Page last updated: 2024-09-05

pregnane-20-one and pregnanolone

pregnane-20-one has been researched along with pregnanolone in 13 studies

Compound Research Comparison

Studies
(pregnane-20-one)
Trials
(pregnane-20-one)
Recent Studies (post-2010)
(pregnane-20-one)
Studies
(pregnanolone)
Trials
(pregnanolone)
Recent Studies (post-2010) (pregnanolone)
14031,984111666

Protein Interaction Comparison

ProteinTaxonomypregnane-20-one (IC50)pregnanolone (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.101
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.117
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.117
Gamma-aminobutyric acid receptor subunit alpha-1Mus musculus (house mouse)0.071
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.101
GABA theta subunitRattus norvegicus (Norway rat)0.101
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.101

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19904 (30.77)18.7374
1990's0 (0.00)18.2507
2000's6 (46.15)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, SS; Waterhouse, BD; Woodward, DJ1
Kaufman, S; Lo, F1
DOORENBOS, H1
JAYLE, MF; PASQUALINI, JR1
GREGOROVA, I; KOBEL, F; KUCHEL, O1
Khisti, RT; Matthews, DB; Morrow, AL; VanDoren, MJ1
Akk, G; Bracamontes, J; Covey, DF; Li, P; Reichert, DE; Steinbach, JH1
De Sarro, G; Dore, R; Maciocco, E; Mostallino, MC; Mura, ML; Pisu, MG; Russo, E; Serra, M1
Aoki, C; Shen, H; Smith, SS1
Biggio, G; Concas, A; Follesa, P; Mostallino, MC; Sanna, E1
Mohammad, A; Ramroop, J; Shen, H; Smith, SS1
Aoki, C; Gong, QH; Kuver, A; Molla, J; Sabaliauskas, N; Shen, H; Smith, SS1
Ackley, MA; Althaus, AL; Bai, Z; Belfort, GM; Beresis, RT; Blanco, MJ; Dai, J; Doherty, JJ; Grossman, SJ; Harrison, BL; Hoffmann, E; Loya, CM; Martinez Botella, G; Robichaud, AJ; Salituro, FG1

Reviews

1 review(s) available for pregnane-20-one and pregnanolone

ArticleYear
Plasticity and function of extrasynaptic GABA(A) receptors during pregnancy and after delivery.
    Psychoneuroendocrinology, 2009, Volume: 34 Suppl 1

    Topics: 5-alpha Reductase Inhibitors; Animals; Brain; Female; Finasteride; Gene Expression Regulation, Developmental; Hippocampus; Membrane Potentials; Neuronal Plasticity; Neurons; Postpartum Period; Pregnancy; Pregnancy, Animal; Pregnanolone; Progesterone; Rats; Receptors, GABA-A; Synaptic Transmission

2009

Other Studies

12 other study(ies) available for pregnane-20-one and pregnanolone

ArticleYear
Locally applied progesterone metabolites alter neuronal responsiveness in the cerebellum.
    Brain research bulletin, 1987, Volume: 18, Issue:6

    Topics: Animals; Drug Interactions; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Iontophoresis; Pregnanediol; Pregnanes; Pregnanolone; Purkinje Cells; Rats; Rats, Inbred Strains

1987
Effect of 5 alpha-pregnan-3 alpha-ol-20-one on nitric oxide biosynthesis and plasma volume in rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:6

    Topics: Animals; Blood Volume; Female; Nitrates; Nitric Oxide; Nitrites; Plasma Volume; Pregnanolone; Rats; Rats, Long-Evans

2001
[The value of determination of 3alpha,17alpha,21-trihydroxy-5beta-pregnane-20-one (H4S) in the urine for the diagnosis of adrenal cortex and pituitary gland diseases].
    Nederlands tijdschrift voor geneeskunde, 1962, Apr-07, Volume: 106

    Topics: Adrenal Cortex; Adrenal Cortex Diseases; Humans; Pituitary Diseases; Pituitary Gland; Pregnanolone

1962
ISOLATION AND IDENTIFICATION OF 3ALPHA,17ALPHA,21TRIHYDROXY-5ALPHA-PREGNAN-20-ONE (ALLO-TETRAHYDRO-COMPOUND S) AFTER ADMINISTRATION OF 3BETA, 17ALPHA,21-TRIHYDROXYPREGN-5-EN-20-ONE(17ALPHA,21-DIHYDROXYPREGNENOLONE).
    The Biochemical journal, 1963, Volume: 88

    Topics: Adrenal Cortex Hormones; Chemistry Techniques, Analytical; Cortodoxone; Humans; Pregnanolone; Urine

1963
[On the problem of the effect of so-called "SEF" substance (salt excreting factor, 3beta, 16alpha-dihydro-5-pregnane-20-one)].
    Casopis lekaru ceskych, 1962, Jul-27, Volume: 101

    Topics: Adrenalectomy; Potassium; Pregnanolone; Sodium; Steroids

1962
Ethanol-induced elevation of 3 alpha-hydroxy-5 alpha-pregnan-20-one does not modulate motor incoordination in rats.
    Alcoholism, clinical and experimental research, 2004, Volume: 28, Issue:8

    Topics: Animals; Ataxia; Ethanol; Male; Pregnanolone; Rats; Rats, Sprague-Dawley; Rotarod Performance Test

2004
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
    Molecular pharmacology, 2008, Volume: 74, Issue:3

    Topics: Amino Acid Substitution; Animals; Cell Line; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Mutant Proteins; Mutation; Piperidines; Pregnanetriol; Pregnanolone; Pregnenolone; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Rats; Receptors, GABA-A; Serine; Steroids; Tryptophan

2008
Neuroactive steroids and GABAA receptor plasticity in the brain of the WAG/Rij rat, a model of absence epilepsy.
    Journal of neurochemistry, 2008, Volume: 106, Issue:6

    Topics: Aging; Animals; Animals, Genetically Modified; Brain; Brain Chemistry; Cerebral Cortex; Desoxycorticosterone; Disease Models, Animal; Down-Regulation; Epilepsy, Absence; gamma-Aminobutyric Acid; Male; Neuronal Plasticity; Pregnanolone; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA-A; Steroids; Stress, Psychological; Synapses; Synaptic Transmission; Thalamus; Up-Regulation

2008
Puberty, steroids and GABA(A) receptor plasticity.
    Psychoneuroendocrinology, 2009, Volume: 34 Suppl 1

    Topics: Animals; Anxiety; CA1 Region, Hippocampal; Corticosterone; Female; Finasteride; GABA Agents; Humans; Membrane Potentials; Mice; Mice, Transgenic; Neural Inhibition; Neuronal Plasticity; Neurotransmitter Agents; Periaqueductal Gray; Pregnanolone; Premenstrual Syndrome; Progesterone; Puberty; Pyramidal Cells; Rats; Receptors, GABA-A; Stress, Psychological; Synaptic Transmission

2009
A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence.
    Neuroscience, 2013, Dec-19, Volume: 254

    Topics: Amphetamine-Related Disorders; Animals; Anxiety; Gene Expression Regulation; Male; Methamphetamine; Mice; Mice, Inbred C57BL; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA-A; Sensory Gating; Stress, Psychological; Substance Withdrawal Syndrome

2013
Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse.
    Brain research, 2015, Sep-24, Volume: 1621

    Topics: Action Potentials; Animals; CA1 Region, Hippocampal; Dendritic Spines; Electric Stimulation; Estradiol; Estrous Cycle; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanolone; Pyramidal Cells; Receptors, GABA-A; Spatial Learning

2015
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)
    Journal of medicinal chemistry, 2017, 09-28, Volume: 60, Issue:18

    Topics: Allosteric Regulation; Animals; Depression, Postpartum; Depressive Disorder, Major; Female; GABA-A Receptor Agonists; Mice; Pregnanolone; Pyrazoles; Rats; Receptors, GABA-A

2017