Page last updated: 2024-09-03

pramipexole and olanzapine

pramipexole has been researched along with olanzapine in 9 studies

Compound Research Comparison

Studies
(pramipexole)
Trials
(pramipexole)
Recent Studies (post-2010)
(pramipexole)
Studies
(olanzapine)
Trials
(olanzapine)
Recent Studies (post-2010) (olanzapine)
1,1032195176,3391,3402,383

Protein Interaction Comparison

ProteinTaxonomypramipexole (IC50)olanzapine (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.097
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.155
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.047
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.04
Alpha-2A adrenergic receptorHomo sapiens (human)0.541
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)2.768
D(2) dopamine receptorHomo sapiens (human)0.118
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.047
Alpha-2B adrenergic receptorHomo sapiens (human)0.421
Alpha-2C adrenergic receptorHomo sapiens (human)0.531
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.392
D(1A) dopamine receptorHomo sapiens (human)0.072
D(4) dopamine receptorHomo sapiens (human)0.173
Alpha-1D adrenergic receptorHomo sapiens (human)0.092
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.038
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.021
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.047
Sodium-dependent serotonin transporterHomo sapiens (human)1.033
Histamine H1 receptorHomo sapiens (human)0.013
D(3) dopamine receptorHomo sapiens (human)0.078
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.057
5-hydroxytryptamine receptor 6Homo sapiens (human)0.013
D(2) dopamine receptorRattus norvegicus (Norway rat)0.158
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2028

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's1 (11.11)29.6817
2010's7 (77.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alelyunas, YW; Bui, K; Empfield, JR; McCarthy, D; Pelosi-Kilby, L; Shen, C; Spreen, RC1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Davidson, M; Levy, A; Weizer, M1
Barsoum, P; Graff-Guerrero, A; Houle, S; Kapur, S; Mamo, D; Marcon, H; Mizrahi, R; Rusjan, P; Shammi, CM; Wilson, AA1
Coburn, KL; Doonan, SM; Lauterbach, EC; Mendez, MF; Shillcutt, SD; Victoroff, J1
Bet, PM; Franken, LG; Klumpers, UM1
Dutta, A; Rana, S; Talukdar, A; Talukdar, P1
Junewar, V; Rathaur, BP; Verma, R1

Reviews

3 review(s) available for pramipexole and olanzapine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[New antipsychotic drugs].
    Harefuah, 1997, Volume: 133, Issue:1-2

    Topics: Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Clinical Trials as Topic; Dibenzothiazepines; Humans; Imidazoles; Indoles; Olanzapine; Piperazines; Pirenzepine; Pramipexole; Psychotic Disorders; Quetiapine Fumarate; Risperidone; Thiazoles

1997
Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data.
    The Journal of neuropsychiatry and clinical neurosciences, 2010,Winter, Volume: 22, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Brain; Clonazepam; Desipramine; Dibenzothiazepines; Dopamine Agonists; Humans; Lithium Carbonate; Maprotiline; Melatonin; Neurodegenerative Diseases; Neuroprotective Agents; Olanzapine; Parkinson Disease; Pramipexole; Quetiapine Fumarate; Selective Serotonin Reuptake Inhibitors; Valproic Acid

2010

Trials

1 trial(s) available for pramipexole and olanzapine

ArticleYear
The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO.
    Archives of general psychiatry, 2009, Volume: 66, Issue:6

    Topics: Adult; Antipsychotic Agents; Basal Ganglia; Benzodiazepines; Benzothiazoles; Binding, Competitive; Carbon Radioisotopes; Caudate Nucleus; Clozapine; Dopamine Agonists; Dopamine Antagonists; Double-Blind Method; Female; Globus Pallidus; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Olanzapine; Oxazines; Positron-Emission Tomography; Pramipexole; Putamen; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D3; Risperidone; Schizophrenia

2009

Other Studies

5 other study(ies) available for pramipexole and olanzapine

ArticleYear
Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate.
    Bioorganic & medicinal chemistry letters, 2010, Dec-15, Volume: 20, Issue:24

    Topics: Central Nervous System Agents; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Solubility

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Could pramipexole induce acute mania? A case report.
    Bipolar disorders, 2013, Volume: 15, Issue:4

    Topics: Akathisia, Drug-Induced; Benzodiazepines; Benzothiazoles; Bipolar Disorder; Dopamine Agonists; Drug Interactions; Drug Therapy, Combination; Hospitalization; Humans; Male; Middle Aged; Olanzapine; Pramipexole; Restless Legs Syndrome; Sleep Initiation and Maintenance Disorders; Treatment Outcome

2013
Catatonia and parkinsonism as a sequelae of typhoid fever: a rare experience.
    BMJ case reports, 2013, Jun-27, Volume: 2013

    Topics: Adolescent; Amantadine; Antiparkinson Agents; Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Catatonia; Humans; Hypnotics and Sedatives; Lorazepam; Male; Olanzapine; Parkinsonian Disorders; Pramipexole; Typhoid Fever

2013
An atypical case of neuroleptic malignant syndrome precipitated by valproate.
    BMJ case reports, 2014, Mar-06, Volume: 2014

    Topics: Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Benzothiazoles; Dopamine Agonists; Drug Therapy, Combination; Female; Fluid Therapy; Humans; Levetiracetam; Lorazepam; Middle Aged; Neuroleptic Malignant Syndrome; Olanzapine; Piracetam; Pramipexole; Psychotic Disorders; Valproic Acid

2014