poziotinib has been researched along with sinapinic-acid* in 1 studies
1 other study(ies) available for poziotinib and sinapinic-acid
| Article | Year |
|---|---|
Poziotinib and bovine serum albumin binding characterization and influence of quercetin, rutin, naringenin and sinapic acid on their binding interaction.
Serum albumin is the major transporter protein present in systemic circulation and the ability to transport ligands can be influenced in presence of other ligands. This interaction can influence the pharmacodynamic and pharmacokinetic property of certain ligands. Spectroscopic and molecular docking studies were conducted to understand the poziotinib binding interaction to bovine serum albumin (BSA). Further, influence of different flavonoids (quercetin, rutin, naringenin and sinapic acid) on displacing poziotinib from BSA binding sites was also studied. The BSA and poziotinib followed a static quenching mechanism as the Stern-Volmer constant showed decrease (7.6 × 10 Topics: Antineoplastic Agents; Binding Sites; Chemistry, Pharmaceutical; Coumaric Acids; Flavanones; Flavonoids; Hydrogen Bonding; Ligands; Molecular Docking Simulation; Protein Binding; Quercetin; Quinazolines; Rutin; Serum Albumin, Bovine; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Temperature; Thermodynamics | 2020 |