Compounds > pramipexole
Page last updated: 2024-09-03

pramipexole and topotecan

pramipexole has been researched along with topotecan in 3 studies

Compound Research Comparison

Studies
(pramipexole)		Trials
(pramipexole)		Recent Studies (post-2010)
(pramipexole)		Studies
(topotecan)		Trials
(topotecan)		Recent Studies (post-2010) (topotecan)
1,1032195172,392626792

Protein Interaction Comparison

ProteinTaxonomypramipexole (IC50)topotecan (IC50)
Cytochrome P450 3A4Homo sapiens (human)1.5211
DNA topoisomerase 1Homo sapiens (human)0.8525
DNA topoisomerase 2-alphaHomo sapiens (human)0.605
DNA topoisomerase 2-betaHomo sapiens (human)0.605
Hypoxia-inducible factor 1-alphaHomo sapiens (human)0.06
Multidrug and toxin extrusion protein 2Homo sapiens (human)8.6
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.17

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andricopulo, AD; Moda, TL; Montanari, CA1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1

Reviews

2 review(s) available for pramipexole and topotecan

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

1 other study(ies) available for pramipexole and topotecan

ArticleYear
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007