Page last updated: 2024-09-03

pramipexole and haloperidol

pramipexole has been researched along with haloperidol in 17 studies

Compound Research Comparison

Studies
(pramipexole)
Trials
(pramipexole)
Recent Studies (post-2010)
(pramipexole)
Studies
(haloperidol)
Trials
(haloperidol)
Recent Studies (post-2010) (haloperidol)
1,10321951720,3301,7533,294

Protein Interaction Comparison

ProteinTaxonomypramipexole (IC50)haloperidol (IC50)
Adenylate cyclase type 1 Rattus norvegicus (Norway rat)2.3
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)1.7
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)1.5
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.6765
Potassium channel subfamily K member 2Homo sapiens (human)5.5
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.836
ATP-dependent translocase ABCB1Homo sapiens (human)5.3
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.054
Cytochrome P450 3A4Homo sapiens (human)0.055
5-hydroxytryptamine receptor 1AHomo sapiens (human)1.5
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.1754
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M5Homo sapiens (human)3.89
Alpha-2A adrenergic receptorHomo sapiens (human)4.973
Beta-2 adrenergic receptorRattus norvegicus (Norway rat)2.3
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.054
Muscarinic acetylcholine receptor M1Homo sapiens (human)5.5
Cytochrome P450 2C9 Homo sapiens (human)4.69
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)7
D(2) dopamine receptorHomo sapiens (human)0.0897
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.1467
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0852
Alpha-2B adrenergic receptorHomo sapiens (human)1.354
Alpha-2C adrenergic receptorHomo sapiens (human)1.845
DRattus norvegicus (Norway rat)0.1103
D(3) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4.3045
D(2) dopamine receptorBos taurus (cattle)0.1332
D(1A) dopamine receptorHomo sapiens (human)0.0575
D(4) dopamine receptorHomo sapiens (human)0.0978
D(1B) dopamine receptorHomo sapiens (human)0.005
Adenylate cyclase type 3Rattus norvegicus (Norway rat)2.3
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0852
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.836
Histamine H2 receptorHomo sapiens (human)1.166
Alpha-1D adrenergic receptorHomo sapiens (human)0.084
D(1B) dopamine receptorRattus norvegicus (Norway rat)0.0067
Adenylate cyclase type 2Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 4Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.1815
5-hydroxytryptamine receptor 2CHomo sapiens (human)3.347
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 1DRattus norvegicus (Norway rat)0.018
D(4) dopamine receptorRattus norvegicus (Norway rat)0.0067
5-hydroxytryptamine receptor 1FRattus norvegicus (Norway rat)0.018
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.1754
Sodium-dependent serotonin transporterHomo sapiens (human)3.386
Histamine H1 receptorHomo sapiens (human)2.781
Mu-type opioid receptorHomo sapiens (human)2.443
D(3) dopamine receptorHomo sapiens (human)0.0065
Sodium channel protein type 1 subunit alphaHomo sapiens (human)7
Sodium channel protein type 4 subunit alphaHomo sapiens (human)7
Adenylate cyclase type 8Rattus norvegicus (Norway rat)2.3
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.05
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0852
Cytochrome P450 2J2Homo sapiens (human)4.69
D(2) dopamine receptorRattus norvegicus (Norway rat)0.0129
N-acetyltransferase EisMycobacterium tuberculosis H37Rv0.39
Sodium channel protein type 7 subunit alphaHomo sapiens (human)7
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)1.5
Adenylate cyclase type 6Rattus norvegicus (Norway rat)2.3
Adenylate cyclase type 5Rattus norvegicus (Norway rat)1.425
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2634
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)1.5
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.5
Sodium channel protein type 5 subunit alphaHomo sapiens (human)7
Sodium channel protein type 9 subunit alphaHomo sapiens (human)7
Adenylyl cyclase 7 Rattus norvegicus (Norway rat)2.3
DBos taurus (cattle)0.2509
Sodium channel protein type 2 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.07
Sodium channel protein type 3 subunit alphaHomo sapiens (human)7
Sigma non-opioid intracellular receptor 1Rattus norvegicus (Norway rat)0.0013
Sodium channel protein type 11 subunit alphaHomo sapiens (human)7
Sodium channel protein type 8 subunit alphaHomo sapiens (human)7
Sodium channel protein type 10 subunit alphaHomo sapiens (human)7

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (47.06)18.2507
2000's2 (11.76)29.6817
2010's7 (41.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chio, CL; Ensinger, HA; Huff, RM; Lajiness, ME; Mierau, J; Schneider, FJ1
Andricopulo, AD; Moda, TL; Montanari, CA1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Mierau, J; Schingnitz, G1
Lin, MY; Walters, DE1
Gerlach, J; Peacock, L1
Barnas, C; Heiden, A; Kasper, S; Laakmann, G; Pfolz, H; Volz, HP; Zeit, H1
Kołodziejczyk, K; Maj, J; Rogóz, Z; Skuza, G1
Hoffmann, WE; Hyslop, DK; Piercey, MF1
Lorenc-Koci, E; Wolfarth, S1
Fujiwara, RA; Siuciak, JA1
Buck, K; Buerger, E; Ferger, B; Koros, E; Shimasaki, M; Voehringer, P1
Deng, CM; Gao, YY; Li, Y; Mu, YL; Ou, BC; So, JH; Tan, ZB; Tang, M; Wang, YQ; Zhang, LQ; Zhu, ZR1
Ananthan, S; Głowacka, U; Kosmowska, B; Ossowska, K; Wardas, J1
Dehpour, AR; Imran Khan, M; Norouzi-Javidan, A; Ostadhadi, S1
Delev, DP; Doncheva, ND; Kostadinov, ID; Mihaylova, AS; Zlatanova, HI1

Reviews

1 review(s) available for pramipexole and haloperidol

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for pramipexole and haloperidol

ArticleYear
Pramipexole as adjunct to haloperidol in schizophrenia. Safety and efficacy.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1997, Volume: 7, Issue:1

    Topics: Adult; Akathisia, Drug-Induced; Antipsychotic Agents; Benzothiazoles; Dopamine Agonists; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Male; Middle Aged; Pramipexole; Prospective Studies; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Thiazoles

1997

Other Studies

15 other study(ies) available for pramipexole and haloperidol

ArticleYear
Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors.
    European journal of pharmacology, 1995, Jun-23, Volume: 290, Issue:1

    Topics: Animals; Benzothiazoles; Binding, Competitive; Cells, Cultured; CHO Cells; Cricetinae; Dopamine Agonists; Humans; Pramipexole; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Dopamine D4; Spiperone; Thiazoles

1995
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Biochemical and pharmacological studies on pramipexole, a potent and selective dopamine D2 receptor agonist.
    European journal of pharmacology, 1992, May-14, Volume: 215, Issue:2-3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzothiazoles; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; Exploratory Behavior; Female; Haloperidol; Male; Medial Forebrain Bundle; Mice; Motor Activity; Norepinephrine; Parkinson Disease, Secondary; Pramipexole; Rats; Receptors, Dopamine D2; Rotation; Stereoisomerism; Synapses; Thiazoles

1992
The D2 autoreceptor agonists SND 919 and PD 128483 decrease stereotypy in developing rats.
    Life sciences, 1994, Volume: 54, Issue:1

    Topics: Aging; Aminoquinolines; Animals; Benzothiazoles; Dopamine Agents; Dose-Response Relationship, Drug; Female; Haloperidol; Male; Motor Activity; Pramipexole; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Thiazoles

1994
Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol.
    European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3

    Topics: Administration, Oral; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Benzothiazoles; Cebus; Disease Models, Animal; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dyskinesia, Drug-Induced; Dystonia; Ergolines; Female; Haloperidol; Lisuride; Male; Piperidines; Pramipexole; Quinpirole; Raclopride; Salicylamides; Thiazoles

1993
The behavioural effects of pramipexole, a novel dopamine receptor agonist.
    European journal of pharmacology, 1997, Apr-11, Volume: 324, Issue:1

    Topics: Animals; Antiparkinson Agents; Benzazepines; Benzothiazoles; Body Temperature; Catalepsy; Clozapine; Dopamine Agents; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Haloperidol; Injections, Subcutaneous; Levodopa; Male; Mice; Motor Activity; Pramipexole; Rats; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Spiperone; Stereotyped Behavior; Sulpiride; Thiazoles

1997
Excitation of type II anterior caudate neurons by stimulation of dopamine D3 receptors.
    Brain research, 1997, Jul-11, Volume: 762, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminoquinolines; Animals; Benzothiazoles; Caudate Nucleus; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Haloperidol; Imidazoles; Neurons; Pramipexole; Quinpirole; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Tetrahydronaphthalenes; Thiazoles

1997
Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats.
    European journal of pharmacology, 1999, Nov-26, Volume: 385, Issue:1

    Topics: alpha-Methyltyrosine; Animals; Benzothiazoles; Dopamine Agonists; Dose-Response Relationship, Drug; Electromyography; Haloperidol; Male; Muscle Rigidity; Muscle, Skeletal; Parkinson Disease, Secondary; Pramipexole; Rats; Rats, Wistar; Reserpine; Thiazoles; Treatment Outcome

1999
The activity of pramipexole in the mouse forced swim test is mediated by D2 rather than D3 receptors.
    Psychopharmacology, 2004, Volume: 175, Issue:2

    Topics: Animals; Benzothiazoles; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Drug Interactions; Haloperidol; Male; Mice; Mice, Knockout; Motor Activity; Pramipexole; Receptors, Dopamine D2; Receptors, Dopamine D3; Species Specificity; Swimming; Thiazoles

2004
Continuous dopaminergic stimulation by pramipexole is effective to treat early morning akinesia in animal models of Parkinson's disease: A pharmacokinetic-pharmacodynamic study using in vivo microdialysis in rats.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:7

    Topics: Animals; Benzothiazoles; Catalepsy; Delayed-Action Preparations; Disease Models, Animal; Dopamine; Dopamine Agonists; Dyskinesia, Drug-Induced; Extracellular Space; Haloperidol; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Parkinson Disease; Parkinsonian Disorders; Photoperiod; Pramipexole; Rats; Rats, Wistar; Reserpine; Time Factors

2010
Dopamine D2/D3 but not dopamine D1 receptors are involved in the rapid antidepressant-like effects of ketamine in the forced swim test.
    Behavioural brain research, 2015, Feb-15, Volume: 279

    Topics: Animals; Antidepressive Agents; Benzazepines; Benzothiazoles; Dizocilpine Maleate; Fluoxetine; Haloperidol; Ketamine; Male; Mice; Motor Activity; Pramipexole; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine D3; Receptors, N-Methyl-D-Aspartate; Swimming

2015
Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline-induced Model of Essential Tremor in Rats.
    CNS neuroscience & therapeutics, 2016, Volume: 22, Issue:1

    Topics: Amisulpride; Animals; Anti-Dyskinesia Agents; Benzothiazoles; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Essential Tremor; Haloperidol; Harmaline; Imidazoles; Male; Movement; Nitriles; Pramipexole; Pyridines; Rats, Wistar; Receptors, Dopamine D2; Receptors, Dopamine D3; Sulpiride; Tetrahydroisoquinolines; Tetrahydronaphthalenes; Treatment Outcome

2016
Antidepressant effect of pramipexole in mice forced swimming test: A cross talk between dopamine receptor and NMDA/nitric oxide/cGMP pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 81

    Topics: Animals; Antidepressive Agents; Arginine; Benzothiazoles; Cyclic GMP; Dizocilpine Maleate; Haloperidol; Immobilization; Injections, Intraperitoneal; Male; Methylene Blue; Mice; Motor Activity; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pramipexole; Receptors, Dopamine; Signal Transduction; Sildenafil Citrate; Swimming

2016
Effects of Pramipexole on Learning and Memory Processes in Naïve and Haloperidol-challenged Rats in Active Avoidance Test.
    Folia medica, 2019, Jun-01, Volume: 61, Issue:2

    Topics: Animals; Avoidance Learning; Behavior, Animal; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Learning; Locomotion; Male; Memory; Pramipexole; Rats; Rats, Wistar

2019