hydroxy-5 alpha-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat.
Topics: Adrenal Glands; Animals; Desoxycorticosterone; Female; Kinetics; Pregnanes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains | 1985 |
Fecal steroid 21-dehydroxylase, a potential marker for colorectal cancer.
Topics: Adult; Aged; Animals; Cell Transformation, Neoplastic; Child, Preschool; Colonic Neoplasms; Cricetinae; Desoxycorticosterone; Feces; Feeding Behavior; Female; Humans; Infant; Intestinal Polyps; Male; Middle Aged; Mutagenicity Tests; New York; Pregnanolone; Rectal Neoplasms; Risk; South Africa; Steroid 21-Hydroxylase; Steroid Hydroxylases | 1983 |
Metabolism of deoxycorticosterone and deoxycorticosterone sulfate in men and women.
Topics: Adult; Bile; Desoxycorticosterone; Female; Humans; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Menopause; Middle Aged; Pregnanediol; Pregnanolone; Progesterone; Sex Factors | 1982 |
GABA binding sites: their density, their affinity to muscimol and their behaviour against neuroactive steroids in human gliomas of different degrees of malignancy.
Topics: Anti-Anxiety Agents; Brain Neoplasms; Desoxycorticosterone; Glioma; Humans; In Vitro Techniques; Membranes; Muscimol; Pregnanolone; Receptors, GABA; Steroids | 1994 |
Drug discrimination analysis of endogenous neuroactive steroids in rats.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Discrimination Learning; Ethanol; Generalization, Stimulus; Lorazepam; Male; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A | 1993 |
Brain region-specific effects of neuroactive steroids on the affinity and density of the GABA-binding site.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Hippocampus; Hypothalamus; Medulla Oblongata; Muscimol; Pregnanediones; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
3 alpha-OH-DHP and 5 alpha-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus.
Topics: Anesthetics; Animals; Cricetinae; Desoxycorticosterone; Drug Implants; Estradiol; Female; Mesocricetus; Ovariectomy; Posture; Pregnanolone; Progesterone; Sexual Behavior, Animal; Tegmentum Mesencephali; Ventromedial Hypothalamic Nucleus | 1993 |
A new highly sensitive procedure--a prerequisite to evaluate the density of GABAA receptors and to study their allosteric properties in distinct areas of rat brain.
Topics: Allosteric Regulation; Animals; Binding Sites; Brain; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; Humans; Hydrogen-Ion Concentration; Muscimol; Pentobarbital; Pregnanediones; Pregnanolone; Progesterone; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; gamma-Aminobutyric Acid; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors | 1993 |
Progesterone receptor-mediated effects of neuroactive steroids.
Topics: Base Sequence; Desoxycorticosterone; DNA; Gene Expression Regulation; Humans; Intracellular Membranes; Molecular Sequence Data; Neurons; Oxidation-Reduction; Pregnanolone; Receptors, Progesterone; Steroids; Tumor Cells, Cultured | 1993 |
Profiles of plasma estrogens, progesterone and their metabolites after oral or vaginal administration of estradiol or progesterone.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Desoxycorticosterone; Estradiol; Estrogens; Estrone; Female; Humans; Pregnanolone; Progesterone | 1993 |
Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.
Topics: Animals; Bicuculline; Cells, Cultured; Desoxycorticosterone; Drug Synergism; GABA Antagonists; GABA Modulators; Hypothalamus; Neurons; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Somatostatin | 1995 |
Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site.
Topics: Allosteric Regulation; Androstanes; Animals; Azasteroids; Cell Membrane; Cerebral Cortex; Desoxycorticosterone; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Pregnanolone; Pregnenolone; Protein Binding; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids | 1996 |
Steroid modulation of central nervous GABAA receptor binding in three female rat brain areas during postnatal development.
Topics: Animals; Brain; Brain Chemistry; Cerebellum; Desoxycorticosterone; Female; Frontal Lobe; GABA Agonists; Medulla Oblongata; Membranes; Muscimol; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Regression Analysis; Steroids | 1995 |
Neurosteroid modulation of the benzodiazepine receptor in developing chick optic lobe.
Topics: Animals; Anti-Anxiety Agents; Chick Embryo; Chickens; Desoxycorticosterone; Dose-Response Relationship, Drug; Flunitrazepam; Isomerism; Kinetics; Neuroprotective Agents; Pregnanolone; Receptors, GABA-A; Tectum Mesencephali | 1996 |
The role of neurosteroids in alcohol-related behaviors: new studies from the laboratory and clinic.
Topics: Affect; Alcoholism; Animals; Arousal; Behavior, Animal; Brain; Desoxycorticosterone; Female; Gas Chromatography-Mass Spectrometry; Gonadal Steroid Hormones; Hormones; Humans; Male; Neurotransmitter Agents; Pregnanolone; Receptors, GABA-A; Synaptic Transmission | 1996 |
Influence of gender and brain region on neurosteroid modulation of GABA responses in rats.
Topics: Amygdala; Androgens; Androsterone; Animals; Brain; Cerebellum; Cerebral Cortex; Chlorides; Desoxycorticosterone; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Hippocampus; Male; Pregnanolone; Rats; Sex Characteristics | 1997 |
Behaviorally selective effects of neuroactive steroids on plus-maze anxiety in mice.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Desoxycorticosterone; Diazepam; Male; Maze Learning; Mice; Mice, Inbred DBA; Pregnanediones; Pregnanolone; Steroids | 1998 |
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Neuroactive steroids induce GABA(A) receptor-mediated depolarizing postsynaptic potentials in hippocampal CA1 pyramidal cells of the rat.
Topics: Animals; Cells, Cultured; Culture Techniques; Desoxycorticosterone; Electric Stimulation; Excitatory Postsynaptic Potentials; Interneurons; Male; Microelectrodes; Pregnanolone; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A | 1998 |
Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.
Topics: Animals; Cell Membrane; Cerebral Cortex; Chlorides; Desoxycorticosterone; Estrus; Female; Finasteride; Gene Expression Regulation; Hippocampus; Muscimol; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Time Factors; Transcription, Genetic | 1998 |
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation | 1998 |
The effects of neurosteroids on rat behavior and 3H-muscimol binding in the brain.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Brain Chemistry; Conflict, Psychological; Desoxycorticosterone; Dose-Response Relationship, Drug; Drinking Behavior; Fear; GABA Agonists; GABA Modulators; Injections, Intraventricular; Male; Midazolam; Muscimol; Neurotransmitter Agents; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 1999 |
Differential modulation of the gamma-aminobutyric acid type C receptor by neuroactive steroids.
Topics: 5-alpha-Dihydroprogesterone; Animals; Anti-Inflammatory Agents; Desoxycorticosterone; gamma-Aminobutyric Acid; Humans; Oocytes; Patch-Clamp Techniques; Pregnanediones; Pregnanolone; Receptors, GABA; Receptors, Purinergic P1; Xenopus laevis | 1999 |
Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action?
Topics: Animals; Central Nervous System Depressants; Cerebral Cortex; Conditioning, Operant; Desoxycorticosterone; Ethanol; Female; Haplorhini; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1999 |
Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.
Topics: Animals; Anxiety; Brain; Cerebral Cortex; Conflict, Psychological; Corticosterone; Dehydroepiandrosterone; Desoxycorticosterone; Electroshock; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Oocytes; Pregnanolone; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Social Isolation; Steroids; Synaptosomes; Time Factors; Xenopus laevis | 2000 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Increased expression of the neuropeptide Y receptor Y(1) gene in the medial amygdala of transgenic mice induced by long-term treatment with progesterone or allopregnanolone.
Topics: Amygdala; Animals; Cerebral Cortex; Desoxycorticosterone; Female; Gene Expression; Mice; Mice, Transgenic; Osmolar Concentration; Pregnanolone; Progesterone; Receptors, Neuropeptide Y; Time Factors | 2001 |
3Alpha-hydroxy-5alpha-pregnan-20-one levels and GABA(A) receptor-mediated 36Cl(-) flux across development in rat cerebral cortex.
Topics: Allosteric Regulation; Animals; Animals, Newborn; Anti-Anxiety Agents; Biological Transport; Cerebral Cortex; Chlorine; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Labor, Obstetric; Male; Muscimol; Pregnancy; Pregnanolone; Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Characteristics | 2001 |
The effects of the neuroactive steroid 3 alpha,5 alpha-THDOC on sleep in the rat.
Topics: Animals; Anti-Anxiety Agents; Desoxycorticosterone; Dose-Response Relationship, Drug; Electroencephalography; Gonadal Steroid Hormones; Male; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Sleep | 2002 |
GABA(B) receptor-mediated increase of neurosteroids by gamma-hydroxybutyric acid.
Topics: Animals; Baclofen; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Hippocampus; Hydroxybutyrates; Male; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-B | 2002 |
A rapid method for obtaining finasteride, a 5alpha-reductase inhibitor, from commercial tablets.
Topics: 5-alpha Reductase Inhibitors; Animals; Cerebral Cortex; Chemistry, Pharmaceutical; Chromatography; Desoxycorticosterone; Dopamine; Enzyme Inhibitors; Finasteride; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Stress, Physiological; Time Factors | 2002 |
Prevention of the stress-induced increase in the concentration of neuroactive steroids in rat brain by long-term administration of mirtazapine but not of fluoxetine.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Second-Generation; Brain Chemistry; Cerebral Cortex; Chromatography, High Pressure Liquid; Desoxycorticosterone; Electroshock; Fluoxetine; Male; Mianserin; Mirtazapine; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids; Stress, Psychological | 2002 |
Changes in expression of the neuropeptide Y Y1 receptor gene in the medial amygdala of transgenic mice during pregnancy and after delivery.
Topics: Amygdala; Animals; Cerebral Cortex; Desoxycorticosterone; Enzyme Inhibitors; Female; Finasteride; Gene Expression Regulation; Genes, Reporter; In Situ Hybridization; Mice; Mice, Transgenic; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Progesterone; Receptors, Neuropeptide Y; RNA, Messenger; Transgenes | 2002 |
Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.
Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Central Nervous System Depressants; Chlorides; Desoxycorticosterone; Drug Tolerance; Ethanol; Exploratory Behavior; Female; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Knockout; Muscimol; Postural Balance; Pregnanolone; Receptors, GABA-A; Steroids | 2003 |
Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats.
Topics: Adrenalectomy; Animals; Brain; Desoxycorticosterone; Ethanol; Male; Orchiectomy; Pregnanolone; Pregnenolone; Rats; Rats, Wistar; Steroids | 2004 |
Sites of positive allosteric modulation by neurosteroids on ionotropic gamma-aminobutyric acid receptor subunits.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Conserved Sequence; Desoxycorticosterone; Dose-Response Relationship, Drug; Electrophysiology; Female; GABA-A Receptor Agonists; Humans; Molecular Sequence Data; Oocytes; Pregnanolone; Protein Subunits; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis; Xenopus Proteins | 2004 |
Plasma concentrations of anxiolytic neurosteroids in men with normal anxiety scores: a correlation analysis.
Topics: Adult; Anxiety; Desoxycorticosterone; Humans; Male; Pregnanolone; Pregnenolone; Progesterone; Psychiatric Status Rating Scales; Reference Values | 2004 |
Long-term treatment with clozapine does not affect morning circulating levels of allopregnanolone and THDOC in patients with schizophrenia: a preliminary study.
Topics: Adult; Analysis of Variance; Circadian Rhythm; Clozapine; Desoxycorticosterone; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pregnanolone; Prospective Studies; Schizophrenia | 2004 |
Rapid non-genomic effect of glucocorticoid metabolites and neurosteroids on the gamma-aminobutyric acid-A receptor.
Topics: Animals; Cerebral Cortex; Chlorides; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Acid; Glucocorticoids; Male; Neurons; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2005 |
High affinity, heterogeneous displacement of [3H]EBOB binding to cerebellar GABA A receptors by neurosteroids and GABA agonists.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Male; Pregnanolone; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A | 2005 |
Neurosteroids exhibit differential effects on mIPSCs recorded from normal and seizure prone rats.
Topics: Analysis of Variance; Animals; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Evoked Potentials; Genetic Predisposition to Disease; Male; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Long-Evans; Rats, Wistar; Seizures | 2005 |
Plasma concentrations of anxiolytic neuroactive steroids in men with panic disorder.
Topics: Adolescent; Adult; Anxiety; Dehydroepiandrosterone; Desoxycorticosterone; Diagnostic and Statistical Manual of Mental Disorders; Humans; Male; Panic Disorder; Pregnanolone; Progesterone; Steroids; Surveys and Questionnaires | 2005 |
Action of two neuroactive steroids against motor seizures induced by pentetrazol in rats during ontogeny.
Topics: Age Factors; Anesthetics; Animals; Animals, Newborn; Convulsants; Desoxycorticosterone; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Pentylenetetrazole; Pregnanolone; Rats; Rats, Wistar | 2006 |
Anticonvulsant action of three neurosteroids against cortical epileptic afterdischarges in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Electroencephalography; Pregnanolone; Rats; Seizures | 2005 |
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Female; Flunitrazepam; GABA Agonists; GABA Modulators; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; In Vitro Techniques; Liver Cirrhosis; Male; Membranes; Middle Aged; Muscimol; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reference Standards | 2006 |
Increased neuroactive steroid concentrations in women with bipolar disorder or major depressive disorder.
Topics: Adult; Anti-Inflammatory Agents; Bipolar Disorder; Case-Control Studies; Depressive Disorder, Major; Desoxycorticosterone; Diagnostic and Statistical Manual of Mental Disorders; Female; Humans; Hydrocortisone; Pregnanolone; Premenopause; Premenstrual Syndrome; Progesterone; Radioimmunoassay; Steroids | 2006 |
Plastic neuronal changes in GABA(A) receptor gene expression induced by progesterone metabolites: in vitro molecular and functional studies.
Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Desoxycorticosterone; DNA, Complementary; Electrophysiology; Fluorescent Antibody Technique; Gene Expression; Neuronal Plasticity; Patch-Clamp Techniques; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; RNA, Messenger; Substance Withdrawal Syndrome | 2006 |
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Topics: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific); 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Amygdala; Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Desoxycorticosterone; Gene Expression Regulation, Enzymologic; Hippocampus; Male; Membrane Proteins; Mice; Neurons; Olfactory Bulb; Pregnanolone; Rats; RNA, Messenger; Thalamus | 2006 |
Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Chromatography, High Pressure Liquid; Corticosterone; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Fluoxetine; Gas Chromatography-Mass Spectrometry; Hippocampus; Male; Olanzapine; Pregnanolone; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors | 2006 |
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites.
Topics: Amino Acid Sequence; Binding Sites; Desoxycorticosterone; Electric Conductivity; Humans; Molecular Sequence Data; Patch-Clamp Techniques; Pregnanolone; Protein Structure, Tertiary; Protein Subunits; Receptors, GABA-A | 2006 |
Acute effects of neurosteroids in a rodent model of primary paroxysmal dystonia.
Topics: Animals; Animals, Genetically Modified; Cricetinae; Dehydroepiandrosterone; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Intraperitoneal; Male; Mesocricetus; Pregnanolone; Pregnenolone | 2007 |
Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei.
Topics: Animals; Bicuculline; Data Interpretation, Statistical; Desoxycorticosterone; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Membrane Potentials; Neurons; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Steroids; Synaptic Transmission; Vestibular Nuclei | 2007 |
GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids.
Topics: Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Female; GABA Antagonists; GABA Modulators; Glycine Agents; Inhibitory Postsynaptic Potentials; Male; Membrane Potentials; Neural Inhibition; Posterior Horn Cells; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Strychnine; Synaptic Transmission | 2007 |
Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids.
Topics: Analysis of Variance; Anesthetics; Animals; Body Temperature; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Drug Tolerance; Ethanol; Hypothermia; Male; Mice; Motor Activity; Pregnanolone; Pregnenolone | 2007 |
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy.
Topics: Adult; Anticonvulsants; Body Mass Index; Dehydroepiandrosterone; Desoxycorticosterone; Electroencephalography; Epilepsy; Estradiol; Female; Humans; Hydrocortisone; Pregnanolone; Pregnenolone; Premenopause; Premenstrual Syndrome; Progesterone; Receptors, GABA | 2008 |
Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ataxia; Brain; Brain Chemistry; Desoxycorticosterone; Hepatic Encephalopathy; Humans; Indomethacin; Male; Molecular Structure; Motor Activity; Portacaval Shunt, Surgical; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Steroids | 2008 |
Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy.
Topics: Aging; Animals; Animals, Genetically Modified; Brain; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Disease Models, Animal; Down-Regulation; Epilepsy, Absence; gamma-Aminobutyric Acid; Male; Neuronal Plasticity; Pregnanolone; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Stress, Psychological; Synapses; Synaptic Transmission; Thalamus; Up-Regulation | 2008 |
Studies on neurosteroids XXV. Influence of a 5alpha-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism.
Topics: 20-alpha-Dihydroprogesterone; 5-alpha Reductase Inhibitors; Animals; Brain Chemistry; Calibration; Desoxycorticosterone; Enzyme Inhibitors; Finasteride; Indicators and Reagents; Injections, Intraperitoneal; Male; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Steroids | 2008 |
Conserved site for neurosteroid modulation of GABA A receptors.
Topics: Animals; Binding Sites; Cell Line, Transformed; Desoxycorticosterone; Dose-Response Relationship, Drug; Electric Stimulation; Humans; Ion Channel Gating; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurotransmitter Agents; Patch-Clamp Techniques; Pregnanolone; Protein Subunits; Receptors, GABA-A; Transfection | 2009 |
Peripheral-type benzodiazepine receptor antagonist is effective in relieving neuropathic pain in mice.
Topics: Analgesics; Animals; Behavior, Animal; Desoxycorticosterone; DNA, Complementary; GABA-A Receptor Antagonists; Immunohistochemistry; Injections, Spinal; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Pain; Peripheral Nervous System Diseases; Pregnanolone; Progesterone; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Spinal Nerves | 2009 |
Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions.
Topics: Adenosine Triphosphate; Animals; Cell Line; Desoxycorticosterone; Drug Interactions; Estradiol; Female; Genomics; Humans; Ion Channel Gating; Neurotransmitter Agents; Oocytes; Pregnanediones; Pregnanolone; Progesterone; Purinergic P2 Receptor Agonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Xenopus laevis | 2009 |
Replacement with GABAergic steroid precursors restores the acute ethanol withdrawal profile in adrenalectomy/gonadectomy mice.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Acute Disease; Alcohol-Induced Disorders, Nervous System; Animals; Castration; Central Nervous System Depressants; Desoxycorticosterone; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Female; Finasteride; gamma-Aminobutyric Acid; Male; Mice; Neural Inhibition; Neurotransmitter Agents; Pregnanolone; Progesterone; Receptors, GABA-A; Substance Withdrawal Syndrome | 2010 |
Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.
Topics: Adult; Androstane-3,17-diol; Androsterone; Animals; Central Nervous System Depressants; Desoxycorticosterone; Ethanol; Gas Chromatography-Mass Spectrometry; Humans; Macaca fascicularis; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pregnanolone; Pregnenolone; Rats; Rats, Sprague-Dawley; Young Adult | 2010 |
Acute neurosteroids inhibit the spinal reflex potentiation via GABAergic neurotransmission.
Topics: Action Potentials; Animals; Bicuculline; Desoxycorticosterone; Electric Stimulation; Electromyography; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Spinal; Neuronal Plasticity; Neurotransmitter Agents; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Spinal Nerves; Synaptic Transmission; Time Factors; Urethra | 2010 |
Differential effects of two major neurosteroids on cerebellar and cortical GABA(A) receptor binding and function.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Cerebral Cortex; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Synergism; Furosemide; GABA-A Receptor Agonists; Gene Knockout Techniques; Male; Mice; Neurotransmitter Agents; Pregnanolone; Protein Binding; Rats; Receptors, GABA-A | 2011 |
Isolation rearing-induced reduction of brain 5α-reductase expression: relevance to dopaminergic impairments.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-alpha Reductase Inhibitors; Animals; Behavior, Animal; Brain; Brain Chemistry; Cholestenone 5 alpha-Reductase; Desoxycorticosterone; Dopamine; Finasteride; Male; Nucleus Accumbens; Prefrontal Cortex; Pregnanolone; Rats; Rats, Sprague-Dawley; Social Isolation | 2011 |
Neurosteroid modulation of benzodiazepine-sensitive GABAA tonic inhibition in supraoptic magnocellular neurons.
Topics: Animals; Benzodiazepines; Desoxycorticosterone; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Imidazoles; Inhibitory Postsynaptic Potentials; Male; Models, Animal; Neurons; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Supraoptic Nucleus | 2011 |
Modulation of the human ρ1 GABAA receptor by inhibitory steroids.
Topics: Animals; Desoxycorticosterone; Estradiol; Female; GABA Antagonists; Humans; Mutation; Neurotransmitter Agents; Oocytes; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; Xenopus laevis | 2014 |
A therapeutic combination of metyrapone and oxazepam increases brain levels of GABA-active neurosteroids and decreases cocaine self-administration in male rats.
Topics: Animals; Brain; Cocaine; Cocaine-Related Disorders; Desoxycorticosterone; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; GABA Modulators; Male; Metyrapone; Motivation; Oxazepam; Pregnanolone; Rats, Wistar; Self Administration | 2015 |
GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.
Topics: Animals; Circadian Rhythm; Desoxycorticosterone; Drug Antagonism; HEK293 Cells; Hepatic Encephalopathy; Humans; Hydroxysteroids; Hyperammonemia; Locomotion; Male; Maze Learning; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 2015 |
Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
Topics: 20-alpha-Dihydroprogesterone; Adult; Case-Control Studies; Depression, Postpartum; Desoxycorticosterone; Female; gamma-Aminobutyric Acid; Humans; Longitudinal Studies; Peripartum Period; Pregnancy; Pregnanolone; Progesterone; Receptors, GABA-A; Risk Factors; Steroids | 2016 |
Effect of the allopregnanolone and allotetrahydrodeoxycorticosteron on spike-wave discharges in the EEG of absence epilepsy rat models.
Topics: Animals; Brain; Desoxycorticosterone; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Male; Pregnanolone; Rats; Rats, Wistar | 2018 |
Analysis of Modulation of the
Topics: Animals; Animals, Genetically Modified; Binding Sites; Desoxycorticosterone; Drug Synergism; Drug Therapy, Combination; Humans; Models, Molecular; Molecular Structure; Neurosteroids; Pregnanolone; Receptors, GABA-A; Xenopus laevis | 2020 |
Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
Topics: 20-alpha-Dihydroprogesterone; Adult; Anxiety; Chromatography, Liquid; Depression; Depression, Postpartum; Depressive Disorder; Desoxycorticosterone; Female; Humans; Longitudinal Studies; Neurosteroids; Parturition; Pregnancy; Pregnanolone; Pregnenolone; Prenatal Care; Progesterone; Prospective Studies; Risk Factors; Tandem Mass Spectrometry | 2020 |