Compounds > pravastatin
Page last updated: 2024-08-23

pravastatin and piperidines

pravastatin has been researched along with piperidines in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (6.67)29.6817
2010's11 (73.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Bachmakov, I; Fromm, MF; Glaeser, H; König, J1
Anwar, S; Baral, C; Hakenberg, J; Liang, S; Tari, L1
Galetin, A; Houston, JB; Kenworthy, KE; Ménochet, K1
Badolo, L; Bundgaard, C; Garmer, M; Jensen, B1
Jiang, K1
Huang, J; Ma, YR; Rao, Z; Wei, YH; Wu, XA; Zhang, GQ; Zhou, Y1
Brazier, J; Brown, WT; Campbell, SE; D'Agostino, RB; Gordon, LB; Kieran, MW; Kleinman, ME; Massaro, J1
Hisama, FM; Martin, GM; Oshima, J1
Li, F; Ling, Z; Liu, C; Liu, L; Liu, X; Shu, N; Xu, D; Zhang, M; Zhong, Z1
Cleveland, RH; D'Agostino, RB; Dowton, AA; Gerhard-Herman, M; Gordon, CM; Gordon, LB; Greer, MM; Huh, SY; Kieran, MW; Kleinman, ME; Liang, MG; Littlefield, K; Massaro, J; Miller, DT; Nazarian, A; Quinn, N; Shappell, H; Silvera, VM; Smoot, LB; Snyder, BD; Ullrich, NJ1
Barton, HA; Li, R1
Baltrusaitis, K; Braddock, DT; Cleveland, RH; D'Agostino, RB; Gordon, CM; Gordon, LB; Kieran, MW; Kleinman, ME; Li, X; Liang, MG; Massaro, J; Snyder, B; Walters, M1
Cabral, WA; Collins, FS; Cubria, MB; DuBose, A; Erdos, MR; Kamalapathy, P; Karim, L; Masoudi, A; Nazarian, A; Oftadeh, R; Snyder, BD; Suarez, S1
Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N1
Bowman, CM; Chen, B; Chen, Y; Cheong, J; Liu, L; Mao, J1

Trials

1 trial(s) available for pravastatin and piperidines

ArticleYear
Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome.
    Circulation, 2016, Jul-12, Volume: 134, Issue:2

    Topics: Bone and Bones; Carotid Arteries; Child, Preschool; Diphosphonates; Drug Therapy, Combination; Female; Humans; Imidazoles; Infant; Male; Piperidines; Pravastatin; Progeria; Prospective Studies; Protein Prenylation; Pyridines; Zoledronic Acid

2016

Other Studies

14 other study(ies) available for pravastatin and piperidines

ArticleYear
Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.
    Diabetes, 2008, Volume: 57, Issue:6

    Topics: Administration, Oral; Animals; Biological Transport; Carbamates; Cell Line; Dogs; Hepatocytes; Humans; Hypoglycemic Agents; Kidney; Kinetics; Liver; Liver-Specific Organic Anion Transporter 1; Metformin; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Piperidines; Pravastatin; Recombinant Proteins; Rosiglitazone; Solute Carrier Organic Anion Transporter Family Member 1B3; Thiazolidinediones

2008
Synthesis of pharmacokinetic pathways through knowledge acquisition and automated reasoning.
    Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing, 2010

    Topics: Artificial Intelligence; Carbamates; Computational Biology; Humans; Knowledge Bases; MEDLINE; Metabolic Networks and Pathways; Models, Biological; Pharmacokinetics; Piperidines; Pravastatin; Synthetic Biology

2010
Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biological Transport; Bosentan; Carbamates; Dose-Response Relationship, Drug; Drug Interactions; Fluorobenzenes; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kinetics; Models, Biological; Organic Anion Transporters; Piperidines; Pravastatin; Pyrimidines; Quinolines; Rats; Rosuvastatin Calcium; Species Specificity; Sulfonamides; Telmisartan; Tetrazoles; Valine; Valsartan

2012
The role of hepatic transport and metabolism in the interactions between pravastatin or repaglinide and two rOatp inhibitors in rats.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2013, Jul-16, Volume: 49, Issue:4

    Topics: Animals; Carbamates; Cells, Cultured; Diphenhydramine; Drug Interactions; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Male; Microsomes, Liver; Organic Anion Transporters; Piperidines; Pravastatin; Rats; Rats, Sprague-Dawley; Spironolactone

2013
Drug development for progeria yields insights into normal aging.
    Nature medicine, 2013, Volume: 19, Issue:5

    Topics: Aging; Child; Clinical Trials as Topic; Diphosphonates; Drug Discovery; Humans; Imidazoles; Lamin Type A; Mutation; Piperidines; Pravastatin; Progeria; Pyridines; Time Factors; Zoledronic Acid

2013
[Simultaneous determination of repaglinide and pravastatin sodium in rat plasma by LC-ms/MS and its application on pharmacokinetic interactions study].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:1

    Topics: Administration, Oral; Animals; Carbamates; Chromatography, High Pressure Liquid; Drug Interactions; Male; Piperidines; Pravastatin; Random Allocation; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2014
Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.
    Circulation, 2014, Jul-01, Volume: 130, Issue:1

    Topics: Adolescent; Adult; Alkyl and Aryl Transferases; Atherosclerosis; Cause of Death; Child; Child, Preschool; Clinical Trials as Topic; Cohort Studies; Dimethylallyltranstransferase; Diphosphonates; Drug Therapy, Combination; Female; Genes, Dominant; Genotype; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Kaplan-Meier Estimate; Lamin Type A; Male; Multicenter Studies as Topic; Nuclear Proteins; Piperidines; Pravastatin; Progeria; Proportional Hazards Models; Protein Precursors; Protein Prenylation; Pyridines; Treatment Outcome; Young Adult; Zoledronic Acid

2014
An encouraging progress report on the treatment of progeria and its implications for atherogenesis.
    Circulation, 2014, Jul-01, Volume: 130, Issue:1

    Topics: Diphosphonates; Female; Humans; Imidazoles; Lamin Type A; Male; Nuclear Proteins; Piperidines; Pravastatin; Progeria; Protein Precursors; Protein Prenylation; Pyridines; Zoledronic Acid

2014
Co-administration of paroxetine increased the systemic exposure of pravastatin in diabetic rats due to the decrease in liver distribution.
    Xenobiotica; the fate of foreign compounds in biological systems, 2015, Volume: 45, Issue:9

    Topics: Administration, Intravenous; Administration, Oral; Animals; Body Fluids; Carbamates; Cell Separation; Diabetes Mellitus, Experimental; Diet, High-Fat; Disease Models, Animal; Feces; Hepatocytes; Intestinal Absorption; Liver; Male; Paroxetine; Piperidines; Pravastatin; Rats, Sprague-Dawley; Tissue Distribution

2015
Explaining Ethnic Variability of Transporter Substrate Pharmacokinetics in Healthy Asian and Caucasian Subjects with Allele Frequencies of OATP1B1 and BCRP: A Mechanistic Modeling Analysis.
    Clinical pharmacokinetics, 2018, Volume: 57, Issue:4

    Topics: Asian People; Atorvastatin; ATP Binding Cassette Transporter, Subfamily G, Member 2; Carbamates; Computer Simulation; Gene Frequency; Genotype; Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Models, Biological; Neoplasm Proteins; Pharmacogenomic Variants; Phenotype; Piperidines; Pravastatin; Quinolines; Rosuvastatin Calcium; White People

2018
Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.
    Bone, 2019, Volume: 125

    Topics: Calcinosis; Calcium; Child; Child, Preschool; Creatinine; Female; Fibroblast Growth Factor-23; Humans; In Vitro Techniques; Lamin Type A; Male; Parathyroid Hormone; Piperidines; Pravastatin; Progeria; Pyridines; Zoledronic Acid

2019
Evaluation of musculoskeletal phenotype of the G608G progeria mouse model with lonafarnib, pravastatin, and zoledronic acid as treatment groups.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 06-02, Volume: 117, Issue:22

    Topics: Aging; Animals; Bone and Bones; Bone Density Conservation Agents; Cartilage; Disease Models, Animal; Femur; Glycosaminoglycans; Joints; Lamin Type A; Mice; Mice, Transgenic; Mutation; Osteoarthritis; Phenotype; Piperidines; Pravastatin; Progeria; Protein Processing, Post-Translational; Pyridines; X-Ray Microtomography; Zoledronic Acid

2020
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
    Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:4

    Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil

2020
Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.
    Drug metabolism and disposition: the biological fate of chemicals, 2021, Volume: 49, Issue:7

    Topics: Administration, Intravenous; Carbamates; Drug Discovery; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1; Models, Biological; Piperidines; Plasma; Pravastatin; Quinolines; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3

2021