pre 084 has been researched along with donepezil in 3 studies
| Studies (pre 084) | Trials (pre 084) | Recent Studies (post-2010) (pre 084) | Studies (donepezil) | Trials (donepezil) | Recent Studies (post-2010) (donepezil) |
|---|---|---|---|---|---|
| 116 | 0 | 73 | 3,193 | 557 | 1,594 |
| Protein | Taxonomy | pre 084 (IC50) | donepezil (IC50) |
|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | 0.4231 | |
| Acetylcholinesterase | Tetronarce californica (Pacific electric ray) | 0.0265 | |
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.022 | |
| Cholinesterase | Homo sapiens (human) | 4.5742 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 7.42 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 5 | |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | 7.4 | |
| Acetylcholinesterase | Mus musculus (house mouse) | 1.5489 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.3257 | |
| Acetylcholinesterase | Bos taurus (cattle) | 0.1644 | |
| Choline O-acetyltransferase | Rattus norvegicus (Norway rat) | 0.0053 | |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | 0.0182 | |
| Beta-secretase 1 | Homo sapiens (human) | 0.8666 | |
| Cholinesterase | Equus caballus (horse) | 3.7325 | |
| Cholinesterase | Mus musculus (house mouse) | 1.992 | |
| Acetylcholine receptor subunit epsilon | Homo sapiens (human) | 0.0324 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 3.7844 | |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | 4.715 | |
| Carboxylic ester hydrolase | Equus caballus (horse) | 4.5551 | |
| Histamine H3 receptor | Homo sapiens (human) | 0.35 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Belyakov, S; Dambrova, M; Kazoka, H; Kuznecovs, J; Lebedev, A; Liepinsh, E; Mishnev, A; Orlova, N; Ponomaryov, Y; Vavers, E; Veinberg, G; Vikainis, S; Vilskersts, R; Vorona, M; Zvejniece, L | 1 |
| Kapai, NA; Popova, OV; Rogozin, PD; Skrebitsky, VG; Solntseva, EI | 1 |
| Maurice, T | 1 |
3 other study(ies) available for pre 084 and donepezil
| Article | Year |
|---|---|
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Topics: Acetamides; Allosteric Regulation; Animals; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism; Structure-Activity Relationship | 2013 |
The involvement of sigma1 receptors in donepezil-induced rescue of hippocampal LTP impaired by beta-amyloid peptide.
Topics: Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Cholinesterase Inhibitors; Donepezil; Haloperidol; Indans; Long-Term Potentiation; Male; Morpholines; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, sigma | 2014 |
Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments.
Topics: Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Furans; Indans; Male; Memantine; Memory Disorders; Mice; Morpholines; Neuroprotective Agents; Peptide Fragments; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2016 |