Compounds > pre 084
Page last updated: 2024-09-03

pre 084 and 1,3-ditolylguanidine

pre 084 has been researched along with 1,3-ditolylguanidine in 7 studies

Compound Research Comparison

Studies
(pre 084)		Trials
(pre 084)		Recent Studies (post-2010)
(pre 084)		Studies
(1,3-ditolylguanidine)		Trials
(1,3-ditolylguanidine)		Recent Studies (post-2010) (1,3-ditolylguanidine)
116073357071

Protein Interaction Comparison

ProteinTaxonomypre 084 (IC50)1,3-ditolylguanidine (IC50)
polyadenylate-binding protein 1Homo sapiens (human)19.8
RevHuman immunodeficiency virus 18.312
Female germline-specific tumor suppressor gld-1Caenorhabditis elegans5.205
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.036
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)0.1816

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Calderon, SN; Gutkind, JS; Heller, B; Izenwasser, S; Mattson, MV; Newman, AH; Su, TP1
Cuevas, J; Guerrero, WR; Herrera, Y; Katnik, C; Pennypacker, KR1
Hiranita, T; Katz, JL; Soto, PL; Tanda, G2
Garcés-Ramírez, L; Green, JL; Hiranita, T; Katz, JL; Kopajtic, TA; McCurdy, CR; Mereu, M; Mesangeau, C; Narayanan, S; Tanda, G; Thomas, AM1
Abdelazeem, AH; Hiranita, T; Katz, JL; Kopajtic, TA; McCurdy, CR; Mesangeau, C; Narayanan, S; Rice, KC1
Amara, SG; Chin, FT; Hiranita, T; Hong, WC; Katz, JL; McCurdy, CR; Su, TP; Yano, H1

Other Studies

7 other study(ies) available for pre 084 and 1,3-ditolylguanidine

ArticleYear
Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.
    Journal of medicinal chemistry, 1994, Jul-22, Volume: 37, Issue:15

    Topics: Animals; Anticonvulsants; Antitussive Agents; Binding Sites; Cyclopentanes; In Vitro Techniques; Male; Myocardial Ischemia; Rats; Rats, Sprague-Dawley; Receptors, sigma; Structure-Activity Relationship

1994
Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:3

    Topics: Analgesics, Opioid; Animals; Brain Ischemia; Calcium; Calcium Signaling; Cerebral Cortex; Cyclopentanes; Cytophotometry; Enzyme Inhibitors; Ethylenediamines; Female; Guanidines; Morpholines; Neurons; Pentazocine; Phencyclidine; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Sodium Azide; Sodium Channel Agonists; Tetrodotoxin

2006
Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:2

    Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Ethylamines; Guanidines; Male; Morpholines; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement Schedule; Reward; Self Administration

2010
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.
    Biological psychiatry, 2011, Feb-01, Volume: 69, Issue:3

    Topics: Animals; Benzoxazoles; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drug Interactions; Ethylamines; Ethylenediamines; Guanidines; Male; Microdialysis; Morpholines; Nucleus Accumbens; Piperazines; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma; Synaptic Transmission

2011
Lack of cocaine-like discriminative-stimulus effects of σ-receptor agonists in rats.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: Animals; Cocaine; Discrimination Learning; Dopamine Uptake Inhibitors; Guanidines; Male; Morpholines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reinforcement Schedule; Self Administration; Time Factors

2011
Blockade of Cocaine or σ Receptor Agonist Self Administration by Subtype-Selective σ Receptor Antagonists.
    The Journal of pharmacology and experimental therapeutics, 2016, Volume: 358, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Cocaine; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; In Vitro Techniques; Ligands; Male; Morpholines; Pentazocine; Protein Binding; Radioligand Assay; Rats, Sprague-Dawley; Receptors, sigma; Self Administration

2016
The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.
    The Journal of biological chemistry, 2017, 07-07, Volume: 292, Issue:27

    Topics: Animals; Behavior, Animal; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Guanidines; Male; Morpholines; Protein Conformation; Rats; Rats, Sprague-Dawley; Receptors, sigma; Synaptosomes

2017