preclamol has been researched along with piperidines in 332 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 160 (48.19) | 18.7374 |
| 1990's | 149 (44.88) | 18.2507 |
| 2000's | 12 (3.61) | 29.6817 |
| 2010's | 11 (3.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klein, M; Musacchio, JM | 2 |
| Lemaire, S; Rogers, C | 1 |
| DeHaven-Hudkins, DL; Fleissner, LC | 1 |
| Hudzik, TJ | 1 |
| Akiyama, K; Okumura, K; Otsuki, S; Ujike, H; Zushi, Y | 1 |
| Ahlenius, S; Hillegaart, V; Lindgren, JE; Lundström, J | 1 |
| Araki, H; Hasegawa, Y; Kaku, S; Otomo, S | 1 |
| Akiyama, K; Otsuki, S; Tsuchida, K; Ujike, H | 1 |
| Ericson, H; Ross, SB | 1 |
| Berardi, F; Daniele, E; Govoni, S; Leopoldo, M; Lograno, MD; Perrone, R; Tortorella, V | 1 |
| Ahlenius, S | 1 |
| Bohmaker, K; Bordi, F; Meller, E | 1 |
| Carlsson, A; Cascella, NG; Lahti, RA; Lindberg, M; Tamminga, CA | 1 |
| Hariton, C | 2 |
| Bohmaker, K; Diamond, J; Lieu, HD; Meller, E; Puza, T | 1 |
| DeHaven-Hudkins, DL; Fleissner, LC; Ford-Rice, FY | 1 |
| Ekman, A; Eriksson, E | 2 |
| Fukamauchi, F; Shibuya, H; Yoshikawa, T | 1 |
| Akiyama, K; Kanzaki, A; Okumura, K; Otsuki, S; Tsuchida, K; Ujike, H | 1 |
| Cook, L; Gilligan, PJ; Schmidt, WK; Steinfels, GF; Tam, SW | 1 |
| Culp, SG; De Souza, EB; Rominger, D; Tam, SW | 1 |
| Connick, JH; Fox, PK; France, L; Hanlon, G; Nicholson, CD; Roberts, J | 1 |
| Chavkin, C; Connor, MA | 2 |
| Blier, P; de Montigny, C; Debonnel, G; Monnet, FP | 1 |
| Codd, EE; Shank, RP | 1 |
| Mash, DC; Zabetian, CP | 1 |
| Ross, SB | 1 |
| Musacchio, JM; Zhou, GZ | 1 |
| Bem, WT; Coscia, CJ; Homan, SM; Johnson, FE; Levy, BK; Mamone, JY; Thomas, GE | 1 |
| Itzhak, Y; Stein, I | 1 |
| Ekman, A; Eriksson, E; Quiding, M | 1 |
| Kruk, ZL; Millar, J; Stamford, JA | 2 |
| Karbon, EW; Naper, K; Pontecorvo, MJ | 1 |
| Burke, M; Earley, B; Gouret, CJ; Junien, JL; Leonard, BE | 1 |
| Carlsson, A; Kujacic, M; Löfberg, L; Svensson, K | 1 |
| Clark, D; Furmidge, L; Petry, N; Tong, ZY | 1 |
| Gillard, J; Knight, AR; Middlemiss, DN; Wong, EH | 1 |
| Cler, JA; Contreras, PC; Dilworth, VM; Emmett, MR; Gray, NM; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Engberg, G; Wikström, H | 1 |
| Code, RA; Tang, AH | 1 |
| Clark, D; Ericsson, M; Furmidge, LJ; Johnson, D; Petry, N; Tong, ZY | 1 |
| Blazynski, C; Cohen, AI | 1 |
| Contreras, PC; Dilworth, VM; Farah, JM; Gray, NM; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Duckles, SP; Massamiri, T | 3 |
| Itzhak, Y; Mash, D; Stein, I; Zhang, SH | 1 |
| Cristante, D; Itzhak, Y; Kassim, CO; Stein, I; Zhang, SH | 1 |
| Bell, JA; London, ED; Spivak, CE; Su, TP; Wu, XZ | 1 |
| Clark, D; Galloway, MP; Salah, RS | 1 |
| Cler, JA; Contreras, PC; Dilworth, VM; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Battaglia, G; Glennon, RA; Smith, JD | 1 |
| Fiorica-Howells, E; Spector, S | 1 |
| Bøgesø, KP; Carlsson, A; Hyttel, J; Liljefors, T; Svensson, K; Wikström, H | 1 |
| Svensson, L | 1 |
| Church, J; Lodge, D | 1 |
| Itzhak, Y; Krähling, H; Ruhland, M | 1 |
| Henderson, G; Kennedy, C | 2 |
| Henderson, G; Jarvis, GE; Kennedy, C | 1 |
| Kuypers, G; Paul, IA; Skolnick, P; Youdim, M | 1 |
| Chaki, S; Muramatsu, M; Otomo, S; Usuki-Ito, C | 1 |
| Bremer, ME; Contreras, PC; Gray, NM | 1 |
| Al'perina, EL; Cheĭdo, MA; Idova, GV | 1 |
| Bremer, ME; Contreras, PC; Rao, TS | 1 |
| Feuerstein, G; Lysko, PG | 1 |
| Dubrovina, NI; Il'iuchenok, RIu; Parkhomenko, RI | 1 |
| Bowen, WD; DeCosta, B; Hellewell, SB; Rice, KC; Thurkauf, A; Walker, JM | 1 |
| Klein, M; Musacchio, J; Paturzo, JJ; Zhou, GZ | 1 |
| Lemaire, S; Rogers, CA | 1 |
| Ferkany, JW; Karbon, EW; Patch, RJ; Pontecorvo, MJ | 1 |
| Bowen, WD; Moses, EL; Tolentino, PJ; Walker, JM | 1 |
| Byrd, JC; Paleos, GA; Yang, ZW | 2 |
| Bowen, WD; De Costa, BR; Hellewell, SB; Hemstreet, MK; Lai, NL; Matsumoto, RR; Rice, KC; Thurkauf, A; Walker, JM | 1 |
| Bauerle, LM; DeNoble, VJ; Jones, KW | 1 |
| Canoll, PD; Gottesman, S; Musacchio, JM; Smith, PR | 1 |
| Carlsson, A; Clark, D; Hjorth, S | 5 |
| Klein, M; Musacchio, JM; Paturzo, JJ | 1 |
| Culp, SG; De Souza, EB; Wolfe, SA | 1 |
| Bluth, LS; Bowen, WD; Jacobson, AE; Rice, KC | 1 |
| Bowen, WD; Hellewell, SB; McGarry, KA | 1 |
| Emori, T; Hirata, Y; Marumo, F; Ohta, K; Shichiri, M | 1 |
| Aanonsen, LM; Seybold, VS | 1 |
| Heym, J; Koe, BK; Lebel, L; Schmidt, A; Seeger, T | 1 |
| Denavit-Saubié, M; Foutz, AS | 1 |
| Itzhak, Y | 2 |
| Canoll, PD; Klein, M; Musacchio, JM | 1 |
| Burkhart, CA; Koe, BK; Lebel, LA | 1 |
| Steinfels, GF; Tam, SW | 1 |
| Bowen, WD; de Costa, BR; Hellewell, SB; Jacobson, AE; Rice, KC; Thurkauf, A; Walker, JM | 1 |
| Carlsson, M; Eriksson, E | 3 |
| Ahlenius, S; Hillegaart, V; Wijkström, A | 1 |
| Cook, L; Steinfels, GF; Tam, SW | 2 |
| Domae, M; Furukawa, T; Matsumoto, S; Nagashima, M; Shirakawa, K; Yamada, K | 1 |
| Fico, TA; Spoerlein, MT; Vanderwende, C; Wilmot, CA | 1 |
| Martínez, JA; Milanés, MV; Vargas, ML | 1 |
| Bobker, DH; Shen, KZ; Surprenant, A; Williams, JT | 1 |
| Bagetta, G; de Sarro, GB; Marra, R; Nisticò, G; Priolo, E | 1 |
| Gundlach, AL; Largent, BL; Snyder, SH; Wikström, H | 1 |
| Hiltunen, AJ; Järbe, TU | 2 |
| Itzhak, Y; Khouri, M | 1 |
| Chavkin, C; Malouf, AT; Swearengen, E | 1 |
| Beart, PM; Manallack, DT | 1 |
| Tam, SW; Zhang, AZ | 1 |
| Claustre, Y; Fage, D; Scatton, B; Zivkovic, B | 1 |
| Sethy, VH; Wenger, D | 1 |
| Horn, AS; Mastebroek, D; Rollema, H; Wikström, H | 1 |
| Andersson, M; Fowler, CJ; Magnusson, O; Thorell, G | 1 |
| Carnoy, P; Puech, AJ; Simon, P; Soubrie, P | 1 |
| Magistretti, PJ; Ofori, S; Schorderet, M | 1 |
| Goiny, M; Uvnäs-Moberg, K | 1 |
| Nichols, NF; Schreur, PJ | 1 |
| Keana, JF; McLean, S; Pou, S; Quarum, M; Sonders, M; Weber, E | 1 |
| Di Chiara, G; Longoni, R; Spina, L | 1 |
| Jenner, P; Kelly, E; Marsden, CD | 2 |
| Bohmaker, K; Friedhoff, AJ; Goldstein, M; Meller, E; Namba, Y | 1 |
| Aihara, H; Hashimoto, S; Okuyama, S | 1 |
| Bagetta, G; Corasaniti, MT; Nisticò, G; Sakurada, S; Strongoli, MC | 1 |
| Bagetta, G; Nistico, G; Priolo, E | 1 |
| George, SR; Seeman, P; Watanabe, M | 1 |
| Bagetta, G; De Sarro, G; Nisticò, G; Priolo, E | 1 |
| Gundlach, AL; Largent, BL; Snyder, SH | 5 |
| Balster, RL | 1 |
| Fowler, CJ; Thorell, G | 1 |
| Bobker, DH; Campbell, BG; Leslie, FM; Mefford, IN; Weber, E | 1 |
| Jenner, P; Marsden, CD; Nomoto, M | 1 |
| Carlsson, A; Engel, JA; Hjorth, S | 1 |
| Hiyama, T; Kikuchi, T; Suzuki, S; Tsutsui, M; Yamada, K; Yasuda, Y | 1 |
| Altar, CA; Gerber, R; Hall, NR; Liebman, JM | 1 |
| Christoffersen, CL; Meltzer, LT | 1 |
| Clark, D; Kovacic, B; Le Witt, P | 1 |
| Di Chiara, G; Frau, R; Imperato, A; Tanda, G | 1 |
| Baldessarini, RJ; Campbell, A; Froimowitz, M; Gao, YG; Neumeyer, JL | 1 |
| Ahlénius, S; Johansson, L; Lennmark, M; Lundström, J; Säfholm, C; Teiling, A; Thorberg, SO | 1 |
| Argiolas, A; Gessa, GL; Melis, MR | 1 |
| Carlsson, M; Clark, D; Eriksson, E; Nilsson, C; Svensson, K | 1 |
| Ahlenius, S; Hillegaart, V | 1 |
| Ahlenius, S; Criborn, CO; Henriksson, C; Hillegaart, V | 1 |
| Berg, S; Lindberg, P; Lundström, J; Nilsson, JL; Pettersson, B; Sanchez, D; Thorberg, SO; Wijkström, A | 1 |
| Ståhle, L; Ungerstedt, U | 2 |
| Carlsson, A; Carlsson, M; Eriksson, E | 1 |
| Bergstrom, DA; Bromley, SD; Carlson, JH; Jackson, DM; Walters, JR | 1 |
| Bonsall, RW; Michael, RP; Schaefer, GJ | 1 |
| Baldessarini, RJ; Froimowitz, M; Neumeyer, JL | 1 |
| Andersson, B; Eriksson, E; Hjorth, S | 1 |
| Carlsson, A; Mastebroek, D; Rollema, H; Sundell, S; Svensson, K; Wikström, H | 1 |
| Liljefors, T; Wikström, H | 1 |
| Andersson, B; Carlsson, A; Hjorth, S; Svensson, K; Wikström, H | 1 |
| Carlsson, A; Carlsson, M; Eriksson, E; Nilsson, C | 1 |
| Clark, D; Elam, M; Svensson, TH | 1 |
| Arnt, J; Bøgesø, KP; Lundmark, M; Sundell, S | 1 |
| Carlsson, A | 2 |
| Broekkamp, CL; Gower, AJ | 1 |
| Hedner, T; Lundborg, P | 1 |
| Howard, HR; Kelly, TR; Koe, BK; Sarges, R | 1 |
| Carlsson, A; Clark, D; Hjorth, S; Svensson, K; Thorberg, O | 1 |
| Collu, M; Gessa, GL; Serra, G | 1 |
| Draper, R; Mulder, AH; Schoffelmeer, AN; Sminia, P; Stoof, JC | 1 |
| Carlsson, A; Clark, D; Hjorth, S; Sanchez, D; Svensson, K | 1 |
| Brown, F; Campbell, W; Mitchell, PJ; Randall, K | 1 |
| Gaillard, JM; Hjorth, S; Kafi-de St Hilaire, S; Sovilla, JY | 1 |
| Bunney, BS; Carlsson, A; Clark, D; Engberg, G; Freeman, AS; Pileblad, E; Svensson, TH | 1 |
| Bhaird, NN; Fowler, CJ; Thorberg, O; Tipton, KF | 1 |
| Glock, D; Goldberg, LI; Kohli, JD | 1 |
| Carlsson, A; Löfberg, L | 1 |
| Arvidsson, LE; Hacksell, U; Hjorth, S; Johansson, AM; Lindberg, P; Nilsson, JL; Sanchez, D; Svensson, K; Thorberg, SO; Wikström, H | 1 |
| Arbilla, S; Langer, SZ | 1 |
| Arvidsson, LE; Carlsson, A; Hacksell, U; Hjorth, S; Lindberg, P; Nilsson, JL; Sanchez, D; Svensson, U; Wikström, H | 1 |
| Carlsson, A; Clark, D; Engel, J; Hjorth, S; Sanchez, D; Svensson, K | 1 |
| Bymaster, FP; Wong, DT | 1 |
| Bendesky, RJ; Jones, JH; Martin, GE | 1 |
| Bacopoulos, NG; Koch, SW; Koe, BK | 1 |
| Carlsson, A; Clark, D; Engel, J; Hjorth, S; Lindberg, P | 1 |
| Hjorth, S | 1 |
| Arnt, J; Bøgesø, KP; Christensen, AV; Hyttel, J; Larsen, JJ; Svendsen, O | 1 |
| Gudelsky, GA; Meltzer, HY; Simonovic, M | 1 |
| Boissard, CG; Delini-Stula, A; Mogilnicka, E | 1 |
| Arnt, J; Bøgesø, KP; Hyttel, J; Larsen, JJ; Svendsen, O | 1 |
| Palacios, JM; Wiederhold, KH | 1 |
| Billingsley, ML; Roth, RH | 1 |
| Daus, FJ; Hansen, HA; Plantjé, JF; Stoof, JC | 1 |
| Watling, KJ; Williams, M | 1 |
| Carlsson, A; Hjorth, S; Jackson, D; Lindberg, P | 2 |
| Jones, JH; Watling, KJ; Williams, M | 1 |
| Fallon, S; Liebman, JM; Pastor, G; Welch, JJ | 1 |
| Mulder, AH; Plantjé, JF; Stoof, JC | 1 |
| Lahaye, D; Markstein, R | 1 |
| Hacksell, U; Hjorth, S; Schorderet, M | 1 |
| Dijkstra, D; Horn, AS; Houwing, HA; Van Oene, JC | 1 |
| Arvidsson, LE; Carlsson, A; Clark, D; Hacksell, U; Hjorth, S; Johansson, A; Lindberg, P; Sanchez, D; Svensson, K; Wikström, H | 1 |
| Arnt, J; Hyttel, J | 1 |
| Ahlenius, S; Archer, T; Hillegaart, V; Tandberg, B | 1 |
| Fenton, HM; Gerhardt, S; Leszczak, E; Liebman, JM | 1 |
| Ahlenius, S; Hillegaart, V; Svensson, L; Thorberg, O | 1 |
| Berendsen, HG; Broekkamp, CL; Gower, AJ; Princen, MM | 1 |
| Ahlenius, S; Hillegaart, V; Lundström, J; Magnusson, O | 1 |
| Ahlenius, S; Larsson, K | 1 |
| Arvidsson, LE; Carlsson, A; Clark, D; Hacksell, U; Hjorth, S; Johansson, A; Lindberg, P; Nilsson, JL; Sanchez, D; Svensson, K; Wikström, H | 1 |
| Adelung, C; Lang, JD; Späth, L; Starke, K | 1 |
| Robinson, JL; Watling, KJ; Williams, M | 1 |
| Arnt, J | 1 |
| Fenton, HM; Gerhardt, S; Hall, NR; Liebman, JM; Neale, R; Noreika, L | 1 |
| Geyer, MA; Lee, EH | 1 |
| Carlsson, A; Eriksson, E; Modigh, K; Wikström, H | 1 |
| Carlsson, A; Gunne, LM; Häggström, JE; Wikström, H | 1 |
| Gudelsky, GA; Meltzer, HY; Mikuni, M; Simonovic, M | 1 |
| Fratta, W; Gessa, GL; Napoli-Farris, L | 1 |
| Pinnock, RD | 1 |
| Haubrich, DR; Martin, GE; Williams, M | 2 |
| Ahlenius, S; Svensson, L | 1 |
| Mulder, AH; Sminia, P | 1 |
| Waldmeier, PC | 1 |
| Gudelsky, GA; Meltzer, HY; Passaro, E | 1 |
| Totaro, JA; Williams, M | 1 |
| Meltzer, HY; Simonovic, M | 1 |
| Carlsson, A; Hjorth, S; Lindberg, P | 1 |
| Bergstrom, DA; Gonzalez, AM; Huang, KX; Kreiss, DS; Sibley, DR; Walters, JR | 1 |
| Sonsalla, PK; Terleckyj, I | 1 |
| Dubrovina, NI | 2 |
| Bowen, WD; Carr, DJ; DeCosta, BR; Garza, HH; Mayo, S | 1 |
| Appleyard, SM; Chavkin, C; Connor, M; Patterson, TA | 1 |
| See, RE | 1 |
| Arnold, FJ; Murphy, RB; Schuster, DI | 1 |
| DeCoster, MA; Klette, KL; Knight, ES; Tortella, FC | 1 |
| Matsunaga, KH; Matsuno, K; Mita, S | 1 |
| Di Giannuario, A; Pieretti, S; Sagratella, S | 1 |
| Leander, JD; Wolff, MC | 1 |
| Lin, MY; Walters, DE | 1 |
| Carlsson, A; Huff, RM; Kling-Petersen, T; Svensson, K; Waters, N | 1 |
| De Costa, BR; Martin, WJ; Walker, JM | 1 |
| Beart, PM; Jarrott, B; Mercer, LD; Ryan, MC; Wong, MG | 1 |
| Jeanjean, AP; Laduron, PM; Maloteaux, JM; Mestre, M | 1 |
| Eguíbar, JR; Holmgren, B; Santos, A; Urbá-Holmgren, R | 1 |
| Bailey, MA; Karbon, EW | 1 |
| Chaki, S; Muramatsu, M; Otomo, S; Tanaka, M | 1 |
| Hashimoto, K; London, ED; Mantione, CR; Neumeyer, JL; Spada, MR | 1 |
| Chiodo, LA; Freeman, AS; Zhang, J | 1 |
| Hirotsu, I; Honbo, N; Koyama, M; Ohno, T | 1 |
| Bonhaus, DW; Eglen, RM; Hsu, SA; Jakeman, LB; Leung, E; Loury, DN; To, ZP; Wong, EH; Zeitung, KD | 1 |
| Bravi, D; Chase, TN; Hoff, JI; Metman, LV; Mouradian, MM; Roberts, JR; Sethy, VH | 1 |
| Davies, JA; Ellis, Y | 1 |
| Matsunaga, K; Matsuno, K; Mita, S; Senda, T | 1 |
| Cooper, TB; Klein, M; Musacchio, JM | 1 |
| Barg, J; Eilam, Y; Ela, C; Hasin, Y; Vogel, Z | 1 |
| Amoo, VE; Cannon, JG; Johnson, AK; Kirschbaum, KS; Long, JP | 1 |
| Gerlach, J; Peacock, L | 1 |
| Kaku, S; Muramatsu, M; Otomo, S; Tanaka, M | 1 |
| Bonhaus, DW; DeSouza, A; Eglen, RM; Jakeman, LB; Loury, DN; To, Z; Wong, EH | 1 |
| Dwoskin, L; Jewell, A; Wedlund, P | 1 |
| Enomoto, R; Ogita, K; Yoneda, Y | 1 |
| Callahan, PM; Cunningham, KA | 1 |
| Bailey, MA; Kaiser, C; Karbon, EW; Mathew, RM; Mewshaw, RE; Sherrill, RG | 1 |
| Järbe, TU | 1 |
| Matsuno, K; Mita, S; Senda, T | 1 |
| Allen, JT; DeHaven-Hudkins, DL; Ford-Rice, FY; Hudkins, RL | 1 |
| Barg, J; Eilam, Y; Ela, C; Hasin, Y; Novakova, M; Vogel, Z | 1 |
| Gudelsky, GA | 1 |
| Brum, JM; Estafanous, FG; Murray, PA; Schubert, A; Tsuchida, H | 1 |
| Carlsson, A; Merello, M; Pirtosek, Z; Stern, G | 2 |
| Kling-Petersen, T; Ljung, E; Svensson, K; Wollter, L | 1 |
| Kobayashi, T; Matsuno, K; Mita, S | 1 |
| Ahtee, L; Kivastik, T; Piepponen, TP; Vuorikallas, K; Zharkovsky, A | 1 |
| Barrett, TW; Chang, S; Ha, BK; Liu, Y; Saini, P; Whitlock, BB; Wolfe, SA | 1 |
| Cochrane, EV; Dijkstra, D; Lahti, RA; Mutin, A; Tamminga, CA; Tepper, PG; Wikström, H | 1 |
| Kling-Petersen, T; Ljung, E; Svensson, K | 1 |
| Fujikawa, M; Furukawa, T; Inoue, T; Nagashima, M; Yamada, K | 1 |
| Brent, PJ | 1 |
| Ha, BK; Saini, P; Whitlock, BB; Wolfe, SA | 1 |
| Akiyama, K; Kuroda, S; Okumura, K; Ujike, H | 1 |
| Furukawa, H; Hasegawa, T; Kitaichi, K; Nabeshima, T; Noda, Y | 1 |
| Kobayashi, T; Matsuno, K; Mita, S; Senda, T | 1 |
| Earley, B; Faherty, CJ; Leonard, BE | 1 |
| Jeanjean, AP; Laterre, EC; Maloteaux, JM | 1 |
| Fang, H; Helmeste, DM; Li, M; Tang, SW | 1 |
| Carlsson, A; Corey, PK; Lahti, AC; Lahti, RA; Tamminga, CA; Weiler, MA | 1 |
| Curzon, P; Decker, MW | 1 |
| Ekman, A; Eriksson, E; Hellstrand, M; Nilsson, CL | 2 |
| Chan, SL; Morgan, NG | 1 |
| Carey, JE; Frey, KA; Kilbourn, MR; Kuhl, DE; Mulholland, GK; Sherman, PS; Wieland, DM | 1 |
| Camarasa, J; Camins, A; Canudas, AM; Escubedo, E; Pallas, M; Pubill, D; Sureda, FX | 1 |
| Kobayashi, T; Matsuno, K; Mita, S; Murai, M; Senda, T | 1 |
| Borowicz, KK; Czuczwar, SJ; Kleinrok, Z | 1 |
| Garrone, B; Magnani, M; Pinza, M; Polenzani, L | 1 |
| Fu, D; Javitch, JA; Lin, H; Strange, PG; Wilson, J | 1 |
| Tamminga, CA | 1 |
| Takigawa, M; Wang, H | 1 |
| Akaike, A; Hashino, A; Kaneko, S; Katsuki, H; Kume, T; Minami, M; Nishikawa, H; Satoh, M; Taguchi, R | 1 |
| Carlsson, A; Carlsson, ML; Nilsson, M | 1 |
| Brown-Borg, HM; Ebadi, M; Muralikrishnan, D | 1 |
| Baeyens, JM; Cobos, EJ; Del Pozo, E | 1 |
| Burris, KD; Kikuchi, T; Miwa, T; Mori, T; Stark, A; Tadori, Y; Tottori, K | 1 |
| Galineau, L; Garcia, A; Houle, S; McCormick, P; Natesan, S; Seeman, P; Stableford, WT; Vasdev, N; Wilson, AA | 1 |
| Chen, R; Johnson, JL; Jordan, S; Kambayashi, J; Kikuchi, T; Kitagawa, H; McQuade, R; Regardie, K; Tadori, Y | 1 |
| Corsini, GU; Maggio, R; Millan, MJ; Novi, F | 1 |
| Calas, AG; Goursaud, S; Hermans, E; Jeanjean, AP; Koener, B; Maloteaux, JM; Van De Stadt, M | 1 |
| Carlsson, A; Carlsson, ML; Johansson, AM; Rung, E; Rung, JP; Svensson, K | 1 |
| Edmunds, AJ; Gao, GL; Morris, JA; Worthington, PA; Ye, M; Yu, JQ | 1 |
| Lowry, JP; O'Connor, JJ | 1 |
| Anwar-Ul Azim, M; Kitamura, Y; Kozaka, T; Miwa, D; Ogawa, K; Shiba, K; Uno, I | 1 |
| Azim, MA; Kitamura, Y; Kiyono, Y; Kozaka, T; Makino, A; Miwa, D; Ogawa, K; Shiba, K; Uno, I | 1 |
| Ma, GF; Ortiz, J; Raivio, N; Sabrià, J | 1 |
| Cao, P; Jia, T; Liao, J; Lou, Y; Wang, B; Wang, M; Yin, X | 1 |
| Canals, M; Capuano, B; Charlton, SJ; Christopoulos, A; Coudrat, T; Donthamsetti, P; Javitch, JA; Klein Herenbrink, C; Lane, JR; Scammells, PJ; Sexton, PM; Shonberg, J; Sykes, DA | 1 |
| Bezprozvanny, I; Geva, M; Grossman, I; Hayden, M; Kusko, R; Ryskamp, D; Wu, J | 1 |
| Bezprozvanny, IB; Bol'shakova, AV; Gainullina, AN; Kraskovskaya, NA; Kukanova, EO; Vlasova, OL | 1 |
7 review(s) available for preclamol and piperidines
| Article | Year |
|---|---|
Dextromethorphan and sigma ligands: common sites but diverse effects.
Topics: Animals; Dextromethorphan; Endorphins; Hallucinogens; Humans; Levorphanol; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism | 1989 |
Dopamine receptor agonists: mechanisms underlying autoreceptor selectivity. II. Theoretical considerations.
Topics: Animals; Antipsychotic Agents; Apomorphine; Behavior, Animal; Corpus Striatum; Cyclic AMP; Dextroamphetamine; Dopamine; Humans; Isomerism; Lisuride; Models, Neurological; Molecular Conformation; Motor Activity; Nucleus Accumbens; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Dopamine; Substantia Nigra; Synaptosomes | 1985 |
Dopamine-receptor agonists: mechanisms underlying autoreceptor selectivity. I. Review of the evidence.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Behavior, Animal; Brain; Caudate Nucleus; Deoxyglucose; Dopamine; Humans; Lisuride; Models, Biological; Nerve Tissue Proteins; Phenanthrenes; Piperidines; Rats; Receptors, Dopamine; Stereoisomerism; Substantia Nigra; Synaptosomes; Tegmentum Mesencephali | 1985 |
Dopaminergic and serotonergic control of neuroendocrine function.
Topics: alpha-Methyltyrosine; Animals; Antipsychotic Agents; Benzamides; Cattle; Dopamine; Hallucinogens; Hypothalamo-Hypophyseal System; Indoles; Methyltyrosines; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Receptors, Dopamine; Serotonin; Tetrahydronaphthalenes | 1984 |
Preclamol. A "designer drug" in the treatment of advanced Parkinson's disease.
Topics: Antiparkinson Agents; Dopamine Agonists; Humans; Parkinson Disease; Piperidines | 1996 |
Partial dopamine agonists in the treatment of psychosis.
Topics: Animals; Apomorphine; Autoreceptors; Brain; Dopamine Agonists; Humans; Piperidines; Psychotic Disorders; Receptors, Dopamine | 2002 |
Schizophrenia: from dopamine to glutamate and back.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Mice; Piperazines; Piperidines; Quinolones; Schizophrenia | 2004 |
5 trial(s) available for preclamol and piperidines
| Article | Year |
|---|---|
Pharmacologic properties of (-)-3PPP (preclamol) in man.
Topics: Administration, Oral; Adult; Chromatography, Gas; Dopamine Agents; Double-Blind Method; Half-Life; Humans; Injections, Intramuscular; Male; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1992 |
Motor effects of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine (preclamol) in Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Injections, Intramuscular; Levodopa; Male; Middle Aged; Neurologic Examination; Parkinson Disease; Piperidines | 1994 |
Morphine- and cocaine-induced conditioned place preference: effects of quinpirole and preclamol.
Topics: Animals; Cocaine; Conditioning, Operant; Dopamine Agonists; Male; Morphine; Narcotics; Piperidines; Rats; Rats, Wistar; Synaptic Transmission | 1996 |
Preclamol and parkinsonian fluctuations.
Topics: Antiparkinson Agents; Apomorphine; Blood Pressure; Dopamine Agonists; Female; Humans; Injections, Subcutaneous; Male; Middle Aged; Movement; Parkinson Disease; Piperidines; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1993 |
Antipsychotic properties of the partial dopamine agonist (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine(preclamol) in schizophrenia.
Topics: Adult; Antiparkinson Agents; Antipsychotic Agents; Cross-Over Studies; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Humans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1998 |
320 other study(ies) available for preclamol and piperidines
| Article | Year |
|---|---|
High-affinity dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine.
Topics: Allosteric Regulation; Animals; Antitussive Agents; Binding Sites; Brain; Computer Simulation; Dextromethorphan; Guinea Pigs; Hydrogen-Ion Concentration; Male; Pentazocine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1992 |
Characterization of [3H]desmethylimipramine binding in bovine adrenal medulla: interactions with sigma- and (or) phencyclidine-receptor ligands.
Topics: Adrenal Medulla; Animals; Binding Sites; Cattle; Desipramine; Dextromethorphan; Dizocilpine Maleate; Phenazocine; Phencyclidine; Piperidines; Potassium Chloride; Receptors, Opioid, delta; Receptors, Phencyclidine; Tranquilizing Agents | 1992 |
Competitive interactions at [3H]1,3-di(2-tolyl)guanidine (DTG)-defined sigma recognition sites in guinea pig brain.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Carbazoles; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Male; Pentazocine; Piperidines; Radioligand Assay; Receptors, Opioid; Receptors, sigma | 1992 |
Sigma ligand-induced emesis in the pigeon.
Topics: Animals; Apomorphine; Columbidae; Dextromethorphan; Dizocilpine Maleate; Dopamine Agents; Guanidines; Haloperidol; Male; Pentobarbital; Phenazocine; Piperidines; Propranolol; Psychotropic Drugs; Pyrimidines; Receptors, Opioid; Receptors, sigma; Vomiting | 1992 |
Persistent supersensitivity of sigma receptors develops during repeated methamphetamine treatment.
Topics: Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Tolerance; Male; Methamphetamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1992 |
Relationship between brain levels of 3-(3-hydroxyphenyl)-N-n-propylpiperidine HCl enantiomers and effects on locomotor activity in rats.
Topics: Animals; Brain; Dopamine Agents; Dose-Response Relationship, Drug; Half-Life; Injections, Subcutaneous; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Stereoisomerism; Tissue Distribution | 1992 |
Sigma receptor modulation of the muscle relaxant action of eperisone.
Topics: Animals; Behavior, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Haloperidol; In Vitro Techniques; Mice; Mice, Inbred ICR; Muscle Relaxants, Central; Piperidines; Propiophenones; Receptors, Opioid; Receptors, sigma | 1992 |
Supersensitivity of sigma receptors after repeated administration of cocaine.
Topics: Animals; Behavior, Animal; Cocaine; Dopamine Agents; Drug Administration Schedule; Injections, Intraperitoneal; Male; Narcotic Antagonists; Piperidines; Psychotropic Drugs; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1992 |
Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain.
Topics: Animals; Antipsychotic Agents; Benzamides; Brain; Corpus Striatum; Dopamine Agents; Dopamine Antagonists; Haloperidol; In Vitro Techniques; Liver; Male; Piperidines; Raclopride; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Opioid; Receptors, sigma; Remoxipride; Salicylamides | 1992 |
Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine.
Topics: Animals; Brain; Dopamine Agents; In Vitro Techniques; Ketanserin; Mice; Oxygen; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiperone | 1992 |
Effects of the local application of 3-PPP and sulpiride enantiomers into the nucleus accumbens or into the ventral tegmental area on rat locomotor activity: evidence for the functional importance of somatodendritic autoreceptors.
Topics: Animals; Dopamine Agents; Male; Motor Activity; Nucleus Accumbens; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sulpiride; Tegmentum Mesencephali | 1992 |
The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Brain; Dopamine Agents; GTP-Binding Proteins; Levodopa; Male; Neurotransmitter Agents; Pertussis Toxin; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Ribose; Virulence Factors, Bordetella | 1992 |
Biphasic dose-dependent effects of dopamine and involvement of dopamine autoreceptors on intra-ocular pressure in the rabbit.
Topics: Animals; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Intraocular Pressure; Male; N-Methylaspartate; Ocular Hypertension; Piperidines; Rabbits; Receptors, Dopamine; Thiothixene | 1992 |
Comparative effects of receptor inactivation, 17 beta-estradiol and pertussis toxin on dopaminergic inhibition of prolactin secretion in vitro.
Topics: Animals; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; Estradiol; GTP-Binding Proteins; Male; Pertussis Toxin; Phenoxybenzamine; Piperidines; Pituitary Gland, Anterior; Prolactin; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Drug; Virulence Factors, Bordetella | 1992 |
Characterization of the binding of [3H](+)-pentazocine to sigma recognition sites in guinea pig brain.
Topics: Animals; Antipsychotic Agents; Binding Sites; Binding, Competitive; Brain; Carbazoles; Dopamine Agents; Guinea Pigs; Haloperidol; Kinetics; Male; Pentazocine; Piperidines; Receptors, sigma | 1992 |
Effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on the prolactin suppression induced by a series of full and partial dopamine D2 receptor agonists in male rats.
Topics: 4-Butyrolactone; Adrenergic alpha-Antagonists; Animals; Apomorphine; Dopamine Agents; Ergolines; Levodopa; Male; Piperidines; Prolactin; Quinolines; Rats; Rats, Sprague-Dawley | 1992 |
Pre-synaptic dopaminergic control mechanisms for CCK-8 like immunoreactivity in the rat medial frontal cortex.
Topics: Animals; Apomorphine; Behavior, Animal; Cholecystokinin; Dopamine; Dopamine Agents; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nerve Degeneration; Neurons; Piperidines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Dopamine | 1992 |
BMY-14802 reverses the reduction of striatal dopamine release induced by (+)-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine.
Topics: Animals; Corpus Striatum; Dialysis; Dopamine; Dopamine Agents; Male; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1992 |
DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Biogenic Amines; Guinea Pigs; Male; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Receptors, sigma; Rotation; Serotonin Antagonists | 1992 |
[3H]DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'- oxoethyl)-piperidine HBr]: a receptor binding profile of a high-affinity novel sigma receptor ligand in guinea pig brain.
Topics: Animals; Antipsychotic Agents; Brain; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Mice; Phenazocine; Phenytoin; Piperidines; Receptors, sigma; Structure-Activity Relationship; Temperature | 1992 |
Multiple sigma binding sites in guinea-pig and rat brain membranes: G-protein interactions.
Topics: Animals; Binding, Competitive; Brain Chemistry; Dextromethorphan; Dopamine Agents; GTP-Binding Proteins; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Membranes; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid, delta | 1992 |
Ionic zinc may function as an endogenous ligand for the haloperidol-sensitive sigma 2 receptor in rat brain.
Topics: Animals; Binding, Competitive; Brain; Cations, Divalent; Copper; Electric Stimulation; Guanidines; Haloperidol; Hippocampus; Hydrogen-Ion Concentration; Kinetics; Male; Membranes; Pentazocine; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sensitivity and Specificity; Tritium; Zinc | 1992 |
Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency.
Topics: Animals; Calcium; Cinnamates; Cyclopropanes; Dose-Response Relationship, Drug; Ethylmaleimide; GTP-Binding Proteins; Guanidines; Haloperidol; Hippocampus; In Vitro Techniques; Magnesium; Male; N-Methylaspartate; Norepinephrine; Pertussis Toxin; Piperidines; Rats; Rats, Inbred Strains; Spiperone; Tritium; Virulence Factors, Bordetella | 1992 |
1,3-Di(2-[5-3H]tolyl)guanidine labels more than one site in rat forebrain.
Topics: Animals; Binding Sites; Binding, Competitive; Carbamazepine; Guanidines; Haloperidol; Male; Pentazocine; Phenytoin; Piperidines; Prosencephalon; Rats; Rats, Wistar; Receptors, sigma; Stereoisomerism | 1992 |
Sigma receptors are associated with cortical limbic areas in the primate brain.
Topics: Animals; Autoradiography; Binding Sites; Brain; Cerebral Cortex; Image Processing, Computer-Assisted; Limbic System; Macaca mulatta; Male; Piperidines; Radioligand Assay; Receptors, sigma; Tissue Distribution | 1992 |
Heterogeneous binding of sigma radioligands in the rat brain and liver: possible relationship to subforms of cytochrome P-450.
Topics: Animals; Brain; Cytochrome P-450 Enzyme System; Guanidines; Haloperidol; Kinetics; Ligands; Liver; Male; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Subcellular Fractions | 1991 |
Computer-assisted modeling of multiple dextromethorphan and sigma binding sites in guinea pig brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Computer Simulation; Dextromethorphan; Guanidines; Guinea Pigs; Haloperidol; Kinetics; Male; Models, Biological; Piperidines; Receptors, Opioid; Receptors, sigma; Tritium | 1991 |
Overexpression of sigma receptors in nonneural human tumors.
Topics: Binding, Competitive; Carcinoma; Colonic Neoplasms; Guanidines; Humans; In Vitro Techniques; Kidney Neoplasms; Neoplasms; Piperidines; Receptors, Opioid; Receptors, sigma; Sarcoma | 1991 |
Regulation of sigma receptors and responsiveness to guanine nucleotides following repeated exposure of rats to haloperidol: further evidence for multiple sigma binding sites.
Topics: Adenosine Triphosphate; Animals; Brain; Cell Membrane; Down-Regulation; Guanidines; Guanine Nucleotides; Guanylyl Imidodiphosphate; Haloperidol; Kinetics; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Reference Values | 1991 |
Effects of the two partial D2 agonists (+)- and (-)-3-PPP on prolactin release in EEDQ treated male rats.
Topics: 4-Butyrolactone; Animals; Brain; Dopamine Agents; Male; Piperidines; Prolactin; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Reference Values | 1991 |
Differential effects of dopamine agonists upon stimulated limbic and striatal dopamine release: in vivo voltammetric data.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Bromocriptine; Corpus Striatum; Dopamine; Dopamine Agents; Electrochemistry; Electrophysiology; Ergolines; In Vitro Techniques; Limbic System; Male; Microelectrodes; Nucleus Accumbens; Pergolide; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1991 |
[3H]DTG and [3H](+)-3-PPP label pharmacologically distinct sigma binding sites in guinea pig brain membranes.
Topics: Animals; Binding, Competitive; Brain; Dextromethorphan; Dopamine Agents; Guanidines; Guinea Pigs; Haloperidol; In Vitro Techniques; Kinetics; Membranes; Phenazocine; Phenytoin; Piperidines; Receptors, Opioid; Receptors, sigma | 1991 |
Evidence for an anti-amnesic effect of JO 1784 in the rat: a potent and selective ligand for the sigma receptor.
Topics: Amnesia; Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Carbazoles; Cinnamates; Cyclopropanes; Dopamine Agents; Dose-Response Relationship, Drug; Guanidines; Ligands; Male; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Scopolamine | 1991 |
Dopamine receptors, controlling dopamine levels in rat adrenal glands-comparison with central dopaminergic autoreceptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Medulla; Animals; Apomorphine; Azepines; Diencephalon; Domperidone; Dopamine; Dopamine Agents; Epinephrine; Ergolines; Lisuride; Male; Norepinephrine; Phenanthrenes; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Telencephalon | 1991 |
Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Electric Stimulation; Guanidines; Haloperidol; Hippocampus; Male; Piperidines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1991 |
Effects of low, autoreceptor selective doses of dopamine agonists on the discriminative cue and locomotor hyperactivity produced by d-amphetamine.
Topics: Animals; Conditioning, Operant; Cues; Dextroamphetamine; Discrimination, Psychological; Dopamine Agents; Ergolines; Male; Motor Activity; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1991 |
The human sigma site, which resembles that in NCB20 cells, may correspond to a low-affinity site in guinea pig brain.
Topics: Animals; Brain Chemistry; Cells, Cultured; Cerebral Cortex; Cricetinae; Cricetulus; Dopamine Agents; Guanidines; Guinea Pigs; Humans; Kinetics; Male; Mice; Neuroblastoma; Pentazocine; Phenazocine; Piperidines; Radioligand Assay; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Tumor Cells, Cultured | 1991 |
Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: further evidence for a functional modulation of N-methyl-D-aspartate (NMDA) receptor complex-mediated events by sigma ligands.
Topics: Animals; Cerebellum; Cyclic GMP; Dopamine Agents; Harmaline; Ligands; Male; Methamphetamine; Mice; Pentylenetetrazole; Piperidines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma; Serine | 1991 |
Sigma-receptors: implication for the control of neuronal activity of nigral dopamine-containing neurons.
Topics: Animals; Apomorphine; Binding, Competitive; Dizocilpine Maleate; Dopamine; Dopamine Agents; Male; Neurons; Piperidines; Quinolines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereotaxic Techniques; Substantia Nigra | 1991 |
Yawning produced by dopamine agonists in rhesus monkeys.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antipsychotic Agents; Apomorphine; Benzazepines; Dopamine; Dopamine Agents; Dopamine Antagonists; Ergolines; Macaca mulatta; Male; Physostigmine; Piperidines; Quinpirole; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Yawning | 1991 |
Behavioural profile of partial D2 dopamine receptor agonists. 1. Atypical inhibition of d-amphetamine-induced locomotor hyperactivity and stereotypy.
Topics: Animals; Dextroamphetamine; Dopamine Agents; Dose-Response Relationship, Drug; Ergolines; Lisuride; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Stereotyped Behavior | 1991 |
Dopamine and its agonists reduce a light-sensitive pool of cyclic AMP in mouse photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzazepines; Cyclic AMP; Dark Adaptation; Dopamine; Dopamine Agents; Ergolines; Ligands; Light; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Photoreceptor Cells; Piperidines; Quinpirole; Receptors, Dopamine | 1990 |
(+) 3-[3-hydroxyphenyl-N-(1-propyl) piperidine] selectively differentiates effects of sigma ligands on neurochemical pathways modulated by sigma receptors: evidence for subtypes, in vivo.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Butaclamol; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Dopamine Agents; Male; Mice; Pentazocine; Phenazocine; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid; Receptors, sigma | 1991 |
Interactions of sigma and phencyclidine receptor ligands with the norepinephrine uptake carrier in both rat brain and rat tail artery.
Topics: Animals; Biological Transport; Brain; Desipramine; Dizocilpine Maleate; Male; Norepinephrine; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tail; Vasoconstriction | 1991 |
Characterization of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) binding sites in C57BL/6 mouse brain: mutual effects of monoamine oxidase inhibitors and sigma ligands on MPTP and sigma binding sites.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cell Membrane; Clorgyline; Kinetics; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Receptors, Opioid; Receptors, sigma; Selegiline | 1991 |
Binding of sigma-ligands to C57BL/6 mouse brain membranes: effects of monoamine oxidase inhibitors and subcellular distribution studies suggest the existence of sigma-receptor subtypes.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Binding Sites; Brain; Guanidines; In Vitro Techniques; Ligands; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Phenazocine; Piperidines; Receptors, Opioid; Receptors, sigma | 1991 |
Electrophysiological and binding studies on intact NCB-20 cells suggest presence of a low affinity sigma receptor.
Topics: Animals; Cricetinae; Cricetulus; Hybrid Cells; Ligands; Mice; Neuroblastoma; Phenazocine; Piperidines; Potassium Channels; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Tumor Cells, Cultured | 1991 |
Differential agonist profile of the enantiomers of 3-PPP at striatal dopamine autoreceptors: dependence on extracellular dopamine.
Topics: Animals; Biogenic Monoamines; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Electrochemistry; Ergolines; In Vitro Techniques; Lisuride; Male; Nerve Tissue Proteins; Nucleus Accumbens; Piperidines; Potassium; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1991 |
Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Ligands; Male; Mice; Opipramol; Organ Specificity; Phencyclidine; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
(-)PPAP: a new and selective ligand for sigma binding sites.
Topics: Animals; Catalysis; Dextroamphetamine; Discrimination, Psychological; Guinea Pigs; Haloperidol; In Vitro Techniques; Male; Piperidines; Propylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
Selectivity of some "specific" opioid ligands?
Topics: Animals; Benzomorphans; Binding, Competitive; Brain; Dynorphins; Female; Haloperidol; In Vitro Techniques; Mice; Morphinans; Peptide Fragments; Phencyclidine; Piperidines; Receptors, Opioid | 1990 |
Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; Animals; Dopamine Agents; Dopamine Antagonists; Male; Models, Structural; Molecular Conformation; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Structure-Activity Relationship | 1990 |
No mediolateral differences in striatal autoreceptor-mediated modulation of dopamine release: in vivo voltammetric data.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Electrochemistry; Male; Metoclopramide; Piperidines; Rats; Rats, Inbred Strains | 1990 |
The role of the dopaminergic system in the modulation of the acoustic startle response in the rat.
Topics: Animals; Apomorphine; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Reflex, Startle; Stereoisomerism | 1990 |
Failure of sigma-receptor ligands to reduce the excitatory actions of N-methyl-DL-aspartate on rat spinal neurons in-vivo.
Topics: Animals; Aspartic Acid; Haloperidol; In Vitro Techniques; Kainic Acid; Ligands; N-Methylaspartate; Neurons; Oxadiazoles; Piperidines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord; Stereoisomerism | 1990 |
Binding of umespirone to the sigma receptor: evidence for multiple affinity states.
Topics: Animals; Antipsychotic Agents; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Chlorpromazine; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techniques; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine | 1990 |
Inhibition of potassium currents by the sigma receptor ligand (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine in sympathetic neurons of the mouse isolated hypogastric ganglion.
Topics: Animals; Atropine; Carbazoles; Dopamine Agents; Evoked Potentials; Ganglia, Sympathetic; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred DBA; Neurons; Piperidines; Potassium Channels; Receptors, Opioid; Receptors, sigma; Sulpiride; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1990 |
The sigma [corrected] ligand rimcazole antagonises (+)SKF 10,047, but not (+)3-PPP, in the mouse isolated vas deferens.
Topics: Animals; Antipsychotic Agents; Carbazoles; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Muscle, Smooth; Phenazocine; Piperidines; Stereoisomerism; Vas Deferens | 1990 |
Polyamines non-competitively inhibit [3H]3-PPP binding to sigma receptors.
Topics: Adrenal Medulla; Animals; Biogenic Polyamines; Brain Chemistry; Cattle; Dopamine Agents; Guinea Pigs; In Vitro Techniques; Kinetics; Piperidines; Rats; Receptors, Opioid; Receptors, sigma | 1990 |
Differentiation of the active site of minaprine from that of phencyclidine in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Binding Sites; Hippocampus; Ketamine; Male; Membranes; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Potassium Channels; Pyridazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1990 |
Ifenprodil and SL 82.0715 potently inhibit binding of [3H](+)-3-PPP to sigma binding sites in rat brain.
Topics: Animals; Binding, Competitive; Brain; Dopamine Agents; Kinetics; Male; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Tritium | 1990 |
[Increase of the number of bone marrow T-suppressor cells under inhibition of immunogenesis during changes of the activity of the neuromediator system].
Topics: 1-Naphthylamine; Animals; Bone Marrow; Bone Marrow Cells; Dopamine Agents; Leukocyte Count; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neuroimmunomodulation; Neurotransmitter Agents; Piperidines; Serotonin Antagonists; Sertraline; T-Lymphocytes, Regulatory | 1990 |
GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain.
Topics: Animals; Antipsychotic Agents; Brain; Dopamine Agents; Fluspirilene; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1990 |
Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: protection by SKF 10,047.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Dopamine Agents; Glutamates; Glutamic Acid; Neurons; Neurotoxins; Phenazocine; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
[GABAergic modulation of amnesic trace reproduction by activation of the dopaminergic system].
Topics: Animals; Avoidance Learning; Bupropion; Diazepam; Dopamine Agents; Ergolines; Male; Mice; Mice, Inbred BALB C; Piperidines; Propiophenones; Quinpirole; Receptors, GABA-A | 1990 |
Characterization of [3H] (+)-pentazocine, a highly selective sigma ligand.
Topics: Animals; Binding, Competitive; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Pentazocine; Phenazocine; Piperidines; Receptors, Opioid; Receptors, sigma | 1990 |
The effect of sigma ligands on dextromethorphan binding sites in the guinea pig.
Topics: Animals; Binding Sites; Dextromethorphan; Guinea Pigs; Hallucinogens; Haloperidol; In Vitro Techniques; Kinetics; Levorphanol; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
Characterization of (+)-[3H]3-PPP and [3H]TCP binding sites in membrane preparations of bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Binding Sites; Binding, Competitive; Cattle; In Vitro Techniques; Membranes; Phencyclidine; Piperidines; Receptors, Opioid; Receptors, sigma | 1990 |
Ifenprodil potently interacts with [3H](+)-3-PPP-labeled sigma binding sites in guinea pig brain membranes.
Topics: Animals; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Piperidines; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors.
Topics: Animals; Brain; Haloperidol; In Vitro Techniques; Male; Motor Activity; Parasympathetic Nervous System; Pentazocine; Phosphatidylinositols; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma | 1990 |
Ontogeny of PCP and sigma receptors in rat brain.
Topics: Aging; Animals; Brain; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1990 |
Multiple vascular effects of sigma and PCP ligands: inhibition of amine uptake and contractile responses.
Topics: Animals; Cocaine; Desoxycorticosterone; Haloperidol; Male; Norepinephrine; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Serotonin; Vasoconstriction | 1990 |
Drug specificity of pharmacological dystonia.
Topics: Animals; Benzomorphans; Drug Interactions; Dystonia; Male; Microinjections; Morphinans; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Red Nucleus | 1990 |
Differential effects of sigma and phencyclidine receptor ligands on learning.
Topics: Animals; Avoidance Learning; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ketamine; Ligands; Male; Memory; Pentazocine; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine; Retention, Psychology | 1990 |
Computer-assisted analysis of dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine.
Topics: Allosteric Site; Animals; Binding, Competitive; Brain; Dextromethorphan; Electronic Data Processing; In Vitro Techniques; Kinetics; Models, Biological; Pentazocine; Piperazines; Piperidines; Rats; Rats, Inbred Strains; Tritium | 1990 |
Multiple sites of action of (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3PPP) in blood vessels.
Topics: Animals; Arteries; Cocaine; Desoxycorticosterone; Ear; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulpiride; Tail | 1990 |
Autoradiographic localization of [3H]dextromethorphan (DM) in guinea pig brain: allosteric enhancement by ropizine.
Topics: Allosteric Regulation; Animals; Autoradiography; Binding Sites; Brain; Dextromethorphan; Guinea Pigs; In Vitro Techniques; Levorphanol; Piperazines; Piperidines; Tissue Distribution | 1990 |
Lack of functional evidence for the involvement of sigma opiate receptors in the actions of the 3-PPP enantiomers on central dopaminergic systems: discrepancies between in vitro and in vivo observations.
Topics: Animals; Butaclamol; Corpus Striatum; Dopamine; Limbic System; Male; Motor Activity; Pentazocine; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Reserpine; Stereoisomerism | 1985 |
Effects of dextromethorphan site ligands and allosteric modifiers on the binding of (+)-[3H]3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine.
Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Dextromethorphan; Guinea Pigs; In Vitro Techniques; Levorphanol; Phenytoin; Piperazines; Piperidines; Receptors, Opioid; Receptors, sigma | 1989 |
Sigma-receptors in endocrine organs: identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary.
Topics: Adrenal Glands; Animals; Autoradiography; Brain Chemistry; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Female; Haloperidol; Hypophysectomy; Male; Ovary; Phencyclidine; Piperidines; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Testis; Tissue Distribution | 1989 |
Acylation of sigma receptors by Metaphit, an isothiocyanate derivative of phencyclidine.
Topics: Acylation; Animals; Behavior, Animal; Brain Chemistry; Electrophysiology; Guinea Pigs; In Vitro Techniques; Membranes; Phencyclidine; Piperidines; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine | 1989 |
Evidence for a multi-site model of the rat brain sigma receptor.
Topics: Animals; Brain; In Vitro Techniques; Male; Membranes; Models, Biological; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Synaptosomes; Ultraviolet Rays | 1989 |
Vasoconstrictor-induced heterologous down-regulation of vascular atrial natriuretic peptide receptor.
Topics: Angiotensin II; Animals; Arginine Vasopressin; Cyclic GMP; Humans; In Vitro Techniques; Iodine Radioisotopes; Muscle, Smooth, Vascular; Piperidines; Rats; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents | 1989 |
Phencyclidine and sigma receptors in rat spinal cord: binding characterization and quantitative autoradiography.
Topics: Animals; Autoradiography; Binding, Competitive; Ganglia, Spinal; Male; Narcotic Antagonists; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Spinal Cord | 1989 |
Sertraline potently displaces (+)-[3H]3-PPP binding to sigma sites in rat brain.
Topics: 1-Naphthylamine; Animals; Binding, Competitive; Brain Chemistry; In Vitro Techniques; Naphthalenes; Piperidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Serotonin Antagonists; Sertraline | 1989 |
Differentiation of phencyclidine and sigma receptor types affecting the central inspiratory termination mechanism in cat.
Topics: Animals; Brain Stem; Cats; Decerebrate State; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Guanidines; Phencyclidine; Phrenic Nerve; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Respiration | 1989 |
Multiple affinity binding states of the sigma receptor: effect of GTP-binding protein-modifying agents.
Topics: Animals; Binding, Competitive; Chlorpromazine; Ethylmaleimide; GTP-Binding Proteins; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Pentazocine; Pertussis Toxin; Piperidines; Rats; Receptors, Opioid; Receptors, sigma; Virulence Factors, Bordetella | 1989 |
An examination of the putative sigma-receptor in the mouse isolated vas deferens.
Topics: Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Muscle Contraction; Muscle, Smooth; Naloxone; Piperidines; Receptors, Opioid; Receptors, sigma; Vas Deferens | 1989 |
(+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)-piperidine binding to sigma receptors in mouse brain in vivo.
Topics: Animals; Brain Chemistry; Dopamine Agents; Dose-Response Relationship, Drug; Mice; Piperidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Time Factors | 1989 |
Selective sigma receptor agonist and antagonist affect dopamine neuronal activity.
Topics: Animals; Antipsychotic Agents; Dopamine; In Vitro Techniques; Male; Membranes; Microelectrodes; Narcotic Antagonists; Narcotics; Neurons; Piperidines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spiperone | 1989 |
Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors.
Topics: Animals; Apomorphine; Binding, Competitive; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Dopamine Agents; Guanidines; Guinea Pigs; Hydroxides; Molecular Structure; Pentazocine; Phencyclidine; Piperidines; Potassium; Potassium Compounds; Receptors, Dopamine; Receptors, Opioid; Receptors, sigma; Tritium | 1989 |
The partial dopamine receptor agonists (--)-3-PPP and transdihydrolisuride enhance prolactin secretion in female but not in male rats.
Topics: Animals; Dopamine Agents; Dose-Response Relationship, Drug; Female; Male; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Sex Factors | 1989 |
Expression of (+)-3-PPP binding sites in the PC12 pheochromocytoma cell line.
Topics: Adrenal Gland Neoplasms; Animals; Cell Line; Cell Membrane; Dopamine Agents; Humans; Pheochromocytoma; Piperidines; Radioligand Assay; Receptors, Drug | 1989 |
Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Corpus Striatum; Depression, Chemical; Dihydroxyphenylalanine; Dopamine; Ergolines; Hydrazines; Limbic System; Male; Naphthalenes; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Reserpine; Serotonin; Tetrahydronaphthalenes; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1989 |
Electrophysiological effects of selective sigma-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbazoles; Cell Membrane; Dibenzocycloheptenes; Dizocilpine Maleate; Dopamine; Dopamine Agents; Male; Neurons; Pentazocine; Phencyclidine; Piperidines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Substantia Nigra | 1989 |
Occurrence of yawning and decrease of prolactin levels via stimulation of dopamine D2-receptors after administration of SND 919 in rats.
Topics: alpha-Methyltyrosine; Animals; Azepines; Behavior, Animal; Benzothiazoles; Dopamine Agents; Male; Methyltyrosines; Piperidines; Pramipexole; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Thiazoles; Yawning | 1989 |
Dopamine autoreceptor agonists attenuate spontaneous motor activity but not spontaneous fighting in individually-housed mice.
Topics: Aggression; Agonistic Behavior; Animals; Apomorphine; Catalepsy; Dopamine Agents; Dose-Response Relationship, Drug; Housing, Animal; Male; Mice; Motor Activity; Piperidines; Social Isolation; Stereoisomerism | 1989 |
Influence of dopaminergic and noradrenergic systems on the release of opioid peptides in guinea-pig ileum.
Topics: Adrenergic alpha-Antagonists; Animals; Domperidone; Dopamine; Endorphins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Myenteric Plexus; Naloxone; Norepinephrine; Piperidines; Prazosin; Receptors, Dopamine; Yohimbine | 1989 |
DTG and (+)-3-PPP inhibit a ligand-activated hyperpolarization in mammalian neurons.
Topics: Animals; Brimonidine Tartrate; Dopamine Agents; Enkephalin, Methionine; Guanidines; Haloperidol; Male; Membrane Potentials; Neurons; Norepinephrine; Piperidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Serotonin | 1989 |
Inhibition by pertussis toxin of the soporific effects induced by stimulation of dopamine D2 autoreceptors in the ventral tegmental area in rats.
Topics: Adenylate Cyclase Toxin; Animals; Apomorphine; Electrocardiography; Male; Pertussis Toxin; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tegmentum Mesencephali; Time Factors; Virulence Factors, Bordetella | 1989 |
The enhanced responsiveness of hypophyseal DA receptors in female rats induced by repeated reserpine treatment is not due to decreased oestrogen secretion.
Topics: Animals; Estradiol; Estrogens; Female; Lisuride; Ovariectomy; Piperidines; Pituitary Gland, Posterior; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine | 1989 |
Structural determinants of sigma receptor affinity.
Topics: Animals; Brain; Hydrogen-Ion Concentration; Male; Molecular Conformation; Narcotics; Phenothiazines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Tritium | 1987 |
Limited stimulus generalization between delta 9-THC and diazepam in pigeons and gerbils.
Topics: Animals; Benzodiazepinones; Columbidae; Diazepam; Discrimination, Psychological; Dronabinol; Generalization, Stimulus; Gerbillinae; Male; Piperidines; Receptors, GABA-A | 1988 |
Regulation of the binding of sigma- and phencyclidine (PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions.
Topics: Animals; Binding, Competitive; Brain; Cations; Guanine Nucleotides; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Receptors, Neurotransmitter; Receptors, Phencyclidine; Subcellular Fractions | 1988 |
Comparison of the actions of phencyclidine and sigma ligands on CA1 hippocampal pyramidal neurons in the rat.
Topics: Action Potentials; Animals; Aspartic Acid; Guanidines; Hippocampus; Male; N-Methylaspartate; Neurons; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1988 |
Up-regulation of rat cortical sigma receptors after subchronic administration of rimcazole and 1,3-di(2-tolyl)guanidine.
Topics: Animals; Carbazoles; Guanidines; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma | 1988 |
Sigma and PCP receptors in human frontal cortex membranes.
Topics: Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Humans; In Vitro Techniques; Membranes; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1988 |
Relative selectivity of 6,7-dihydroxy-2-dimethylaminotetralin, N-n-propyl-3-(3-hydroxyphenyl)piperidine, N-n-propylnorapomorphine and pergolide as agonists at striatal dopamine autoreceptors and postsynaptic dopamine receptors.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Ergolines; Haloperidol; Homovanillic Acid; Male; Naphthalenes; Pergolide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Sodium Oxybate; Tetrahydronaphthalenes; Tyrosine 3-Monooxygenase | 1985 |
Effect of dopaminergic drugs on striatal acetylcholine concentration.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
In-vitro and in-vivo metabolism of the presynaptic dopamine agonist 3-PPP to a catecholic analogue in rats.
Topics: Animals; Biotransformation; Catecholamines; Female; Hydrogen-Ion Concentration; Hydroxylation; In Vitro Techniques; Kinetics; Methylation; Microsomes, Liver; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Stereoisomerism | 1985 |
Is inhibition of striatal synaptosomal tyrosine hydroxylation by dopamine agonists a measure of dopamine autoreceptor function?
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Azepines; Corpus Striatum; Depression, Chemical; Dopamine; Ergolines; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Pergolide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter; Synaptosomes; Tyrosine 3-Monooxygenase | 1985 |
Performance deficit induced by low doses of dopamine agonists in rats. Toward a model for approaching the neurobiology of negative schizophrenic symptomatology?
Topics: Amisulpride; Animals; Antipsychotic Agents; Apomorphine; Disease Models, Animal; Male; Phenothiazines; Pimozide; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reinforcement Schedule; Reinforcement, Psychology; Schizophrenia; Schizophrenic Psychology; Sulpiride | 1986 |
Investigation of dopamine content, synthesis, and release in the rabbit retina in vitro: II. Effects of high potassium, adenylate cyclase activators, and N-n-propyl-3-(3-hydroxyphenyl) piperidine.
Topics: 2-Chloroadenosine; Adenosine; Adenylyl Cyclases; Animals; Calcium; Colforsin; Dopamine; Enzyme Activation; Female; Male; Piperidines; Potassium; Rabbits; Retina; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 1986 |
Effects of dopaminomimetics on the secretion of VIP-like immunoreactivity in conscious dogs.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Apomorphine; Benzazepines; Dogs; Ergolines; Nitroglycerin; Pergolide; Piperidines; Prazosin; Receptors, Dopamine; Somatostatin; Vasoactive Intestinal Peptide | 1986 |
Two automated locomotor activity tests for dopamine autoreceptor agonists.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Drug Evaluation, Preclinical; Exploratory Behavior; Indoles; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1986 |
1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Benzomorphans; Binding Sites; Brain; Guanidines; Guinea Pigs; Hallucinogens; In Vitro Techniques; Ligands; Male; Morphinans; Piperidines; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tritium | 1986 |
Permissive role of D-1 receptor stimulation by endogenous dopamine for the expression of postsynaptic D-2-mediated behavioural responses. Yawning in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic alpha-Agonists; Animals; Azepines; Benzazepines; Brain Chemistry; Dopamine; Ergolines; Kainic Acid; Ketanserin; Male; Metergoline; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Sulpiride; Yawning | 1987 |
Comparison of changes in locomotor activity with striatal homovanillic acid and 3,4-dihydroxyphenylacetic acid concentrations following the bilateral intranigral injection of dopamine agonist drugs in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Motor Activity; Phenylacetates; Piperidines; Rats; Rats, Inbred Strains; Substantia Nigra; Sucrose | 1987 |
Relationship between receptor occupancy and response at striatal dopamine autoreceptors.
Topics: 4-Butyrolactone; Adrenergic alpha-Antagonists; Animals; Apomorphine; Corpus Striatum; Dihydroxyphenylalanine; Homeostasis; Hydrazines; Levodopa; Male; Piperidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1987 |
Effects of apomorphine and (+/-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine, injected into the striatum, on the caudate spindle in the rat.
Topics: Animals; Antipsychotic Agents; Apomorphine; Corpus Striatum; Dopamine; Electric Stimulation; Electrophysiology; Injections; Male; Piperidines; Rats; Rats, Inbred Strains | 1987 |
Behavioural and ECoG spectrum power effects after intraventricular injection of drugs altering dopaminergic transmission in rats.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzazepines; Brain; Catheters, Indwelling; Dopamine; Dose-Response Relationship, Drug; Electroencephalography; Electrophysiology; Injections, Intraventricular; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Synaptic Transmission | 1987 |
Pharmacological specificity of some psychotomimetic and antipsychotic agents for the sigma and PCP binding sites.
Topics: Animals; Antipsychotic Agents; Binding, Competitive; Haloperidol; In Vitro Techniques; Male; Phenazocine; Phencyclidine; Piperidines; Psychotropic Drugs; Rats; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1988 |
Dopamine D-2 receptors in the ventral tegmental area mediate behavioural and electrocortical sleep of dopaminergic drugs in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cerebral Cortex; Dopamine Agents; Electric Stimulation; Electroencephalography; Piperidines; Rats; Receptors, Dopamine; Sleep; Tegmentum Mesencephali | 1988 |
Dopamine D2 receptors in brain and anterior pituitary recognize agonist and antagonist actions of (-)-3-PPP.
Topics: Animals; Brain; Cattle; Caudate Nucleus; Cell Membrane; Corpus Striatum; Dopamine Antagonists; Guanine Nucleotides; Male; Piperidines; Pituitary Gland, Anterior; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sodium Chloride; Swine | 1985 |
Ventral tegmental area: site through which dopamine D2-receptor agonists evoke behavioural and electrocortical sleep in rats.
Topics: Animals; Apomorphine; Cerebral Cortex; Electroencephalography; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Sleep; Sulpiride; Tegmentum Mesencephali | 1988 |
Phencyclidine and sigma opiate receptors in brain: biochemical and autoradiographical differentiation.
Topics: Autoradiography; Brain; Humans; In Vitro Techniques; Membranes; Phenazocine; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Phencyclidine | 1985 |
Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons.
Topics: Animals; Cannabidiol; Cannabinoids; Columbidae; Discrimination Learning; Discrimination, Psychological; Dronabinol; Male; Piperidines; Rats; Rats, Inbred Strains; Species Specificity; Time Factors | 1986 |
Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Guinea Pigs; Male; Piperidines; Rats; Receptors, Opioid; Spinal Cord; Tritium | 1986 |
Sigma receptors on NCB-20 hybrid neurotumor cells labeled with (+)[3H]SKF 10,047 and (+)[3H]3-PPP.
Topics: Animals; Brain; Cells, Cultured; Cricetinae; Cricetulus; Hybrid Cells; Kinetics; Neuroblastoma; Phenazocine; Phencyclidine; Piperidines; Receptors, Opioid; Receptors, Opioid, delta; Stereoisomerism | 1986 |
Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.
Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; In Vitro Techniques; Kinetics; Male; Phenazocine; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Stereoisomerism | 1986 |
(+)-3-PPP antagonizes the discriminative stimulus effects of (+)-N-allylnormetazocine.
Topics: Animals; Binding Sites; Conditioning, Operant; Discrimination, Psychological; Generalization, Stimulus; Phenazocine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Antagonist effects of the enantiomers of 3-PPP towards alpha 1-adrenoceptors coupled to inositol phospholipid breakdown in the rat cerebral cortex.
Topics: Animals; Antiparkinson Agents; Atropine; Carbachol; Cerebral Cortex; Haloperidol; In Vitro Techniques; Inositol Phosphates; Male; Norepinephrine; Phenoxybenzamine; Piperidines; Prazosin; Raclopride; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Salicylamides; Stereoisomerism; Sugar Phosphates | 1987 |
Both the sigma receptor-specific ligand (+)3-PPP and the PCP receptor-specific ligand TCP act in the mouse vas deferens via augmentation of electrically evoked norepinephrine release.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Contraction; Norepinephrine; Phencyclidine; Piperidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Vas Deferens | 1987 |
Alterations in motor behaviour produced by the isomers of 3-PPP in the MPTP-treated marmoset.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Callitrichinae; Female; Isomerism; Levodopa; Male; Motor Activity; Piperidines; Pyridines; Receptors, Dopamine; Time Factors | 1986 |
Anxiolytic-like action of the 3-PPP enantiomers in the Vogel conflict paradigm.
Topics: Animals; Arousal; Avoidance Learning; Conflict, Psychological; Dose-Response Relationship, Drug; Drinking; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1987 |
7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Diencephalon; Dihydroxyphenylalanine; Frontal Lobe; Hydroxydopamines; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Piperazines; Piperidines; Quinolines; Quinolones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Telencephalon | 1988 |
Dopamine (DA) autoreceptor efficacy of 3-PPP enantiomers after short-term synaptic DA deprivation.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Brain; Brain Chemistry; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Limbic System; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism; Synapses | 1988 |
Heterogeneous rotational responsiveness in 6-hydroxydopamine-denervated rats: pharmacological and neurochemical characterization.
Topics: Animals; Apomorphine; Benzopyrans; Brain Chemistry; Corpus Striatum; Dopamine; Ergolines; Hydroxydopamines; Male; Oxidopamine; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Rotation; Stereotyped Behavior; Sympathectomy, Chemical | 1988 |
Effects of intraperitoneal administration of apomorphine and the isomers of 3-(1-propyl-3-piperidinyl)phenol on the firing activity of substantia nigra dopamine neurons: comparison of agonist efficacies and development of acute tolerance.
Topics: Action Potentials; Animals; Apomorphine; Drug Tolerance; Injections, Intraperitoneal; Injections, Intravenous; Male; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Substantia Nigra | 1988 |
Suppression of neuroleptic-induced persistent abnormal movements in Cebus apella monkeys by enantiomers of 3-PPP.
Topics: Animals; Cebus; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Fluphenazine; Piperidines; Stereoisomerism; Time Factors | 1988 |
Pharmacological profile of dopamine receptor agonists as studied by brain dialysis in behaving rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Azepines; Behavior, Animal; Benzazepines; Brain; Dialysis; Dopamine; Ergolines; Homovanillic Acid; Isomerism; Male; Motor Activity; Neurons; Pergolide; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Time Factors | 1988 |
The intrinsic activity of (-)-3-PPP (preclamol) on pituitary DA receptors in female rats is enhanced following chronic DA depletion.
Topics: Animals; Dopamine; Female; Hyperprolactinemia; Piperidines; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine | 1988 |
Neuropharmacology and stereochemistry of dopamine receptor agonist and antagonist enantiomeric pairs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aporphines; Dopamine; Molecular Conformation; Naphthalenes; Piperidines; Receptors, Dopamine; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes | 1988 |
O-methylated catechol metabolites of 3-(3-hydroxy-phenyl)-N-propyl piperidine (3-PPP): synthesis, pharmacological and acute toxicological evaluation.
Topics: Animals; Antiparkinson Agents; Chemical Phenomena; Chemistry; Female; Male; Piperidines; Rats; Rats, Inbred Strains | 1987 |
Apomorphine-induced penile erection and yawning: site of action in brain.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Brain; Dopamine; Dopamine Antagonists; Ergolines; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Penile Erection; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Yawning | 1987 |
Compounds with selectivity for dopamine autoreceptors: effects on prolactin secretion in male and female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Azepines; Female; Male; Phenanthrenes; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes | 1986 |
Effects of raclopride on exploratory locomotor activity, treadmill locomotion, conditioned avoidance behaviour and catalepsy in rats: behavioural profile comparisons between raclopride, haloperidol and preclamol.
Topics: Animals; Avoidance Learning; Behavior, Animal; Catalepsy; Exploratory Behavior; Haloperidol; Male; Motor Activity; Piperidines; Raclopride; Rats; Rats, Inbred Strains; Salicylamides; Scopolamine | 1987 |
Partial protection against hyperbaric oxygen induced convulsions by dopaminergic agents in mice: possible involvement of autoreceptors?
Topics: Animals; Antiparkinson Agents; Apomorphine; Body Temperature; Dose-Response Relationship, Drug; Haloperidol; Hyperbaric Oxygenation; Levodopa; Male; Mice; Mice, Inbred CBA; Piperidines; Reaction Time; Receptors, Dopamine; Respiration; Seizures | 1987 |
Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine.
Topics: Animals; Carbamates; Pharmaceutical Preparations; Piperidines; Prodrugs; Rats; Rats, Inbred Strains; Receptors, Dopamine; Structure-Activity Relationship | 1987 |
On the mode of action of six putative dopamine receptor agonists on suppression of exploratory behaviour in rats.
Topics: Animals; Bromocriptine; Ergolines; Exploratory Behavior; Habituation, Psychophysiologic; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1987 |
The intrinsic activities of the partial dopamine receptor agonists (-)-3-PPP and TDHL on pituitary dopamine receptors are lower in female than in male rats.
Topics: Animals; Antiparkinson Agents; Ergolines; Female; In Vitro Techniques; Lisuride; Male; Piperidines; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sex Factors; Stereoisomerism | 1987 |
Differential electrophysiological effects of 3-PPP and its enantiomers on dopamine autoreceptors and postsynaptic receptors.
Topics: Action Potentials; Animals; Apomorphine; Electrodes, Implanted; Globus Pallidus; Male; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Substantia Nigra; Synapses | 1986 |
An automatic device for measuring speed of movement and time spent at rest: its application to testing dopaminergic drugs.
Topics: Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Female; Haloperidol; Motor Activity; Neurophysiology; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1986 |
A stereochemical explanation of the dopamine agonist and antagonist activity of stereoisomeric pairs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Apomorphine; Chemical Phenomena; Chemistry; Dopamine; Dopamine Antagonists; Molecular Conformation; Naphthalenes; Piperidines; Receptors, Dopamine; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes; Thermodynamics | 1986 |
Stereoselective inhibition of prolactin secretion by (-)-HW-165, a novel 3-PPP congener; further support for similarities between central DA autoreceptors and pituitary lactotroph DA receptors.
Topics: 4-Butyrolactone; Animals; Apomorphine; Depression, Chemical; Male; Phenanthrenes; Piperidines; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism | 1986 |
Enantiomers of 3-(3,4-dihydroxyphenyl)- and 3-(3-hydroxyphenyl)-N-n-propylpiperidine: central pre- and postsynaptic dopaminergic effects and pharmacokinetics.
Topics: Animals; Brain; Kinetics; Male; Methylation; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1986 |
A molecular mechanics approach to the understanding of presynaptic selectivity for centrally acting dopamine receptor agonists of the phenylpiperidine series.
Topics: Brain; Models, Molecular; Molecular Conformation; Piperidines; Receptors, Dopamine; Structure-Activity Relationship | 1986 |
Central dopaminergic properties of HW-165 and its enantiomers; trans-octahydrobenzo(f)quinoline congeners of 3-PPP.
Topics: 4-Butyrolactone; Animals; Behavior, Animal; Catecholamines; Corpus Striatum; Limbic System; Male; Motor Activity; Phenanthrenes; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism | 1986 |
Sexually differentiated actions of 3-PPP enantiomers on prolactin secretion.
Topics: 4-Butyrolactone; Animals; Female; Furans; Male; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sex Factors; Stereoisomerism | 1986 |
Electrophysiological effects of the enantiomers of 3-PPP on neurons in the locus coeruleus of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Injections, Intravenous; Iontophoresis; Locus Coeruleus; Male; Neurons; Piperidines; Prazosin; Rats; Rats, Inbred Strains; Stereoisomerism; Yohimbine | 1986 |
(+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine [(+)-3-PPP] but not (-)-3-PPP produces (+)-N-allylnormetazocine-like (SKF 10,047) discriminative stimuli.
Topics: Animals; Apomorphine; Discrimination Learning; Dose-Response Relationship, Drug; Isomerism; Male; Phenazocine; Phencyclidine; Piperidines; Rats; Rats, Inbred F344 | 1986 |
Indolizidine and quinolizidine derivatives of the dopamine autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP).
Topics: alpha-Methyltyrosine; Animals; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Methyltyrosines; Molecular Conformation; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereotyped Behavior; Structure-Activity Relationship | 1987 |
Pharmacological properties of presynaptic dopamine receptor agonists.
Topics: Animals; Binding, Competitive; Brain; Corpus Striatum; Dogs; Dopamine; Piperidines; Prolactin; Rats; Receptors, Dopamine; Stereoisomerism; Substantia Nigra; Synapses; Vomiting | 1985 |
Dopaminergic agents including 3-PPP and its enantiomers on medial septal self-stimulation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Appetite Depressants; Benzazepines; Dextroamphetamine; Drug Interactions; Haloperidol; Male; Nomifensine; Piperidines; Rats; Receptors, Dopamine; Self Stimulation; Stereoisomerism; Sulpiride; Tetrahydronaphthalenes | 1985 |
Development of dopamine autoreceptors in the postnatal rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Brain; Brain Chemistry; Dihydroxyphenylalanine; Motor Activity; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1985 |
Synthesis and dopamine autoreceptor activity of a 5-(methylmercapto)methyl-substituted derivative of (+/-)-3-PPP (3-(3-hydroxyphenyl)-1-n-propylpiperidine).
Topics: 4-Butyrolactone; Animals; Chemical Phenomena; Chemistry; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Mice; Piperidines; Rats; Receptors, Dopamine; Structure-Activity Relationship | 1985 |
Sub-chronic administration of (-)-3-PPP and central dopamine receptor sensitivity changes.
Topics: Animals; Body Weight; Brain; Corpus Striatum; Dihydroxyphenylalanine; Limbic System; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Dopamine receptors mediating yawning: are they autoreceptors?
Topics: Animals; Domperidone; Drug Synergism; Haloperidol; Male; Methyltyrosines; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reflex; Reserpine; Stereoisomerism; Sulpiride | 1986 |
Agonist and antagonist effects of 3-PPP enantiomers on functional dopamine autoreceptors and postsynaptic dopamine receptors in vitro.
Topics: Acetylcholine; Animals; Cholera Toxin; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Melanocyte-Stimulating Hormones; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Sulpiride | 1985 |
Dopamine receptor-mediated hypothermia induced in rats by (+)-, but not by (-)-3-PPP.
Topics: Animals; Apomorphine; Biogenic Amines; Body Temperature; Brain Chemistry; Dose-Response Relationship, Drug; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1985 |
Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis.
Topics: alpha-Methyltyrosine; Animals; Dopamine; Levodopa; Locomotion; Male; Methyltyrosines; Mice; Mice, Inbred Strains; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1985 |
Lack of effect of intranigral administration of a dopamine analogue, (+/-)-3-(3-hydroxyphenyl)-N,n-propylpiperidine [(+/-)-3-PPP], on nigrostriatal dopamine neurones.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Female; Homovanillic Acid; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra | 1985 |
Modifications of sleep parameters in the rat by (+)- and (-)-3-PPP.
Topics: Animals; Isomerism; Male; Piperidines; Rats; Rats, Inbred Strains; Reaction Time; Sleep; Sleep Stages | 1985 |
An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system.
Topics: Animals; Caudate Nucleus; Chloral Hydrate; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; Iontophoresis; Male; Piperidines; Rats; Rats, Inbred Strains; Stereoisomerism; Substantia Nigra | 1985 |
Involvement of catechol-O-methyl transferase in the metabolism of the putative dopamine autoreceptor agonist 3-PPP(3-(3-hydroxyphenyl)-N-n-propylpiperidine).
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Catechol O-Methyltransferase; Cattle; Dopamine; Kinetics; Liver; Methylation; Piperidines; Pyrogallol | 1985 |
Effects of the enantiomers of 3-PPP on DA1 and DA2 dopamine receptors in the dog.
Topics: Animals; Dogs; Femoral Artery; Models, Biological; Piperidines; Receptors, Dopamine; Regional Blood Flow; Renal Artery; Stereoisomerism | 1985 |
In vivo displacement by 3-PPP enantiomers of N,N-dipropyl-5,6-ADTN from dopamine receptor-binding sites in rat striatum.
Topics: Animals; Binding, Competitive; Brain; Cerebellum; Corpus Striatum; Haloperidol; Isomerism; Male; Naphthalenes; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes | 1985 |
Resolved 3-(3-hydroxyphenyl)-N-n-propylpiperidine and its analogues: central dopamine receptor activity.
Topics: Animals; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Male; Motor Activity; Norepinephrine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Reserpine; Serotonin; X-Ray Diffraction | 1984 |
Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.
Topics: Animals; Brain Mapping; Brain Stem; Cerebellum; Guinea Pigs; Haloperidol; Hypothalamus; Limbic System; Mesencephalon; Piperidines; Rats; Receptors, Dopamine; Receptors, Opioid; Stereoisomerism | 1984 |
Differential effects of the stereoisomers of 3PPP on dopaminergic and cholinergic neurotransmission in superfused slices of the corpus striatum.
Topics: Acetylcholine; Animals; Corpus Striatum; Dextroamphetamine; Dopamine; Electric Stimulation; In Vitro Techniques; Male; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Synaptic Transmission; Tritium | 1984 |
(+)- and (-)-3-PPP exhibit different intrinsic activity at striatal dopamine autoreceptors controlling dopamine synthesis.
Topics: 4-Butyrolactone; Animals; Apomorphine; Corpus Striatum; Dopamine; Isomerism; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Neurotransmitter | 1984 |
3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptors.
Topics: Animals; Behavior, Animal; Brain; Dopamine; Drug Interactions; Humans; Kinetics; Male; Motor Activity; Piperidines; Rats; Receptors, Dopamine; Stereotyped Behavior; Tyrosine 3-Monooxygenase | 1981 |
Is 3-PPP a potential antipsychotic agent? Evidence from animal behavioral studies.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Dextroamphetamine; Humans; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Stereotyped Behavior; Time Factors | 1982 |
LY141865, a D2-dopamine agonist, increases acetylcholine concentration in rat corpus striatum.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Corpus Striatum; Ergolines; Male; Piperidines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1983 |
Different actions of TL-99 and 3-PPP in producing contraversive turning in the 6-OHDA-lesioned rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Female; Hydroxydopamines; Motor Activity; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Substantia Nigra; Tetrahydronaphthalenes; Yohimbine | 1983 |
Differential effects of the enantiomers of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) at dopamine receptor sites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Apomorphine; Corpus Striatum; Dopamine; Homovanillic Acid; Male; Mice; Molecular Conformation; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Synaptosomes; Tyrosine 3-Monooxygenase | 1983 |
The effect of the enantiomers of 3-PPP on conditioned avoidance responding in the rat.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Catalepsy; Humans; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Stereoisomerism; Time Factors | 1983 |
On the mode of action of 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP, and its enantiomers. With particular reference to dopaminergic mechanisms in the central nervous system.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Brain; Cyclic AMP; Escape Reaction; Humans; Locomotion; Male; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Stereotyped Behavior | 1983 |
Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers.
Topics: Adenylyl Cyclases; Animals; Antiemetics; Antipsychotic Agents; Catalepsy; Dogs; Dopamine; Female; Guinea Pigs; Humans; Male; Mice; Motor Activity; Norepinephrine; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Serotonin; Stereoisomerism; Stereotyped Behavior; Synaptosomes | 1983 |
Effects of apomorphine, TL-99 and 3-PPP on yawning in rats.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Apomorphine; Behavior, Animal; Haloperidol; Male; Naphthalenes; Piperidines; Rats; Tetrahydronaphthalenes | 1984 |
Effects of S (+)-3-phenethyl-PP, a putative dopamine autoreceptors agonist with greater autoreceptor selectivity than 3-PPP enantiomers.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiemetics; Catalepsy; Dogs; Dopamine; Female; Guinea Pigs; Histamine Antagonists; Humans; Male; Mice; Motor Activity; Norepinephrine; Parasympatholytics; Piperidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Stereotyped Behavior; Synaptosomes | 1984 |
Presynaptic dopaminergic agonists modify brain glucose metabolism in a way similar to the neuroleptics.
Topics: Animals; Antipsychotic Agents; Apomorphine; Brain; Catecholamines; Ergolines; Glucose; Naphthalenes; Piperidines; Rats; Reserpine; Tetrahydronaphthalenes | 1984 |
Dopamine agonists stimulate protein carboxylmethylation in striatal synaptosomes.
Topics: Animals; Apomorphine; Butaclamol; Corpus Striatum; Dopamine; Hydroxydopamines; In Vitro Techniques; Male; Nerve Tissue Proteins; Piperidines; Potassium; Protein Methyltransferases; Protein O-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Synaptosomes | 1982 |
The effects of SCH 23390, YM 09151-2, (+)- and (-)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Antipsychotic Agents; Aporphines; Benzamides; Benzazepines; Caudate Nucleus; Chlorpromazine; Clozapine; Flupenthixol; Haloperidol; In Vitro Techniques; Male; Piperidines; Potassium; Putamen; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1984 |
Interaction of the putative dopamine autoreceptor agonists, 3-PPP and TL-99, with the dopamine-sensitive adenylate cyclase of carp retina.
Topics: Adenylyl Cyclases; Animals; Carps; Cyclic AMP; Enzyme Activation; Naphthalenes; Piperidines; Receptors, Dopamine; Retina; Tetrahydronaphthalenes | 1982 |
A behavioural study of the changes in the central nervous system of mice after subchronic treatment with the selective dopamine autoreceptor agonist 3-PPP (dl-3-[3-hydroxyphenyl]-N-n-propylpiperidine).
Topics: Animals; Apomorphine; Behavior, Animal; Dextroamphetamine; Dose-Response Relationship, Drug; Male; Motor Activity; Muridae; Piperidines; Receptors, Dopamine; Synaptic Transmission | 1982 |
Inhibition of postsynaptic dopamine-sensitive adenylate cyclase in carp retina by the putative dopamine autoreceptor agonist, 3-PPP.
Topics: Adenylyl Cyclases; Animals; Carps; Cyclic AMP; Cyprinidae; In Vitro Techniques; Piperidines; Receptors, Dopamine; Retina; Synapses | 1982 |
Postsynaptic dopamine agonist properties of TL-99 are revealed by yohimbine co-treatment.
Topics: Animals; Male; Motor Activity; Naphthalenes; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Rotation; Tetrahydronaphthalenes; Yohimbine | 1983 |
3-PPP antagonizes the in vitro effects of D-1 and D-2 dopamine receptor agonists in rat neostriatum.
Topics: Acetylcholine; Animals; Corpus Striatum; Cyclic AMP; In Vitro Techniques; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1983 |
In vitro effect of the racemic mixture and the (-)enantiomer of N-n-propyl-3-(3-hydroxyphenyl)-piperidine (3-PPP) on postsynaptic dopamine receptors and on a presynaptic dopamine autoreceptor.
Topics: Adenylyl Cyclases; Animals; Corpus Striatum; Cyclic AMP; Male; Models, Neurological; Piperidines; Rats; Receptors, Dopamine; Stereoisomerism | 1983 |
Differential effects of the enantiomers of 3-PPP on dopamine D1-receptors of isolated rabbit retina.
Topics: Animals; Cyclic AMP; Dopamine; In Vitro Techniques; Isomerism; Piperidines; Rabbits; Receptors, Dopamine; Receptors, Dopamine D1; Retina | 1984 |
trans-N-n-Propyl-7-hydroxy-octahydrobenzo(f)quinoline, a rigid 3-PPP analogue with greater potency but lack of selectivity for dopamine autoreceptors.
Topics: 4-Butyrolactone; Animals; Corpus Striatum; Dihydroxyphenylalanine; Female; Hydroxyquinolines; Male; Mice; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine | 1983 |
Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP.
Topics: Animals; Apomorphine; Behavior, Animal; Biogenic Amines; Brain Chemistry; Dextroamphetamine; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism | 1983 |
Dopamine receptor agonists: intrinsic activity vs. state of receptor.
Topics: Animals; Apomorphine; Brain; Denervation; Exploratory Behavior; Hydroxydopamines; Oxidopamine; Piperidines; Prolactin; Rats; Receptors, Dopamine; Stereoisomerism; Sympathectomy, Chemical | 1983 |
Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats.
Topics: Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Drug Interactions; Hydroxydopamines; Male; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Stereoisomerism; Stimulation, Chemical | 1984 |
Effects of (-)3-PPP on acquisition and retention of a conditioned avoidance response in the rat.
Topics: Animals; Avoidance Learning; Conditioning, Operant; Discrimination Learning; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains | 1984 |
Evidence for heterogeneous rotational responsiveness to apomorphine, 3-PPP and SKF 38393 in 6-hydroxydopamine-denervated rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Benzazepines; Clozapine; Ergolines; Humans; Hydroxydopamines; Male; Oxidopamine; Pergolide; Piperidines; Postural Balance; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Sympathectomy, Chemical | 1984 |
Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat.
Topics: Animals; Exploratory Behavior; Haloperidol; Male; Motor Activity; Nucleus Accumbens; Piperidines; Rats; Rats, Inbred Strains; Septal Nuclei | 1984 |
The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity.
Topics: Animals; Apomorphine; Drug Interactions; Haloperidol; Inhalation; Isomerism; Male; Models, Psychological; Penis; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Respiration; Sexual Behavior, Animal; Syndrome | 1984 |
Behavioral and biochemical effects of subchronic treatment with (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine in the rat: dopamine receptor sensitivity and tolerance.
Topics: Animals; Body Weight; Corpus Striatum; Dopamine; Kinetics; Male; Motor Activity; Nucleus Accumbens; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine | 1984 |
Apomorphine and haloperidol-induced effects on male rat sexual behavior: no evidence for actions due to stimulation of central dopamine autoreceptors.
Topics: Animals; Apomorphine; Brain; Haloperidol; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal | 1984 |
The search for selective dopaminergic autoreceptor agonists.
Topics: Animals; Apomorphine; Dextroamphetamine; Dose-Response Relationship, Drug; Motor Activity; Optical Rotation; Piperidines; Rats; Receptors, Dopamine; Reserpine | 1983 |
Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Apomorphine; Benzazepines; Caudate Nucleus; Choline; Clonidine; Female; Male; Piperidines; Rabbits; Receptors, Dopamine | 1983 |
Assessment of the chloroethyl analog of 3-PPP (N-n-propyl-3-(3-hydroxyphenyl)-piperidine), 3-PPP-C1 as an irreversible ligand for central dopaminergic recognition sites.
Topics: Animals; Aporphines; Brain; In Vitro Techniques; Ligands; Piperidines; Rats; Receptors, Dopamine | 1983 |
Differential behavioural effects of dopamine agonists in developing rats: a study of 3-PPP enantiomers.
Topics: Age Factors; Animals; Dextroamphetamine; Female; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism | 1983 |
Avoidance and ICSS behavioral models dissociate TL-99 and 3-PPP from dopamine receptor antagonists.
Topics: Animals; Avoidance Learning; Haloperidol; Male; Models, Psychological; Naphthalenes; Piperidines; Rats; Rats, Inbred F344; Receptors, Dopamine; Saimiri; Self Stimulation; Tetrahydronaphthalenes | 1983 |
Similarities of the effects of apomorphine and 3-PPP on serotonin neurons.
Topics: Animals; Apomorphine; Chromatography, High Pressure Liquid; Corpus Striatum; Haloperidol; Hippocampus; Male; Neurons; Piperidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin; Spectrometry, Fluorescence | 1983 |
Dopamine receptors involved in prolactin secretion pharmacologically characterized by means of 3-PPP enantiomers.
Topics: Animals; Isomerism; Male; Piperidines; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Reserpine; Tranquilizing Agents | 1983 |
Antidyskinetic action of 3-PPP, a selective dopaminergic autoreceptor agonist, in Cebus monkeys with persistent neuroleptic-induced dyskinesias.
Topics: Animals; Cebus; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Fluphenazine; Haloperidol; Male; Piperidines; Stereoisomerism | 1983 |
Interaction of (+)- and (-)-3-PPP with the dopamine receptor in the anterior pituitary gland.
Topics: Animals; Apomorphine; Binding Sites; Cell Membrane; Depression, Chemical; In Vitro Techniques; Male; Methyltyrosines; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereoisomerism | 1984 |
Stimulation of dopamine autoreceptors elicits "premature ejaculation" in rats.
Topics: Animals; Apomorphine; Copulation; Domperidone; Dopamine Antagonists; Ejaculation; Female; Haloperidol; Lisuride; Male; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal | 1984 |
Action of putative dopamine receptor agonists, TL-99, 3-PPP and RDS-127 on substantia nigra neurons.
Topics: Action Potentials; Animals; Depression, Chemical; Dopamine Antagonists; Indans; Indenes; Male; Naphthalenes; Piperidines; Rats; Substantia Nigra; Tetrahydronaphthalenes | 1984 |
Assessment of dopamine autoreceptor agonist properties of apomorphine, (+)-3-PPP and (-)-3-PPP by recording of yawning behaviour in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Domperidone; Male; Motor Activity; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereoisomerism; Sulpiride | 1984 |
A pharmacological comparison of 6,7-dihydroxy-2-dimethylaminotetralin (TL-99) and N-n-propyl-3-(3-hydroxyphenyl)piperidine with (3-PPP) selected dopamine agonists.
Topics: 4-Butyrolactone; Animals; Apomorphine; Cell Membrane; Corpus Striatum; Female; Humans; Hydroxydopamines; Naphthalenes; Oxidopamine; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Tetrahydronaphthalenes | 1982 |
Suppression of exploratory locomotor activity in the rat by the local application of 3-PPP enantiomers into the nucleus accumbens.
Topics: Animals; Exploratory Behavior; Male; Motor Activity; Nucleus Accumbens; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Septal Nuclei; Stereoisomerism | 1983 |
Failure of 3-PPP to activate dopamine autoreceptors in vitro.
Topics: Acetylcholine; Animals; In Vitro Techniques; Naphthalenes; Piperidines; Potassium; Rats; Receptors, Dopamine; Tetrahydronaphthalenes | 1983 |
Biphasic effects of some dopamine agonists on striatal acetylcholine concentrations.
Topics: Acetylcholine; Animals; Apomorphine; Corpus Striatum; Dopamine; Male; Piperidines; Piribedil; Rats; Tetrahydronaphthalenes; Time Factors | 1983 |
Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat.
Topics: Animals; Male; Naphthalenes; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes | 1983 |
A behavioral study of the changes in the CNS of mice after subchronic treatment with the dopamine autoreceptor agonist 3-PPP.
Topics: Animals; Behavior, Animal; Male; Mice; Piperidines; Receptors, Dopamine | 1982 |
Interaction of the putative dopamine autoreceptor agonists 3-PPP and TL-99 with [3H]apomorphine binding sites in rat striatal membranes.
Topics: Animals; Apomorphine; Binding Sites; Binding, Competitive; Corpus Striatum; In Vitro Techniques; Kinetics; Membranes; Naphthalenes; Piperidines; Rats; Receptors, Dopamine; Spiperone; Tetrahydronaphthalenes | 1982 |
Effect of 3-PPP, a putative dopamine autoreceptor agonist, on rat serum prolactin levels.
Topics: Animals; Apomorphine; Binding, Competitive; Humans; Male; Piperidines; Prolactin; Rats; Receptors, Dopamine; Reserpine; Spiperone; Stereotyped Behavior | 1981 |
Pharmacological profiles of the putative dopamine autoreceptor agonists 3-PPP and TL-99.
Topics: 4-Butyrolactone; Animals; Apomorphine; Brain; Dogs; Dopamine; Female; Male; Mice; Motor Activity; Naphthalenes; Piperidines; Rats; Receptors, Dopamine; Tetrahydronaphthalenes | 1981 |
A new centrally acting DA-receptor agonist with selectivity for autoreceptors.
Topics: Animals; Behavior, Animal; Brain; Dopamine; Piperidines; Rats; Receptors, Dopamine | 1980 |
Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3 receptor binding affinities.
Topics: Aminoquinolines; Animals; Apomorphine; Azepines; Benzothiazoles; Binding, Competitive; CHO Cells; Cricetinae; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Imidazoles; Male; Neurons; Phenethylamines; Piperidines; Pramipexole; Quinolines; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Substantia Nigra; Tetrahydronaphthalenes; Thiazoles; Thiophenes; Transfection | 1995 |
The sigma receptor ligand (+/-)-BMY 14802 prevents methamphetamine-induced dopaminergic neurotoxicity via interactions at dopamine receptors.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain Diseases; Butaclamol; Carbazoles; Dizocilpine Maleate; Dopamine; Dopamine Agents; Drug Interactions; Drug Synergism; Guanidines; Ligands; Male; Methamphetamine; Mice; MPTP Poisoning; Neostriatum; Piperidines; Psychotropic Drugs; Pyrimidines; Receptors, Dopamine; Receptors, sigma; Stereoisomerism; Tyrosine 3-Monooxygenase | 1994 |
[Contribution of dopamine autoreceptors in the reactive effect of opioid antagonists].
Topics: Animals; Avoidance Learning; Dopamine Agonists; Enkephalin, Leucine; Male; Mice; Mice, Inbred BALB C; Naloxone; Narcotic Antagonists; Piperidines; Receptors, Dopamine; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Characterization of a (+)-azidophenazocine-sensitive sigma receptor on splenic lymphocytes.
Topics: Affinity Labels; Animals; Binding Sites; Binding, Competitive; Female; Haloperidol; Interferons; Lymphocytes; Mice; Mice, Inbred C57BL; Phenazocine; Piperidines; Receptors, sigma; Spleen | 1993 |
Oocytes from Xenopus laevis contain an intrinsic sigma 2-like binding site.
Topics: Animals; Binding Sites; Binding, Competitive; Carbazoles; Dextromethorphan; Female; Guanidines; Haloperidol; Liver; Mazindol; Oocytes; Pentazocine; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Rats; Receptors, sigma; Xenopus laevis; Zinc | 1994 |
Differential effects of 3-PPP enantiomers on extracellular dopamine concentration in the caudate-putamen and nucleus accumbens of rats.
Topics: Animals; Caudate Nucleus; Dopamine; Dopamine Agonists; Extracellular Space; Female; Nomifensine; Nucleus Accumbens; Piperidines; Putamen; Rats; Rats, Sprague-Dawley | 1994 |
Purification, pharmacological characterization and photoaffinity labeling of sigma receptors from rat and bovine brain.
Topics: Animals; Binding Sites; Cattle; Cerebellum; Dopamine Agonists; Haloperidol; Male; Phenazocine; Piperidines; Rats; Receptors, sigma | 1995 |
Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures.
Topics: Animals; Calcium; Cells, Cultured; Cyclazocine; Cyclopentanes; Dextromethorphan; Glutamic Acid; Guanidines; Haloperidol; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Pentazocine; Phenazocine; Piperidines; Rats; Receptors, sigma | 1995 |
Acute effects of sigma ligands on the extracellular DOPAC level in rat frontal cortex and striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Corpus Striatum; Extracellular Space; Frontal Lobe; Guanidines; Kinetics; Ligands; Male; Microdialysis; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Time Factors | 1995 |
3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine elicits convulsant effects in mice.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Convulsants; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Electroencephalography; Male; Mice; Piperidines; Receptors, sigma; Seizures; Stereoisomerism | 1995 |
Antiemetic effects of 5-HT1A agonists in the pigeon.
Topics: Animals; Anticonvulsants; Antiemetics; Columbidae; Conditioning, Classical; Dopamine Agonists; Dose-Response Relationship, Drug; Emetics; Guanidines; Male; Pentobarbital; Piperidines; Serotonin Receptor Agonists | 1994 |
Dopamine D2 autoreceptors in rats are behaviorally functional at 21 but not 10 days of age.
Topics: Aging; Aminoquinolines; Animals; Apomorphine; Azepines; Behavior, Animal; Benzothiazoles; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Motor Activity; Piperidines; Pramipexole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Thiazoles | 1994 |
Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors.
Topics: Analysis of Variance; Animals; Apomorphine; Benzothiazoles; CHO Cells; Cricetinae; Cricetulus; Dihydroxyphenylalanine; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Male; Microdialysis; Mitogens; Motor Activity; Piperidines; Pramipexole; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Thiazoles; Transfection | 1994 |
Effects of sigma ligands on rat cerebellar Purkinje neuron firing: an iontophoretic study.
Topics: Animals; Ethylamines; Guanidines; Iontophoresis; Levallorphan; Male; Pentazocine; Piperidines; Purkinje Cells; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1994 |
Heterocyclic amino alcohols related to ifenprodil as sigma receptor ligands: binding and conformational analyses.
Topics: Adrenergic alpha-Antagonists; Amino Alcohols; Animals; Binding, Competitive; Cerebral Cortex; Crystallization; Dopamine Agonists; Heterocyclic Compounds; In Vitro Techniques; Ligands; Models, Molecular; Molecular Conformation; Piperidines; Propanolamines; Rats; Receptors, Adrenergic, alpha-1; Receptors, sigma | 1994 |
Is the sigma 2 receptor in rat brain related to the K+ channel of class III antiarrhythmic drugs?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Binding, Competitive; Cerebral Cortex; Dopamine Agents; Electrophysiology; Glioma; Guinea Pigs; In Vitro Techniques; Male; Piperidines; Potassium Channels; Purkinje Fibers; Rats; Rats, Wistar; Receptors, sigma; Tumor Cells, Cultured | 1993 |
Two inbred rat sublines that differ in spontaneous yawning behavior also differ in their responses to cholinergic and dopaminergic drugs.
Topics: Animals; Apomorphine; Dopamine Agents; Dose-Response Relationship, Drug; Male; Parasympathomimetics; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Dopamine; Species Specificity; Yawning | 1993 |
Haloperidol treatment differentially regulates [3H]DTG and [3H](+)-3-PPP labeled sigma binding sites.
Topics: Animals; Antipsychotic Agents; Binding Sites; Brain; Dopamine Agents; Drug Administration Schedule; Guanidines; Guinea Pigs; Haloperidol; Male; Phenytoin; Piperidines; Receptors, sigma | 1993 |
A high dose of EEDQ reduces pituitary dopamine D2 receptor density and the prolactin suppressive potency of agonists.
Topics: Animals; Azepines; Dopamine Agents; Male; Piperidines; Pituitary Gland; Prolactin; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 1993 |
Discrimination of (+)-3-PPP sites from DTG sites by FH-510, a novel potent sigma ligand, in rat brain.
Topics: Animals; Anticonvulsants; Binding Sites; Brain; Carbazoles; Dopamine Agents; Guanidines; In Vitro Techniques; Male; Piperidines; Propylamines; Radioligand Assay; Rats; Rats, Wistar | 1993 |
Further characterization of [3H]ifenprodil binding in rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Dizocilpine Maleate; Dopamine Agents; Dose-Response Relationship, Drug; Guanidines; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Piperidines; Rats; Rats, Inbred F344; Receptors, sigma | 1994 |
Further characterization of the effects of BMY 14802 on dopamine neuronal activity.
Topics: Adrenergic alpha-Antagonists; Animals; Dopamine; Dopamine Agents; Ergolines; Injections, Intravenous; Iontophoresis; Male; Neurons; Piperidines; Pyrimidines; Quinpirole; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Stereoisomerism; Sulpiride | 1993 |
Pharmacological characteristics of hyperambulation induced by the sigma ligand (+)-3-PPP in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Dopamine Agents; Dopamine D2 Receptor Antagonists; Ligands; Male; Motor Activity; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Serotonin Receptor Agonists; Stereoisomerism; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1994 |
Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors.
Topics: Administration, Topical; Animals; Dopamine Agents; Glucose; Male; Ocular Hypotension; Ophthalmic Solutions; Pentoxifylline; Phosphodiesterase Inhibitors; Piperidines; Rabbits; Stereoisomerism; Trifluperidol; Xanthines | 1994 |
[3H]RS-23597-190, a potent 5-hydroxytryptamine4 antagonist labels sigma-1 but not sigma-2 binding sites in guinea pig brain.
Topics: Aminobenzoates; Animals; Binding Sites; Brain; Guinea Pigs; Male; para-Aminobenzoates; Piperidines; Receptors, Serotonin; Receptors, sigma; Serotonin Antagonists | 1994 |
The effects of sigma ligands on the release of glutamate from rat striatal slices.
Topics: Animals; Corpus Striatum; Female; Glutamic Acid; Haloperidol; In Vitro Techniques; Ligands; Neuropeptide Y; Piperidines; Potassium; Rats; Rats, Wistar; Receptors, sigma | 1994 |
Ameliorating effects of sigma receptor ligands on the impairment of passive avoidance tasks in mice: involvement in the central acetylcholinergic system.
Topics: Acetylcholine; Amnesia; Animals; Anticonvulsants; Avoidance Learning; Brain; Cholinesterase Inhibitors; Dopamine Agonists; Electroshock; Guanidines; Ligands; Male; Memory; Mice; Mice, Inbred Strains; p-Chloroamphetamine; Phenazocine; Piperidines; Receptors, sigma; Serotonin Antagonists | 1994 |
Effects of haloperidol and reduced haloperidol on binding to sigma sites.
Topics: Animals; Binding Sites; Brain; Dextromethorphan; Guinea Pigs; Haloperidol; Male; Oxidation-Reduction; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1994 |
Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes.
Topics: Animals; Calcium; Cells, Cultured; GTP-Binding Proteins; Guanidines; Haloperidol; Heart Rate; Myocardial Contraction; Pentazocine; Piperidines; Rats; Receptors, sigma; Sarcoplasmic Reticulum | 1994 |
2,5-Dimethoxy congeners of (+)-and (-)-3-(3-hydroxyphenyl)-N-n- propylpiperidine.
Topics: Animals; Bradycardia; Dopamine Agents; Hypotension; Piperidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1993 |
Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol.
Topics: Administration, Oral; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Benzothiazoles; Cebus; Disease Models, Animal; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dyskinesia, Drug-Induced; Dystonia; Ergolines; Female; Haloperidol; Lisuride; Male; Piperidines; Pramipexole; Quinpirole; Raclopride; Salicylamides; Thiazoles | 1993 |
Binding of [3H]FH-510 to sigma ligand recognition sites in guinea-pig brain membranes.
Topics: Animals; Anti-Anxiety Agents; Binding Sites; Binding, Competitive; Brain; Carbazoles; Dopamine Agents; Guinea Pigs; Histamine; In Vitro Techniques; Kinetics; Male; Microsomes; Phenazocine; Piperidines; Propylamines; Pyrimidines; Radioligand Assay; Receptors, sigma; Serotonin | 1993 |
[3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus.
Topics: Animals; Autoradiography; Benzimidazoles; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Guinea Pigs; Hippocampus; Male; Membranes; Mice; Neuroblastoma; Piperidines; Rats; Receptors, Serotonin; Receptors, sigma; Sensitivity and Specificity; Tritium; Tumor Cells, Cultured | 1993 |
Strain differences in rat brain and liver sigma binding: lack of cytochrome P450-2D1 involvement.
Topics: Analysis of Variance; Animals; Binding Sites; Brain; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Liver; Mixed Function Oxygenases; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, sigma; Sex Factors; Species Specificity | 1993 |
Multiplicity of [3H]1,3-di-o-tolylguanidine binding sites with low affinity for haloperidol in rat brain.
Topics: Animals; Binding Sites; Brain; Guanidines; Haloperidol; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1993 |
Discriminative stimulus properties of cocaine in relation to dopamine D2 receptor function in rats.
Topics: Animals; Bromocriptine; Cocaine; Discrimination Learning; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 1993 |
Synthesis and in vitro evaluation of 5,6,7,8,9,10-hexahydro-7,10-iminocyclohept[b]indoles: high-affinity ligands for the N,N'-di-o-tolylguanidine-labeled sigma binding site.
Topics: Animals; Binding, Competitive; Brain; Carbolines; Guanidines; Guinea Pigs; In Vitro Techniques; Piperidines; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, sigma; Stereoisomerism; Structure-Activity Relationship; Sulpiride; X-Ray Diffraction | 1993 |
Repeated testing within drug discrimination learning: time course studies with cocaine, amphetamine, and 3-PPP.
Topics: Amphetamine; Animals; Cocaine; Columbidae; Discrimination Learning; Dopamine Antagonists; Male; Piperidines; Time Factors | 1993 |
Correlation between potentiation of neurogenic twitch contraction and benzomorphan sigma receptor binding potency in the mouse vas deferens.
Topics: Animals; Antiparkinson Agents; Brain; Drug Synergism; Guinea Pigs; Haloperidol; Ligands; Male; Mice; Phenazocine; Piperidines; Receptors, sigma; Spasm; Vas Deferens | 1993 |
Allosteric modulation of ligand binding to [3H](+)pentazocine-defined sigma recognition sites by phenytoin.
Topics: Allosteric Regulation; Animals; Binding Sites; Cyclopentanes; Dextromethorphan; Dextrorphan; Guinea Pigs; Ligands; Male; Pentazocine; Phenazocine; Phenytoin; Piperidines; Radioligand Assay; Receptors, sigma; Tritium | 1993 |
Inotropic action of sigma receptor ligands in isolated cardiac myocytes from adult rats.
Topics: Animals; Binding Sites; Calcium; Guanidines; In Vitro Techniques; Ligands; Myocardial Contraction; Myocardium; Pentazocine; Piperidines; Rats; Receptors, sigma; Stimulation, Chemical | 1995 |
Effects of sigma receptor ligands on the extracellular concentration of dopamine in the striatum and prefrontal cortex of the rat.
Topics: Animals; Benzomorphans; Corpus Striatum; Dopamine; Guanidines; Ligands; Male; Pentazocine; Piperazines; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1995 |
Sigma receptor activation does not mediate fentanyl-induced attenuation of muscarinic coronary contraction.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Coronary Vessels; Cyclazocine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fentanyl; Guanidines; Haloperidol; Muscarine; Muscarinic Agonists; Narcotic Antagonists; Narcotics; Pentazocine; Phencyclidine; Piperidines; Potassium Channel Blockers; Receptors, Dopamine; Receptors, sigma; Signal Transduction; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat.
Topics: Animals; Brain; Conditioning, Operant; Dextroamphetamine; Dopamine Agonists; Dopamine Antagonists; Dopamine Uptake Inhibitors; Indans; Male; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Self Stimulation; Tetrahydronaphthalenes | 1995 |
Involvement of sigma-receptors in the increase in contraction of mouse vas deferens induced by exogenous ATP.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Carbazoles; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Guanidines; Haloperidol; Ligands; Male; Mice; Muscle Contraction; Muscle, Smooth; Pentazocine; Phenazocine; Piperidines; Receptors, sigma; Regression Analysis; Structure-Activity Relationship; Vas Deferens | 1996 |
Initial characterization and autoradiographic localization of a novel sigma/opioid binding site in immune tissues.
Topics: Animals; Anticonvulsants; Autoradiography; Binding Sites; Binding, Competitive; Brain Chemistry; Cytochrome P-450 Enzyme System; Dopamine Agonists; Dopamine Antagonists; Female; Guanidines; Haloperidol; Hydrogen-Ion Concentration; Kinetics; Leukocytes; Monoamine Oxidase; Naltrexone; Narcotic Antagonists; Narcotics; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Spleen; Tritium | 1996 |
Affinities and intrinsic activities of dopamine receptor agonists for the hD21 and hD4.4 receptors.
Topics: Aminoquinolines; Animals; Cell Membrane; CHO Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Humans; Piperidines; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D4; Salicylamides | 1996 |
Effects on locomotor activity after local application of D3 preferring compounds in discrete areas of the rat brain.
Topics: Animals; Brain; Cortical Spreading Depression; Dextroamphetamine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Indans; Injections, Intraventricular; Male; Microinjections; Motor Activity; Nucleus Accumbens; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrahydronaphthalenes; Ventral Tegmental Area | 1995 |
Partial agonistic effects of OPC-14597, a potential antipsychotic agent, on yawning behavior in rats.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Azepines; Dopamine Agonists; Drug Synergism; Male; Oxidopamine; Piperazines; Piperidines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine; Stereotyped Behavior; Sympathectomy, Chemical; Yawning | 1996 |
Kappa opioid receptor agonists inhibit sigma-1 (sigma 1) receptor binding in guinea-pig brain, liver and spleen: autoradiographical evidence.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Autoradiography; Benzomorphans; Binding Sites; Brain; Guinea Pigs; Liver; Piperidines; Pyrrolidines; Receptors, Opioid, kappa; Receptors, sigma; Spinal Cord; Spleen | 1996 |
Dopamine and opioid regulation of the memory retrieval recovery in mice.
Topics: Animals; Avoidance Learning; Dopamine Agonists; Enkephalin, Leucine; Male; Memory; Mice; Mice, Inbred BALB C; Narcotic Antagonists; Piperidines; Quinpirole; Receptors, Dopamine D2; Receptors, Opioid, delta | 1996 |
Differential localization of three distinct binding sites for sigma receptor ligands in rat spleen.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Antipsychotic Agents; Autoradiography; Binding Sites; Dopamine Agonists; Dopamine Antagonists; Female; Guanidines; Haloperidol; Image Processing, Computer-Assisted; Ligands; Male; Naltrexone; Narcotic Antagonists; Pentazocine; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Spleen; Tritium | 1997 |
BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats.
Topics: Animals; Antipsychotic Agents; Dibenzothiepins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dystonia; Guanidines; Haloperidol; Male; Microinjections; Nerve Tissue Proteins; Perphenazine; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Red Nucleus; Sulpiride; Torticollis | 1996 |
In vivo functional interaction between phencyclidine binding sites and sigma receptors to produce head-weaving behavior in rats.
Topics: Animals; Anisoles; Behavior, Animal; Binding Sites; Dizocilpine Maleate; Guanidines; Male; Phenazocine; Piperidines; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, Phencyclidine; Receptors, sigma | 1996 |
Reduction of the scopolamine-induced impairment of passive-avoidance performance by sigma receptor agonist in mice.
Topics: Acetylcholinesterase; Animals; Antipsychotic Agents; Avoidance Learning; Brain; Dose-Response Relationship, Drug; Guanidines; Male; Mental Recall; Mice; Mice, Inbred Strains; Phenazocine; Piperidines; Receptors, sigma; Scopolamine | 1997 |
Behavioural effects of selective serotonin reuptake inhibitors following direct micro injection into the left red nucleus of the rat.
Topics: 1-Naphthylamine; Animals; Behavior, Animal; Chlorpromazine; Citalopram; Fluoxetine; Fluvoxamine; Guanidines; Haloperidol; Male; Microinjections; Motor Activity; Paroxetine; Piperidines; Posture; Rats; Rats, Sprague-Dawley; Receptors, sigma; Red Nucleus; Selective Serotonin Reuptake Inhibitors; Sertraline | 1997 |
Neuroleptic binding to sigma receptors: possible involvement in neuroleptic-induced acute dystonia.
Topics: Animals; Antipsychotic Agents; Dopamine Agonists; Dyskinesia, Drug-Induced; Male; Piperidines; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, sigma; Spiperone | 1997 |
Multiple [3H]-nemonapride binding sites in calf brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Benzamides; Binding, Competitive; Brain; Cattle; Cerebellum; Cerebral Cortex; Corpus Striatum; Dioxanes; Dopamine Agonists; Dopamine Antagonists; Guanidines; Haloperidol; In Vitro Techniques; Isotope Labeling; Narcotic Antagonists; Pentazocine; Piperidines; Propylamines; Pyrrolidines; Receptors, Dopamine D2; Receptors, sigma; Sulpiride; Tritium | 1997 |
Effects of phencyclidine (PCP) and (+)MK-801 on sensorimotor gating in CD-1 mice.
Topics: Acoustic Stimulation; Animals; Apomorphine; Clozapine; Dextroamphetamine; Dizocilpine Maleate; Dopamine Agonists; Dose-Response Relationship, Drug; Haloperidol; Male; Mice; Mice, Inbred Strains; Phencyclidine; Piperidines; Rats; Receptors, sigma; Reflex, Startle; Species Specificity | 1998 |
The intrinsic activity of (-)-3-PPP vis-à-vis prolactin-suppressing dopamine D2 receptors in transfected GH4C1 cells is dependent on which secretagogue that is used to provoke prolactin release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cell Line; Dopamine; Dopamine Agonists; Humans; Piperidines; Potassium; Prolactin; Receptors, Dopamine D2; Tetraethylammonium; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1998 |
Sigma receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets.
Topics: Adrenergic alpha-Antagonists; Animals; Azides; Benzofurans; Dopamine Agonists; Dose-Response Relationship, Drug; Guanidines; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Ligands; Male; Piperidines; Rats; Rats, Wistar; Receptors, Drug; Receptors, sigma | 1998 |
Direct dopamine D2-receptor-mediated modulation of arachidonic acid release in transfected CHO cells without the concomitant administration of a Ca2+-mobilizing agent.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Calcium Channel Blockers; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Gallic Acid; Pertussis Toxin; Piperidines; Receptors, Dopamine D2; Transfection; Virulence Factors, Bordetella | 1998 |
[18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses.
Topics: Acetylcholine; Animals; Autoradiography; Brain; Calibration; Carrier Proteins; Cholinesterase Inhibitors; Donepezil; Dopamine Agonists; Female; Fluorine Radioisotopes; Haloperidol; Humans; Indans; Kinetics; Male; Membrane Transport Proteins; Mice; Organ Specificity; Piperidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synapses; Tissue Distribution; Tomography, Emission-Computed; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1998 |
Effect of PCP and sigma ligands on both noradrenaline- and electrically-induced contractions and on [3H]-noradrenaline uptake in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Animals; Dextromethorphan; Dizocilpine Maleate; Dopamine Agonists; Electric Stimulation; Excitatory Amino Acid Antagonists; Ligands; Male; Muscle Contraction; Neuroprotective Agents; Norepinephrine; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Phencyclidine; Receptors, sigma; Tritium; Vas Deferens | 1998 |
Reduction of 4-cyclohexyl-1-[(1R)-1,2-diphenylethyl]-piperazine-induced memory impairment of passive avoidance performance by sigma 1 receptor agonists in mice.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Brain Chemistry; Dopamine Agonists; Guinea Pigs; Male; Membranes; Memory Disorders; Mice; Phenazocine; Piperazines; Piperidines; Radioligand Assay; Receptors, sigma | 1998 |
Influence of 3-PPP, a sigma receptor ligand, on the anticonvulsive action of conventional antiepileptic drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Dizocilpine Maleate; Female; Guanidines; Mice; Phenobarbital; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Valproic Acid | 1999 |
Effects of trazodone on neurotransmitter release from rat mossy fibre cerebellar synaptosomes.
Topics: Animals; Antidepressive Agents, Second-Generation; Cerebellum; Ethylenediamines; gamma-Aminobutyric Acid; Glutamic Acid; Male; Nerve Fibers; Phenazocine; Piperidines; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin; Synaptosomes; Trazodone | 2000 |
Mechanisms of inverse agonism of antipsychotic drugs at the D(2) dopamine receptor: use of a mutant D(2) dopamine receptor that adopts the activated conformation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Apomorphine; Binding, Competitive; Bromocriptine; Butaclamol; Chlorpromazine; CHO Cells; Clozapine; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; GTP-Binding Proteins; Haloperidol; Humans; Macromolecular Substances; Mutagenesis, Site-Directed; Phenethylamines; Piperidines; Protein Binding; Protein Conformation; Radioligand Assay; Receptors, Dopamine D2; Recombinant Fusion Proteins; Sodium; Spiperone; Structure-Activity Relationship; Sulpiride; Transfection; Tyramine | 2001 |
The selective sigma ligand MS-377 attenuates the blockade by phencyclidine of NMDA-induced intracellular calcium.
Topics: Algorithms; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Image Processing, Computer-Assisted; Ligands; Microscopy, Confocal; Neocortex; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Tartrates | 2002 |
Antagonism of NMDA receptors by sigma receptor ligands attenuates chemical ischemia-induced neuronal death in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclopentanes; Deoxyglucose; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fetus; Glucose; Glutamates; Haloperidol; Neurons; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sodium Azide | 2002 |
Dopamine agonist 3-PPP fails to protect against MPTP-induced toxicity.
Topics: Animals; Behavior, Animal; Cell Division; Cell Line, Tumor; Corpus Striatum; Dopamine; Dopamine Agonists; Humans; Mice; Mice, Inbred C57BL; Monoamine Oxidase; MPTP Poisoning; Neuroprotective Agents; Piperidines; Treatment Failure | 2004 |
Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain.
Topics: Allosteric Regulation; Animals; Anisoles; Anticonvulsants; Binding, Competitive; Brain; Dextromethorphan; Drug Interactions; Ethylenediamines; Guinea Pigs; Haloperidol; Ligands; Male; Morpholines; Neurons; Phenazocine; Phenytoin; Piperazines; Piperidines; Progesterone; Propylamines; Receptors, sigma; Synaptic Transmission | 2005 |
Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; DNA, Complementary; Dopamine; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Humans; Lisuride; Piperazines; Piperidines; Quinolones; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Risperidone; Transfection; Tritium | 2005 |
Radiosynthesis, ex vivo and in vivo evaluation of [11C]preclamol as a partial dopamine D2 agonist radioligand for positron emission tomography.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Chemical Phenomena; Chemistry, Physical; Dopamine Agonists; Indicators and Reagents; Injections, Intravenous; Isotope Labeling; Male; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 2006 |
In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Calcium Signaling; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Immunoblotting; Lisuride; MAP Kinase Signaling System; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Phosphorylation; Piperazines; Piperidines; Quinolones; Raclopride; Receptors, Dopamine D2; Schizophrenia; Time Factors; Transfection | 2007 |
Partial agonist actions of aripiprazole and the candidate antipsychotics S33592, bifeprunox, N-desmethylclozapine and preclamol at dopamine D(2L) receptors are modified by co-transfection of D(3) receptors: potential role of heterodimer formation.
Topics: Adenylyl Cyclases; Animals; Antipsychotic Agents; Aripiprazole; Benzamides; Benzoxazoles; Carrier Proteins; Chlorocebus aethiops; Clozapine; COS Cells; Cricetinae; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Piperazines; Piperidines; Quinolones; Receptors, Dopamine D2; Receptors, Dopamine D3; Transfection | 2007 |
Pharmacological blockade of dopamine D2 receptors by aripiprazole is not associated with striatal sensitization.
Topics: Animals; Apomorphine; Aripiprazole; Buffers; Catalepsy; Cell Membrane; Cerebral Cortex; Corpus Striatum; Domperidone; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Antagonism; Drug Partial Agonism; Guanosine 5'-O-(3-Thiotriphosphate); Haloperidol; Hippocampus; Male; Piperazines; Piperidines; Pyridines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Stereotyped Behavior; Up-Regulation | 2011 |
Effects of the dopamine stabilizers (S)-(-)-OSU6162 and ACR16 on prolactin secretion in drug-naive and monoamine-depleted rats.
Topics: Animals; Aripiprazole; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Haloperidol; Hyperprolactinemia; Lactotrophs; Male; Methyltyrosines; Piperazines; Piperidines; Prolactin; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Reserpine | 2011 |
Ligand-promoted C3-selective arylation of pyridines with Pd catalysts: gram-scale synthesis of (±)-preclamol.
Topics: Ligands; Molecular Structure; Organometallic Compounds; Palladium; Piperidines; Pyridines; Stereoisomerism | 2011 |
A comparison of the effects of the dopamine partial agonists aripiprazole and (-)-3-PPP with quinpirole on stimulated dopamine release in the rat striatum: Studies using fast cyclic voltammetry in vitro.
Topics: Animals; Aripiprazole; Corpus Striatum; Dopamine; Dopamine Agonists; Drug Partial Agonism; In Vitro Techniques; Male; Piperazines; Piperidines; Quinolones; Quinpirole; Rats; Rats, Wistar | 2012 |
Regional brain imaging of vesicular acetylcholine transporter using o-[125 I]iodo-trans-decalinvesamicol as a new potential imaging probe.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Brain; Iodine Radioisotopes; Ligands; Male; Narcotic Antagonists; Pentazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Tomography, Emission-Computed, Single-Photon; Vesicular Acetylcholine Transport Proteins | 2014 |
The potential of o-bromo-trans-decalinvesamicol as a new PET ligand for vesicular acetylcholine transporter imaging.
Topics: Animals; Autoradiography; Brain; Bromine Radioisotopes; Central Nervous System Agents; Male; Pentazocine; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Rats, Sprague-Dawley; Receptors, sigma; Vesicular Acetylcholine Transport Proteins | 2014 |
Agonist and antagonist effects of aripiprazole on D₂-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone.
Topics: Animals; Aripiprazole; Autoreceptors; Corpus Striatum; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Piperidines; Potassium; Presynaptic Terminals; Quinpirole; Rats, Sprague-Dawley; Receptors, Dopamine D2 | 2014 |
A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes.
Topics: Alkenes; Allyl Compounds; Boranes; Catalysis; Copper; Molecular Structure; Organometallic Compounds; Palladium; Piperidines; Stereoisomerism | 2015 |
The role of kinetic context in apparent biased agonism at GPCRs.
Topics: Animals; Aripiprazole; CHO Cells; Cricetulus; Dopamine; Dopamine Agonists; Indoles; Kinetics; Ligands; Piperazines; Piperidines; Principal Component Analysis; Protein Stability; Receptors, Dopamine D2 | 2016 |
The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.
Topics: Aging; Animals; Calbindins; Calcium; Cations, Divalent; Coculture Techniques; Corpus Striatum; Dendritic Spines; Disease Models, Animal; Endoplasmic Reticulum; Humans; Huntington Disease; Mice; Mice, Transgenic; Neuroprotective Agents; Piperidines; Rats, Inbred SHR; Receptors, sigma; Sigma-1 Receptor; Synapses | 2017 |
Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington's Disease.
Topics: Animals; Anisoles; Calcium; Cerebral Cortex; Corpus Striatum; Dendritic Spines; Gene Expression; Homeostasis; Huntington Disease; Male; Mice; Models, Biological; Morpholines; Neurons; Piperidines; Primary Cell Culture; Propylamines; Receptors, sigma; RNA, Small Interfering; Sigma-1 Receptor; Synapses; Synaptic Transmission; Transduction, Genetic | 2017 |