pravastatin and y 27632

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Amides; Arteriosclerosis; Base Sequence; Botulinum Toxins; Cells, Cultured; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Monocytes; Plasminogen Activator Inhibitor 1; Polyisoprenyl Phosphates; Pravastatin; Protein Prenylation; Protein Serine-Threonine Kinases; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction

Topics: ADP Ribose Transferases; Amides; Analysis of Variance; Animals; Botulinum Toxins; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Interleukin-6; Intracellular Signaling Peptides and Proteins; Lovastatin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pravastatin; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; RNA, Messenger

Topics: ADP Ribose Transferases; Amides; Animals; Atrial Natriuretic Factor; Botulinum Toxins; Cell Size; Cells, Cultured; Endothelin-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Mevalonic Acid; Myocytes, Cardiac; Phenylalanine; Polyisoprenyl Phosphates; Pravastatin; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger

Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Amides; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Cells, Cultured; Chemotaxis; Coronary Vessels; Enalapril; Farnesyltranstransferase; Free Radical Scavengers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Lipoproteins, LDL; Losartan; Mammary Arteries; Metalloporphyrins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidative Stress; Pravastatin; Protein Serine-Threonine Kinases; Pyridines; Receptors, Oxidized LDL; rho-Associated Kinases

Topics: Amides; Anthracenes; Aorta; Blotting, Western; Boron Compounds; cdc42 GTP-Binding Protein; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Endothelial Cells; Enzyme Activation; Flavonoids; Humans; Imidazoles; Leucine; Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Protein Transport; Pyridines; rac1 GTP-Binding Protein; Thrombomodulin; Time Factors; Tumor Necrosis Factor-alpha

Topics: 3T3-L1 Cells; Adipocytes; Amides; Animals; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipopolysaccharides; Mevalonic Acid; Mice; Monomeric GTP-Binding Proteins; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Pravastatin; Pyridines; rho-Associated Kinases; Simvastatin; Tumor Necrosis Factor-alpha

Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; ADP Ribose Transferases; Amides; Animals; Atorvastatin; Botulinum Toxins; Dose-Response Relationship, Drug; Glucose; Glucose Transporter Type 4; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin Receptor Substrate Proteins; Mice; Phosphorylation; Polyisoprenyl Phosphates; Pravastatin; Protein Kinase Inhibitors; Protein Prenylation; Protein Transport; Proto-Oncogene Proteins c-akt; Pyridines; Pyrroles; rab4 GTP-Binding Proteins; Receptor, Insulin; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction

Topics: Acyl Coenzyme A; Amides; Anticholesteremic Agents; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-6; Kidney; Leucine; Lipopolysaccharides; NF-kappa B; Pravastatin; Pyridines; Signal Transduction; Simvastatin; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

Topics: Amides; Androstadienes; Animals; Caspase 3; Cell Culture Techniques; Cell Survival; Creatine Kinase; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fibroblasts; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Infusions, Intravenous; L Cells; Mice; Muscle, Skeletal; Pravastatin; Pyridines; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Simvastatin; Subcellular Fractions; Time Factors; Wortmannin

Topics: Amides; Animals; Bleomycin; Connective Tissue Growth Factor; Cytoskeleton; Endomyocardial Fibrosis; Female; Heart; Lung; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Pravastatin; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Radiation Injuries; Radiation Pneumonitis; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; rho-Associated Kinases; rhoB GTP-Binding Protein; Simvastatin; Smad Proteins; Thorax

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cyclohexenes; Cytokines; Diphosphonates; Fibroblasts; Fluvastatin; Gene Expression Regulation; Heart; Heart Diseases; Humans; Interleukin-33; Lovastatin; Mevalonic Acid; Monoterpenes; Myocardium; Myocytes, Cardiac; Pravastatin; Pyridines; rhoA GTP-Binding Protein; Simvastatin; Thiazolidines