Page last updated: 2024-09-03

pramipexole and gamma-aminobutyric acid

pramipexole has been researched along with gamma-aminobutyric acid in 16 studies

Compound Research Comparison

Studies
(pramipexole)
Trials
(pramipexole)
Recent Studies (post-2010)
(pramipexole)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
1,10321951740,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomypramipexole (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (25.00)29.6817
2010's12 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ciraulo, DA; Hennen, J; Jensen, JE; Ke, Y; Knapp, C; Kwak, T; Meyer, AA; Nassar, LE; Renshaw, PF; Sarid-Segal, O; Streeter, CC1
Molnar, MZ; Mucsi, I; Novak, M1
Callejas-Rubio, JL; López-Pérez, L; Navarro-Pelayo, F; Ortego-Centeno, N1
Allen, RP; Hening, W; Tenzer, P; Winkelman, JW1
de Biase, S; Gigli, GL; Lorenzut, S; Merlino, G; Valente, M1
Aurora, RN; Bista, SR; Casey, KR; Kristo, DA; Lamm, CI; Rosenberg, RS; Rowley, JA; Tracy, SL; Zak, RS1
Aricò, D; Ferri, R; Raggi, A; Siragusa, M; Zucconi, M1
Amos, LB; Collins, MM; D'Andrea, LA; Grekowicz, ML; Kuhn, EM; Norins, NA; Olstad, JD1
Allen, RP; Chen, C; DuBrava, S; Garcia-Borreguero, D; Knapp, L; Miceli, J; Polo, O; Winkelman, JW1
Chokroverty, S1
Markun, S1
Allen, RP; Becker, PM; Chen, C; DuBrava, S; Garcia-Borreguero, D; Knapp, L; Lankford, A; Miceli, J; Patrick, J1
Morel, T; Sun, Y; van Valkenhoef, G1
Cho, YW; Jeon, JY; Lee, HB; Moon, HJ; Song, ML1
Jankovic, J; Wijemanne, S1
Jo, J; Mousa, SA; Sahli, ZT; Tarazi, FI1

Reviews

6 review(s) available for pramipexole and gamma-aminobutyric acid

ArticleYear
Management of restless legs syndrome in patients on dialysis.
    Drugs, 2006, Volume: 66, Issue:5

    Topics: Amines; Anticonvulsants; Benzothiazoles; Clonazepam; Cyclohexanecarboxylic Acids; Dopamine Agents; Gabapentin; gamma-Aminobutyric Acid; Humans; Kidney Failure, Chronic; Levodopa; Narcotics; Pramipexole; Renal Dialysis; Restless Legs Syndrome; Thiazoles; Uremia

2006
Restless legs syndrome: nonpharmacologic and pharmacologic treatments.
    Geriatrics, 2007, Volume: 62, Issue:10

    Topics: Amines; Anemia, Iron-Deficiency; Anticonvulsants; Benzothiazoles; Clonazepam; Cyclohexanecarboxylic Acids; Dopamine Agents; Dopamine Agonists; Ferritins; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Iron; Levodopa; Pramipexole; Restless Legs Syndrome; Trace Elements

2007
ADMET considerations for restless leg syndrome drug treatments.
    Expert opinion on drug metabolism & toxicology, 2012, Volume: 8, Issue:10

    Topics: Amines; Anticonvulsants; Benzothiazoles; Carbamates; Cyclohexanecarboxylic Acids; Dopamine Agents; Dopamine Agonists; Ergolines; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Levodopa; Neuralgia; Pramipexole; Pregabalin; Randomized Controlled Trials as Topic; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome

2012
The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline.
    Sleep, 2012, Aug-01, Volume: 35, Issue:8

    Topics: Academies and Institutes; Benzothiazoles; Cabergoline; Carbamates; Dopamine Agents; Ergolines; Evidence-Based Medicine; gamma-Aminobutyric Acid; Humans; Indoles; Levodopa; Nocturnal Myoclonus Syndrome; Pergolide; Peripheral Nervous System Diseases; Pramipexole; Restless Legs Syndrome; Sleep Medicine Specialty; United States; Venous Insufficiency

2012
Restless legs syndrome: clinical presentation diagnosis and treatment.
    Sleep medicine, 2015, Volume: 16, Issue:6

    Topics: Amines; Analgesics, Opioid; Benzothiazoles; Cyclohexanecarboxylic Acids; Dopamine Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Methadone; Pramipexole; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes

2015
Clinical management of restless legs syndrome in end-stage renal disease patients.
    CNS spectrums, 2017, Volume: 22, Issue:1

    Topics: Amines; Analgesics, Opioid; Benzodiazepines; Benzothiazoles; Comorbidity; Cyclohexanecarboxylic Acids; Dopamine Agonists; Excitatory Amino Acid Antagonists; Exercise Therapy; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Intermittent Pneumatic Compression Devices; Kidney Failure, Chronic; Levodopa; Massage; Pramipexole; Quality of Life; Renal Dialysis; Restless Legs Syndrome; Sleep Hygiene; Tetrahydronaphthalenes; Thiophenes

2017

Trials

4 trial(s) available for pramipexole and gamma-aminobutyric acid

ArticleYear
Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment.
    Psychopharmacology, 2005, Volume: 182, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Antioxidants; Benzothiazoles; Cocaine-Related Disorders; Cyclohexanols; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Nicotine; Pramipexole; Prefrontal Cortex; Protons; Retrospective Studies; Thiazoles; Time Factors; Venlafaxine Hydrochloride

2005
Comparison of pregabalin with pramipexole for restless legs syndrome.
    The New England journal of medicine, 2014, Feb-13, Volume: 370, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzothiazoles; Dopamine Agonists; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pramipexole; Pregabalin; Restless Legs Syndrome; Severity of Illness Index; Suicidal Ideation; Young Adult

2014
[Pramipexol or pregabalin in restless legs? The difference is in the side effects].
    Praxis, 2014, May-21, Volume: 103, Issue:11

    Topics: Benzothiazoles; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Pramipexole; Pregabalin; Restless Legs Syndrome; Treatment Outcome

2014
Pregabalin versus pramipexole: effects on sleep disturbance in restless legs syndrome.
    Sleep, 2014, Apr-01, Volume: 37, Issue:4

    Topics: Adolescent; Adult; Aged; Arousal; Benzothiazoles; Cross-Over Studies; Dopamine Agonists; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Movement; Polysomnography; Pramipexole; Pregabalin; Restless Legs Syndrome; Sleep; Sleep Wake Disorders; Young Adult

2014

Other Studies

6 other study(ies) available for pramipexole and gamma-aminobutyric acid

ArticleYear
[More on therapeutic options in fibromyalgia].
    Medicina clinica, 2006, Jun-10, Volume: 127, Issue:2

    Topics: Analgesics; Benzothiazoles; Dopamine Agonists; Fibromyalgia; gamma-Aminobutyric Acid; Humans; Pramipexole; Pregabalin

2006
Restless legs syndrome as the presenting symptom of multiple myeloma.
    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2013, Apr-15, Volume: 9, Issue:4

    Topics: Aged; Amines; Anemia, Iron-Deficiency; Antiparkinson Agents; Benzothiazoles; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Multiple Myeloma; Polysomnography; Pramipexole; Restless Legs Syndrome

2013
Treatment of pediatric restless legs syndrome.
    Clinical pediatrics, 2014, Volume: 53, Issue:4

    Topics: Adolescent; Amines; Analgesics; Anticonvulsants; Antioxidants; Benzothiazoles; Child; Child, Preschool; Clonidine; Cyclohexanecarboxylic Acids; Dopamine Agonists; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Iron; Male; Melatonin; Mental Disorders; Pediatrics; Polysomnography; Pramipexole; Restless Legs Syndrome; Retrospective Studies; Sleep Wake Disorders; Treatment Outcome

2014
Therapeutic dilemma for restless legs syndrome.
    The New England journal of medicine, 2014, Feb-13, Volume: 370, Issue:7

    Topics: Anticonvulsants; Benzothiazoles; Dopamine Agonists; Female; gamma-Aminobutyric Acid; Humans; Male; Pramipexole; Pregabalin; Restless Legs Syndrome

2014
A mixed treatment comparison of gabapentin enacarbil, pramipexole, ropinirole and rotigotine in moderate-to-severe restless legs syndrome.
    Current medical research and opinion, 2014, Volume: 30, Issue:11

    Topics: Adult; Aged; Bayes Theorem; Benzothiazoles; Carbamates; Dopamine Agonists; Female; gamma-Aminobutyric Acid; Humans; Indoles; Male; Middle Aged; Pramipexole; Restless Legs Syndrome; Tetrahydronaphthalenes; Thiophenes; Treatment Outcome

2014
Augmentation in restless legs syndrome patients in Korea.
    Sleep & breathing = Schlaf & Atmung, 2015, Volume: 19, Issue:2

    Topics: Aged; Aged, 80 and over; Amines; Benzothiazoles; Cross-Sectional Studies; Cyclohexanecarboxylic Acids; Disease Progression; Dopamine Agents; Drug Therapy, Combination; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Humans; Indoles; Korea; Long-Term Care; Male; Middle Aged; Pramipexole; Pregabalin; Restless Legs Syndrome; Risk Factors

2015