pregnanolone has been researched along with bicuculline in 57 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.75) | 18.7374 |
| 1990's | 20 (35.09) | 18.2507 |
| 2000's | 23 (40.35) | 29.6817 |
| 2010's | 12 (21.05) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
| Authors | Studies |
|---|---|
| Blakeman, DP; Im, WB | 1 |
| Cottrell, GA; Mistry, DK | 1 |
| Belelli, D; Gee, KW | 1 |
| Akhondzadeh, S; Stone, TW | 2 |
| Devaud, LL; Morrow, AL; Purdy, RH | 1 |
| Bähring, R; Grantyn, R; Martelli, EA; Standhardt, H | 1 |
| Berger, TW; Grace, AA; Nisenbaum, ES | 1 |
| Finn, DA; Gee, KW | 1 |
| André, M; Arancibia, S; Belmar, J; Tapia-Arancibia, L | 1 |
| Dayanithi, G; Tapia-Arancibia, L | 1 |
| Akaike, N; Harata, N; Shimura, M; Tamai, M | 1 |
| Lee, WS; Limmroth, V; Moskowitz, MA | 1 |
| Bracamontes, J; Steinbach, JH; Ueno, S; Weiss, DS; Zorumski, C | 1 |
| Simmonds, MA; Zhong, Y | 1 |
| Davies, PA; Hales, TG; Hanna, MC; Kirkness, EF | 1 |
| Gillies, GE; Murray, HE | 1 |
| Campos, MG; Hernández, R; Montaño, LM; Perusquía, M; Villalón, CM | 1 |
| Biggio, G; Concas, A; Marino, G; Minei, R; Mostallino, MC; Pierobon, P; Porcu, P | 1 |
| Hirst, JJ; Nicol, MB; Walker, D | 1 |
| Reith, CA; Sillar, KT | 1 |
| Devaud, LL; Grobin, AC; Janis, GC; Matthews, DB; Morrow, AL; VanDoren, MJ | 1 |
| Sapp, DW; Yeh, HH | 1 |
| Chopde, CT; Jain, SP; Khisti, RT | 1 |
| Bidziński, A; Członkowska, AI; Krzaścik, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J | 1 |
| Gillardin, JM; Neliat, G; Pansart, Y; Schlichter, R; Verleye, M | 1 |
| Chopde, CT; Deshpande, LS; Khisti, RT | 1 |
| Bregonzio, C; Cabrera, RJ; Casteller, G; Gargiulo, PA; Laconi, MR | 1 |
| Findlay, GS; Harris, RA; Harrison, NL; Ueno, S | 1 |
| Chigr, F; M'hamed, SB; Najimi, M | 1 |
| Cabrera, RJ; Laconi, MR | 1 |
| Altobelli, D; Cannizzaro, C; Martire, M; Maurizi, S; Preziosi, P | 1 |
| Ferguson, C; Grobin, AC; Homanics, GE; Kralic, JE; Morrow, AL; O'Buckley, TK; Renzi, K; Wheeler, M | 1 |
| Molina-Hernández, M; Olivera Lopez, JI; Pérez García, J; Tellez-Alcántara, NP; Teresa Jaramillo, M | 1 |
| Chopde, CT; Hirani, K; Jain, NS | 1 |
| Gong, QH; Shen, H; Smith, SS; Yuan, M | 1 |
| Papazafiri, P; Xilouri, M | 1 |
| Biggio, G; Carta, M; Floris, I; Maciocco, E; Mostallino, MC; Mura, ML; Pisu, MG; Sanna, E; Serra, M; Talani, G | 1 |
| Smith, SS; Zhou, X | 1 |
| Dieni, C; Dutia, MB; Frondaroli, A; Grassi, S; Pettorossi, VE | 1 |
| Belelli, D; Dempster, J; Gentet, LJ; Mitchell, EA | 1 |
| Chopde, CT; Hirani, K; Kokare, DM; Sharma, AN; Subhedar, NK; Ugale, RR | 1 |
| Charlet, A; Darbon, P; Lasbennes, F; Poisbeau, P | 1 |
| Brinton, RD; Wang, JM | 1 |
| Chang, JL; Chen, MJ; Lin, TB; Lu, HT; Pan, SF; Peng, HY; Wu, HC | 1 |
| Ikeda, T; Kasahara, Y; Ohshima, M; Taguchi, A; Tsuji, M | 1 |
| Cao, Z; Hammock, BD; Lein, PJ; McCoy, M; Pessah, IN; Rogawski, MA | 1 |
| Akaike, N; Fukuda, A; Iwata, S; Shin, MC; Wakita, M | 1 |
| Chesnoy-Marchais, D | 2 |
| Ishida, A; Ishihara, Y; Kawami, T; Yamazaki, T | 1 |
| Yamaguchi, K | 1 |
| do Rego, JL; Vaudry, D; Vaudry, H | 1 |
| Jin, YH; Kim, S; Kim, SM; Oh, B; Tak, J; Yang, E | 1 |
| Chuang, SH; Reddy, DS | 1 |
| Kalakh, S; Mouihate, A | 1 |
| Andrade-Soto, J; Cueto-Escobedo, J; Hernández-López, F; Lima-Maximino, M; Maximino, C; Rodríguez-Landa, JF | 1 |
1 review(s) available for pregnanolone and bicuculline
| Article | Year |
|---|---|
Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal.
Topics: Animals; Animals, Newborn; Bicuculline; Biophysics; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutamic Acid; Muscimol; Patch-Clamp Techniques; Potassium Channel Blockers; Pregnanolone; Presynaptic Terminals; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Tetraethylammonium; Valine | 2013 |
56 other study(ies) available for pregnanolone and bicuculline
| Article | Year |
|---|---|
Correlation between gamma-aminobutyric acidA receptor ligand-induced changes in t-butylbicyclophosphoro[35S]thionate binding and 36Cl- uptake in rat cerebrocortical membranes.
Topics: Animals; Bicuculline; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebral Cortex; Chloride Channels; Chlorides; Desoxycorticosterone; Diazepam; Ethanol; Flumazenil; gamma-Aminobutyric Acid; In Vitro Techniques; Ligands; Membrane Proteins; Pentobarbital; Pregnanolone; Rats; Receptors, GABA-A; Synaptosomes | 1991 |
Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture.
Topics: Animals; Bemegride; Bicuculline; Cells, Cultured; GABA-A Receptor Antagonists; Membrane Potentials; Mice; Neurons; Pregnanediones; Pregnanes; Pregnanolone; Receptors, GABA-A; Spinal Cord | 1990 |
5 alpha-pregnan-3 alpha,20 alpha-diol behaves like a partial agonist in the modulation of GABA-stimulated chloride ion uptake by synaptoneurosomes.
Topics: Animals; Benzodiazepines; Bicuculline; Chlorides; Clonazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Ionophores; Pregnanediol; Pregnanolone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1989 |
Potentiation by neurosteroids of muscimol/adenosine interactions in rat hippocampus.
Topics: Adenosine; Anesthetics; Animals; Anti-Anxiety Agents; Barium; Bicuculline; Chloride Channel Agonists; Drug Synergism; GABA-A Receptor Agonists; Hippocampus; Male; Muscimol; Neural Inhibition; Pregnanediones; Pregnanolone; Rats; Rats, Wistar | 1995 |
Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors.
Topics: Action Potentials; Adenosine; Alanine; Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Corpus Striatum; Culture Techniques; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Hippocampus; Male; Muscimol; Neuronal Plasticity; Pregnanediones; Pregnanolone; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA; Receptors, Metabotropic Glutamate; Valine | 1995 |
The neurosteroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one, protects against bicuculline-induced seizures during ethanol withdrawal in rats.
Topics: Alcohol Withdrawal Delirium; Animals; Anticonvulsants; Bicuculline; Brain; Dose-Response Relationship, Drug; Electroencephalography; Female; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 1995 |
GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons?
Topics: Acetylcarnitine; Acetylcholine; Action Potentials; Animals; Bicuculline; Chloride Channels; Clonazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Potassium Chloride; Pregnanolone; Quinoxalines; Retina; Retinal Ganglion Cells; Strychnine; Substrate Specificity; Tetrodotoxin; Zinc | 1994 |
Depression of glutamatergic and GABAergic synaptic responses in striatal spiny neurons by stimulation of presynaptic GABAB receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; Corpus Striatum; Electric Stimulation; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Lidocaine; Male; Neurons; Pregnanolone; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Sodium Channel Blockers; Synapses | 1993 |
The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.
Topics: Animals; Bicuculline; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Desoxycorticosterone; Estrus; Female; gamma-Aminobutyric Acid; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sex Factors | 1993 |
Neuroactive steroids modulate GABA inhibition of hypothalamic somatostatin release.
Topics: Animals; Bicuculline; Cells, Cultured; Desoxycorticosterone; Drug Synergism; GABA Antagonists; GABA Modulators; Hypothalamus; Neurons; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Somatostatin | 1995 |
Rise in intracellular calcium via a nongenomic effect of allopregnanolone in fetal rat hypothalamic neurons.
Topics: Animals; Bicuculline; Calcium; Cell Membrane; Electrophysiology; Fetus; GABA Modulators; Hypothalamus; Neurons; Pertussis Toxin; Picrotoxin; Pregnanolone; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Virulence Factors, Bordetella | 1996 |
Allosteric modulation of GABAA receptors in acutely dissociated neurons of the suprachiasmatic nucleus.
Topics: Allosteric Regulation; Animals; Bicuculline; Chlorides; Diazepam; Electric Conductivity; Female; GABA Antagonists; GABA-A Receptor Agonists; Intracellular Membranes; Male; Neurons; Pentobarbital; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Suprachiasmatic Nucleus | 1996 |
GABAA-receptor-mediated effects of progesterone, its ring-A-reduced metabolites and synthetic neuroactive steroids on neurogenic oedema in the rat meninges.
Topics: Animals; Bicuculline; Brain Edema; Capillary Permeability; Dose-Response Relationship, Drug; Female; GABA Antagonists; Isomerism; Male; Meninges; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Serum Albumin, Bovine; Substance P | 1996 |
Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Bicuculline; Binding Sites; Binding, Competitive; Cell Line; Coturnix; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Ion Channel Gating; Ion Transport; Models, Chemical; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pentobarbital; Point Mutation; Pregnanediones; Pregnanolone; Protein Binding; Pyridazines; Receptors, GABA-A; Structure-Activity Relationship | 1997 |
Pharmacological characterisation of multiple components in the enhancement by pregnanolone and propofol of [3H]flunitrazepam binding to GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Flunitrazepam; GABA Agonists; GABA Modulators; In Vitro Techniques; Male; Muscimol; Pregnanolone; Progesterone; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Membranes | 1996 |
Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit.
Topics: Amino Acid Sequence; Anesthetics, Intravenous; Animals; Bicuculline; Brain; Cell Line; Consensus Sequence; DNA, Complementary; Flumazenil; Flunitrazepam; GABA Agents; gamma-Aminobutyric Acid; Humans; Molecular Sequence Data; Muscimol; Pentobarbital; Picrotoxin; Pregnanolone; Propofol; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger; Transfection | 1997 |
Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures.
Topics: Animals; Bicuculline; Cells, Cultured; Dehydroepiandrosterone Sulfate; Dopamine; Drug Synergism; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Muscimol; Pregnanolone; Pregnenolone; Rats; Somatostatin | 1997 |
Inhibitory effect of sex steroids on guinea-pig airway smooth muscle contractions.
Topics: Animals; Bicuculline; Calcium; GABA Antagonists; GABA-A Receptor Antagonists; Guinea Pigs; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Picrotoxin; Pregnanolone; Progesterone; Trachea | 1997 |
Modulation of gamma-aminobutyric acid (GABA) receptors and the feeding response by neurosteroids in Hydra vulgaris.
Topics: Anesthetics; Animals; Anti-Anxiety Agents; Bicuculline; Carbolines; Cerebral Cortex; Chemoreceptor Cells; Clonazepam; Desoxycorticosterone; Diazepam; Feeding Behavior; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glutathione; Hydra; Neurotransmitter Agents; Pregnanolone; Progesterone; Pyridazines; Radioligand Assay; Rats; Receptors, GABA-A; Tritium | 1998 |
Effects of pregnanolone on behavioural parameters and the responses to GABA(A) receptor antagonists in the late gestation fetal sheep.
Topics: Animals; Bicuculline; Electroencephalography; Electromyography; Electrooculography; Embryonic and Fetal Development; Female; GABA Antagonists; Gestational Age; Picrotoxin; Pregnancy; Pregnanolone; Receptors, GABA-A; Respiration; Sheep | 1999 |
Development and role of GABA(A) receptor-mediated synaptic potentials during swimming in postembryonic Xenopus laevis tadpoles.
Topics: Animals; Bicuculline; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glycine Agents; Larva; Neurons; Nipecotic Acids; Pregnanolone; Proline; Receptors, GABA-A; Rhombencephalon; Spinal Cord; Strychnine; Swimming; Synapses; Xenopus laevis | 1999 |
Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Chemistry; Central Nervous System Depressants; Cerebral Cortex; Convulsants; Cyclooxygenase Inhibitors; Dihydrotestosterone; Electrophysiology; Enzyme Inhibitors; Epilepsy; Ethanol; Finasteride; Indomethacin; Male; Neuroprotective Agents; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2000 |
Heterogeneity of GABA(A) receptor-mediated responses in the human IMR-32 neuroblastoma cell line.
Topics: Anticonvulsants; Bicuculline; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; gamma-Aminobutyric Acid; Humans; Neuroblastoma; Patch-Clamp Techniques; Pentobarbital; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles; Tumor Cells, Cultured; Zinc | 2000 |
Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test.
Topics: Animals; Antidepressive Agents; Benzodiazepinones; Bicuculline; Fluoxetine; Indoleacetic Acids; Male; Mice; Pregnanolone; Receptors, GABA-A; Swimming; Time Factors | 2000 |
The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol.
Topics: Animals; Bicuculline; Central Nervous System Depressants; Convulsants; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Dose-Response Relationship, Drug; Ethanol; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; N-Methylaspartate; Picrotoxin; Pregnanediones; Pregnanolone; Pregnenolone; Progesterone; Reflex; Seizures; Sleep; Steroids | 2000 |
Functional modulation of gamma-aminobutyric acid(A) receptors by etifoxine and allopregnanolone in rodents.
Topics: Allosteric Site; Animals; Anticonvulsants; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Chloride Channels; Convulsants; Drug Interactions; GABA Antagonists; Male; Oxazines; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sulfur Radioisotopes | 2001 |
Cataleptic effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice: modulation by serotonergic agents.
Topics: 5,7-Dihydroxytryptamine; Animals; Bicuculline; Catalepsy; Drug Synergism; Enzyme Inhibitors; GABA Antagonists; Indoleacetic Acids; Indomethacin; Male; Mice; Pregnanolone; Serotonin; Serotonin Agents; Serotonin Receptor Agonists; Synaptic Transmission | 2001 |
The anxiolytic effect of allopregnanolone is associated with gonadal hormonal status in female rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; Estrogens; Estrus; Exploratory Behavior; Female; GABA Antagonists; Hormones; Maze Learning; Motor Activity; Ovariectomy; Ovary; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley | 2001 |
Allosteric modulation in spontaneously active mutant gamma-aminobutyric acidA receptors.
Topics: Allosteric Regulation; Animals; Bicuculline; Electric Conductivity; Female; Flunitrazepam; GABA Antagonists; GABA Modulators; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Pregnanolone; Protein Isoforms; Receptors, GABA-A; Xenopus laevis | 2001 |
Modulation Of [35S]-tert-butylbicyclophosphorothionate binding by somatostatin in rat hypothalamus.
Topics: Animals; Bicuculline; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Male; Muscimol; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Somatostatin; Sulfur Radioisotopes | 2002 |
Effect of centrally injected allopregnanolone on sexual receptivity, luteinizing hormone release, hypothalamic dopamine turnover, and release in female rats.
Topics: Animals; Bicuculline; Dopamine; Female; GABA Antagonists; Hypothalamus; Luteinizing Hormone; Ovariectomy; Posture; Pregnanolone; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal | 2002 |
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
Topics: Allosteric Regulation; Animals; Baclofen; Bicuculline; Diazepam; Female; Fetal Proteins; GABA Agonists; GABA Antagonists; Hippocampus; Male; Mental Disorders; Nerve Tissue Proteins; Norepinephrine; Picrotoxin; Pregnancy; Pregnanolone; Prenatal Exposure Delayed Effects; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes | 2002 |
Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics.
Topics: Anesthetics; Animals; Anxiety; Behavior, Animal; Bicuculline; Brain; Central Nervous System Depressants; Chlorides; Desoxycorticosterone; Drug Tolerance; Ethanol; Exploratory Behavior; Female; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Knockout; Muscimol; Postural Balance; Pregnanolone; Receptors, GABA-A; Steroids | 2003 |
Anti-conflict-like actions of intralateral septal infusions of allopregnanolone in Wistar rats.
Topics: Animals; Behavior, Animal; Bicuculline; Conflict, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; Functional Laterality; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Gonadal Steroid Hormones; Ovariectomy; Pregnanolone; Rats; Rats, Wistar; Septum of Brain; Stereotaxic Techniques | 2003 |
Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.
Topics: Adrenalectomy; Analysis of Variance; Anesthetics; Animals; Anxiety; Bicuculline; Caffeine; Central Nervous System Stimulants; Corticotropin-Releasing Hormone; Diazepam; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Hormone Antagonists; Injections, Intraventricular; Male; Maze Learning; Muscimol; Peptide Fragments; Pregnanolone; Progestins; Rats; Rats, Sprague-Dawley; Reaction Time | 2005 |
Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Blotting, Western; Cell Separation; Electrophysiology; Estradiol; Female; GABA Agonists; GABA Antagonists; Hippocampus; Homeostasis; In Vitro Techniques; Isoxazoles; Lanthanum; Lorazepam; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Steroids | 2005 |
Anti-apoptotic effects of allopregnanolone on P19 neurons.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Bicuculline; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cytochromes c; Cytosol; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Drug Interactions; Fluorescent Antibody Technique; GABA Antagonists; Mice; Mitochondria; N-Methylaspartate; Neurons; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptophysin; Time Factors; Tubulin | 2006 |
Social isolation-induced increase in alpha and delta subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA receptor function.
Topics: Analysis of Variance; Animals; Bicuculline; Blotting, Western; Central Nervous System Depressants; Enzyme Inhibitors; Ethanol; Finasteride; GABA Antagonists; Gene Expression Regulation; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Social Isolation | 2006 |
Steroid requirements for regulation of the alpha4 subunit of the GABA(A) receptor in an in vitro model.
Topics: Analysis of Variance; Androgen Antagonists; Azasteroids; Bicuculline; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Dihydrotestosterone; Drug Interactions; GABA Antagonists; gamma-Aminobutyric Acid; Gene Expression Regulation, Neoplastic; Humans; Membrane Potentials; Nerve Growth Factor; Neuroblastoma; Patch-Clamp Techniques; Pregnanolone; Receptors, GABA-A; RNA, Messenger | 2007 |
Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei.
Topics: Animals; Bicuculline; Data Interpretation, Statistical; Desoxycorticosterone; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Membrane Potentials; Neurons; Neurotransmitter Agents; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Glutamate; Steroids; Synaptic Transmission; Vestibular Nuclei | 2007 |
GABAA and glycine receptor-mediated transmission in rat lamina II neurones: relevance to the analgesic actions of neuroactive steroids.
Topics: Anesthetics; Animals; Bicuculline; Desoxycorticosterone; Female; GABA Antagonists; GABA Modulators; Glycine Agents; Inhibitory Postsynaptic Potentials; Male; Membrane Potentials; Neural Inhibition; Posterior Horn Cells; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Strychnine; Synaptic Transmission | 2007 |
Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats.
Topics: Adrenalectomy; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; Male; Maze Learning; Muscimol; Oxazines; Pregnanolone; Rats; Rats, Sprague-Dawley; Reaction Time | 2007 |
Fast non-genomic effects of progesterone-derived neurosteroids on nociceptive thresholds and pain symptoms.
Topics: Allosteric Regulation; Analgesics, Non-Narcotic; Animals; Bicuculline; Carrageenan; Drug Evaluation, Preclinical; Hot Temperature; Hyperalgesia; Inflammation; Male; Molecular Conformation; Pain Threshold; Pregnanolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Stereoisomerism; Structure-Activity Relationship; Strychnine; Touch | 2008 |
Allopregnanolone-induced rise in intracellular calcium in embryonic hippocampal neurons parallels their proliferative potential.
Topics: Anesthetics; Animals; Bicuculline; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Proliferation; Cells, Cultured; Cytoplasm; Female; GABA Antagonists; Hippocampus; Neurons; Nifedipine; Picrotoxin; Pregnancy; Pregnanolone; Rats; Rats, Sprague-Dawley; Review Literature as Topic | 2008 |
Acute neurosteroids inhibit the spinal reflex potentiation via GABAergic neurotransmission.
Topics: Action Potentials; Animals; Bicuculline; Desoxycorticosterone; Electric Stimulation; Electromyography; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Injections, Spinal; Neuronal Plasticity; Neurotransmitter Agents; Pregnanolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reflex; Spinal Nerves; Synaptic Transmission; Time Factors; Urethra | 2010 |
Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature rats.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Bicuculline; Brain; Brain Injuries; Disease Models, Animal; Drug Administration Routes; Functional Laterality; GABA-A Receptor Antagonists; Hypoxia-Ischemia, Brain; Pregnanolone; Progesterone; Rats; Rats, Wistar; Time Factors | 2012 |
Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation.
Topics: Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Convulsants; Diazepam; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; High-Throughput Screening Assays; Hippocampus; Mice; Mice, Inbred C57BL; Microelectrodes; Neurons; Picrotoxin; Pregnanolone; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Time Factors | 2012 |
Bicuculline- and neurosteroid-sensitive tonic chloride current in rat hypoglossal motoneurons and atypical dual effect of SR95531.
Topics: Action Potentials; Animals; Bicuculline; Brain Stem; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Motor Neurons; Picrotoxin; Pregnanolone; Protein Subunits; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A | 2013 |
Allopregnanolone-mediated protective effects of progesterone on tributyltin-induced neuronal injury in rat hippocampal slices.
Topics: 5-alpha Reductase Inhibitors; Anesthetics; Animals; Bicuculline; Cell Death; Cytochrome P-450 Enzyme Inhibitors; Finasteride; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Hippocampus; Hormone Antagonists; Mifepristone; Muscimol; Neurons; Neuroprotective Agents; Organ Culture Techniques; Pregnanolone; Progesterone; Progestins; Rats; Rats, Wistar; Tetrahydronaphthalenes; Trialkyltin Compounds | 2013 |
Evaluation for roles of neurosteroids in modulating forebrain mechanisms controlling vasopressin secretion and related phenomena in conscious rats.
Topics: Aminoglutethimide; Animals; Aromatase Inhibitors; Autonomic Nervous System; Bicuculline; Blood Glucose; Blood Pressure; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Heart Rate; Male; Muscimol; Pregnanolone; Prosencephalon; Rats; Rats, Wistar; Receptors, GABA; Vasopressins | 2015 |
The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosynthesis.
Topics: 17-alpha-Hydroxypregnenolone; 20-alpha-Dihydroprogesterone; Animals; Anti-Anxiety Agents; Bicuculline; Complex Mixtures; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; GABA-A Receptor Antagonists; Gene Expression; Hypothalamus; Isoquinolines; Male; Neuropeptides; Oxazines; Peptide Fragments; Pregnanolone; Progesterone; Rana esculenta; Receptors, GABA-A; Tissue Culture Techniques | 2015 |
Persistent GABAA/C responses to gabazine, taurine and beta-alanine in rat hypoglossal motoneurons.
Topics: Animals; beta-Alanine; Bicuculline; Brain Stem; Central Nervous System Agents; Chlorine; GABA Agents; Hypoglossal Nerve; Midazolam; Motor Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pentobarbital; Phosphinic Acids; Pregnanolone; Pyridazines; Pyridines; Rats, Sprague-Dawley; Receptors, GABA; Receptors, GABA-A; Strychnine; Taurine; Tissue Culture Techniques | 2016 |
Allopregnanolone Effects on Transmission in the Brain Stem Solitary Tract Nucleus (NTS).
Topics: Animals; Bicuculline; Central Nervous System Agents; Female; gamma-Aminobutyric Acid; Neurons, Afferent; Patch-Clamp Techniques; Pregnanolone; Pyridazines; Rats, Sprague-Dawley; Receptors, GABA-A; Solitary Nucleus; Synaptic Transmission; Tissue Culture Techniques | 2018 |
Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; GABA-A Receptor Antagonists; Hippocampus; Kindling, Neurologic; Male; Mice; Microinjections; Neural Inhibition; Neurosteroids; Pregnanolone; Pyridazines; Receptors, GABA-A; Seizures; Zinc | 2019 |
Enhanced remyelination during late pregnancy: involvement of the GABAergic system.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Animals; Bicuculline; Corpus Callosum; Demyelinating Diseases; Disease Models, Animal; Female; Finasteride; GABA Antagonists; Lysophosphatidylcholines; Male; Microglia; Multiple Sclerosis; Myelin Proteins; Myelin Sheath; Nerve Tissue Proteins; Oligodendrocyte Precursor Cells; Oligodendroglia; Pregnancy; Pregnancy Complications; Pregnanolone; Puerperal Disorders; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Remyelination | 2019 |
Involvement of GABAergic system in the antidepressant-like effects of chrysin (5,7-dihydroxyflavone) in ovariectomized rats in the forced swim test: comparison with neurosteroids.
Topics: Animals; Antidepressive Agents; Bicuculline; Depression; Female; Flavonoids; GABAergic Neurons; Locomotion; Neurosteroids; Ovariectomy; Pregnanolone; Progesterone; Rats; Rats, Wistar; Receptors, GABA-A | 2020 |