Page last updated: 2024-08-23

pravastatin and pitavastatin

pravastatin has been researched along with pitavastatin in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (4.17)18.2507
2000's16 (22.22)29.6817
2010's47 (65.28)24.3611
2020's6 (8.33)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Aoki, T; Kimata, H; Kitahara, M; Kojima, J; Nakagawa, S; Nishimura, H; Saito, Y; Sakashita, M; Sato, F; Suzuki, H; Tamaki, T; Toyoda, K; Wada, Y; Yokoo, N1
Kanaki, T; Kitahara, M; Miyakoshi, C; Saito, Y; Tamaki, T; Tanaka, S; Toyoda, K1
Fukuda, N; Goto, H; Jayasooriya, AP; Ogawa, Y; Sakono, M; Todaka, N; Yamamoto, K1
Hamakubo, T; Inoue, K; Kitahara, M; Kodama, T; Morikawa, S; Nakagawa, S; Saito, Y; Suganami, H; Umetani, M; Yamazaki, H1
Goto, Y; Hata, Y; Itakura, H; Mabuchi, H; Nakaya, N; Ogawa, N; Saito, Y; Sasaki, J; Teramoto, T; Tushima, M; Yamada, N1
Abe, T; Endou, H; Kikuchi, R; Kusuhara, H; Sugiyama, Y1
Asano, Y; Asanuma, H; Fujita, M; Hirata, A; Hori, M; Kim, J; Kitakaze, M; Kitamura, S; Minamino, T; Mori, H; Node, K; Ogai, A; Okuda, H; Sanada, S; Shinozaki, Y; Takashima, S; Tomoike, H1
Hasegawa, R; Hirata-Koizumi, M; Miyake, S; Saito, M; Urano, T1
Miyashita, Y; Murano, T; Oyama, T; Saiki, A; Shirai, K; Watanabe, F1
Fujino, M; Kawamura, A; Matsuo, Y; Miura, S; Saku, K; Tanigawa, H1
Jadhav, SB; Jain, GK1
Hayashi, T; Ka, Y; Kitamura, A; Matsumura, Y; Mori, T; Ohkita, M; Sugii, M; Takaoka, M1
Deng, JW; Kim, KB; Liu, KH; Shin, JG; Shon, JH; Song, IS; Zhou, HH1
Abe, M; Fukuhara, A; Kobayashi, H; Komuro, R; Matsuda, M; Miyata, Y; Nakayama, Y; Shimomura, I1
Cho, DY; Deng, JW; Shin, HJ; Shin, JG; Shon, JH; Song, IS; Yeo, CW1
Fujii, T; Kuwano, H; Onimaru, M; Sueishi, K; Yonemitsu, Y1
Kadonosono, K; Takano, T; Tanaka, S; Terauchi, Y; Yamakawa, T1
Fukumoto, Y; Rashid, M; Seto, M; Shimokawa, H; Tawara, S; Yano, K1
Hibi, K; Kunishima, T; Michishita, I; Miyake, S; Morino, Y; Muramatsu, T; Nozue, T; Sato, A; Sozu, T; Takeyama, Y; Tohyama, S; Umezawa, S; Yamamoto, S; Yamauchi, T1
Endo, C; Kitamura, S; Kusuhara, H; Miyajima, M; Ose, A; Sugiyama, Y; Tohyama, K1
Watson, KE1
Akishita, M; Eto, M; Iijima, K; Kahyo, T; Kano, MR; Ogawa, S; Ota, H; Ouchi, Y; Setou, M1
Abe, A; Katayama, Y; Katsura, K; Nagayama, H; Nishiyama, Y; Otsuka, T; Ueda, M1
Betteridge, J1
Kadonosono, K; Kaneko, T; Kawaguchi, J; Morita, S; Shigematu, E; Terauchi, Y; Yamakawa, T1
Arai, H; Minami, M; Murayama, T; Tamura, Y; Yokode, M1
Lin, ZQ; Yang, J; Yin, XF1
Inoguchi, T; Kimura, S; Maeda, Y; Sonoda, N; Takayanagi, R; Yokomizo, H1
Hibi, K; Kunishima, T; Michishita, I; Miyake, S; Morino, Y; Muramatsu, T; Nozue, T; Sato, A; Sozu, T; Takeyama, Y; Terashima, M; Tohyama, S; Umezawa, S; Yamamoto, S; Yamauchi, T1
Galetin, A; Houston, JB; Kenworthy, KE; Ménochet, K1
Budinski, D; Gosho, M; Hounslow, N; Stender, S1
Fukui, K; Hibi, K; Kunishima, T; Michishita, I; Nozue, T; Onishi, Y; Terashima, M; Tohyama, S; Umezawa, S; Yamamoto, S1
Fukui, K; Hibi, K; Kunishima, T; Michishita, I; Miyake, S; Morino, Y; Muramatsu, T; Nozato, T; Nozue, T; Onishi, Y; Sato, A; Takeyama, Y; Terashima, M; Tohyama, S; Umezawa, S; Yamamoto, S; Yamauchi, T4
Fukui, K; Hibi, K; Kunishima, T; Michishita, I; Miyake, S; Morino, Y; Muramatsu, T; Nozato, T; Nozue, T; Onishi, Y; Sato, A; Takeyama, Y; Tohyama, S; Umezawa, S; Yamamoto, S; Yamauchi, T1
Hattori, H; Hirano, T; Ishihara, M; Iwasaki, T; Kawashiri, MA; Michishita, I; Nozue, T; Yamagishi, M1
Fukumoto, Y; Kudo, S; Liao, JK; Minami, T; Nochioka, K; Shiba, N; Shimokawa, H; Takai, Y; Tanaka, S; Williams, CL1
Fukui, K; Hibi, K; Kunishima, T; Michishita, I; Morino, Y; Nozue, T; Onishi, Y; Sozu, T; Takeyama, Y; Terashima, M; Tohyama, S; Umezawa, S; Yamamoto, S; Yamauchi, T1
Chapman, MJ; Giral, P; Hounslow, N; Orsoni, A; Robillard, P; Sponseller, CA1
Campbell, SE; Davidson, MH; Kryzhanovski, VA; Morgan, RE; Sponseller, CA1
Ahn, CW; Cha, BS; Cho, Y; Choe, E; Choi, Y; Kang, ES; Lee, HC; Lee, YH; Seo, JW; Wang, HJ; Yun, Y1
Baek, SH; Cho, HJ; Jeon, HK; Kang, SM; Kim, HY; Lee, HY; Shin, JH1
Choi, D; Hong, MK; Jang, Y; Kim, BK; Kim, JS; Ko, YG; Shin, DH; Suh, Y1
Arai, M; Kako, N; Kawasaki, M; Minatoguchi, S; Miwa, H; Nagaya, M; Noda, T; Onishi, N; Ono, K; Saeki, M; Sato, N; Tanaka, R; Watanabe, S; Watanabe, T1
Zhao, SP; Zhao, W1
D'Agostino, RB; Jones, SR; Joshi, PH; Martin, SS; Massaro, JM; Miller, PE; Sponseller, CA; Toth, PP1
Asaumi, R; Kotani, N; Kusuhara, H; Maeda, K; Nakada, T; Sugiyama, Y; Toshimoto, K; Yoshida, K; Yoshikado, T1
Jiang, M; Liu, TT; Pan, DQ; Shi, JH; Wang, Q1
Banach, M; Blaha, MJ; Chruściel, P; Jones, SR; Lip, GY; Martin, SS; Mikhailidis, DP; Mosteoru, S; Pencina, MJ; Ray, KK; Rembek-Wieliczko, M; Rysz, J; Sahebkar, A; Serban, MC; Toth, PP; Ursoniu, S1
Bai, Y; Chan, C; Chang, X; Cheng, N; Cheng, Z; Lu, Y; Zhao, Y1
D'Agostino, RB; Jones, SR; Joshi, PH; Kulkarni, KR; Martin, SS; Massaro, JM; Miller, PE; Sponseller, C; Toth, PP1
Aberg, JA; Burdo, TH; Fitch, KV; Grinspoon, SK; McCurdy Pate, M; Sanchez, L; Sponseller, CA; Toribio, M; Williams, KC; Zanni, MV1
Aberg, JA; Campbell, SE; Kryzhanovski, VA; Sponseller, CA; Thompson, MA; Ward, DJ1
Kanamitsu, K; Kusuhara, H; Schuetz, JD; Sugiyama, Y; Takeuchi, K1
Ikejiri, K; Kusuhara, H; Maeda, K; Nakada, T; Sugiyama, Y; Toshimoto, K; Yoshikado, T1
Anoopkumar-Dukie, S; Davey, AK; McFarland, AJ1
Barton, HA; Li, R1
Kume, T; Takahashi, T; Uno, Y; Yamazaki, H1
Benet, LZ; Bowman, CM; Okochi, H1
Betteridge, DJ; Carmena, R1
Bowman, CM; Chen, E; Chen, L; Chen, Y; Chen, YC; Liang, X; Mao, J; Wright, M1
Avihingsanon, A; Bautista-Arredondo, S; Bendavid, E; Boettiger, DC; Chaiwarith, R; Chattranukulchai, P; Kahn, JG; Khusuwan, S; Kiertiburanakul, S; Law, MG; Newall, AT; Phillips, A; Ross, J1
Kang, HT; Kim, HS; Kim, J; Lee, JW; Yang, W1
Butterton, JR; Caro, L; Fandozzi, CM; Feng, HP; Fraser, IP; Guo, Z; Iwamoto, M; Levine, V; Panebianco, D; Prueksaritanont, T; Swearingen, D; Wolford, D; Yeh, WW1
Bowman, CM; Chen, B; Chen, Y; Cheong, J; Liu, L; Mao, J1
Alkaabi, M; Amoodi, AA; Baraka, MA; Don, J; Elnour, AA; Farah, FH; Mazrouei, NA; Ramadan, A; Sadeq, A; Sam, KG1

Reviews

7 review(s) available for pravastatin and pitavastatin

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Statins and osteoporosis: new role for old drugs.
    The Journal of pharmacy and pharmacology, 2006, Volume: 58, Issue:1

    Topics: Animals; Atorvastatin; Bone and Bones; Clinical Trials as Topic; Drug Delivery Systems; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Fractures, Bone; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Lovastatin; Osteogenesis; Osteoporosis; Pharmacokinetics; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Quinolines; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2006
Pitavastatin - results from phase III & IV.
    Atherosclerosis. Supplements, 2010, Volume: 11, Issue:3

    Topics: Atorvastatin; Clinical Trials, Phase III as Topic; Clinical Trials, Phase IV as Topic; Dyslipidemias; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Pravastatin; Pyrroles; Quinolines; Simvastatin

2010
Impact of statin therapy on plasma adiponectin concentrations: A systematic review and meta-analysis of 43 randomized controlled trial arms.
    Atherosclerosis, 2016, Volume: 253

    Topics: Adiponectin; Adult; Aged; Atorvastatin; Cardiovascular Diseases; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pravastatin; Quinolines; Randomized Controlled Trials as Topic; Regression Analysis; Rosuvastatin Calcium; Simvastatin

2016
Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis.
    Atherosclerosis, 2016, Volume: 254

    Topics: Anticholesteremic Agents; Atorvastatin; Bayes Theorem; Coronary Disease; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Kidney Diseases; Lipids; Lovastatin; Muscles; Network Meta-Analysis; Patient Safety; Pravastatin; Quinolines; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome

2016
Diabetogenic Action of Statins: Mechanisms.
    Current atherosclerosis reports, 2019, 04-30, Volume: 21, Issue:6

    Topics: Aged; Animals; Blood Glucose; Cardiovascular Diseases; Cholesterol; Diabetes Mellitus, Type 2; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Insulin; Male; Metabolic Syndrome; Mice; Middle Aged; Pravastatin; Quinolines; Risk Factors

2019
A Systematic Review of Randomized Clinical Trials on the Efficacy and Safety of Pitavastatin.
    Current reviews in clinical and experimental pharmacology, 2023, Volume: 18, Issue:2

    Topics: Atorvastatin; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Dyslipidemias; HIV Infections; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Syndrome; Pravastatin; Randomized Controlled Trials as Topic; Rosuvastatin Calcium; Simvastatin

2023

Trials

27 trial(s) available for pravastatin and pitavastatin

ArticleYear
A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia.
    Atherosclerosis, 2002, Volume: 162, Issue:2

    Topics: Adult; Aged; Cholesterol; Cholesterol, LDL; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Pravastatin; Quinolines; Safety

2002
The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.
    Pharmacogenetics and genomics, 2008, Volume: 18, Issue:5

    Topics: Adult; Anticholesteremic Agents; Biological Transport; Cross-Over Studies; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Inactivation, Metabolic; Indoles; Liver-Specific Organic Anion Transporter 1; Male; Metabolic Clearance Rate; Oocytes; Organic Anion Transporters; Polymorphism, Single Nucleotide; Pravastatin; Protein Binding; Quinolines; Substrate Specificity

2008
Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors.
    Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult; Angiotensin II; Animals; Atorvastatin; Cells, Cultured; Cross-Over Studies; Endothelium, Vascular; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Leukocytes; Male; Pravastatin; Pyrroles; Quinolines; rac1 GTP-Binding Protein; ras Proteins; Rats; Rats, Inbred WKY; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction

2009
Treatment with statin on atheroma regression evaluated by intravascular ultrasound with Virtual Histology (TRUTH Study): rationale and design.
    Circulation journal : official journal of the Japanese Circulation Society, 2009, Volume: 73, Issue:2

    Topics: Atherosclerosis; Coronary Artery Disease; Coronary Vessels; Endpoint Determination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Pravastatin; Prospective Studies; Quinolines; Ultrasonography, Interventional; User-Computer Interface

2009
Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients.
    Journal of atherosclerosis and thrombosis, 2011, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Arginine; Atherosclerosis; Atorvastatin; Brain Ischemia; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Linear Models; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Quinolines; Stroke

2011
Randomized comparison of pitavastatin and pravastatin treatment on the reduction of urinary albumin in patients with type 2 diabetic nephropathy.
    Diabetes, obesity & metabolism, 2012, Volume: 14, Issue:7

    Topics: Aged; Albuminuria; Biomarkers; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Humans; Male; Pravastatin; Quinolines; Treatment Outcome

2012
Statin treatment for coronary artery plaque composition based on intravascular ultrasound radiofrequency data analysis.
    American heart journal, 2012, Volume: 163, Issue:2

    Topics: Aged; Coronary Artery Disease; Coronary Vessels; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Plaque, Atherosclerotic; Pravastatin; Prospective Studies; Quinolines; Treatment Outcome; Ultrasonography, Interventional

2012
Pitavastatin shows greater lipid-lowering efficacy over 12 weeks than pravastatin in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia.
    European journal of preventive cardiology, 2013, Volume: 20, Issue:1

    Topics: Aged; Aged, 80 and over; Cholesterol, LDL; Double-Blind Method; Drug Tolerance; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Pravastatin; Quinolines; Time Factors; Treatment Outcome

2013
Impacts of estimated glomerular filtration rate on coronary atherosclerosis and plaque composition before and during statin therapy in patients with normal to mild renal dysfunction: subanalysis of the TRUTH study.
    Nephrology (Carlton, Vic.), 2012, Volume: 17, Issue:7

    Topics: Aged; Biomarkers; Coronary Artery Disease; Coronary Vessels; Dyslipidemias; Female; Fibrosis; Glomerular Filtration Rate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Kidney; Kidney Diseases; Lipids; Male; Middle Aged; Multivariate Analysis; Percutaneous Coronary Intervention; Plaque, Atherosclerotic; Pravastatin; Prospective Studies; Quinolines; Risk Assessment; Risk Factors; Severity of Illness Index; Time Factors; Treatment Outcome; Ultrasonography, Interventional

2012
Effects of serum n-3 to n-6 polyunsaturated fatty acids ratios on coronary atherosclerosis in statin-treated patients with coronary artery disease.
    The American journal of cardiology, 2013, Jan-01, Volume: 111, Issue:1

    Topics: Aged; Biomarkers; Chromatography, Gas; Coronary Artery Disease; Coronary Vessels; Disease Progression; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pravastatin; Prospective Studies; Quinolines; Treatment Outcome; Ultrasonography, Interventional

2013
Effects of statins on serum n-3 to n-6 polyunsaturated fatty acid ratios in patients with coronary artery disease.
    Journal of cardiovascular pharmacology and therapeutics, 2013, Volume: 18, Issue:4

    Topics: Aged; alpha-Linolenic Acid; Arachidonic Acid; Cholesterol, LDL; Coronary Artery Disease; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Longitudinal Studies; Male; Middle Aged; Pravastatin; Prospective Studies; Quinolines

2013
Comparison of change in coronary atherosclerosis in patients with stable versus unstable angina pectoris receiving statin therapy (from the Treatment With Statin on Atheroma Regression Evaluated by Intravascular Ultrasound With Virtual Histology [TRUTH] s
    The American journal of cardiology, 2013, Apr-01, Volume: 111, Issue:7

    Topics: Aged; Angina, Stable; Angina, Unstable; Biomarkers; Coronary Artery Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Lipids; Male; Plaque, Atherosclerotic; Pravastatin; Quinolines; Regression Analysis; Treatment Outcome; Ultrasonography, Interventional

2013
Comparison of effects of pitavastatin versus pravastatin on serum proprotein convertase subtilisin/kexin type 9 levels in statin-naive patients with coronary artery disease.
    The American journal of cardiology, 2013, May-15, Volume: 111, Issue:10

    Topics: Aged; Apoptosis; Biomarkers; Coronary Artery Disease; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pravastatin; Proprotein Convertase 9; Proprotein Convertases; Prospective Studies; Quinolines; Serine Endopeptidases; Severity of Illness Index; Treatment Outcome

2013
Comparison of effects of serum n-3 to n-6 polyunsaturated fatty acid ratios on coronary atherosclerosis in patients treated with pitavastatin or pravastatin undergoing percutaneous coronary intervention.
    The American journal of cardiology, 2013, Jun-01, Volume: 111, Issue:11

    Topics: Aged; Atherosclerosis; Biomarkers; Coronary Artery Disease; Dose-Response Relationship, Drug; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Percutaneous Coronary Intervention; Pravastatin; Prospective Studies; Quinolines; Severity of Illness Index; Treatment Outcome; Ultrasonography, Interventional

2013
Statins exert the pleiotropic effects through small GTP-binding protein dissociation stimulator upregulation with a resultant Rac1 degradation.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:7

    Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Atorvastatin; Biomarkers; Cardiomegaly; Cells, Cultured; Cholesterol; Cholesterol, LDL; Coronary Vessels; Cross-Over Studies; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guanine Nucleotide Exchange Factors; Heptanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Japan; Male; Mice; Mice, Knockout; Neuropeptides; Oxidative Stress; Phosphatidylinositol 3-Kinase; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; rac GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA Interference; Signal Transduction; Transfection

2013
C-reactive protein and future cardiovascular events in statin-treated patients with angina pectoris: the extended TRUTH study.
    Journal of atherosclerosis and thrombosis, 2013, Volume: 20, Issue:9

    Topics: Aged; Angina Pectoris; C-Reactive Protein; Cardiovascular Diseases; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Japan; Male; Middle Aged; Myocardial Infarction; Plaque, Atherosclerotic; Pravastatin; Prospective Studies; Quinolines; Regression Analysis; Risk Factors; Treatment Outcome; Ultrasonography, Interventional

2013
Effect of high-dose pitavastatin on glucose homeostasis in patients at elevated risk of new-onset diabetes: insights from the CAPITAIN and PREVAIL-US studies.
    Current medical research and opinion, 2014, Volume: 30, Issue:5

    Topics: Blood Glucose; Cholesterol, LDL; Cohort Studies; Diabetes Mellitus; Dose-Response Relationship, Drug; Homeostasis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Male; Metabolic Syndrome; Middle Aged; Pravastatin; Quinolines; Triglycerides

2014
Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound.
    Heart and vessels, 2015, Volume: 30, Issue:1

    Topics: Acute Coronary Syndrome; Aged; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Necrosis; Phenotype; Plaque, Atherosclerotic; Pravastatin; Prospective Studies; Quinolines; Ultrasonography, Interventional

2015
Comparison of the lipid-lowering effects of pitavastatin 4 mg versus pravastatin 40 mg in adults with primary hyperlipidemia or mixed (combined) dyslipidemia: a Phase IV, prospective, US, multicenter, randomized, double-blind, superiority trial.
    Clinical therapeutics, 2014, Aug-01, Volume: 36, Issue:8

    Topics: Aged; Apolipoproteins B; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Dyslipidemias; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Male; Middle Aged; Pravastatin; Prospective Studies; Quinolines; Triglycerides

2014
Effects of intensive versus mild lipid lowering by statins in patients with ischemic congestive heart failure: Korean Pitavastatin Heart Failure (SAPHIRE) study.
    The Korean journal of internal medicine, 2014, Volume: 29, Issue:6

    Topics: Aged; Biomarkers; Cholesterol, LDL; Down-Regulation; Dyslipidemias; Exercise Tolerance; Female; Heart Failure; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Myocardial Ischemia; Pravastatin; Prospective Studies; Quinolines; Recovery of Function; Republic of Korea; Stroke Volume; Time Factors; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling

2014
Impact of statin treatment on strut coverage after drug-eluting stent implantation.
    Yonsei medical journal, 2015, Volume: 56, Issue:1

    Topics: Adult; Coronary Angiography; Drug-Eluting Stents; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Male; Middle Aged; Pravastatin; Prosthesis Implantation; Quinolines; Tomography, Optical Coherence; Treatment Outcome

2015
Anti-inflammatory and morphologic effects of pitavastatin on carotid arteries and thoracic aorta evaluated by integrated backscatter trans-esophageal ultrasound and PET/CT: a prospective randomized comparative study with pravastatin (EPICENTRE study).
    Cardiovascular ultrasound, 2015, Apr-02, Volume: 13

    Topics: Aged; Anti-Inflammatory Agents; Atherosclerosis; Carotid Arteries; Echocardiography, Transesophageal; Female; Humans; Male; Multimodal Imaging; Positron-Emission Tomography; Pravastatin; Quinolines; Reproducibility of Results; Sensitivity and Specificity; Systems Integration; Thoracic Arteries; Tomography, X-Ray Computed; Treatment Outcome

2015
Pitavastatin 4 mg Provides Significantly Greater Reduction in Remnant Lipoprotein Cholesterol Compared With Pravastatin 40 mg: Results from the Short-term Phase IV PREVAIL US Trial in Patients With Primary Hyperlipidemia or Mixed Dyslipidemia.
    Clinical therapeutics, 2016, Volume: 38, Issue:3

    Topics: Aged; Cholesterol; Cholesterol, LDL; Double-Blind Method; Dyslipidemias; Female; Humans; Hyperlipidemias; Lipids; Lipoproteins; Male; Middle Aged; Pravastatin; Quinolines

2016
Greater remnant lipoprotein cholesterol reduction with pitavastatin compared with pravastatin in HIV-infected patients.
    AIDS (London, England), 2017, 04-24, Volume: 31, Issue:7

    Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Cholesterol; Double-Blind Method; Dyslipidemias; Female; HIV Infections; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins; Male; Middle Aged; Pravastatin; Quinolines; Treatment Outcome; Ultracentrifugation; Young Adult

2017
Effects of pitavastatin and pravastatin on markers of immune activation and arterial inflammation in HIV.
    AIDS (London, England), 2017, 03-27, Volume: 31, Issue:6

    Topics: Anticholesteremic Agents; Arteritis; Biomarkers; Double-Blind Method; HIV Infections; Humans; Immunologic Factors; Pravastatin; Quinolines; Treatment Outcome

2017
Pitavastatin versus pravastatin in adults with HIV-1 infection and dyslipidaemia (INTREPID): 12 week and 52 week results of a phase 4, multicentre, randomised, double-blind, superiority trial.
    The lancet. HIV, 2017, Volume: 4, Issue:7

    Topics: Adolescent; Adult; Aged; Anti-HIV Agents; Anticholesteremic Agents; Cholesterol, LDL; Double-Blind Method; Dyslipidemias; Female; HIV Infections; Humans; Male; Middle Aged; Placebos; Pravastatin; Puerto Rico; Quinolines; Treatment Outcome; United States; Young Adult

2017
Evaluation of Pharmacokinetic Drug Interactions of the Direct-Acting Antiviral Agents Elbasvir and Grazoprevir with Pitavastatin, Rosuvastatin, Pravastatin, and Atorvastatin in Healthy Adults.
    Clinical drug investigation, 2021, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Amides; Antiviral Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzofurans; Carbamates; Cyclopropanes; Drug Interactions; Female; Humans; Imidazoles; Male; Middle Aged; Neoplasm Proteins; Pravastatin; Quinolines; Quinoxalines; Rosuvastatin Calcium; Sulfonamides; Young Adult

2021

Other Studies

38 other study(ies) available for pravastatin and pitavastatin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.
    Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3

    Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship

2016
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:8

    Topics: Animals; Dogs; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Kinetics; Lipids; Liver; Lovastatin; Male; Pravastatin; Quinolines; Rats; Rats, Wistar; Simvastatin; Sterols

1997
NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery.
    Japanese journal of pharmacology, 1998, Volume: 77, Issue:2

    Topics: Animals; Aorta; Carotid Arteries; Carotid Artery Injuries; Catheterization; Cell Division; Cell Line; DNA; Eukaryotic Cells; Extracellular Matrix; Fibronectins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipids; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Quinolines; Rabbits; Simvastatin; Transforming Growth Factor beta; Tunica Intima; Tunica Media

1998
Effect of NK-104, a new synthetic HMG-CoA reductase inhibitor, on triglyceride secretion and fatty acid oxidation in rat liver.
    Life sciences, 1999, Volume: 65, Issue:14

    Topics: Animals; Binding, Competitive; Fatty Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Microsomes, Liver; Oxidation-Reduction; Pravastatin; Quinolines; Rats; Rats, Wistar; Simvastatin; Triglycerides

1999
Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells.
    Journal of atherosclerosis and thrombosis, 2000, Volume: 7, Issue:3

    Topics: Atorvastatin; Cell Line; Heptanoic Acids; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Pravastatin; Pyrroles; Quinolines; Receptors, LDL; RNA, Messenger; Simvastatin

2000
Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain; Carrier Proteins; Digoxin; DNA, Complementary; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Kinetics; Male; Microinjections; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Pravastatin; Quinolines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Taurocholic Acid

2004
Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase.
    Circulation, 2004, Oct-12, Volume: 110, Issue:15

    Topics: 5'-Nucleotidase; Adenosine Triphosphate; Androstadienes; Animals; Cardiotonic Agents; Chromones; Coronary Disease; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pravastatin; Pyridines; Quinolines; Signal Transduction; Theophylline; Wortmannin

2004
A literature search on pharmacokinetic drug interactions of statins and analysis of how such interactions are reflected in package inserts in Japan.
    Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:1

    Topics: Area Under Curve; Atorvastatin; Biomedical Research; Databases, Bibliographic; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Indoles; Japan; Pharmacology, Clinical; Pravastatin; Product Labeling; Pyrroles; Quinolines; Simvastatin; United States; United States Food and Drug Administration

2005
Pitavastatin enhanced lipoprotein lipase expression in 3T3-L1 preadipocytes.
    Journal of atherosclerosis and thrombosis, 2005, Volume: 12, Issue:3

    Topics: 3T3-L1 Cells; Animals; Atorvastatin; Cell Culture Techniques; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoprotein Lipase; Mevalonic Acid; Mice; Pioglitazone; PPAR gamma; Pravastatin; Pyrroles; Quinolines; RNA, Messenger; Simvastatin; Thiazolidinediones

2005
Pitavastatin-induced downregulation of CCR2 and CCR5 in monocytes is associated with the arrest of cell-cycle in S phase.
    Atherosclerosis, 2006, Volume: 187, Issue:2

    Topics: Anticholesteremic Agents; Cell Division; Chemokine CCL2; Chemokine CCL5; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Humans; Monocytes; Pravastatin; Quinolines; Receptors, CCR2; Receptors, CCR5; Receptors, Chemokine; S Phase; U937 Cells; Up-Regulation

2006
Differential effects of different statins on endothelin-1 gene expression and endothelial NOS phosphorylation in porcine aortic endothelial cells.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:6

    Topics: Animals; Aorta; Atorvastatin; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelium, Vascular; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Nitric Oxide Synthase Type III; Phosphorylation; Pravastatin; Pyridines; Pyrroles; Quinolines; RNA, Messenger; Swine

2006
Determination of two HMG-CoA reductase inhibitors, pravastatin and pitavastatin, in plasma samples using liquid chromatography-tandem mass spectrometry for pharmaceutical study.
    Biomedical chromatography : BMC, 2008, Volume: 22, Issue:2

    Topics: Chromatography, Liquid; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Pravastatin; Quinolines; Tandem Mass Spectrometry

2008
Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages.
    Arteriosclerosis, thrombosis, and vascular biology, 2008, Volume: 28, Issue:5

    Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interferon Regulatory Factor-3; Interferon-beta; Interleukin-6; Macrophages; Male; Mice; Mice, Obese; Myeloid Differentiation Factor 88; Obesity; Pravastatin; Quinolines; Signal Transduction; Toll-Like Receptor 4

2008
Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:6

    Topics: Animals; Becaplermin; Blood Glucose; Cells, Cultured; Cholesterol, LDL; Combined Modality Therapy; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Foot; Enzyme Inhibitors; Genetic Therapy; Glycation End Products, Advanced; Hindlimb; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemia; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Platelet-Derived Growth Factor; Pravastatin; Proto-Oncogene Proteins c-sis; Quinolines; Regional Blood Flow; Signal Transduction; Time Factors; Up-Regulation

2008
Influence of pitavastatin on glucose tolerance in patients with type 2 diabetes mellitus.
    Journal of atherosclerosis and thrombosis, 2008, Volume: 15, Issue:5

    Topics: Atorvastatin; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation; Glucose Intolerance; Glycated Hemoglobin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Pravastatin; Pyrroles; Quinolines; Retrospective Studies

2008
Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1

    Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Capillaries; Cell Line; Cell Membrane; Cerebral Cortex; Choroid Plexus; Digoxin; Enkephalin, D-Penicillamine (2,5)-; Fluorobenzenes; Gene Expression; Humans; Ion Pumps; Kinetics; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Ochratoxins; Organic Anion Transporters; Organic Cation Transport Proteins; Pharmaceutical Preparations; Pravastatin; Pyrimidines; Quinolines; Recombinant Proteins; Rosuvastatin Calcium; Sulfonamides; Taurocholic Acid; Tetrahydroisoquinolines; Transfection

2010
Pitavastatin: the newest HMG-CoA reductase inhibitor.
    Reviews in cardiovascular medicine, 2010,Winter, Volume: 11, Issue:1

    Topics: Atorvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Pravastatin; Product Surveillance, Postmarketing; Pyrroles; Quinolines; Simvastatin

2010
Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:11

    Topics: Animals; Atorvastatin; Catalase; Cellular Senescence; Endothelial Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Nitric Oxide Synthase Type III; Oxidative Stress; Pravastatin; Proto-Oncogene Proteins c-akt; Pyrroles; Quinolines; Sirtuin 1; Umbilical Veins

2010
Glucose-lowering effect of colestimide is associated with baseline HbA1c in type 2 diabetic patients with hypercholesterolemia.
    Endocrine journal, 2011, Volume: 58, Issue:3

    Topics: Aged; Atorvastatin; Blood Glucose; Comorbidity; Diabetes Mellitus, Type 2; Epichlorohydrin; Female; Glycated Hemoglobin; Heptanoic Acids; Humans; Hypercholesterolemia; Hypoglycemic Agents; Imidazoles; Lipids; Male; Middle Aged; Multivariate Analysis; Pravastatin; Pyrroles; Quinolines; Resins, Synthetic; Retrospective Studies; Treatment Outcome

2011
Differential effect of statins on diabetic nephropathy in db/db mice.
    International journal of molecular medicine, 2011, Volume: 28, Issue:5

    Topics: Adiposity; Albuminuria; Animals; Blood Pressure; Body Weight; Creatinine; Diabetic Nephropathies; Fluorobenzenes; Insulin Resistance; Male; Mice; Oxidative Stress; Pravastatin; Pyrimidines; Quinolines; Real-Time Polymerase Chain Reaction; Rosuvastatin Calcium; Sulfonamides

2011
[Prediction of the pharmacokinetic drug-drug interaction of pravastatin and pitavastatin with cyclosporine by a digital liver model based on metabolism and transporter].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2011, Volume: 46, Issue:9

    Topics: Animals; Area Under Curve; Biological Transport; Computer Simulation; Cyclosporine; Drug Interactions; Humans; Liver; Metabolic Clearance Rate; Models, Biological; Pravastatin; Quinolines

2011
Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biological Transport; Bosentan; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Fluorobenzenes; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kinetics; Models, Biological; Organic Anion Transporters; Piperidines; Pravastatin; Pyrimidines; Quinolines; Rats; Rosuvastatin Calcium; Species Specificity; Sulfonamides; Telmisartan; Tetrazoles; Valine; Valsartan

2012
Risk of diabetes in patients treated with HMG-CoA reductase inhibitors.
    Metabolism: clinical and experimental, 2015, Volume: 64, Issue:4

    Topics: Aged; Atorvastatin; Diabetes Mellitus; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Pravastatin; Pyrimidines; Pyrroles; Quinolines; Retrospective Studies; Risk Factors; Rosuvastatin Calcium; Simvastatin; Sulfonamides

2015
Different effects of statins on induction of diabetes mellitus: an experimental study.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Atorvastatin; Cell Cycle; Cell Survival; Cells, Cultured; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucose; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Muscle, Skeletal; Pravastatin; Quinolines; Rosuvastatin Calcium; Signal Transduction; Structure-Activity Relationship

2015
Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method.
    Clinical pharmacology and therapeutics, 2016, Volume: 100, Issue:5

    Topics: Antibiotics, Antitubercular; Computer Simulation; Cyclosporine; Drug Interactions; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Models, Biological; Organic Anion Transporters; Pravastatin; Quinolines; Rifampin

2016
Characterization of interactions of simvastatin, pravastatin, fluvastatin, and pitavastatin with bovine serum albumin: multiple spectroscopic and molecular docking.
    Journal of biomolecular structure & dynamics, 2017, Volume: 35, Issue:7

    Topics: Animals; Binding Sites; Cattle; Fatty Acids, Monounsaturated; Fluvastatin; Hydrogen Bonding; Indoles; Kinetics; Molecular Docking Simulation; Pravastatin; Protein Binding; Quinolines; Serum Albumin, Bovine; Simvastatin; Solutions; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Thermodynamics

2017
Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
    Journal of pharmaceutical sciences, 2017, Volume: 106, Issue:9

    Topics: 2,4-Dichlorophenoxyacetic Acid; Acridines; Adenosine Triphosphate; Animals; Biological Transport; Blood-Brain Barrier; Brain; Central Nervous System; Cyclic GMP; Humans; Kinetics; Male; Methotrexate; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Ochratoxins; Pravastatin; Quinazolines; Quinolines; Tetrahydroisoquinolines; Thiophenes; Uric Acid

2017
Comparison of Methods for Estimating Unbound Intracellular-to-Medium Concentration Ratios in Rat and Human Hepatocytes Using Statins.
    Drug metabolism and disposition: the biological fate of chemicals, 2017, Volume: 45, Issue:7

    Topics: Animals; Biological Transport; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Male; Membrane Potentials; Organic Anion Transporters; Permeability; Pravastatin; Quinolines; Rats; Rats, Sprague-Dawley; Rosuvastatin Calcium

2017
Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-Like Cells.
    Mediators of inflammation, 2017, Volume: 2017

    Topics: Anti-Inflammatory Agents; Antioxidants; Atorvastatin; Cell Proliferation; Chronic Disease; Dinoprostone; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Inflammation; Interleukin-1beta; Lipids; Lipopolysaccharides; Microglia; Monocytes; Nitric Oxide; Pravastatin; Quinolines; Reactive Oxygen Species; Rosuvastatin Calcium; Simvastatin; THP-1 Cells; Tumor Necrosis Factor-alpha

2017
Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis.
    Clinical pharmacokinetics, 2018, Volume: 57, Issue:4

    Topics: Asian People; Atorvastatin; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carbamates; Computer Simulation; Gene Frequency; Genotype; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Models, Biological; Neoplasm Proteins; Pharmacogenomic Variants; Phenotype; Piperidines; Pravastatin; Quinolines; Rosuvastatin Calcium; White People

2018
Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes.
    Biopharmaceutics & drug disposition, 2019, Volume: 40, Issue:2

    Topics: Animals; Drug Interactions; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1; Macaca fascicularis; Macaca mulatta; Organic Anion Transporters; Plasmids; Pravastatin; Quinolines; Recombinant Proteins; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3; Substrate Specificity; Telmisartan

2019
The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation.
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:4

    Topics: Animals; Atorvastatin; Biological Transport; Cells, Cultured; Hepatocytes; Kinetics; Liver; Membrane Transport Proteins; Metabolic Clearance Rate; Organic Anion Transporters; Pravastatin; Protein Binding; Quinolines; Rats; Rosuvastatin Calcium

2019
Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma.
    Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 48, Issue:1

    Topics: Blood Proteins; Cell Culture Techniques; Culture Media; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1; Pravastatin; Protein Binding; Quinolines; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3; Substrate Specificity

2020
Statins for atherosclerotic cardiovascular disease prevention in people living with HIV in Thailand: a cost-effectiveness analysis.
    Journal of the International AIDS Society, 2020, Volume: 23 Suppl 1

    Topics: Adult; Atherosclerosis; Cost-Benefit Analysis; Drug Costs; Female; HIV Infections; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pravastatin; Quality-Adjusted Life Years; Quinolines; Thailand

2020
Primary Prevention of Cardiocerebrovascular Diseases and Related Deaths According to Statin Type.
    International journal of environmental research and public health, 2020, 08-30, Volume: 17, Issue:17

    Topics: Adult; Aged; Atorvastatin; Cardiovascular Diseases; Cerebrovascular Disorders; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Pravastatin; Primary Prevention; Pyrroles; Quinolines; Retrospective Studies; Rosuvastatin Calcium; Simvastatin

2020
Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.
    Drug metabolism and disposition: the biological fate of chemicals, 2021, Volume: 49, Issue:7

    Topics: Administration, Intravenous; Carbamates; Drug Discovery; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1; Models, Biological; Piperidines; Plasma; Pravastatin; Quinolines; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3

2021