Page last updated: 2024-09-03

pramipexole and risperidone

pramipexole has been researched along with risperidone in 8 studies

Compound Research Comparison

Studies
(pramipexole)
Trials
(pramipexole)
Recent Studies (post-2010)
(pramipexole)
Studies
(risperidone)
Trials
(risperidone)
Recent Studies (post-2010) (risperidone)
1,1032195176,9241,5052,477

Protein Interaction Comparison

ProteinTaxonomypramipexole (IC50)risperidone (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.015
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0027
Alpha-2A adrenergic receptorHomo sapiens (human)0.0097
Cytochrome P450 2D6Homo sapiens (human)5.2734
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)4.1901
D(2) dopamine receptorHomo sapiens (human)0.0167
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0991
Alpha-2B adrenergic receptorHomo sapiens (human)0.026
Alpha-2C adrenergic receptorHomo sapiens (human)0.0096
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.799
D(1A) dopamine receptorHomo sapiens (human)0.479
Histamine H2 receptorHomo sapiens (human)1.483
Alpha-1D adrenergic receptorHomo sapiens (human)0.01
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.0016
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.0057
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.799
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.0027
5-hydroxytryptamine receptor 2C Mus musculus (house mouse)0.0015
Alpha-1A adrenergic receptorHomo sapiens (human)0.0105
5-hydroxytryptamine receptor 2AMus musculus (house mouse)0.0015
Histamine H1 receptorHomo sapiens (human)0.4515
D(3) dopamine receptorHomo sapiens (human)0.024
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.023
D(2) dopamine receptorMus musculus (house mouse)0.023
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0154
5-hydroxytryptamine receptor 2BMus musculus (house mouse)0.0015
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.6303
5-hydroxytryptamine receptor 1AMus musculus (house mouse)0.43
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)4.1901
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.6

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Andricopulo, AD; Moda, TL; Montanari, CA1
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Davidson, M; Levy, A; Weizer, M1
Barsoum, P; Graff-Guerrero, A; Houle, S; Kapur, S; Mamo, D; Marcon, H; Mizrahi, R; Rusjan, P; Shammi, CM; Wilson, AA1
Ishitobi, M; Kosaka, H; Murata, T; Shukunami, K; Wada, Y1
Del Castillo, RM; Martínez, A; Ramos, E1

Reviews

2 review(s) available for pramipexole and risperidone

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[New antipsychotic drugs].
    Harefuah, 1997, Volume: 133, Issue:1-2

    Topics: Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Clinical Trials as Topic; Dibenzothiazepines; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Pramipexole; Psychotic Disorders; Quetiapine Fumarate; Risperidone; Thiazoles

1997

Trials

1 trial(s) available for pramipexole and risperidone

ArticleYear
The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO.
    Archives of general psychiatry, 2009, Volume: 66, Issue:6

    Topics: Adult; Antipsychotic Agents; Basal Ganglia; Benzodiazepines; Benzothiazoles; Binding, Competitive; Carbon Radioisotopes; Caudate Nucleus; Clozapine; Dopamine Agonists; Dopamine Antagonists; Double-Blind Method; Female; Globus Pallidus; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Olanzapine; Oxazines; Positron-Emission Tomography; Pramipexole; Putamen; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D3; Risperidone; Schizophrenia

2009

Other Studies

5 other study(ies) available for pramipexole and risperidone

ArticleYear
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Adjunctive treatment with low-dosage pramipexole for risperidone-associated hyperprolactinemia and sexual dysfunction in a male patient with schizophrenia.
    Journal of clinical psychopharmacology, 2011, Volume: 31, Issue:2

    Topics: Adult; Benzothiazoles; Drug Therapy, Combination; Erectile Dysfunction; Humans; Hyperprolactinemia; Male; Pramipexole; Risperidone; Schizophrenia

2011
Interaction of graphene with antipsychotic drugs: Is there any charge transfer process?
    Journal of computational chemistry, 2021, 01-05, Volume: 42, Issue:1

    Topics: Antipsychotic Agents; Dopamine; Graphite; Humans; Models, Chemical; Pramipexole; Receptors, Dopamine D2; Risperidone

2021