pre 084 has been researched along with cocaine in 10 studies
| Studies (pre 084) | Trials (pre 084) | Recent Studies (post-2010) (pre 084) | Studies (cocaine) | Trials (cocaine) | Recent Studies (post-2010) (cocaine) |
|---|---|---|---|---|---|
| 116 | 0 | 73 | 32,461 | 1,096 | 9,400 |
| Protein | Taxonomy | pre 084 (IC50) | cocaine (IC50) |
|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.338 | |
| Fatty acid-binding protein, heart | Homo sapiens (human) | 0.367 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0855 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0855 | |
| D | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.2861 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.4321 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0855 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.5442 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.8885 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.3796 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5.541 | |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | 0.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.05 | |
| Transporter | Rattus norvegicus (Norway rat) | 3.2277 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bowen, WD; Cao, J; George, C; Husbands, SM; Katz, JL; Kopajtic, T; Kulkarni, SS; Newman, AH; Williams, W | 1 |
| Maurice, T; Phan, VL; Romieu, P; Urani, A | 1 |
| Atianzar, K; Dubinett, SM; Escuadro, B; Gardner, B; Sharma, S; Tashkin, DP; Zhu, LX | 1 |
| Dubinett, SM; Gardner, B; Roth, MD; Sharma, S; Tashkin, DP; Zhu, LX | 1 |
| Hiranita, T; Katz, JL; Soto, PL; Tanda, G | 2 |
| Garcés-Ramírez, L; Green, JL; Hiranita, T; Katz, JL; Kopajtic, TA; McCurdy, CR; Mereu, M; Mesangeau, C; Narayanan, S; Tanda, G; Thomas, AM | 1 |
| Abdelazeem, AH; Hiranita, T; Katz, JL; Kopajtic, TA; McCurdy, CR; Mesangeau, C; Narayanan, S; Rice, KC | 1 |
| Amara, SG; Chin, FT; Hiranita, T; Hong, WC; Katz, JL; McCurdy, CR; Su, TP; Yano, H | 1 |
| Álvarez, M; Andino Norat, MC; Gorantla, S; López, OV; Meléndez, LM; Segarra, AC; Skolasky, RL | 1 |
10 other study(ies) available for pre 084 and cocaine
| Article | Year |
|---|---|
Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.
Topics: Animals; Binding, Competitive; Brain; Cocaine-Related Disorders; Crystallography, X-Ray; Dopamine; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Models, Molecular; Nerve Tissue Proteins; Piperazines; Radioligand Assay; Rats; Receptors, sigma; Structure-Activity Relationship | 2003 |
Strain differences in sigma(1) receptor-mediated behaviours are related to neurosteroid levels.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Binding Sites; Brain; Brain Chemistry; Cinnamates; Cocaine; Conditioning, Psychological; Cyclopropanes; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Morpholines; Neurons; Nootropic Agents; Phenazocine; Radioligand Assay; Receptors, sigma; Sigma-1 Receptor; Steroids | 2002 |
IL-10 mediates sigma 1 receptor-dependent suppression of antitumor immunity.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adjuvants, Immunologic; Adoptive Transfer; Animals; Antibodies, Monoclonal; Cell Division; Cocaine; Cytokines; Down-Regulation; Growth Inhibitors; Immunocompetence; Injections, Intraperitoneal; Injections, Subcutaneous; Interferon-gamma; Interleukin-10; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Morpholines; Neoplasm Transplantation; Receptors, sigma; Sigma-1 Receptor; Spleen; Tumor Cells, Cultured; Up-Regulation | 2003 |
Cocaine modulates cytokine and enhances tumor growth through sigma receptors.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Anesthetics, Local; Animals; Antibodies; Cell Line, Tumor; Cell Size; Cocaine; Cytokines; Drug Interactions; Ethylenediamines; Interferon-gamma; Interleukin-10; Mice; Mice, Inbred BALB C; Morpholines; Neoplasms; Receptors, sigma; Th2 Cells; Transplants | 2004 |
Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Ethylamines; Guanidines; Male; Morpholines; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement Schedule; Reward; Self Administration | 2010 |
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.
Topics: Animals; Benzoxazoles; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Ethylamines; Ethylenediamines; Guanidines; Male; Microdialysis; Morpholines; Nucleus Accumbens; Piperazines; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Synaptic Transmission | 2011 |
Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats.
Topics: Animals; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Guanidines; Male; Morpholines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement Schedule; Self Administration; Time Factors | 2011 |
Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.
Topics: Animals; Behavior, Animal; Brain; Cocaine; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Ligands; Male; Morpholines; Pentazocine; Protein Binding; Radioligand Assay; Rats, Sprague-Dawley; Receptors, sigma; Self Administration | 2016 |
The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.
Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Guanidines; Male; Morpholines; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, sigma; Synaptosomes | 2017 |
Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine.
Topics: Animals; Apoptosis; Brain; Caspase 3; Cathepsin B; Cell Line; Cocaine; Ethylenediamines; Female; HIV Core Protein p24; HIV Infections; Humans; Immunohistochemistry; Macrophages; Mice; Mice, Inbred ICR; Morpholines; Receptors, sigma; Sigma-1 Receptor; Young Adult | 2019 |